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1.发明申请MICROORGANISMS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1,2-PROPANEDIOL 审中-公开用于提高甲醇存在下降低等效物质和生产1,2-丙二醇的可利用性的微生物
公开(公告)号：WO2014071286A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/068254
申请日：2013-11-04
Applicant: GENOMATICA, INC.
Inventor： BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , VAN DIEN, Stephen, J. , TRACEWELL, Cara, Ann , PHARKYA, Priti , ANDRE, Stefan
CPC classification number: C12P7/24 , C12N1/14 , C12N1/16 , C12N1/20 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N15/52 , C12P7/04 , C12P7/18 , C12P7/20 , C12Y101/01244 , C12Y105/0102
Abstract: Provided herein is a non-naturally occurring microbial organism (NNOMO) having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,2-propanediol (1,2-PDO), n- propanol (n-PrOH), 1,3-propanediol (1,3-PDO) or glycerol. Also provided herein are methods for using such an organism to produce 1,2-PDO, n-PrOH, 1,3-PDO or glycerol.
Abstract translation: 本文提供了具有甲醇代谢途径（MMP）的非天然存在的微生物生物体（NNOMO），其可以在甲醇存在下增强还原当量的可用性。 这种还原当量可用于提高由微生物生产的有机化合物的产物产率，例如1,2-丙二醇（1,2-PDO），正丙醇（n-PrOH），1,3-丙二醇（ 1,3-PDO）或甘油。 本文还提供了使用这种生物体产生1,2-PDO，n-PrOH，1,3-PDO或甘油的方法。
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2.发明申请MICROORGANISMS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 3-HYDROXYISOBUTYRATE 审中-公开用于提高甲醇存在下降低等效物质和生产3-羟基异丁酸酯的可利用性的微生物
公开(公告)号：WO2014071289A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/068265
申请日：2013-11-04
Applicant: GENOMATICA, INC.
Inventor： BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , VAN DIEN, Stephen, J. , TRACEWELL, Cara, Ann , PHARKYA, Priti , ANDRAE, Stefan
CPC classification number: C12N15/52 , C08F120/06 , C08G63/664 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N15/63 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/62 , C12Y101/01244 , C12Y105/0102 , C12Y201/0109
Abstract: Provided herein is a non-naturally occurring microbial organism (NNOMO) having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate (3-HIB) or methacrylic acid (MAA). Also provided herein are methods for using such an organism to produce 3-HIB or MAA.
Abstract translation: 本文提供了具有甲醇代谢途径（MMP）的非天然存在的微生物生物体（NNOMO），其可以在甲醇存在下增强还原当量的可用性。 可以使用这种还原当量来提高由微生物生物产生的有机化合物的产物，例如3-羟基异丁酸（3-HIB）或甲基丙烯酸（MAA）。 本文还提供了使用这种生物体产生3-HIB或MAA的方法。
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3.发明申请MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING SUCCINATE RELATED THERETO 审中-公开用于提高甲醇存在下减少等效物的可行性的微生物和方法以及用于生产与其相关的成分
公开(公告)号：WO2014066235A1
公开(公告)日：2014-05-01
申请号：PCT/US2013/065887
申请日：2013-10-21
Applicant: GENOMATICA, INC.
Inventor： BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , VAN DIEN, Stephen, J. , TRACEWELL, Cara, Ann , PHARKYA, Priti , ANDRAE, Stefan
IPC: C12P1/04
CPC classification number: C12P7/46 , C07C55/10 , C07C59/235 , C08G63/00 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N15/70 , C12N15/74 , C12N15/77 , C12N15/81 , C12N15/815 , C12P7/24 , C12Y101/01244 , C12Y105/0102
Abstract: Provided herein is a non-naturally occurring microbial organism (NNOMO) having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as succinate. Also provided herein are methods for using such an organism to produce succinate.
Abstract translation: 本文提供了具有甲醇代谢途径（MMP）的非天然存在的微生物生物体（NNOMO），其可以在甲醇存在下增强还原当量的可用性。 这种还原当量可以用于增加由微生物生物如琥珀酸酯产生的有机化合物的产物产率。 本文还提供了使用这种生物体来生产琥珀酸盐的方法。
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4.发明申请MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1,4-BUTANEDIOL RELATED THERETO 审中-公开用于提高甲醇存在下降低等效物质和生产1,4-丁二醇相关物质的可行性的微生物和方法
公开(公告)号：WO2014035925A1
公开(公告)日：2014-03-06
申请号：PCT/US2013/056725
申请日：2013-08-27
Applicant: GENOMATICA, INC.
Inventor： BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , VAN DIEN, Stephen, J. , TRACEWELL, Cara, Ann , PHARKYA, Priti , ANDRAE, Stefan
CPC classification number: C12P7/18 , C07D207/12 , C08G18/3206 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N9/88 , C12P7/24 , C12P19/02 , C12Y101/01224 , C12Y101/01244 , C12Y101/02007 , C12Y105/0102 , C12Y201/01 , C12Y201/0109 , C12Y402/01 , Y02P20/52
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
Abstract translation: 本文提供了具有甲醇代谢途径（MMP）的非天然存在的微生物生物，其可以在甲醇存在下增强还原当量的可用性。 这种还原当量可用于增加由微生物生物例如1,4-丁二醇（BDO）产生的有机化合物的产物产率。 本文还提供了使用这种生物体产生BDO的方法。
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公开(公告)号：WO2018183664A1
公开(公告)日：2018-10-04
申请号：PCT/US2018/025122
申请日：2018-03-29
Applicant: GENOMATICA, INC.
Inventor： HOFF, Kevin , TRACEWELL, Cara, Ann , CHAN, Kui , SHAH, Amit , WARNER, Joseph , NOBLE, Michael
IPC: C12N9/02
Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3 -butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.
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Patent Agency Ranking
公开(公告)号：WO2018183640A1
公开(公告)日：2018-10-04
申请号：PCT/US2018/025086
申请日：2018-03-29
Applicant: GENOMATICA, INC.
Inventor： HOFF, Kevin , TRACEWELL, Cara, Ann , CHAN, Kui , KUCHINSKAS, Michael , NAGARAJAN, Harish
Abstract: The present disclosure provides thiolases and polypeptide variants of 3-hydroxybutyryl- CoA dehydrogenase, nucleic acids encoding the same, vectors comprising the nucleic acids, and cells comprising the polypeptide variants and/or thiolase, the nucleic acids, and/or the vectors. The present disclosure also provides methods of making and using the same, including methods for culturing cells, and for the production of various products, including 3-hydroxybutyryl-CoA (3-HB-CoA), 3-hydroxybutyraldehyde (3-HBal), 3-hydroxybutyrate (3-HB), 1,3-butanediol (1,3-BDO), and esters and amides thereof, and products made from any of these.
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公开(公告)号：WO2014106122A1
公开(公告)日：2014-07-03
申请号：PCT/US2013/078117
申请日：2013-12-27
Applicant: GENOMATICA, INC.
Inventor： BURK, Mark, J. , OSTERHOUT, Robin, E. , TORCHIA, Timothy, E. , TRACEWELL, Cara, Ann , KHANDURINA, Julia
CPC classification number: C12P5/026 , Y02E50/343
Abstract: In alternative embodiments, the invention provides compositions and methods for the detection of organisms having butadiene biosynthetic capability. In alternative embodiments, the invention provides high-throughput detection methods of products of biosynthetic processes, more specifically to detection of organisms having or having improved butadiene biosynthetic capability. In alternative embodiments, the invention provides compositions and methods for screening or assaying a population of cells for: the production of a butadiene; or, for the rate of production of a butadiene; or, for the improved production of a butadiene.
Abstract translation: 在替代实施方案中，本发明提供了用于检测具有丁二烯生物合成能力的生物体的组合物和方法。 在替代实施方案中，本发明提供生物合成方法产物的高通量检测方法，更具体地，涉及具有或具有改进的丁二烯生物合成能力的生物体的检测。 在替代实施方案中，本发明提供用于筛选或测定细胞群的组合物和方法，用于：生产丁二烯; 或者，对于丁二烯的生产速率; 或者为了改进丁二烯的生产。
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8.发明申请MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING ADIPATE, 6-AMINOCAPROATE, HEXAMETHYLENEDIAMINE OR CAPROLACTAM RELATED THERETO 审中-公开用于提高甲醇存在下降低等效物的可行性的微生物和方法，以及用于生产与其相关的丙氨酸，6-氨基己酸，十六烷二胺或其衍生物的微生物和方法
公开(公告)号：WO2014099725A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/075287
申请日：2013-12-16
Applicant: GENOMATICA, INC.
Inventor： BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , VAN DIEN, Stephen, J. , TRACEWELL, Cara, Ann , PHARKYA, Priti , ANDRAE, Stefan
IPC: C12N1/21
CPC classification number: C12P17/10 , A23L29/065 , C08G63/78 , C08G69/08 , C08G69/16 , C08G73/0213 , C12N9/0006 , C12N15/52 , C12P7/24 , C12P7/44 , C12P13/001 , C12P13/005 , C12Y101/01244
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.
Abstract translation: 本文提供了具有甲醇代谢途径的非天然存在的微生物生物，其可以在甲醇存在下增强还原当量的可用性。 这样的还原当量可用于增加微生物生物体如己二酸，6-氨基己酸，六亚甲基二胺或己内酰胺产生的有机化合物的产物产率。 本文还提供了使用这种生物体产生己二酸，6-氨基己酸，六亚甲基二胺或己内酰胺的方法。
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9.发明公开MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1,4-BUTANEDIOL RELATED THERETO 审中-公开微生物与一种提高还原当量的可用性甲醇的存在以及对1,4-丁二醇的制备
公开(公告)号：EP2888369A1
公开(公告)日：2015-07-01
申请号：EP13832246.6
申请日：2013-08-27
Applicant: Genomatica, Inc.
Inventor： BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , VAN DIEN, Stephen, J. , TRACEWELL, Cara, Ann , PHARKYA, Priti , ANDRAE, Stefan
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
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公开(公告)号：EP2888369B1
公开(公告)日：2020-07-15
申请号：EP13832246.6
申请日：2013-08-27
Applicant: Genomatica, Inc.
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