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    INCREASED YIELDS OF BIOSYNTHESIZED PRODUCTS
    21.
    发明申请
    INCREASED YIELDS OF BIOSYNTHESIZED PRODUCTS 审中-公开
    增加生物产品产量

    公开(公告)号：WO2014089025A1

    公开(公告)日：2014-06-12

    申请号：PCT/US2013/072781

    申请日：2013-12-03

    Applicant: GENOMATICA, INC.

    Inventor： BURK, Mark, J. ,  BURGARD, Anthony, P. ,  VAN DIEN, Steven, J.

    IPC: C12N1/21

    CPC classification number: C12N9/0004 ,  C12P5/026

    Abstract: The invention provides a non-naturally occurring microbial organism having a butadiene biosynthetic pathway, a denitrification enzyme or pathway for reducing nitrate (N03-) or nitrite (N02-) and a metabolic modification attenuating the amount or activity of a cytoplasmic nitrite reductase. Also provided is a composition including a non-naturally occurring microbial organism having a butadiene biosynthetic pathway, a denitrification enzyme or pathway for reducing nitrate (N03-) or nitrite (N02-) and a medium containing nitrate. Methods of producting bioderived butadiene are also provided.

    Abstract translation: 本发明提供了具有丁二烯生物合成途径的非天然存在的微生物生物体，用于还原硝酸盐（N03-）或亚硝酸盐（N02-）的脱氮酶或途径）以及削弱细胞质亚硝酸盐还原酶的量或活性的代谢修饰。 还提供了包含具有丁二烯生物合成途径的非天然存在的微生物生物体，用于还原硝酸盐（N03-）或亚硝酸盐（N02-）的脱氮酶或途径）和含有硝酸盐的培养基的组合物。 还提供了生物丁二烯生产方法。

    MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF FUMARATE, MALATE, AND ACRYLATE
    27.
    发明申请
    MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF FUMARATE, MALATE, AND ACRYLATE 审中-公开
    富马酸和丙烯酸的生物合成的微生物和方法

    公开(公告)号：WO2009155382A1

    公开(公告)日：2009-12-23

    申请号：PCT/US2009/047715

    申请日：2009-06-17

    Applicant: GENOMATICA, INC. ,  BURK, Mark, J. ,  BURGARD, Anthony, P. ,  PHARKYA, Priti

    Inventor： BURK, Mark, J. ,  BURGARD, Anthony, P. ,  PHARKYA, Priti

    IPC: C12P5/02 ,  C12P7/42

    CPC classification number: C12P7/46 ,  C12N9/88 ,  C12P7/40

    Abstract: A non-naturally occurring eukaryotic or prokaryotic organism includes one or more gene disruptions occurring in genes encoding enzymes imparting increased fumarate, malate or acrylate production in the organism when the gene disruption reduces an activity of the enzyme. The one or more gene disruptions confers increased production of acrylate onto the organism. Organisms that produce acrylate have an acrylate pathway that at least one exogenous nucleic acid encoding an acrylate pathway enzyme expressed in a sufficient amount to produce acrylate, the acrylate pathway comprising a decarboxylase. Methods of producing fumarate, malate or acrylate include culturing these organisms.

    Abstract translation: 非天然存在的真核生物或原核生物包括当基因破坏降低酶的活性时，编码在赋予生物体中增加的富马酸盐，苹果酸或丙烯酸酯产生的酶的基因中发生的一种或多种基因破坏。 一个或多个基因破坏使丙烯酸酯的生产增加到生物体上。 生产丙烯酸酯的生物体具有丙烯酸酯途径，至少一种编码丙烯酸酯途径酶的外源核酸以足够的量表达以产生丙烯酸酯，丙烯酸酯途径包含脱羧酶。 产生富马酸盐，苹果酸盐或丙烯酸盐的方法包括培养这些生物体。

    COMPOSITIONS AND METHODS FOR BIO-BUTADIENE PRODUCTION SCREENING
    29.
    发明申请
    COMPOSITIONS AND METHODS FOR BIO-BUTADIENE PRODUCTION SCREENING 审中-公开
    生物丁二烯生产筛选的组合物和方法

    公开(公告)号：WO2014106122A1

    公开(公告)日：2014-07-03

    申请号：PCT/US2013/078117

    申请日：2013-12-27

    Applicant: GENOMATICA, INC.

    Inventor： BURK, Mark, J. ,  OSTERHOUT, Robin, E. ,  TORCHIA, Timothy, E. ,  TRACEWELL, Cara, Ann ,  KHANDURINA, Julia

    IPC: C12P5/02 ,  C12M1/34

    CPC classification number: C12P5/026 ,  Y02E50/343

    Abstract: In alternative embodiments, the invention provides compositions and methods for the detection of organisms having butadiene biosynthetic capability. In alternative embodiments, the invention provides high-throughput detection methods of products of biosynthetic processes, more specifically to detection of organisms having or having improved butadiene biosynthetic capability. In alternative embodiments, the invention provides compositions and methods for screening or assaying a population of cells for: the production of a butadiene; or, for the rate of production of a butadiene; or, for the improved production of a butadiene.

    Abstract translation: 在替代实施方案中，本发明提供了用于检测具有丁二烯生物合成能力的生物体的组合物和方法。 在替代实施方案中，本发明提供生物合成方法产物的高通量检测方法，更具体地，涉及具有或具有改进的丁二烯生物合成能力的生物体的检测。 在替代实施方案中，本发明提供用于筛选或测定细胞群的组合物和方法，用于：生产丁二烯; 或者，对于丁二烯的生产速率; 或者为了改进丁二烯的生产。

    MICROORGANISMS AND METHODS FOR THE PRODUCTION OF CAPROLACTONE
    30.
    发明申请
    MICROORGANISMS AND METHODS FOR THE PRODUCTION OF CAPROLACTONE 审中-公开
    用于生产CAPROLACTONE的微生物和方法

    公开(公告)号：WO2013067432A1

    公开(公告)日：2013-05-10

    申请号：PCT/US2012/063424

    申请日：2012-11-02

    Applicant: GENOMATICA, INC.

    Inventor： BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  PHARKYA, Priti ,  BURK, Mark, J.

    IPC: C12P17/02

    CPC classification number: C12P17/08 ,  C07D313/04 ,  C08G18/4277 ,  C08G63/08 ,  C12N5/0018 ,  C12N15/52 ,  C12N15/63 ,  C12N15/70 ,  C12P17/02

    Abstract: The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone. The invention additionally provides methods of using such microbial organisms to produce caprolactone by culturing a non-naturally occurring microbial organism containing caprolactone pathways as described herein under conditions and for a sufficient period of time to produce caprolactone.

    Abstract translation: 本发明提供了含有己内酯途径的非天然存在的微生物，其具有至少一种编码丁二烯途径酶的外源核酸，其以足够的量表达以产生己内酯。 本发明另外提供了使用这种微生物生物体制备己内酯的方法，通过在条件和足够的时间内培养含有本文所述的己内酯途径的非天然存在的微生物生物体以制备己内酯。

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