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    METHOD AND APPARATUS FOR VARIABLE-FIELD ILLUMINATION
    21.
    发明申请
    METHOD AND APPARATUS FOR VARIABLE-FIELD ILLUMINATION 审中-公开
    用于可变场照明的方法和装置

    公开(公告)号：WO2006083715A3

    公开(公告)日：2007-05-10

    申请号：PCT/US2006002975

    申请日：2006-01-30

    Applicant: CHEMIMAGE CORP ,  VOIGHT THOMAS ,  ZHANG JINGYUN ,  TREADO PATRICK J ,  TUSCHEL DAVID

    Inventor： VOIGHT THOMAS ,  ZHANG JINGYUN ,  TREADO PATRICK J ,  TUSCHEL DAVID

    IPC: G01J3/44

    CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0224 ,  G01N21/65

    Abstract: The disclosure relates to identifying one or more regions (100) of interest within a broader field of view (104) of a dynamic sample using one or more optical components (110 & 120) and illuminating photons. Once the region of interest (100) is identified within a section of the broader field of view (104), chemical information in the form of Raman spectrum is obtained from the region of interes (100) by focusing the illuminating photons of the optical components (110 & 120) on the region of interest (100).

    Abstract translation: 本公开涉及使用一个或多个光学部件（110和120）和照射光子来识别动态样品的更宽视场（104）内的感兴趣的一个或多个区域（100）。 一旦在较宽视场（104）的一部分内识别出感兴趣区域（100），则通过聚焦光学部件的照明光子，从内部区域（100）获得呈拉曼光谱形式的化学信息 （100）上的（110和120）。

    METHOD AND APPLICATIONS TO ENHANCE AND IMAGE OPTICAL SIGNALS FROM BIOLOGICAL OBJECTS
    22.
    发明申请
    METHOD AND APPLICATIONS TO ENHANCE AND IMAGE OPTICAL SIGNALS FROM BIOLOGICAL OBJECTS 审中-公开
    从生物学对象增强和图像光学信号的方法和应用

    公开(公告)号：WO2006113537A2

    公开(公告)日：2006-10-26

    申请号：PCT/US2006014252

    申请日：2006-04-14

    Applicant: CHEMIMAGE CORP ,  DEMUTH JOSEPH ,  TUSCHEL DAVID ,  MAIER JOHN S ,  TREADO PATRICK J

    Inventor： DEMUTH JOSEPH ,  TUSCHEL DAVID ,  MAIER JOHN S ,  TREADO PATRICK J

    IPC: G01J3/44 ,  G01N21/65

    CPC classification number: G01J3/44 ,  G01J3/32 ,  G01N21/658

    Abstract: A method and apparatus for imaging biological objects. A SERS surface is provided having enhancing structures uniformly distributed on the surface. The surface includes a two dimensional area of at least 5 x 105 nm. The enhancing structures may have a size, in at least one dimension of height, width and length, ranging from 100 nm to 1000 nm. A biological material is deposited on the SERS surface. The biological material on the SERS surface is illuminated using a monochromatic light source producing Raman scattered photons. The Raman scattered photons are filtered using a tunable filter into a plurality of predetermined wavelength bands. A two-dimensional array detector detects the filtered Raman scattered photons, in a spatially accurate manner. The results of filtering and detecting steps are combined to produce a plurality of spectrally resolved Raman images of the biological material.

    Abstract translation: 一种用于成像生物体的方法和装置。 提供了具有均匀分布在表面上的增强结构的SERS表面。 该表面包括至少5×105nm的二维区域。 增强结构可以在100nm至1000nm范围内的高度，宽度和长度的至少一个尺寸中具有尺寸。 生物材料沉积在SERS表面上。 使用产生拉曼散射光子的单色光源照射SERS表面上的生物材料。 使用可调滤波器将拉曼散射光子滤波成多个预定波长带。 二维阵列检测器以空间准确的方式检测经过滤波的拉曼散射光子。 滤波和检测步骤的结果被组合以产生生物材料的多个光谱分辨的拉曼图像。

    METHOD AND APPARATUS FOR INTERACTIVE HYPERSPECTRAL IMAGE SUBTRACTION
    23.
    发明申请
    METHOD AND APPARATUS FOR INTERACTIVE HYPERSPECTRAL IMAGE SUBTRACTION 审中-公开
    交互式高分辨图像处理方法与装置

    公开(公告)号：WO2006107309A2

    公开(公告)日：2006-10-12

    申请号：PCT/US2005014448

    申请日：2005-04-28

    Applicant: CHEMIMAGE CORP ,  BANGALORE ARJUN S ,  TUSCHEL DAVID

    Inventor： BANGALORE ARJUN S ,  TUSCHEL DAVID

    IPC: H01L27/00 ,  G01J3/44 ,  G01N21/65

    CPC classification number: G01J3/44 ,  G01J3/2823 ,  G01N21/65

    Abstract: The disclosure relates to method and apparatus for interactive hyperspectral image subtraction. In one embodiment, the disclosure relates to a method for obtaining a spectral image of a first specie from a frame of a plurality of pixels defining a composition ~f the first specie with a second specie. The method may include (i) identifying, for each of the first and second species, an appropriate Raman wavelength; (ii) defining at least owe background wavelength for the frame; (iii) identifying pixels defied oily by background wavelength; (iv) identifying pixels defined only by the first specie or the second specie; (v) identifying the remaining pixels, the remaining pixels defined by at least a combination of the first and second species; and (vi) forming a spectral image for the first specie.

    Abstract translation: 本公开涉及用于交互式高光谱图像减法的方法和装置。 在一个实施例中，本公开涉及一种用于从定义第一特定物体的组合的多个像素的帧中获得第一物体的光谱图像的方法。 该方法可以包括（i）为第一和第二种类中的每一种识别适当的拉曼波长; （ii）为帧定义至少欠背景波长; （iii）通过背景波长识别油性反射的像素; （iv）识别仅由第一物种或第二物种定义的像素; （v）识别剩余像素，由至少第一和第二种类的组合限定的剩余像素; 和（vi）形成第一种物质的光谱图像。

    SYSTEM AND METHOD FOR CHEMICAL IMAGING OF MICROARRAYS
    25.
    发明公开
    SYSTEM AND METHOD FOR CHEMICAL IMAGING OF MICROARRAYS 审中-公开
    系统和方法微阵列的化学成像

    公开(公告)号：EP1866613A4

    公开(公告)日：2009-06-03

    申请号：EP05735084

    申请日：2005-04-08

    Applicant: CHEMIMAGE CORP

    Inventor： TUSCHEL DAVID ,  VOIGT THOMAS C

    IPC: G01J3/00 ,  G01J3/12 ,  G01J3/44

    CPC classification number: G01J3/42 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/253 ,  G01N21/6452 ,  G01N21/65

    Abstract: The disclosure relates to systems and method for chemical imaging of microarrays. In one embodiment, the disclosure relates to a system for simultaneous spectral imaging of a plurality of samples arranged on an array (300). The system includes an illumination source (310) for providing illuminating photons to said plurality of samples, the illuminating photons interacting with each of the plurality of samples to emit interacted photons; an array (300) for receiving said plurality of samples, the array (300) having an external dimension such that the samples are within a simultaneous field of view of the optical device (320); an optical device (320) for collecting the interacted photons and directing the photons to an imaging device (350), the imaging device (350) simultaneously forming a plurality of images corresponding to each of the plurality of samples.

    METHOD AND APPARATUS FOR DARK FIELD CHEMICAL IMAGING
    27.
    发明公开
    METHOD AND APPARATUS FOR DARK FIELD CHEMICAL IMAGING 审中-公开
    方法和装置化工暗场成像

    公开(公告)号：EP1766348A4

    公开(公告)日：2008-04-30

    申请号：EP05761059

    申请日：2005-05-06

    Applicant: CHEMIMAGE CORP

    Inventor： TUSCHEL DAVID ,  HUTCHISON WESLEY H ,  BERKMAN MYLES P

    IPC: G01J3/30 ,  G01J3/28 ,  G01J3/44

    CPC classification number: G01N21/65 ,  G01J3/0227

    Abstract: The disclosure is generally directed to a method and apparatus for providing an image of a sample. The apparatus includes an illuminating source for transmitting photons to a sample. The transmitted photons illuminate the sample or are scattered upon reaching the sample. A lens collects the scattered photons and transmits the scattered photons to a tunable filter for forming an image. The illuminating photons traveling from the illuminating source to the sample do not pass through the lens.

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