公开(公告)号：US3686486A

公开(公告)日：1972-08-22

申请号：US3686486D

申请日：1970-12-02

Applicant: COULTER ELECTRONICS

Inventor： COULTER WALLACE H ,  HOGG WALTER R

IPC: G01N15/12 ,  G06G7/75 ,  G06G7/12 ,  G01N27/00

CPC classification number: G01N15/1227 ,  G06G7/75

Abstract: Apparatus which receives a train of electrical pulses from a particle analyzing device such as one which is operated in accordance with the Coulter principle, derives statistical hematological indices from such train of pulses, stores the same in suitable storage means, receives a second train of pulses and derives the same indices from the second train of pulses, and compares the two indices. A readout device provides the comparison information. In this manner indices from normal blood may be obtained and thereafter the same indices from unknown blood may be obtained and compared with the normal indices for diagnosis of pathology.

Abstract translation: 从诸如根据库尔特原理操作的粒子分析装置接收来自这种脉冲串的统计血液指标的粒子分析装置的电脉冲序列的装置将其存储在合适的存储装置中，接收第二脉冲串 并从第二列脉冲得出相同的指标，并比较两个指标。 读出装置提供比较信息。 以这种方式，可以获得来自正常血液的指数，然后可以获得来自未知血液的相同指数，并与正常的病理指标进行比较。

公开(公告)号：US3668531A

公开(公告)日：1972-06-06

申请号：US3668531D

申请日：1970-06-15

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R

IPC: G01N15/12 ,  H03K5/1532 ,  H03K17/00

CPC classification number: G01N15/1227 ,  H03K5/1532

Abstract: Apparatus finding the amplitude of a pulse at its center by comparing the pulse with its integral, adjusted to pass through the amplitude of the pulse at its time center, and passing to coincident gating means a signal having the pulse center amplitude at that time and a signal of fixed duration initiated at the finding of the pulse center. Also, a particle analyzing a system intercoupling the amplitude finding apparatus between a pulse generating transducer of liquid suspended particles and pulse classification structure.

Abstract translation: 设备通过将脉冲与其积分进行比较来测量其中心处的脉冲幅度，经调整以在其时间中心通过脉冲的幅度，并且通过重合的门控装置是指在该时间具有脉冲中心幅度的信号，以及 在脉搏中心发现时启动固定持续时间的信号。 另外，分析在液体悬浮粒子的脉冲发生换能器与脉冲分类结构之间相互耦合振幅发现装置的系统的粒子。

公开(公告)号：US3295059A

公开(公告)日：1966-12-27

申请号：US46740665

申请日：1965-06-28

Applicant: COULTER ELECTRONICS

Inventor： COULTER WALLACE H ,  HOGG WALTER R ,  MORAN JOSEPH P ,  CLAPS WILLIAM A

IPC: G01N15/12 ,  H03K21/02

CPC classification number: G01N15/1227 ,  G01N2015/1263 ,  H03K21/02

公开(公告)号：US3259842A

公开(公告)日：1966-07-05

申请号：US83486059

申请日：1959-08-19

Applicant: COULTER ELECTRONICS

Inventor： COULTER WALLACE H ,  HOGG WALTER R ,  MORAN JOSEPH P ,  CLAPS WILLIAM A

IPC: G01N15/12

CPC classification number: G01N15/1227 ,  G01N2015/1263

公开(公告)号：US3893766A

公开(公告)日：1975-07-08

申请号：US36991073

申请日：1973-06-14

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R

IPC: G01N15/14 ,  G01N21/26

CPC classification number: G01N15/1404

Abstract: A flow chamber which is particularly useful in slit-scan photometry and which has a predetermined configuration for orienting generally flat oval particles such as squamous cells in the direction of fluid flow such that the maximum cross-sectional area of each particle is substantially normal to a light path traversing the flow of particles at an observing station situated along the flow path of the particles.

Abstract translation: 一种流动腔室，其特别适用于狭缝扫描测光学，并且具有预定的构造，用于在流体流动方向上定向大致扁平的椭圆形颗粒如鳞状细胞，使得每个颗粒的最大横截面面积基本上垂直于 沿着沿着颗粒流动路径的观测站的颗粒流动的光路。

公开(公告)号：US3890569A

公开(公告)日：1975-06-17

申请号：US47312774

申请日：1974-05-24

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R

IPC: G01N15/12 ,  G01N27/00

CPC classification number: G01N15/12

Abstract: A particle study device wherein a non-diluted specific minute amount of fluid sample containing particles is ejected by an ejecting mechanism into a flow stream leading to a sensing zone in the particle study device. The ejecting mechanism includes a hollow body having a thermal expansion device mounted therein and a power supply circuit which supplies a predetermined amount of electrical energy to the thermal expansion device to raise the temperature of same a predetermined amount and cause the same to expand thereby to eject from the hollow body a specific amount of fluid sample having a volume displacement equal to the volume increase of the thermal expansion device. Preferably the hollow body is part of a syringe including a plunger. The syringe facilitates the picking up of fluid sample of which only a minute specific portion is ejected toward the sensing zone of the particle study device.

Abstract translation: 一种颗粒研究装置，其中将未稀释的特定微量的含有颗粒的流体样品通过喷射机构喷射到通向颗粒研究装置中的感测区域的流动流中。 排出机构包括：具有安装在其中的热膨胀装置的中空体和向热膨胀装置供给预定量的电能的电源电路，以将预定量的温度升高到预定量，并使其膨胀，从而弹出 来自中空体的特定量的流体样品的体积位移等于热膨胀装置的体积增加。 优选地，中空体是包括柱塞的注射器的一部分。 注射器便于拾取其中只有一分钟的特定部分朝向颗粒研究装置的感测区域喷射的流体样品。

公开(公告)号：US3603875A

公开(公告)日：1971-09-07

申请号：US3603875D

申请日：1969-05-12

Applicant: COULTER ELECTRONICS

Inventor： COULTER WALLACE H ,  HOGG WALTER R

IPC: G01N15/12 ,  G01N33/49 ,  G01N27/00

CPC classification number: G01N15/1245

Abstract: Disclosed is an improved method and apparatus for analyzing particles by the Coulter principle of employing an impedance responsive detecting aperture through which pass particles in suspension. Employed herein are a plurality of logically parallel detecting apertures, preferably of different microscopic sizes, each aperture feeding circuitry which is subdivided into a plurality of channels, each responsive to a different narrow subrange of particle size. By time and volume related elements, there is generated an output voltage which is proportional to particle volume per unit time over the entire particle system; hence, statistically valid data is available at all times during an analysis run, even in the event of a malfunctioning blockage of an aperture.

公开(公告)号：US3567321A

公开(公告)日：1971-03-02

申请号：US3567321D

申请日：1968-07-22

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R

IPC: G01N15/12 ,  G01N21/26 ,  G01N27/42

CPC classification number: G01N15/1245

Abstract: A BATH HAVING A POCKET PORTION FOR RETAINING TESTTUBELIKE APERTURE TUBES KNOWN IN THE ELECTRONIC PARTICLE ANALYSIS ART. THE BATH HAS A DEPENDING, ELONGATED, FLUID PASSAGE BORE, PREFERABLY DEFINED BY SIDE WALLS TRACING A SEGMENT OF AN EXPONENTIAL CURVED. FLUID ENTRANCE AND EXIT LINES ENTER THE PASSAGE BORE NEAR ITS BOTTOM, SUCH THAT FLUID FLOW UPWARD INTO THE POCKET CHAMBER IS SMOOTH AND WITHOUT SIGNIFICANT TURBULENCE, SQUIRTING, OR BUBBLING THE BATH, ASSOCIATED APERTURE TUBES, ELECTRONIC AND OPTICAL DETECTING ELEMENTS PROVIDE AN IMPROVED COMBINATION USEFUL IN PARTICLE ANALYSIS.

公开(公告)号：US3566133A

公开(公告)日：1971-02-23

申请号：US3566133D

申请日：1968-03-18

Applicant: COULTER ELECTRONICS

Inventor： DORMAN ERVIN L JR ,  HOGG WALTER R

IPC: G01J1/16 ,  G01J1/18 ,  H01J39/12

CPC classification number: G01J1/18 ,  G01J1/16

Abstract: Method for determining the hemoglobin content of a sample by the photoelectric monitoring of a reference and the sample and the transducing thereof into a pair of electrical signals representative of the relative light transmission of the two media. The reference signal is applied to a store and, through comparison with the sample signal, an output signal having a duration directly proportional to the hemoglobin content is elicited. Also, apparatus for carrying out such method in which a capacitive storage circuit is charged proportionally to the reference light transmission through use of a monochromatic light and photocell and is discharged to an intermediate value dependent upon the transmission of the sample, the duration of such discharging being the desired output. Interposed in series between the photocell and the storage circuit is an operational amplifier a diode and a switch. The amplifier provides a voltage follower enabling the diode to be a precise comparator between the two signal levels. The time dependent output is taken from the anode side of the diode.

公开(公告)号：US3539919A

公开(公告)日：1970-11-10

申请号：US3539919D

申请日：1968-04-25

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R

IPC: G01N15/12 ,  G01N27/00 ,  C03B23/24

CPC classification number: G01N15/1218 ,  Y10S65/06