Patent search ap:("HARVARD COLLEGE") AND inv:"MARTINEZ ANDRES W" Page 3

21.

发明申请
PAPER-BASED MICROFLUIDIC SYSTEMS 审中-公开
Title translation: 基于纸张的微流体系统

公开(公告)号：WO2009121041A3

公开(公告)日：2009-12-17

申请号：PCT/US2009038699

申请日：2009-03-27

Applicant: HARVARD COLLEGE , SIEGEL ADAM C , PHILLIPS SCOTT T , DICKEY MICHAEL D , ROZKIEWICZ DOROTA , WILEY BENJAMIN , WHITESIDES GEORGE M , MARTINEZ ANDRES W

Inventor： SIEGEL ADAM C , PHILLIPS SCOTT T , DICKEY MICHAEL D , ROZKIEWICZ DOROTA , WILEY BENJAMIN , WHITESIDES GEORGE M , MARTINEZ ANDRES W

IPC: G01N35/00 , G01N27/26 , G01N33/48

CPC classification number: B01L3/502707 , B01L2200/027 , B01L2200/0642 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/025 , B01L2300/0636 , B01L2300/0645 , B01L2300/0809 , B01L2300/0819 , B01L2300/087 , B01L2300/12 , B01L2300/126 , B01L2300/161 , B01L2300/1827 , B01L2400/0406 , Y10T436/25 , Y10T436/2575

Abstract: The invention features an assay device, a microfluidic device, and a method of detecting the presence of high electrolyte concentration in a fluid sample. The assay device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier defining a boundary of an assay region and a boundary of a main channel region, the main channel region fluidically connected to the assay region; and a strip of conductive material disposed on the porous, hydrophilic substrate. The microfluidic device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier, the barrier permeating the thickness of the porous, hydrophilic substrate and defining within the porous, hydrophilic substrate a boundary of an open-ended channel having first and second lateral walls; and an electrically conductive pathway disposed on the porous, hydrophilic substrate, the electrically conductive pathway comprising (i) a strip of conductive material forming an open circuit in the absence of an electrically conductive material bridging the first and second lateral walls; and (ii) a battery, an electrically-responsive indicator, and a resistor electrically connected to the strip of conductive material.

Abstract translation: 本发明的特征在于测定装置，微流体装置和检测流体样品中高电解质浓度的存在的方法。测定装置包括多孔亲水底物; 限定测定区域和主通道区域边界的流体不渗透屏障，主通道区域与流体连接到测定区域的主通道区域; 以及设置在多孔亲水基底上的导电材料条。微流体装置包括多孔的亲水基底; 流体不可渗透的屏障，所述屏障渗透所述多孔亲水基底的厚度，并且在所述多孔亲水基底内限定具有第一和第二侧壁的开放式通道的边界; 以及设置在所述多孔亲水基底上的导电通路，所述导电路径包括（i）在桥接所述第一和第二侧壁的导电材料不存在的情况下形成开路的导电材料条; 以及（ii）电池，电响应指示器和电连接到导电材料条的电阻器。

22.

发明申请
METHODS OF PATTERNING PAPER 审中-公开
Title translation: 纸张图案化方法

公开(公告)号：WO2010022324A3

公开(公告)日：2010-06-03

申请号：PCT/US2009054601

申请日：2009-08-21

Applicant: HARVARD COLLEGE , MARTINEZ ANDRES W , PHILLIPS SCOTT T , WILEY BENJAMIN , WHITESIDES GEORGE M

Inventor： MARTINEZ ANDRES W , PHILLIPS SCOTT T , WILEY BENJAMIN , WHITESIDES GEORGE M

IPC: D21H19/72 , D21H25/06

CPC classification number: D21H27/02 , B01L3/5023 , B01L3/502707 , B01L2300/0816 , B01L2300/0864 , B01L2300/126 , B01L2300/165 , D21H21/16 , D21H25/06

Abstract: Methods of patterning hydrophobic materials onto hydrophilic substrates are described. Also described are articles comprising a hydrophilic substrate impregnated with a hydrophobic material, and a transparent layer capable of being patterned in contact with one surface of the substrate.

Abstract translation: 描述了将疏水性材料图案化到亲水性基材上的方法。还描述了包含浸渍有疏水材料的亲水基材和能够与基材的一个表面接触图案化的透明层的制品。

23.

发明申请
LATERAL FLOW AND FLOW-THROUGH BIOASSAY BASED ON PATTERNED POROUS MEDIA, METHODS OF MAKING SAME, AND METHODS OF USING SAME 审中-公开
Title translation: 基于图形多孔介质的横向流动和流动性生物多样性，其制造方法及其使用方法

公开(公告)号：WO2008049083A3

公开(公告)日：2009-03-12

申请号：PCT/US2007081848

申请日：2007-10-18

Applicant: HARVARD COLLEGE , WHITESIDES GEORGE M , PHILLIPS SCOTT T , MARTINEZ ANDRES W , BUTTE MANISH J , WONG AMY , THOMAS SAMUEL , SINDI HAYAT , VELLA SARAH JANE , CARRILHO EMANUEL , MIRICA KATHERINE A , LIU YANYAN

Inventor： WHITESIDES GEORGE M , PHILLIPS SCOTT T , MARTINEZ ANDRES W , BUTTE MANISH J , WONG AMY , THOMAS SAMUEL , SINDI HAYAT , VELLA SARAH JANE , CARRILHO EMANUEL , MIRICA KATHERINE A , LIU YANYAN

IPC: G01N33/558

CPC classification number: G01N33/558

Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.

Abstract translation: 本发明的实施方案提供了基于图案化多孔介质的横向流动和流通生物测定装置，其制备方法及其使用方法。在一个方面，测定装置包括多孔亲水介质; 包含聚合的光致抗蚀剂的流体不透过屏障，所述屏障基本上渗透所述多孔亲水介质的厚度，并且限定所述多孔亲水介质内的测定区域的边界; 和测定区域中的测定试剂。

24.

发明申请
DENSITY-BASED METHODS FOR SEPARATION OF MATERIALS, MONITORING OF SOLID SUPPORTED REACTIONS AND MEASURING DENSITIES OF SMALL LIQUID VOLUMES AND SOLIDS 审中-公开
Title translation: 基于密度的方法分离材料，监测固体支撑反应和测量小液体体积和固体密度

公开(公告)号：WO2009006409A2

公开(公告)日：2009-01-08

申请号：PCT/US2008068797

申请日：2008-06-30

Applicant: HARVARD COLLEGE , PHILLIPS SCOTT T , WHITESIDES GEORGE M , MIRICA KATHERINE A , CARRILHO EMANUEL , MARTINEZ ANDRES W , SHEVKOPLYAS SERGEY S , SNYDER PHILLIP W , PEREZ-CASTILLEJOS RAQUEL , GUPTA MALANCHA , WINKLEMAN ADAM , GUDIKSEN KATHERINE L

Inventor： PHILLIPS SCOTT T , WHITESIDES GEORGE M , MIRICA KATHERINE A , CARRILHO EMANUEL , MARTINEZ ANDRES W , SHEVKOPLYAS SERGEY S , SNYDER PHILLIP W , PEREZ-CASTILLEJOS RAQUEL , GUPTA MALANCHA , WINKLEMAN ADAM , GUDIKSEN KATHERINE L

IPC: G01N33/53

CPC classification number: G01N33/5434 , B01L3/502761 , B01L3/502776 , B01L3/50825 , B01L2200/0652 , B01L2300/045 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , B01L2400/0457 , B01L2400/0487 , G01N33/54333 , G01R33/1269

Abstract: The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.

Abstract translation: 描述了悬浮在使用不均匀磁场的含有顺磁性阳离子的溶液中的反磁性粒子悬浮，分离和检测密度变化的能力。该分离装置的主要优点是：i）它是一种不需要电力的简单装置（一组永磁体和重力足以使抗磁分离和收集系统工作）; ii）它与简单的光学检测兼容（只要透明材料用于制造分离发生的容器/通道; iii）收集分离的颗粒以便进一步处理是简单的; iv）它不需要磁性标记颗粒/材料; 和v）它小巧便携。所提供的方法和试剂盒用于分离和收集不同密度的物质，用于检测感兴趣分析物的诊断，固体支持的化学反应的监测以及固体和液体混合物密度的测定。