公开(公告)号：US20150276089A1

公开(公告)日：2015-10-01

申请号：US14188664

申请日：2014-02-24

Applicant: California Institute of Technology

Inventor： Marc Alexander Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake ,  Markus Enzelberger ,  Mark L. Adams ,  Carl L. Hansen

IPC: F16K99/00

CPC classification number: B05D3/04 ,  B01J2219/00355 ,  B01J2219/00378 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00439 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/54 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2300/18 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/06 ,  B01L2400/0655 ,  B01L2400/0688 ,  B32B2037/1081 ,  B65B31/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  C12Q1/6832 ,  C12Q1/6874 ,  C30B29/54 ,  F04B43/043 ,  F15C1/06 ,  F15C3/00 ,  F15C5/00 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T137/0324 ,  Y10T137/0379 ,  Y10T137/0424 ,  Y10T137/206 ,  Y10T137/2082 ,  Y10T137/2164 ,  Y10T137/2169 ,  Y10T137/2174 ,  Y10T137/2202 ,  Y10T137/2224 ,  Y10T137/3084 ,  Y10T137/7837 ,  Y10T137/86027 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24612 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：US08841712B2

公开(公告)日：2014-09-23

申请号：US13852480

申请日：2013-03-28

Applicant: California Institute of Technology

Inventor： Aditya Rajagopal ,  Axel Scherer ,  Michael D. Henry ,  Sameer Walavalkar ,  Thomas A. Tombrello ,  Andrew P. Homyk

IPC: H01L29/76 ,  G01N27/327 ,  H01L29/66 ,  H01L29/78

CPC classification number: C12Q1/02 ,  A61B5/04001 ,  G01N27/3275 ,  G01N27/4146 ,  G01R1/06711 ,  G01R1/07342 ,  H01L29/413 ,  H01L29/42376 ,  H01L29/4966 ,  H01L29/66477 ,  H01L29/78 ,  H01L29/7831

Abstract: A field effect nano-pillar transistor has a pillar shaped gate element incorporating a biomimitec portion that provides various advantages over prior art devices. The small size of the nano-pillar transistor allows for advantageous insertion into cellular membranes, and the biomimitec character of the gate element operates as an advantageous interface for sensing small amplitude voltages such as transmembrane cell potentials. The nano-pillar transistor can be used in various embodiments to stimulate cells, to measure cell response, or to perform a combination of both actions.

Abstract translation: 场效应纳米柱晶体管具有结合有生物医学部分的柱形门元件，其提供了优于现有技术器件的各种优点。 纳米柱晶体管的小尺寸允许有利地插入到细胞膜中，并且栅极元件的生物学特性作为用于感测小幅度电压（例如跨膜电池电位）的有利接口。 纳米柱晶体管可用于各种实施例中以刺激细胞，测量细胞反应或执行两种动作的组合。

公开(公告)号：US20140134078A1

公开(公告)日：2014-05-15

申请号：US14069697

申请日：2013-11-01

Applicant: California Institute of Technology

Inventor： Samuel Njoroge ,  George Maltezos ,  Axel Scherer ,  John B. Gorman

IPC: C12N15/10

CPC classification number: C12N15/101 ,  B01D15/22

Abstract: An apparatus for purifying nucleic acid can include a disposable cartridge having a layered configuration, and a disposable syringe for coupling to the disposable cartridge such that a fluid can be delivered to or withdrawn fluid from the disposable cartridge using the syringe. At least one layer of the disposable cartridge can include a cut-out for forming a functional unit of the disposable cartridge, and at least one layer of the disposable cartridge can be joined to an adjacent layer of the disposable cartridge by an adhesive material layer. The functional unit can include a fluid channel between an access port on the first surface of the disposable cartridge and the fluid pouch. The apparatus can include a disposable silica-containing material for binding with the nucleic acid. The apparatus can include a heating element and a temperature sensor for heating the disposable silica-containing material.

Abstract translation: 用于纯化核酸的装置可以包括具有分层构造的一次性盒，以及用于连接到一次性盒的一次性注射器，使得可以使用注射器将流体从一次性盒输送到或从其中抽出流体。 一次性盒的至少一层可以包括用于形成一次性盒的功能单元的切口，并且一次性盒的至少一层可以通过粘合材料层连接到一次性盒的相邻层。 功能单元可以包括在一次性盒的第一表面上的进入端口和流体袋之间的流体通道。 该装置可以包括用于与核酸结合的一次性含二氧化硅的材料。 该装置可以包括用于加热一次性二氧化硅的材料的加热元件和温度传感器。

公开(公告)号：US20130207639A1

公开(公告)日：2013-08-15

申请号：US13764612

申请日：2013-02-11

Applicant: California Institute of Technology

Inventor： Aditya Rajagopal ,  Chieh-Feng Chang ,  Akram Sarwat Sadek ,  Axel Scherer ,  Raymond Jimenez

IPC: G01R19/00

CPC classification number: G01R19/00 ,  A61B5/0031 ,  A61B5/04001 ,  A61B2560/0214 ,  A61B2562/0209 ,  A61B2562/0233 ,  A61B2562/164 ,  A61B2562/166 ,  A61B2562/223

Abstract: A voltage sensing apparatus on a semiconductor substrate, including one or more inputs comprising metal contacts, an output comprising a laser transmitter, circuitry electrically connecting and interfacing the inputs to the output; and a power module. A method of fabricating the apparatus is also described.

Abstract translation: 一种半导体衬底上的电压感测装置，包括一个或多个包括金属触点的输入端，包括激光发射器的输出端，将输入电连接到输出端的电路; 和电源模块。 还描述了制造该装置的方法。

公开(公告)号：US12144620B2

公开(公告)日：2024-11-19

申请号：US17489610

申请日：2021-09-29

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Axel Scherer ,  Meisam Honarvar Nazari ,  Muhammad Mujeeb-U-Rahman ,  Mehmet Sencan ,  Arti Gaur

IPC: A61B5/1473 ,  A61B5/00 ,  A61B5/07 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1486 ,  A61B17/34 ,  A61M5/142 ,  A61M5/172

Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.

公开(公告)号：US11904045B2

公开(公告)日：2024-02-20

申请号：US17321296

申请日：2021-05-14

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson Chen ,  Axel Scherer ,  Richard Daniel Smith, Jr.

IPC: A61B5/00 ,  A61K9/00 ,  A61B5/145 ,  A61J1/14

CPC classification number: A61K9/0009 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/686 ,  A61J1/1412 ,  A61J1/1468 ,  A61K9/0024 ,  A61K9/0097

Abstract: An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.

公开(公告)号：US11666216B2

公开(公告)日：2023-06-06

申请号：US15987843

申请日：2018-05-23

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel Scherer ,  Peter A Petillo ,  Samson Chen ,  Azita Emami

IPC: A61B5/00 ,  A01K1/03 ,  A01K11/00 ,  A01K29/00 ,  A61B5/11 ,  H04B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/01

CPC classification number: A61B5/002 ,  A01K1/031 ,  A01K11/006 ,  A01K29/00 ,  A61B5/1113 ,  H04B5/0075 ,  A61B5/01 ,  A61B5/1486 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/6832 ,  A61B5/6868 ,  A61B2503/40 ,  A61B2503/42

Abstract: A smart cage includes radiofrequency transceivers and tags attached to laboratory animals. The tags include sensors to detect monitorable conditions of the laboratory animals. The sensors include working electrodes, counter electrodes, reference electrodes, and potentiostats. The top surface of the electrodes is coated with ionophores or enzymes which detect the monitorable conditions of the laboratory animals.

公开(公告)号：US11060511B1

公开(公告)日：2021-07-13

申请号：US16442092

申请日：2019-06-14

Applicant: California Institute of Technology ,  The Government of the United States of America, as represented by the Secretary of the Navy

Inventor： Emil P. Kartalov ,  Axel Scherer

IPC: H02N1/00 ,  H02N1/06 ,  A61F2/08 ,  A61F2/70 ,  F03G7/06 ,  A61H3/00 ,  A61H1/02 ,  B25J9/10 ,  A61F2/48

Abstract: Artificial muscles comprising a body of dielectric elastomer, wherein the body contains a pair of microfluidic networks are presented. Each microfluidic network includes a plurality of channels fluidically coupled via a manifold. The channels of the microfluidic networks are interdigitated and filled with conductive fluid such that each set of adjacent channels functions as the electrodes of an electroactive polymer (EAP) actuator. By using the manifolds as compliant wiring to energize the electrodes, artificial muscles in accordance with the present disclosure mitigate some or all of the reliability problems associated with prior-art artificial muscles.

公开(公告)号：US11009658B2

公开(公告)日：2021-05-18

申请号：US16803938

申请日：2020-02-27

Applicant: California Institute of Technology

Inventor： William M. Jones ,  Lucia B. De Rose ,  Axel Scherer

IPC: G02B6/122 ,  H01L31/0232 ,  G01J1/04

Abstract: Light detectors that combine field emission with light focusing by surface plasmon polaritons. Methods and devices that allow detection and measurement of light at high frequencies in the THz range are described. The disclosed devices include plasmonic metal contacts with a narrow nanometer-sized gap to couple an optical waveguide mode into a plasmonic mode thereby generating filed emission currents by biasing the contacts.

公开(公告)号：US20210140817A1

公开(公告)日：2021-05-13

申请号：US17093211

申请日：2020-11-09

Applicant: California Institute of Technology

Inventor： Axel Scherer ,  Taeyoon Jeon ,  Jieun Myung

IPC: G01J3/12 ,  G01J3/10

Abstract: An infrared spectrometer for operation in the mid-infrared spectral range is disclosed, where the spectrometer includes a Bragg-mirror-based spectral filter that is operative for providing an output optical signal whose spectral content is spatially dispersed along a first direction, where the Bragg mirrors include low-refractive-index layers comprising a polymer material that is transmissive across the mid-infrared spectral range and is characterized by less than ten absorption peaks with the operating spectral range of the spectrometer.