公开(公告)号：CZ9203811A3

公开(公告)日：1993-12-15

申请号：CS381192

申请日：1992-12-21

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  WAGNER ADALBERT DR ,  GERHARDS HERMANN DR ,  BECKER REINHARD DR ,  SCHOLKENS BERNWARD PROF DR

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/64 ,  A61P9/10 ,  A61P9/12 ,  C07D233/84 ,  C07D233/86 ,  C07D233/90

CPC classification number: C07D233/84 ,  C07D233/90

公开(公告)号：CZ416291A3

公开(公告)日：1993-09-15

申请号：CS416291

申请日：1991-12-30

Applicant: HOECHST AG

Inventor： TEETZ VOLKER DR ,  GEIGER ROLF PROF DR ,  URBACH HANSJORG DR ,  BECKER REINHARD DR ,  SCHOLKENS BERNWARD DR

IPC: C07C227/08 ,  A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61P9/12 ,  C07C227/10 ,  C07C227/16 ,  C07C229/28 ,  C07C229/36 ,  C07C237/06 ,  C07D209/52 ,  C07D451/04 ,  C07K5/02 ,  C07K5/06

Abstract: Compounds of the formula I (I) in which the carboxyl group on carbon atom 3 is orientated in the endo-position relative to the bicyclic ring system of cis-configuration, and in which R1 denotes hydrogen, allyl, vinyl or a side-chain of a naturally occurring alpha -aminoacid, which may be protected, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl and Z denotes hydrogen, or Y and Z together denote oxygen, and X denotes alkyl, alkenyl or cycloalkyl, or aryl which is optionally mono-, di- or tri-substituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or denotes indol-3-yl, a process for their preparation, agents containing these compounds and their use.

公开(公告)号：BR9200011A

公开(公告)日：1992-09-08

申请号：BR9200011

申请日：1992-01-03

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  ENGLERT HEINRICH DR ,  KLEEMANN HEINZ-WERNER DR ,  GERHARDS HERMANN DR ,  SCHOELKENS BERNWARD DR ,  BECKER REINHARD DR ,  LINZ WOLFGANG DR

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00 ,  C07D231/12 ,  C07D409/14

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：DE3685177D1

公开(公告)日：1992-06-11

申请号：DE3685177

申请日：1986-08-29

Applicant: HOECHST AG

Inventor： BECKER REINHARD DR ,  GEIGER ROLF PROF DR ,  HENNING RAINER DR ,  TEETZ VOLKER DR ,  URBACH HANSJOERG DR

IPC: A61K45/06 ,  A61K31/40 ,  A61K31/635 ,  A61K38/00 ,  A61K38/55 ,  A61P7/10 ,  A61P9/12 ,  A61P43/00

Abstract: The preparation contains an angiotensin converting enzyme inhibitor and a loop diuretic.

公开(公告)号：AT75610T

公开(公告)日：1992-05-15

申请号：AT86111973

申请日：1986-08-29

Applicant: HOECHST AG

Inventor： BECKER REINHARD DR ,  GEIGER ROLF PROF DR ,  HENNING RAINER DR ,  TEETZ VOLKER DR ,  URBACH HANSJOERG DR

IPC: A61K45/06 ,  A61K31/40 ,  A61K31/635 ,  A61K38/00 ,  A61K38/55 ,  A61P7/10 ,  A61P9/12 ,  A61P43/00

公开(公告)号：CS9104095A3

公开(公告)日：1992-04-15

申请号：CS409591

申请日：1991-12-27

Applicant: HOECHST AG

Inventor： URBACH HANSJORG DR ,  HENNING RAINER DR ,  TEETZ VOLKER DR ,  GEIGER ROLF PROF DR ,  BECKER REINHARD DR ,  GAUL HOLGER

IPC: A61K38/55 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K38/00 ,  A61P7/10 ,  A61P9/08 ,  A61P9/12 ,  C07D209/02 ,  C07D209/08 ,  C07D209/32 ,  C07D209/34 ,  C07D209/42 ,  C07D209/52 ,  C07D215/22 ,  C07D215/227 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06

CPC classification number: C07D215/227 ,  A61K38/00 ,  C07D209/08 ,  C07D209/34 ,  C07D209/42 ,  C07D209/52 ,  C07K5/0222

公开(公告)号：AT74366T

公开(公告)日：1992-04-15

申请号：AT86106515

申请日：1986-05-14

Applicant: HOECHST AG

Inventor： URBACH HANSJOERG DR ,  HENNING RAINER DR ,  BECKER REINHARD DR

IPC: C07D521/00 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P43/00 ,  C07D209/52 ,  C07K1/02 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/068 ,  C07K14/81 ,  A61K37/02

公开(公告)号：AT53203T

公开(公告)日：1990-06-15

申请号：AT84107607

申请日：1984-06-30

Applicant: HOECHST AG

Inventor： URBACH HANSJOERG DR ,  HENNING RAINER DR ,  BECKER REINHARD DR

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/405 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P43/00 ,  C07D209/52 ,  C07D221/04 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08 ,  C07K14/81

公开(公告)号：DE3731085A1

公开(公告)日：1989-04-06

申请号：DE3731085

申请日：1987-09-16

Applicant: HOECHST AG

Inventor： RUEGER WOLFGANG DR ,  URBACH HANSJOERG DR ,  BECKER REINHARD DR ,  HOCK FRANZ DR

IPC: C07D317/34 ,  A61K38/00 ,  A61K38/55 ,  A61P25/28 ,  A61P29/00 ,  C07D317/36 ,  C07D317/40 ,  C07D405/12 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81

Abstract: The esters have the formula I … … in which n is 1 or 2, R, R , R and R are hydrogen or a defined radical, R together with R and the atoms carrying them form a heterocyclic ring system.

公开(公告)号：DE3476067D1

公开(公告)日：1989-02-16

申请号：DE3476067

申请日：1984-01-09

Applicant: HOECHST AG

Inventor： HENNING RAINER DR ,  URBACH HANSJORG DR ,  TEETZ VOLKER DR ,  BECKER REINHARD DR

IPC: A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P43/00 ,  C07D209/96 ,  C07D317/28 ,  C07D317/30 ,  C07D317/32 ,  C07D317/72 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  C07K14/81 ,  A61K37/02

Abstract: The invention relates to new spirocyclic aminoacid derivatives of the formula I (I) in which m denotes 1 or 2, n denotes 0 or 1, R denotes hydrogen, alkyl or aralkyl, R1 denotes hydrogen or alkyl which can be optionally substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each of which can be substituted by alkyl, alkoxy or halogen, arylalkyl or aroylalkyl, both of which can be substituted as defined above in the aryl radical, an S- or O- and/or N-heterocyclic radical or a side chain of an alpha -aminoacid, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen, or Y and Z together denote oxygen and X denotes alkyl, alkenyl, cycloalkyl, aryl, which can be monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino and/or methylenedioxy, or 3-indolyl, processes for their preparation, agents containing them and their use and new spirocyclic aminoacids as intermediates and a process for their preparation.