公开(公告)号：EP2577296A4

公开(公告)日：2015-07-15

申请号：EP11787514

申请日：2011-05-27

Applicant: CALIFORNIA INST OF TECHN

Inventor： TAI YU-CHONG ,  LU BO

IPC: G01N33/48 ,  B01D65/10 ,  C40B30/04 ,  G01N33/15 ,  G01N33/50 ,  G01N33/574

CPC classification number: G01N33/5011 ,  B01D65/10

Abstract: The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of “key engineering design parameters” that are crucial to achieve high tumor cell viability. These important design parameters include the filter geometry design, fluid delivery method, drive pressure and filtration time.

Abstract translation: 本发明提供了用于设计用于捕获活肿瘤细胞的过滤系统的方法，例如以高效率和高生存力循环肿瘤细胞。 该方法涉及开发一组对实现高肿瘤细胞活力至关重要的“关键工程设计参数”。 这些重要的设计参数包括过滤器几何设计，流体输送方法，驱动压力和过滤时间。

公开(公告)号：EP2661307A4

公开(公告)日：2014-08-06

申请号：EP12732280

申请日：2012-01-03

Applicant: UNIV CALIFORNIA ,  CALIFORNIA INST OF TECHN ,  UNIV LOUISVILLE RES FOUND

Inventor： GERASIMENKO YURY ,  BURDICK JOEL ,  HODES JONATHAN ,  TAI YU-CHONG ,  ANGELI CLAUDIA A ,  EDGERTON VICTOR REGGIE ,  ROY ROLAND R ,  DESAUTELS THOMAS ANTHONY ,  HARKEMA SUSAN J ,  NANDRA MANDHEEREJ S

IPC: A61N1/36 ,  A61H1/00 ,  A61N1/04 ,  A61N1/05

CPC classification number: A61N1/36103 ,  A61H1/0237 ,  A61H1/0274 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/0556 ,  A61N1/36003 ,  A61N1/36153 ,  A63B21/00181 ,  A63B22/0235 ,  A63B69/0064 ,  A63B2213/004 ,  A63B2220/805 ,  A63B2230/60 ,  F04C2270/0421

公开(公告)号：EP2593117A4

公开(公告)日：2014-01-15

申请号：EP11807411

申请日：2011-07-12

Applicant: UNIV SOUTHERN CALIFORNIA ,  CALIFORNIA INST OF TECHN ,  UNIV CALIFORNIA AT SANTA BARBARA

Inventor： HUMAYUN MARK ,  AHUJA ASHISH ,  TAI YU-CHONG ,  HINTON DAVID ,  GRUBBS ROBERT ,  CLEGG DENNIS ,  JOHNSON LINCOLN VALLANCE ,  HIKITA SHERRY T

IPC: A61K35/54 ,  A61F2/14 ,  A61K35/44 ,  A61L27/38 ,  B32B3/00

CPC classification number: A61L27/18 ,  A61K9/0051 ,  A61K35/30 ,  A61K35/545 ,  A61K47/34 ,  A61L27/3813 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/00 ,  A61L2430/16 ,  Y10T428/24479

Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

Abstract translation: 在本发明公开了基材细胞递送到靶组织需要治疗各种疾病并诱导细胞死亡，损伤或功能丧失。 基板被配置为提供接种的细胞，包括干细胞，具有结构支撑确实允许与互连和细胞和靶组织之间的生物信号的传输。

公开(公告)号：EP1603672A4

公开(公告)日：2007-05-23

申请号：EP04757825

申请日：2004-03-17

Applicant: CALIFORNIA INST OF TECHN

Inventor： XIE JUN ,  SHIH JASON ,  TAI YU-CHONG

IPC: G01N27/22 ,  B01L1/00 ,  G01N27/447

CPC classification number: G01N27/226 ,  B81B7/02 ,  B81B2201/0292 ,  B81B2201/058 ,  G01L9/0042 ,  G01L9/0072

Abstract: A microfluidic device and method for capacitive sensing. The device includes a fluid channel including an inlet at a first end and an outlet at a second end, a cavity region coupled to the fluid channel, and a polymer based membrane coupled between the fluid channel and the cavity region. Additionally, the device includes a first capacitor electrode coupled to the membrane, a second capacitor electrode coupled to the cavity region and physically separated from the first capacitor electrode by at least the cavity region, and an electrical power source coupled between the first capacitor electrode and the second capacitor electrode and causing an electric field at least within the cavity region. The polymer based membrane includes a polymer.

公开(公告)号：EP3046510A4

公开(公告)日：2017-06-07

申请号：EP14846564

申请日：2014-09-12

Applicant: CALIFORNIA INST OF TECHN

Inventor： TAI YU-CHONG ,  CHANG HAN-CHIEH

IPC: A61F2/14 ,  A61N1/05 ,  A61N1/36 ,  H05K1/18

CPC classification number: H05K1/189 ,  A61N1/0543 ,  A61N1/36046 ,  H05K3/064 ,  H05K2201/0154 ,  H05K2201/052 ,  H05K2201/1003 ,  H05K2201/10151

Abstract: A biocompatible, micro-fabricated ribbon cable is described in which at least one set of conductors diverges laterally into a bypass wing that forms an aperture through the ribbon cable. The bypass wing is folded in a line through the aperture and over a central portion of the ribbon cable, resulting in a ribbon cable with a narrow, stacked region. The narrow region can fit through small incisions in membranes, such as through an incision in a sclera of an eyeball. The ribbon cable can have an integrally-formed electrode array for attaching to a retina of an eyeball and other electronics for sending signals to the electrode array.

Abstract translation: 描述了一种生物相容的，微制造的带状电缆，其中至少一组导体横向分叉成旁路翼，该旁路翼形成穿过带状电缆的孔。 旁路机翼通过孔折叠并穿过带状电缆的中心部分，从而形成具有狭窄堆叠区域的带状电缆。 狭窄的区域可以穿过膜的小切口，例如通过眼球巩膜的切口。 带状电缆可以具有用于连接到眼球的视网膜的整体形成的电极阵列和用于将信号发送到电极阵列的其他电子器件。

公开(公告)号：EP2713951A4

公开(公告)日：2015-04-22

申请号：EP12790087

申请日：2012-01-13

Applicant: CALIFORNIA INST OF TECHN ,  UNIV SOUTHERN CALIFORNIA

Inventor： DEBOER CHARLES ,  TAI YU-CHONG ,  HUMAYUN MARK

IPC: A61F2/16 ,  A61L27/14 ,  C08L101/16

CPC classification number: A61F2/1635 ,  A61F2/1613 ,  A61F9/007 ,  A61F2250/0003 ,  A61L27/48 ,  A61L2430/16 ,  C08G2261/3424 ,  C08L65/04

Abstract: Systems, devices, and methods are presented for a prosthetic injectable intraocular lens. One or more silicone elastomeric patches located outside the optical path on the anterior side but away from the equator can be accessed by surgical needles in order to fill or adjust optically clear fluid within the lens. The fluid can be adjusted in order to set a base dioptric power of the lens and otherwise adjust a lens after its initial insertion. The elastomeric patches are sized so that they self-seal after a needle is withdrawn. A straight or stepped slit in the patch can allow a blunt needle to more easily access the interior of the lens.

公开(公告)号：EP2665514A4

公开(公告)日：2014-06-18

申请号：EP12736491

申请日：2012-01-23

Applicant: CALIFORNIA INST OF TECHN ,  UNIV LOUISVILLE RES FOUND ,  UNIV CALIFORNIA

Inventor： TAI YU-CHONG ,  NANDRA MANDHEEREJ S ,  RODGER DAMIEN CRAIG ,  FONG ANDY ,  LAVROV IGOR ,  ANGELI CLAUDIA A ,  BURDICK JOEL ,  HARKEMA SUSAN J ,  EDGERTON VICTOR REGGIE ,  ROY ROLAND R ,  GERASIMENKO YURY

IPC: A61N1/05 ,  A61B18/00 ,  A61N1/18 ,  A61N1/36

CPC classification number: A61N1/0551 ,  A61N1/0553 ,  A61N1/0558

公开(公告)号：EP1888238A4

公开(公告)日：2009-12-30

申请号：EP06751274

申请日：2006-04-21

Applicant: CALIFORNIA INST OF TECHN ,  UNIV SOUTHERN CALIFORNIA

Inventor： TAI YU-CHONG ,  ZHENG SIYANG ,  LIN HENRY ,  DATAR RAM ,  COTE RICHARD

IPC: B01L3/00 ,  G01N33/483

CPC classification number: B01D67/0034 ,  B01D61/14 ,  B01D61/18 ,  B01D61/20 ,  B01D67/0088 ,  B01D69/02 ,  B01D71/022 ,  B01D71/72 ,  B01D2325/021 ,  B01L3/5635 ,  B01L2300/0681 ,  B01L2400/0415 ,  B01L2400/0487 ,  C12M47/04 ,  C12N1/02

公开(公告)号：EP1879645A4

公开(公告)日：2009-11-04

申请号：EP06751676

申请日：2006-04-28

Applicant: CALIFORNIA INST OF TECHN ,  UNIV SOUTHERN CALIFORNIA

Inventor： TAI YU-CHONG ,  RODGER DAMIEN C ,  LI WEN ,  HUMAYUN MARK ,  WEILAND JAMES D ,  AMERI HOSSEIN

IPC: A61F2/14 ,  A61F9/08 ,  A61N1/28 ,  A61N1/36

CPC classification number: A61N1/0543 ,  A61F9/08 ,  A61N1/36046 ,  Y10T29/49002 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49156 ,  Y10T29/49224

公开(公告)号：EP1166340A4

公开(公告)日：2009-04-22

申请号：EP99965842

申请日：1999-11-18

Applicant: CALIFORNIA INST OF TECHN

Inventor： TAI YU-CHONG ,  WANG XUAN-QI ,  DESAI AMISH ,  LEE TERRY D ,  LICKLIDER LAWRENCE

IPC: G01N30/72 ,  B01D59/44 ,  G01N30/60 ,  H01J49/04 ,  H01L21/302

CPC classification number: H01J49/167 ,  G01N30/6095 ,  G01N30/7266 ,  H01J49/0018

Abstract: A MEMS device with an overhanging "polymer" capillary (20) provides vital and significant improvements in interfacing a MEMS electrospray nozzle (50) to an MS inlet or other macroscopic instrumentation. The fabrication methodology associated therewith is easily expanded to include built-in micro particle filters (71) and centimeter long serpentine micro channels (75) provided on-chip (19) and fabricated using a low temperature process.