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    23.
    发明专利
    未知

    公开(公告)号：SE7714685L

    公开(公告)日：1978-06-25

    申请号：SE7714685

    申请日：1977-12-22

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  THORWART W ,  KOMAREK J ,  CARTHEUSER C ,  POPENDIKER K ,  GREVE H-G

    IPC: C07D295/08 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/451 ,  A61K31/455 ,  A61K31/495 ,  A61K31/52 ,  A61K31/522 ,  A61P7/10 ,  A61P9/08 ,  A61P9/12 ,  A61P25/02 ,  A61P25/20 ,  C07D209/14 ,  C07D211/22 ,  C07D213/53 ,  C07D213/80 ,  C07D231/16 ,  C07D231/38 ,  C07D233/54 ,  C07D233/64 ,  C07D295/088 ,  C07D303/12 ,  C07D311/22 ,  C07D317/58 ,  C07D317/62 ,  C07D317/64 ,  C07D333/22 ,  C07D473/12 ,  C07D295/12

    Abstract: Compounds of general formula (I) wherein R1 represents a radical selected from the group consisting of (a) hydrogen, carboxyl; (b) alkyl, alkenyl each having up to 6 carbon atoms and their phenyl substituted derivatives; (c) at most binuclear unsubstituted aryl, at most binuclear aryl substituted by from 1 to 3 substituents selected from the group consisting of alkyl and alkoxy each having up to 6 carbon atoms, benzloxy, haloalkyl having up to 2 carbon atoms, halogen, cyano and nitro; amino, carboxyl and hydroxy; amino, carboxyl and hydroxy each being substituted by alkyl having at most 2 carbon atoms, methylenedioxy groups and O- -hydroximinom ethyl groups; (d) at most bicyclic unsubstituted heteroaromatic group having 1 to 4 heteroatoms selected from the group consisting of nitrogen, one sulphur and one oxygen in the ring system and such a heteroaromatic group being substituted by at most 3 substituents selected from the group consisting of alkyl, alkoxy each having up to 2 carbon atoms, phenylalkyl having up to 3 carbon atoms in the alkyl moiety, halogen, methylamino and dimethylamino; R2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, cycloalkyl having up to 6 carbon atoms and phenyl; and R1 and R2, together with the carbon atom to which they are attached, form a radical selected from the group consisting of fluorene-9-ylidene and a cycloaliphatic group having up to 10 carbon atoms and such a cycloaliphatic group containing a hydrocarbon bridging group; R3 represents a member selected from the group consisting of hydrogen hydroxy and acyloxy; R4 represents a member selected from the group consisting of hydrogen alkyl having up to 3 carbon atoms and phenyl; R5 represents a member selected from the group consisting of halogen, alkoxy having up to 2 carbon atoms and hydroxy; and X represents a member selected from the group consisting of nitrogen and methine and physiologically acceptable acid addition salts thereof; a pharmaceutical composition containing said compounds.

    ALKYLATED HYDROXYLAMINES
    28.
    发明专利
    ALKYLATED HYDROXYLAMINES 未知

    公开(公告)号：ZA776670B

    公开(公告)日：1978-08-30

    申请号：ZA776670

    申请日：1977-11-08

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  KOMAREK J ,  THORWART W ,  CARTHEUSER C

    IPC: A61K31/395 ,  A61K31/13 ,  A61K31/24 ,  A61P9/12 ,  C07C215/30 ,  C07C239/12 ,  C07C239/20 ,  C07C255/53 ,  C07C255/54 ,  C07C319/14 ,  C07C323/12 ,  C07D207/06 ,  C07D211/00 ,  C07D211/14 ,  C07D233/60 ,  C07D233/74 ,  C07D235/06 ,  C07D295/06 ,  C07D295/08 ,  C07D295/088 ,  C07D295/12 ,  C07D473/08 ,  C07D521/00 ,  C07C83/02

    Abstract: A compound of general formula (I) wherein X represents a radical selected from the group consisting of one of the formulae in which R1 represents a radical selected from the group (a) a hydrogen atom, (b) an amino group, when X represents an -OR1 moiety, (c) an alkyl group having from 1 to 6 carbon atoms (d) an at most binuclear aryl group being unsubstituted or substituted by at most 3 substituents of the group halogen atoms, alkyl, alkoxy, halogenalkyl groups each having up to 4 carbon atoms, cycloalkyl groups having 3 to 6 carbon atoms, nitro and cyano groups; and R2 and R3, which may be the same or different, each represents a radical selected from the group (a) a hydrogen atom, (b) an alkyl group having from 1 to 6 carbon atoms, an unsubstituted cycloalkyl group having from 3 to 7 carbon atoms, such cycloalkyl group substituted by at most 3 substituents of the group hydroxy groups and alkoxycarbonyl groups having 1 to 4 carbon atoms, (c) an aralkyl group, a diaralkyl group each having 1 to 4 carbon atoms in the alkyl moiety and being unsubstituted or substituted in at least one of the radicals in the alkyl moiety by hydroxy groups, and in the aryl moieties by at most 3 substituents selected from the group consisting of alkoxy groups having from 1 to 4 carbon atoms and halogen atoms, (d) an at most binuclear aryl group being unsubstituted or substituted by at most 3 substituents selected from the group consisting of alkyl, alkoxy, halogenoalkyl groups each having up to 4 carbon atoms and halogen atoms, (e) a hydroxy group when the other of R2 and R3 is hydrogen, (f) R2 and R3, together with the nitrogen atom to which they are attached, represent a 5- to 7-membered ring selected from the group consisting of an unsubstituted ring, a ring being substituted by an alkyl group having from 1 to 4 carbon atoms, and a ring being interrupted by a heteroatom selected from the group consisting of oxygen, sulphur and further nitrogen atom, and (g) R2 and R3 together with the nitrogen atom to which they are attached, represent a ring from the group a 5-membered heteroaromatic ring containing up to 4 nitrogen atoms and such a ring being anelled to a benzene- or uracil-ring, and physiologically acceptable acid addition salts thereof, a process for their preparation and a pharmaceutical composition containing them.

    30.
    发明专利
    未知

    公开(公告)号：DK496977A

    公开(公告)日：1978-05-10

    申请号：DK496977

    申请日：1977-11-08

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  THORWART W ,  KOMAREK J ,  CARTHEUSER C

    IPC: A61K31/395 ,  A61K31/13 ,  A61K31/24 ,  A61P9/12 ,  C07C215/30 ,  C07C239/12 ,  C07C239/20 ,  C07C255/53 ,  C07C255/54 ,  C07C319/14 ,  C07C323/12 ,  C07D207/06 ,  C07D211/00 ,  C07D211/14 ,  C07D233/60 ,  C07D233/74 ,  C07D235/06 ,  C07D295/06 ,  C07D295/08 ,  C07D295/088 ,  C07D295/12 ,  C07D473/08 ,  C07D521/00 ,  C07C

    Abstract: A compound of general formula (I) wherein X represents a radical selected from the group consisting of one of the formulae in which R1 represents a radical selected from the group (a) a hydrogen atom, (b) an amino group, when X represents an -OR1 moiety, (c) an alkyl group having from 1 to 6 carbon atoms (d) an at most binuclear aryl group being unsubstituted or substituted by at most 3 substituents of the group halogen atoms, alkyl, alkoxy, halogenalkyl groups each having up to 4 carbon atoms, cycloalkyl groups having 3 to 6 carbon atoms, nitro and cyano groups; and R2 and R3, which may be the same or different, each represents a radical selected from the group (a) a hydrogen atom, (b) an alkyl group having from 1 to 6 carbon atoms, an unsubstituted cycloalkyl group having from 3 to 7 carbon atoms, such cycloalkyl group substituted by at most 3 substituents of the group hydroxy groups and alkoxycarbonyl groups having 1 to 4 carbon atoms, (c) an aralkyl group, a diaralkyl group each having 1 to 4 carbon atoms in the alkyl moiety and being unsubstituted or substituted in at least one of the radicals in the alkyl moiety by hydroxy groups, and in the aryl moieties by at most 3 substituents selected from the group consisting of alkoxy groups having from 1 to 4 carbon atoms and halogen atoms, (d) an at most binuclear aryl group being unsubstituted or substituted by at most 3 substituents selected from the group consisting of alkyl, alkoxy, halogenoalkyl groups each having up to 4 carbon atoms and halogen atoms, (e) a hydroxy group when the other of R2 and R3 is hydrogen, (f) R2 and R3, together with the nitrogen atom to which they are attached, represent a 5- to 7-membered ring selected from the group consisting of an unsubstituted ring, a ring being substituted by an alkyl group having from 1 to 4 carbon atoms, and a ring being interrupted by a heteroatom selected from the group consisting of oxygen, sulphur and further nitrogen atom, and (g) R2 and R3 together with the nitrogen atom to which they are attached, represent a ring from the group a 5-membered heteroaromatic ring containing up to 4 nitrogen atoms and such a ring being anelled to a benzene- or uracil-ring, and physiologically acceptable acid addition salts thereof, a process for their preparation and a pharmaceutical composition containing them.

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