公开(公告)号：US11725984B2

公开(公告)日：2023-08-15

申请号：US17408976

申请日：2021-08-23

Applicant: CytoVeris Inc.

Inventor： Alan Kersey ,  Rishikesh Pandey ,  David Fournier ,  Gary Root

IPC: G01J3/44 ,  G01J3/02 ,  G01N21/65 ,  G02B26/08

CPC classification number: G01J3/0208 ,  G01J3/44 ,  G01N21/65 ,  G02B26/0833 ,  G01N2201/12

Abstract: A system for processing Raman scattering light from a sample is provided. The system includes a source, a digital mirror device (DMD), a detector, and an analyzer. The DMD is configured to reflect Raman scattering light and includes micromirrors selectively controllable between ON and OFF states. The detector is configured to detect Raman scattering light and to produce signals representative of the Raman scattering light. The analyzer is in communication with the light source, the DMD, the detector, and a memory storing instructions, which instructions when executed cause the processor to: a) control the light source to produce a beam of light for interrogating the sample; b) control the DMD to place in an ON or OFF state based on one or more known spectral shapes stored in the memory; and c) process the Raman scattering light reflected by the micromirrors in the ON state.

公开(公告)号：US20220099580A1

公开(公告)日：2022-03-31

申请号：US17427391

申请日：2020-01-31

Applicant: CytoVeris Inc.

Inventor： Alan Kersey ,  Rishikesh Pandey

IPC: G01N21/65 ,  G01N33/58 ,  G01N33/574

Abstract: A method and system for determining the presence or absence of cancerous cells within subject tissue. The method includes: providing a material that includes a peptide component configurable in a non-binding form when disposed in a neutral pH environment, and in a binding form when disposed in an acidic pH environment, wherein the peptide component is configured to produce a first Raman spectrum when subjected to one or more predetermined wavelengths of light; administering the material to a subject tissue; interrogating the subject tissue with light; sensing the subject tissue for light emitted from the subject tissue, and producing signals representative of the sensed emitted light; analyzing the signals to determine a presence or absence of the first Raman spectrum; and determining the presence or absence of cancerous cells based on the presence or absence of the first Raman spectrum within the sensed light emitted from the subject tissue.

公开(公告)号：US20220065791A1

公开(公告)日：2022-03-03

申请号：US17464380

申请日：2021-09-01

Applicant: CytoVeris Inc.

Inventor： Alan Kersey ,  Rishikesh Pandey

IPC: G01N21/65 ,  G01J3/44 ,  G01N33/483

Abstract: A system for and method of examining a tissue sample using stimulated Raman spectroscopy is provided. The method includes: a) producing a first beam of light at a first wavelength; b) producing a second beam of light at at least a second wavelength, the second wavelength different from the first wavelength; c) combining the first and second beams of light to provide a combined output; d) interrogating a tissue sample with the combined output to produce Raman scattering light, the tissue sample prepared with at least one target molecule having a targeting agent conjugated with a Raman silent dye, the targeting agent configured to bind with at least one biomarker; e) detecting at least a portion of the produced Raman scattering light using a photodetector; and f) producing immunohistological data relating to the tissue sample using photodetector signals representative of the detected Raman scattering light.

公开(公告)号：US20210325302A1

公开(公告)日：2021-10-21

申请号：US17236962

申请日：2021-04-21

Applicant: CytoVeris Inc.

Inventor： Alan Kersey ,  Michael A. Sapack ,  Patrick M. Curry

IPC: G01N21/64 ,  G01N1/31 ,  G01N21/65

Abstract: A tumor responsive tissue marking dye is provided that includes a tissue marking dye and at least one cancer activated agent. The at least one cancer activated agent is configured to assume a first state in the absence of cancerous tissue or a microenvironment associated with said cancerous tissue, and a second state in the presence of said cancerous tissue or said microenvironment associated with said cancerous tissue, wherein the first state is photometrically distinguishable from the second state.