公开(公告)号：CA1118312A

公开(公告)日：1982-02-16

申请号：CA317892

申请日：1978-12-13

Applicant: BAXTER TRAVENOL LAB

Inventor： BECKER LAWRENCE F ,  GAJEWSKI HENRY M

IPC: A61L29/04 ,  A61L29/14 ,  A61M25/00 ,  C08L43/04

Abstract: CATHETER MADE OF A THERMOPLASTIC MATERIAL HAVING IMPROVED SOFTNESS AND LOW FRICTION INVENTORS: Lawrence F. Becker Henry M. Gajewski A catheter, preferably a balloon-type catheter, is disclosed in which the catheter shaft is made of a thermoplastic material and thus may be extrudable, the shaft consisting essentially of (a) from 40 to 70 percent by weight of an elastic composition which comprises: from 50 to 99.5 percent by weight of a block copolymer having thermoplastic rubber characteristics with a central, rubbery polyolefin block and terminal blocks of polystyrene, and optionally including up to about 45 percent by weight of polypropylene, plus from 0.5 to 10 percent by weight of a cross-linked organic silicone elastomer; and (b) from 30 to 60 percent by weight of a hydrophobic oil-type plasticizer to provide the desired degree of softness to said elastic composition.

公开(公告)号：CA1106519A

公开(公告)日：1981-08-04

申请号：CA306735

申请日：1978-07-04

Applicant: BAXTER TRAVENOL LAB

Inventor： GAJEWSKI HENRY M ,  MEASELLS PAUL E ,  LAURIN DEAN G ,  CZUBA LEONARD F

IPC: C08L23/00 ,  A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  C08L7/00 ,  C08L21/00 ,  C08L23/04 ,  C08L23/10 ,  C08L51/00 ,  C08L51/02 ,  C08L53/00 ,  C08L77/00 ,  C08L101/00

Abstract: A clear, autoclavable, blow-moldable plastic formulation for medical and other uses comprises a two, or optionally three, component system including (1) a polyolefin consisting of propylene units as a first component, (2) a block copolymer having thermoplastic rubber characteristics with a central block of ethylenebutylene copolymer and terminal blocks of polystyrene, and (3) an optional third ingredient comprising a softening agent of polyethylene or poly(ethylene-vinyl acetate), which is particularly desirably used if the thermoplastic rubber copolymer has a molecular weight of more than 70,000. The formulation is essentially free of liquid plasticizers.

公开(公告)号：NO793417A

公开(公告)日：1980-04-29

申请号：NO793417

申请日：1979-10-25

Applicant: BAXTER TRAVENOL LAB

Inventor： COLLINS HENRY W ,  MEASELLS PAUL E ,  GAJEWSKI HENRY M ,  MIRIPOL JEFFREY E ,  GEISSLER ULRICH C ,  STITH WILLIAM J ,  GRODE GERALD A ,  WILLIAMS RONALD A

IPC: A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  A61K35/14 ,  A61L33/00 ,  A61M1/36 ,  A61M5/14 ,  C08K5/12 ,  A61M

CPC classification number: A61J1/10 ,  A61L33/0005 ,  A61L33/0052 ,  A61M1/3687 ,  C08K5/12 ,  Y10S128/24 ,  C08L67/02

公开(公告)号：NO792012L

公开(公告)日：1979-12-20

申请号：NO792012

申请日：1979-06-18

Applicant: BAXTER TRAVENOL LAB

Inventor： GAJEWSKI HENRY M ,  LAURIN DEAN G ,  MEASELLS PAUL ,  WEBSTER R DANIEL

IPC: A61J1/00 ,  A61J1/05 ,  B32B27/08 ,  B32B27/28 ,  B32B27/32 ,  B65D65/40 ,  C08L23/02 ,  C09D153/00 ,  B29D

Abstract: A multiple-layered, autoclavable, flexible plastic sheet comprises (a) at least one first layer consisting essentially of 30 to 90 percent by weight of a block copolymer having thermoplastic rubbery characteristics and having rubbery olefin blocks and blocks of a polystyrene; and from 10 to 70 percent by weight of a polyolefin derived principally from at least one of propylene, ethylene and 4-methylpentene-1, said polyolefin having a Vicat Softening Temperature of about 120 DEG C.; and (b) at least one second layer consisting essentially of a polyolefin derived principally by from at least one of propylene, ethylene, and 4-methylpentene-1 and being of semi-crystalline characteristics to exhibit low permeability to water vapor, the first and second layers being bonded together in alternating arrangement.

公开(公告)号：AU573181B2

公开(公告)日：1988-06-02

申请号：AU1880783

申请日：1983-07-21

Applicant: BAXTER TRAVENOL LAB

Inventor： GAJEWSKI HENRY M ,  MEASELLS PAUL

IPC: A61M1/00 ,  A61J1/10 ,  A61L31/14 ,  A61L33/00 ,  A61M1/02 ,  A61M5/14 ,  A61N1/00 ,  C08K5/09 ,  C08L27/06 ,  A61J1/00

Abstract: A method of storing blood components uses a blood component storage container which is made of a plasticized polyvinyl chloride formulation which includes a heat stabilizer system selected from the group consisting of salts of C10 to C26 saturated fatty acids present in an amount of less than about one percent by weight of the composition. Surprisingly, use of only minimal amounts of these higher molecular weight fatty acids results in an effectively heat stabilized product suited for mass production techniques. As a result, the total amount of the heat stabilizer which can possibly leach into blood plasma is significantly reduced. The material from which the container is made preferably includes an effective amount of a plasticizer which is also essentially nonextractable in blood plasma.

公开(公告)号：DE2943179A1

公开(公告)日：1980-05-08

申请号：DE2943179

申请日：1979-10-25

Applicant: BAXTER TRAVENOL LAB

Inventor： COLLINS HENRY W ,  GAJEWSKI HENRY M ,  GEISSLER ULRICH C ,  GRODE GERALD A ,  MEASELLS PAUL E ,  MIRIPOL JEFFREY E ,  STITH WILLIAM J ,  WILLIAMS RONALD A

IPC: A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  A61K35/14 ,  A61L33/00 ,  A61M1/36 ,  A61M5/14 ,  C08K5/12 ,  A61M5/00

Abstract: Blood-compatible, chlorine-free polymers such as a flexible, non-toxic, sterilizable polyester plastic formulation may contain from 5 to 70 percent by weight of a blood-extractable plasticizer such as di-2-ethylhexylphthalate, to cause blood which is stored in contact with the polymer to exhibit a surprisingly low hemolysis rate when compared with corresponding polymers which are free of the plasticizer. Accordingly, blood bags, tubing and other medical blood-contacting devices may be advantageously made from these polymers.

公开(公告)号：AU4731879A

公开(公告)日：1980-01-03

申请号：AU4731879

申请日：1979-05-23

Applicant: BAXTER TRAVENOL LAB

Inventor： GAJEWSKI HENRY M ,  LAURIN DEAN G ,  MEASELLS PAUL ,  WEBSTER R DANIEL

IPC: A61J1/00 ,  A61J1/05 ,  B32B27/08 ,  B32B27/28 ,  B32B27/32 ,  B65D65/40 ,  C08L23/02 ,  C09D153/00 ,  B32B7/02 ,  B32B27/30 ,  B32B1/02 ,  B32B25/14

Abstract: A multiple-layered, autoclavable, flexible plastic sheet comprises (a) at least one first layer consisting essentially of 30 to 90 percent by weight of a block copolymer having thermoplastic rubbery characteristics and having rubbery olefin blocks and blocks of a polystyrene; and from 10 to 70 percent by weight of a polyolefin derived principally from at least one of propylene, ethylene and 4-methylpentene-1, said polyolefin having a Vicat Softening Temperature of about 120 DEG C.; and (b) at least one second layer consisting essentially of a polyolefin derived principally by from at least one of propylene, ethylene, and 4-methylpentene-1 and being of semi-crystalline characteristics to exhibit low permeability to water vapor, the first and second layers being bonded together in alternating arrangement.

公开(公告)号：IT7926788D0

公开(公告)日：1979-10-25

申请号：IT2678879

申请日：1979-10-25

Applicant: BAXTER TRAVENOL LAB

Inventor： HENRY COLLINS W ,  GAJEWSKI HENRY M ,  GEISSLER ULRICH C ,  GRODE GERALD A ,  MEASELLS PAUL E ,  MIRIPOL JEFFREY E ,  WILLIAM STITH J ,  WILLIAMS RONALD A

IPC: A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  A61K35/14 ,  A61L33/00 ,  A61M1/36 ,  A61M5/14 ,  C08K5/12 ,  C08L

Abstract: Blood-compatible, chlorine-free polymers such as a flexible, non-toxic, sterilizable polyester plastic formulation may contain from 5 to 70 percent by weight of a blood-extractable plasticizer such as di-2-ethylhexylphthalate, to cause blood which is stored in contact with the polymer to exhibit a surprisingly low hemolysis rate when compared with corresponding polymers which are free of the plasticizer. Accordingly, blood bags, tubing and other medical blood-contacting devices may be advantageously made from these polymers.

公开(公告)号：IT7922961V0

公开(公告)日：1979-10-25

申请号：IT2296179

申请日：1979-10-25

Applicant: BAXTER TRAVENOL LAB

Inventor： COLLINS HENRY W ,  GAJEWSKI HENRY M ,  GEISSLER ULRICH C ,  GRODE GERALD A

IPC: A61J1/10 ,  A61J1/00 ,  A61J1/05 ,  A61L29/00 ,  A61L31/00 ,  A61M1/36 ,  A61M5/00 ,  C08K5/12

Abstract: A blood bag or other container which is made of a flexible, hemocompatible, sterilizable plastic material free of blood-extractable plasticizer. The blood bag contains an insert member which comprises a non-toxic, sterilizable plastic formulation which contains from 5 to 70 percent by weight of a blood-extractable plasticizer selected from the group consisting of the dioctylphthalates and dioctyladipates. Such a blood bag is capable of reducing the plasma hemoglobin in stored blood, when compared with similar blood bags without the insert member.

公开(公告)号：NO782549L

公开(公告)日：1979-01-30

申请号：NO782549

申请日：1978-07-25

Applicant: BAXTER TRAVENOL LAB

Inventor： GAJEWSKI HENRY M ,  LAURIN DEAN G ,  MEASELLS PAUL E ,  CZUBA LEONARD F

IPC: C08L23/00 ,  A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  C08L7/00 ,  C08L21/00 ,  C08L23/04 ,  C08L23/10 ,  C08L51/00 ,  C08L51/02 ,  C08L53/00 ,  C08L77/00 ,  C08L101/00 ,  C08L

Abstract: A clear, autoclavable, blow-moldable plastic formulation for medical and other uses comprises a two, or optionally three, component system including (1) a polyolefin consisting of propylene units as a first component, (2) a block copolymer having thermoplastic rubber characteristics with a central block of ethylenebutylene copolymer and terminal blocks of polystyrene, and (3) an optional third ingredient comprising a softening agent of polyethylene or poly(ethylene-vinyl acetate), which is particularly desirably used if the thermoplastic rubber copolymer has a molecular weight of more than 70,000. The formulation is essentially free of liquid plasticizers.