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公开(公告)号：DK0455133T3
公开(公告)日：1997-08-25
申请号：DK91106663
申请日：1991-04-25
Applicant: HOECHST AG
Inventor： HENKE STEPHAN DR , HOCK FRANZ DR , BREIPOHL GERHARD DR , KNOLLE JOCHEN DR , SCHOELKENS BERNWARD PROF DR
Abstract: Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aliphatic or alicyclic-aliphatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or a direct bond, I is -OH, -NH2 or -NHC2H5, and K is a radical -NH-(CH2)1-4-CO-, or is a direct bond, have a bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are mediated, induced or assisted by bradykinin and bradykinin-related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.
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公开(公告)号：ES2061447T3
公开(公告)日：1994-12-16
申请号：ES87103938
申请日：1987-03-18
Applicant: HOECHST AG
Inventor： HOCK FRANZ DR , SCHOLTHOLT JOSEF PROF DR , URBACH HANSJORG DR , HENNING RAINER DR , LERCH ULRICH DR , NICKEL WOLF-ULRICH DR , RUGER WOLFGANG DR
IPC: C07K14/81 , A61K38/00 , A61P9/12 , A61P25/28 , C07C235/02 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/06 , A61K37/02 , A61K37/64
Abstract: The invention relates to novel compounds having a nootropic activity, the use of ACE inhibitors as medicaments having nootropic activity, agents containing them, and their use in the treatment and prophylaxis of cognitive malfunctions.
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公开(公告)号：CS8906519A3
公开(公告)日：1992-05-13
申请号：CS651989
申请日：1987-03-27
Applicant: HOECHST AG
Inventor： HOCK FRANZ DR , SCHOLTHOLT JOSEF PROF DR , URBACH HANSJORG DR , HENNING RAINER DR , LERCH ULRICH DR , NICKEL WOLF-ULRICH DR , RUGER WOLFGANG DR
IPC: C07K14/81 , A61K38/00 , A61P9/12 , A61P25/28 , C07C235/02 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/06 , C07C103/50 , C07C103/68
CPC classification number: C07K5/0222 , A61K38/00
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公开(公告)号：CS8702126A3
公开(公告)日：1992-04-15
申请号：CS212687
申请日：1987-03-27
Applicant: HOECHST AG
Inventor： HOCK FRANZ DR , SCHOLTHOLT JOSEF PROF DR , URBACH HANSJORG DR , HENNING RAINER DR , LERCH ULRICH DR , NICKEL WOLF-ULRICH DR , RUGER WOLFGANG DR
IPC: C07K14/81 , A61K38/00 , A61P9/12 , A61P25/28 , C07C235/02 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/06 , C07C233/50 , C07C233/68
CPC classification number: C07K5/0222 , A61K38/00
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公开(公告)号：DE4013270A1
公开(公告)日：1991-10-31
申请号：DE4013270
申请日：1990-04-26
Applicant: HOECHST AG
Inventor： BREIPOHL GERHARD DR , HENKE STEPHAN DR , KNOLLE JOCHEN DR , SCHOELKENS BERNWARD PROF , HOCK FRANZ DR
Abstract: Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aliphatic or alicyclic-aliphatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or a direct bond, I is -OH, -NH2 or -NHC2H5, and K is a radical -NH-(CH2)1-4-CO-, or is a direct bond, have a bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are mediated, induced or assisted by bradykinin and bradykinin-related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.
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Patent Agency Ranking
公开(公告)号：DE3931788A1
公开(公告)日：1991-04-04
申请号：DE3931788
申请日：1989-09-23
Applicant: HOECHST AG
Inventor： JAEGER GEORG DR , GERHARDS HERMANN DR , HOCK FRANZ DR
IPC: A61K38/00 , A61P25/28 , C07K1/06 , C07K7/06 , C07K14/695
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公开(公告)号：DE3803225A1
公开(公告)日：1989-08-17
申请号：DE3803225
申请日：1988-02-04
Applicant: HOECHST AG
Inventor： RUEGER WOLFGANG DR , URBACH HANSJOERG DR , BECKER REINHARD DR , HOCK FRANZ DR
IPC: C07D209/02 , A61K31/55 , A61K38/00 , A61K38/55 , A61P9/12 , A61P25/28 , C07C237/02 , C07D207/08 , C07D207/16 , C07D209/42 , C07D209/54 , C07D209/56 , C07D487/04 , C07K5/02
Abstract: The invention relates to amides of the formula in which R is NR R and the other radicals have the meaning stated in the description, to processes for the preparation thereof, to intermediates in the preparation thereof, to agents containing them and the use thereof as pharmaceuticals with a psychotropic action. The invention furthermore relates to the use of known amides as pharmaceuticals with a psychotropic action.
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公开(公告)号：DE3712364A1
公开(公告)日：1988-10-27
申请号：DE3712364
申请日：1987-04-11
Applicant: HOECHST AG
Inventor： HENNING RAINER DR , URBACH HANSJOERG DR , HOCK FRANZ DR
IPC: A61K31/40 , A61K31/401 , A61K31/44 , A61P25/18 , A61P43/00 , C07D207/08 , C07D207/16 , C07D401/14 , C07D403/12 , C07D403/14 , C07D521/00 , C07D401/06 , C07D413/06 , C07D417/06
Abstract: Pyrrolidine derivatives of the formula … … in which R , R , R , R , R and R have the meaning given in the description, X denotes oxygen, imino or alkylimino, m is 0-5, n is 0-2 and s is 0 or 1.
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公开(公告)号：DK0424670T3
公开(公告)日：1995-07-17
申请号：DK90118102
申请日：1990-09-20
Applicant: HOECHST AG
Inventor： GERHARDS HERMANN JOSEF DR , JAEGER GEORG DR , HOCK FRANZ DR
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公开(公告)号：ES2070229T3
公开(公告)日：1995-06-01
申请号：ES90118102
申请日：1990-09-20
Applicant: HOECHST AG
Inventor： JAGER GEORG DR , GERHARDS HERMANN JOSEF DR , HOCK FRANZ DR
IPC: A61K38/00 , A61P25/28 , C07K1/06 , C07K7/06 , C07K14/695
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