公开(公告)号：US3566133A

公开(公告)日：1971-02-23

申请号：US3566133D

申请日：1968-03-18

Applicant: COULTER ELECTRONICS

Inventor： DORMAN ERVIN L JR ,  HOGG WALTER R

IPC: G01J1/16 ,  G01J1/18 ,  H01J39/12

CPC classification number: G01J1/18 ,  G01J1/16

Abstract: Method for determining the hemoglobin content of a sample by the photoelectric monitoring of a reference and the sample and the transducing thereof into a pair of electrical signals representative of the relative light transmission of the two media. The reference signal is applied to a store and, through comparison with the sample signal, an output signal having a duration directly proportional to the hemoglobin content is elicited. Also, apparatus for carrying out such method in which a capacitive storage circuit is charged proportionally to the reference light transmission through use of a monochromatic light and photocell and is discharged to an intermediate value dependent upon the transmission of the sample, the duration of such discharging being the desired output. Interposed in series between the photocell and the storage circuit is an operational amplifier a diode and a switch. The amplifier provides a voltage follower enabling the diode to be a precise comparator between the two signal levels. The time dependent output is taken from the anode side of the diode.

公开(公告)号：US3622795A

公开(公告)日：1971-11-23

申请号：US3622795D

申请日：1968-10-10

Applicant: COULTER ELECTRONICS

Inventor： DORMAN ERVIN L JR ,  KLEIN ROBERT I ,  KREISELMAN ROBERT L ,  COULTER WALLACE H

IPC: G01J3/51 ,  G01G3/02 ,  G01G3/08 ,  G01G23/14 ,  G01N21/05 ,  G01N21/85 ,  G01N21/26 ,  E03B ,  G01N33/16

CPC classification number: G01G23/14 ,  G01G3/02 ,  G01G3/08 ,  G01N21/05 ,  G01N21/85 ,  Y10T137/86405

Abstract: Apparatus to be used in making hemoglobin determinations of samples of blood and other colorimetric fluid tests, which includes colorimetric computing circuitry and a flow-through cuvette in the same housing, the flow-through cuvette being normally covered by a lid which is raised by the operator when pouring the test sample into the cuvette. The construction is such that the technician need use only one hand for raising the lid and pouring the sample, leaving the other hand free for making notes or other purpose. The lid movement initiates programming means and the operating cycle, which includes: draining a blanking fluid with which the cuvette is filled between the cycles of use of the apparatus, accepting the sample poured into the cuvette, making the colorimetric measurement thereof, emptying the sample from the cuvette, rinsing the cuvette, and refilling the cuvette with the blanking fluid for the next measuring cycle. All fluid movement is achieved through the use of a system operating in conjunction with suitable valves, solenoids and at least one spring-return operated, piston-type liquid dispenser. A novel cuvette construction provides concentric fluid-receiving mouths leading to inner and outer receptacles, the inner being the receptacle for the sample fluid, the outer being an overflow basin. The receptacles lead to respective independent drains, the inner being provided with a light transmitting section at which the fluid is traversed by a beam of radiant energy.

公开(公告)号：CA939527A

公开(公告)日：1974-01-08

申请号：CA64283

申请日：1969-10-06

Applicant: COULTER ELECTRONICS

Inventor： DORMAN ERVIN L JR ,  KLEIN ROBERT I ,  KREISELMAN ROBERT L ,  COULTER WALLACE H

IPC: G01J3/51 ,  G01G3/02 ,  G01G3/08 ,  G01G23/14 ,  G01N21/05 ,  G01N21/85 ,  G01J3/46

Abstract: 1276105 Automatic analysis COULTER ELECTRONICS Inc 6 Oct 1969 [10 Oct 1968] 48991/69 Heading B1X [Also in Divisions G1 and G2] Apparatus for dispensing diluent from reservoir 20 into cuvette 50 for measurement comprises spring-loaded piston 32 moving in cylinder 28, one end of the cylinder being connectable to atmosphere through normally closed valve V1B and the other end being connected to liners 22, 26 as shown. When the sample in the cuvette has been measured, valve V3 is opened under control of programming device 72 and the sample is tucked away by pump 46. Valve V3 is closed, valve VIA is closed and valve V1B opened to produce atmospheric pressure in line 36. Piston 32 then moves to force diluent already in line 26 into the cuvette.

公开(公告)号：GB1276105A

公开(公告)日：1972-06-01

申请号：GB4899169

申请日：1969-10-06

Applicant: COULTER ELECTRONICS

Inventor： DORMAN ERVIN L JR ,  KLEIN ROBERT I ,  KREISELMAN ROBERT L ,  COULTER WALLACE H

IPC: G01J3/51 ,  G01G3/02 ,  G01G3/08 ,  G01G23/14 ,  G01N21/05 ,  G01N21/85

Abstract: 1276105 Automatic analysis COULTER ELECTRONICS Inc 6 Oct 1969 [10 Oct 1968] 48991/69 Heading B1X [Also in Divisions G1 and G2] Apparatus for dispensing diluent from reservoir 20 into cuvette 50 for measurement comprises spring-loaded piston 32 moving in cylinder 28, one end of the cylinder being connectable to atmosphere through normally closed valve V1B and the other end being connected to liners 22, 26 as shown. When the sample in the cuvette has been measured, valve V3 is opened under control of programming device 72 and the sample is tucked away by pump 46. Valve V3 is closed, valve VIA is closed and valve V1B opened to produce atmospheric pressure in line 36. Piston 32 then moves to force diluent already in line 26 into the cuvette.