公开(公告)号：US20210325302A1

公开(公告)日：2021-10-21

申请号：US17236962

申请日：2021-04-21

Applicant: CytoVeris Inc.

Inventor： Alan Kersey ,  Michael A. Sapack ,  Patrick M. Curry

IPC: G01N21/64 ,  G01N1/31 ,  G01N21/65

Abstract: A tumor responsive tissue marking dye is provided that includes a tissue marking dye and at least one cancer activated agent. The at least one cancer activated agent is configured to assume a first state in the absence of cancerous tissue or a microenvironment associated with said cancerous tissue, and a second state in the presence of said cancerous tissue or said microenvironment associated with said cancerous tissue, wherein the first state is photometrically distinguishable from the second state.

公开(公告)号：US20230366795A1

公开(公告)日：2023-11-16

申请号：US18196411

申请日：2023-05-11

Applicant: CytoVeris Inc.

Inventor： Morgan McNamara ,  David Fournier ,  Noel Diagneault ,  Michael A. Sapack ,  Gary Root

IPC: G01N1/36 ,  A61B90/00 ,  A61B90/90

CPC classification number: G01N1/36 ,  A61B90/39 ,  A61B90/90 ,  A61B2090/3937 ,  B01L2200/141 ,  B01L2300/123 ,  B01L2300/041 ,  B01L2300/021 ,  B01L2300/12

Abstract: An apparatus for holding a tissue specimen during imaging is provided. The tissue specimen has a 3D geometry and a region of interest. The apparatus includes a cover panel and a specimen support structure. The cover panel has upper and bottom panel surfaces and a viewing aperture that extends between the upper and bottom panel surfaces. The specimen support structure is configured to support the tissue specimen in an imaging orientation. The specimen support structure is configured to permit alignment of the tissue specimen ROI with the viewing aperture. The apparatus is configurable in a secured configuration in which the specimen support structure is positionally fixed relative to the cover panel, the tissue specimen ROI is exposed through the viewing aperture for imaging, and the tissue specimen ROI is held motionless relative to the cover panel.

公开(公告)号：US20220079450A1

公开(公告)日：2022-03-17

申请号：US17478513

申请日：2021-09-17

Applicant: CytoVeris Inc.

Inventor： David Fournier ,  Rishikesh Pandey ,  Michael A. Sapack ,  Patrick M. Curry ,  Alan Kersey

IPC: A61B5/00

Abstract: A system and method for determining the presence of cancerous tissue within a tissue cavity is provided. The system includes one or more excitation light sources, a photodetector, a probe, and a system controller. The probe includes an optically transparent probe body configured to fit within the tissue cavity. The system controller is in communication with the excitation light sources, the photodetector, and a memory storing instructions. The instructions when executed cause the system controller to a) control the excitation light sources to produce excitation light beams within the probe body, the excitation light beams operable to produce a response of the tissue to the interrogation and control the photodetector to detect the response and produce signals representative thereof; and b) produce information indicative of a presence of the cancerous tissue using the signals representative of the response.