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    MICROORGANISMS AND METHODS FOR THE CO-PRODUCTION OF ISOPROPANOL WITH PRIMARY ALCOHOLS, DIOLS AND ACIDS
    22.
    发明申请
    MICROORGANISMS AND METHODS FOR THE CO-PRODUCTION OF ISOPROPANOL WITH PRIMARY ALCOHOLS, DIOLS AND ACIDS 审中-公开
    用主要醇，二醇和酸共同生产异丙酚的微生物和方法

    公开(公告)号：WO2011031897A1

    公开(公告)日：2011-03-17

    申请号：PCT/US2010/048318

    申请日：2010-09-09

    Applicant: GENOMATICA, INC. ,  PHARKYA, Priti ,  BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  BURK, Mark, J. ,  SUN, Jun

    Inventor： PHARKYA, Priti ,  BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  BURK, Mark, J. ,  SUN, Jun

    IPC: C12P7/04 ,  C12N15/74

    CPC classification number: C12P7/40 ,  C12N15/52 ,  C12P7/04 ,  C12P7/18

    Abstract: The invention provides a non-naturally occurring microbial organism having n-propanol and isopropanol pathways, 1,4-butanediol (14-BDO) and isopropanol pathways, 1,3-butanediol (13- BDO) and isopropanol pathways or methylacrylic acid (MAA) and isopropanolpathways. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in each of the respective n-propanol, 14-BDO, 13-BDO or MAA and isopropanol pathways. The invention additionally provides a method for co-producing n-propanol and isopropanol, 14-BDO and isopropanol, 13-BDO and isopropanol or MAA and isopropanol. The method can include culturing an n-propanol and an isopropanol co-producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an n-propanol, an isopropanol, a 14-BDO, a 13-BDO and/or a MAA pathway enzyme in a sufficient amount to produce each of the respective products, under conditions and for a sufficient period of time to produce each of the respective products.

    Abstract translation: 本发明提供具有正丙醇和异丙醇途径的非天然存在的微生物生物，1,4-丁二醇（14-BDO）和异丙醇途径，1,3-丁二醇（13-BDO）和异丙醇途径或甲基丙烯酸（MAA ）和异丙醇通道。 微生物生物体含有至少一种外源核酸，其编码在各自的正丙醇，14-BDO，13-BDO或MAA和异丙醇途径中的酶。 本发明另外提供了共同生产正丙醇和异丙醇，14-BDO和异丙醇，13-BDO和异丙醇或MAA和异丙醇的方法。 该方法可以包括培养正丙醇和异丙醇共同生产微生物，其中微生物生物体表达至少一种编码正丙醇，异丙醇，14-BDO，13-BDO和/或 足够量的MAA途径酶，以在产生各个产物的条件下和足够的时间段内产生各个产物。

    MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID
    23.
    发明申请
    MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID 审中-公开
    丙二酸，十六烷二胺和6-氨基酸的生物合成的微生物和方法

    公开(公告)号：WO2010129936A1

    公开(公告)日：2010-11-11

    申请号：PCT/US2010/034144

    申请日：2010-05-07

    Applicant: GENOMATICA, INC. ,  BURK, Mark, J. ,  BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  PHARKYA, Priti

    Inventor： BURK, Mark, J. ,  BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  PHARKYA, Priti

    IPC: C12N1/21 ,  C12P13/04 ,  C12P7/44

    CPC classification number: C12P17/10 ,  C12N1/38 ,  C12N15/52 ,  C12P7/40 ,  C12P7/44 ,  C12P13/001 ,  C12P13/005 ,  C12P13/02 ,  C12P17/12

    Abstract: The invention provides a non-naturally occurring microbial organism having a 6- aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.

    Abstract translation: 本发明提供了具有6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸途径的非天然存在的微生物。 微生物生物体含有至少一种编码各自的6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸途径中的酶的外源核酸。 本发明另外提供了制备6-氨基己酸，己内酰胺，己二胺或乙酰丙酸的方法。 该方法可以包括培养6-氨基己酸，己内酰胺或六亚甲基二胺生产微生物，其中微生物生物表达至少一种编码6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸途径酶的外源核酸，其量足以产生 各自的产物在条件下和足够的时间内产生6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸。

    MICROORGANISMS FOR THE PRODUCTION OF METHACRYLIC ACID
    24.
    发明申请
    MICROORGANISMS FOR THE PRODUCTION OF METHACRYLIC ACID 审中-公开

    公开(公告)号：WO2009135074A3

    公开(公告)日：2009-11-05

    申请号：PCT/US2009/042426

    申请日：2009-04-30

    Applicant: GENOMATICA, INC. ,  BURK, Mark, J. ,  BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  PHARKYA, Priti

    Inventor： BURK, Mark, J. ,  BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  PHARKYA, Priti

    IPC: C12P7/42 ,  C12N1/20

    Abstract: The invention provides a non-naturally occurring microbial organism having a 2- hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2- hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. The method can include culturing a 2-hydroxyisobutyric acid, 3- hydroxyisobutyric acid or methacrylic acid producing microbial organism expressing at least one exogenous nucleic acid encoding a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway enzyme in a sufficient amount and culturing under conditions and for a sufficient period of time to produce 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid.

    MICROORGANISMS FOR PRODUCING ETHYLENE GLYCOL USING SYNTHESIS GAS
    27.
    发明申请
    MICROORGANISMS FOR PRODUCING ETHYLENE GLYCOL USING SYNTHESIS GAS 审中-公开
    使用合成气生产乙烯甘油的微生物

    公开(公告)号：WO2014004625A1

    公开(公告)日：2014-01-03

    申请号：PCT/US2013/047821

    申请日：2013-06-26

    Applicant: GENOMATICA, INC.

    Inventor： OSTERHOUT, Robin, E. ,  BURGARD, Anthony, P. ,  BURK, Mark, J.

    IPC: C12N1/21 ,  C12N15/53 ,  C12N15/54 ,  C12P7/04

    CPC classification number: C12N15/52 ,  C12P7/18

    Abstract: The invention provides a non-naturally occurring microbial organism containing an ethylene glycol pathway, wherein the pathway includes at least one exogenous nucleic acid encoding an ethylene glycol pathway enzyme expressed in a sufficient amount to produce ethylene glycol. The non-naturally occurring microorganisms of the invention can express exogenous nucleic acids that catalyze the fixation of C02 or CO to ethylene glycol. The microorganisms of the invention can further include enzymes to generate energy and reducing equivalents from methanol, syngas and other gaseous sources. The invention additionally provides methods of using such microbial organisms to produce ethylene glycol, by culturing a non-naturally occurring microbial organism containing an ethylene glycol pathway under conditions and for a sufficient period of time to produce ethylene glycol.

    Abstract translation: 本发明提供了含有乙二醇途径的非天然存在的微生物生物，其中该途径包括至少一种编码乙醇途径酶的外源核酸，其以足够的量表达以产生乙二醇。 本发明的非天然存在的微生物可以表达催化将CO 2或CO固定于乙二醇的外源核酸。 本发明的微生物可进一步包括产生能量和减少甲醇，合成气和其它气体源的当量的酶。 本发明还提供使用这种微生物生产乙二醇的方法，通过在条件和足够的时间内培养含有乙二醇途径的非天然存在的微生物生物来生产乙二醇。

    MICROORGANISMS AND METHODS FOR PRODUCING ALKENES
    28.
    发明申请
    MICROORGANISMS AND METHODS FOR PRODUCING ALKENES 审中-公开
    生物碱的微生物和方法

    公开(公告)号：WO2013040383A1

    公开(公告)日：2013-03-21

    申请号：PCT/US2012/055469

    申请日：2012-09-14

    Applicant: GENOMATICA, INC. ,  BURK, Mark, J. ,  OSTERHOUT, Robin, E.

    Inventor： BURK, Mark, J. ,  OSTERHOUT, Robin, E.

    IPC: C12N15/74

    CPC classification number: C12P5/026 ,  C12N9/1205 ,  C12N9/1229 ,  C12N9/1235 ,  C12N9/88 ,  C12N15/52 ,  C12P5/002 ,  C12Y402/03

    Abstract: Non-naturally occurring microbial organisms are disclosed containing an alkene pathway having at least one exogenous nucleic acid encoding an alkene pathway enzyme expressed in a sufficient amount to convert an alcohol to an alkene. The disclosure additionally provides methods of using such microbial organisms to produce an alkene, by culturing a non-naturally occurring microbial organism containing an alkene pathway as described herein under conditions and for a sufficient period of time to produce an alkene.

    Abstract translation: 公开了非天然存在的微生物，其含有具有至少一种编码烯烃途径酶的外源核酸的烯烃途径，所述烯酸途径酶以足够的量转化成烯烃的醇。 本公开另外提供了使用这种微生物生产烯烃的方法，通过在条件和足够的时间段内培养含有如本文所述的烯烃途径的非天然存在的微生物生物产生烯烃。

    MICROORGANISMS FOR PRODUCING ISOBUTANOL AND METHODS RELATED THERETO
    29.
    发明申请
    MICROORGANISMS FOR PRODUCING ISOBUTANOL AND METHODS RELATED THERETO 审中-公开
    用于生产ISOBUTANOL的微生物及其相关方法

    公开(公告)号：WO2012177601A2

    公开(公告)日：2012-12-27

    申请号：PCT/US2012/043091

    申请日：2012-06-19

    Applicant: GENOMATICA, INC. ,  BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  SUN, Jun ,  PHARKYA, Priti

    Inventor： BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  SUN, Jun ,  PHARKYA, Priti

    IPC: C12P7/16

    CPC classification number: C12P7/16 ,  C12N15/52 ,  Y02E50/10

    Abstract: Provided herein is a non-naturally occurring microbial organism having an isopropanol pathway and comprising at least one exogenous nucleic acid encoding an isopropanol pathway enzyme. In certain embodiments, the pathway includes an enzyme selected from a 4-hydroxybutyryl-CoA dehydratase, a crotonase, a 3-hydroxybutyryl-CoA dehydrogenase, an acetoacetyl-CoA synthetase, an acetyl-CoA:acetoacetate-CoA transferase, an acetoacetyl-CoA hydrolase, an acetoacetate decarboxylase, and an acetone reductase. Also provided herein is anon-naturally occurring microbial organism having an n -butanol pathway and comprising at least one exogenous nucleic acid encoding an n -butanol pathway enzyme. Other non-naturally occurring microbial organism having n -butanol or isobutanol pathways are also provided herein. In certain embodiments, isobutanol pathways utilizing reverse TCA and/or reducing equivalents from CO and/or hydrogen are used to enhance product yields. The organisms provided herein can be cultured to produce isopropanol, n -butanol, or isobutanol.

    Abstract translation: 本文提供了具有异丙醇途径并且包含至少一种编码异丙醇途径酶的外源核酸的非天然存在的微生物生物。 在某些实施方案中，该途径包括选自4-羟基丁酰-CoA脱水酶，巴豆酸酶，3-羟基丁酰辅酶A脱氢酶，乙酰乙酰辅酶A合成酶，乙酰辅酶A：乙酰乙酸酯-CoA转移酶，乙酰乙酰辅酶A 水解酶，乙酰乙酸脱羧酶和丙酮还原酶。 本文还提供了具有正丁醇途径的非天然存在的微生物生物，并且包含至少一种编码正丁醇途径酶的外源核酸。 本文还提供了其它具有正丁醇或异丁醇途径的非天然存在的微生物。 在某些实施方案中，使用利用反向TCA和/或来自CO和/或氢的还原当量的异丁醇途径来提高产物产率。 本文提供的生物体可以培养以产生异丙醇，正丁醇或异丁醇。

    MICROORGANISMS FOR PRODUCING N-PROPANOL 1, 3-PROPANEDIOL, 1,2-PROPANEDIOL OR GLYCEROL AND METHODS RELATED THERETO
    30.
    发明申请
    MICROORGANISMS FOR PRODUCING N-PROPANOL 1, 3-PROPANEDIOL, 1,2-PROPANEDIOL OR GLYCEROL AND METHODS RELATED THERETO 审中-公开
    用于生产N-丙醇1,3-丙二醇，1,2-丙二醇或甘油的微生物及其相关方法

    公开(公告)号：WO2012177599A2

    公开(公告)日：2012-12-27

    申请号：PCT/US2012/043086

    申请日：2012-06-19

    Applicant: GENOMATICA, INC. ,  BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  SUN, Jun ,  PHARKYA, Priti

    Inventor： BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  SUN, Jun ,  PHARKYA, Priti

    IPC: C12P7/04 ,  C12P7/20

    CPC classification number: C12P7/18 ,  C12N9/0008 ,  C12N9/0067 ,  C12P7/04 ,  C12P7/20

    Abstract: Provided herein is a non-naturally occurring microbial organism having a reductive TCA or Wood-Ljungdahl pathway and comprising at least one exogenous nucleic acid encoding said pathway enzymes expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. Also provided herein is a method for enhancing carbon flux through acetyl-CoA and in some embodiments includes culturing these non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism provided herein includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. Also provided herein is a method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, and can include culturing this organism for a sufficient period of time to produce a product.

    Abstract translation: 本文提供了具有还原性TCA或Wood-Ljungdahl途径的非天然存在的微生物生物体，并且包含至少一种编码所述途径酶的外源核酸，其以足够的量表达以增强通过乙酰辅酶A的碳通量。 本文还提供了通过乙酰辅酶A增强碳通量的方法，并且在一些实施方案中包括在条件和足够的时间段内培养这些非天然存在的微生物生物体以产生具有乙酰辅酶A作为结构单元的产物。 本文提供的另一种非天然存在的微生物包括至少一种编码以足够量表达的酶的外源核酸，以增强在一氧化碳或氢气存在下还原当量的可用性，从而通过经由 碳水化合物碳原料。 本文还提供了在一氧化碳或氢气存在下增强还原当量的可用性的方法，并且可以包括在足够的时间内培养该生物体以产生产物。

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