公开(公告)号：AU512130B2

公开(公告)日：1980-09-25

申请号：AU1636376

申请日：1976-07-29

Applicant: HOECHST AG

Inventor： MCFADDEN A R ,  AULTZ D E

IPC: A61K31/55 ,  A61P25/04 ,  A61P29/00 ,  C07D313/12 ,  A61K31/335 ,  C07C65/02

公开(公告)号：AU499709B2

公开(公告)日：1979-05-03

申请号：AU7296274

申请日：1974-09-04

Applicant: HOECHST AG

Inventor： HELSLEY G C ,  MCFADDEN A R ,  HOFFMAN D

IPC: C07C59/70 ,  C07C65/24 ,  C07D313/12 ,  C07D9/00 ,  A61K27/00

Abstract: 6,11-Dihydrodibenz[b,e]oxepin-acetic acids and derivatives having the general formula are prepared by multi-step sequences. X is C=O, CHCl, CHBr, CH2 or CHOR4; Y is alkyl or alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; n is 0, 1, 2 or 3; Z is COOR5, CH2OR5, CONR25 or CONHOR5; and R1-R5 are hydrogen or alkyl of 1 to 4 carbon atoms. These compounds and the physiologically tolerable salts thereof are useful as antiinflammatory and analgesic agents.

公开(公告)号：SE7810895A

公开(公告)日：1979-04-20

申请号：SE7810895

申请日：1978-10-19

Applicant: HOECHST AG

Inventor： MCFADDEN A R ,  ALLEN R C ,  LEE T B K

IPC: A61K31/335 ,  A61P25/04 ,  A61P29/00 ,  C07D295/185 ,  C07D313/12

CPC classification number: C07D295/185 ,  C07D313/12

公开(公告)号：SE7706527L

公开(公告)日：1977-12-04

申请号：SE7706527

申请日：1977-06-03

Applicant: HOECHST AG

Inventor： MCFADDEN A R ,  HELSLEY G C

IPC: A61K31/335 ,  A61P29/00 ,  C07D313/12

Abstract: Benzyl and related esters of 6,11-dihydrodibenz[b,e]oxepin-acetic and method for preparing same are described. These compounds are valuable as systemic and topical anti-inflammatory agents.

公开(公告)号：NO762647L

公开(公告)日：1977-02-01

申请号：NO762647

申请日：1976-07-29

Applicant: HOECHST AG

Inventor： MCFADDEN A R ,  AULTZ D E

IPC: A61K31/55 ,  A61P25/04 ,  A61P29/00 ,  C07D313/12 ,  C07D

公开(公告)号：SE7608546L

公开(公告)日：1977-01-31

申请号：SE7608546

申请日：1976-07-29

Applicant: HOECHST AG

Inventor： MCFADDEN A R ,  AULTZ D E

IPC: A61K31/55 ,  A61P25/04 ,  A61P29/00 ,  C07D313/12

公开(公告)号：SE7608546A

公开(公告)日：1977-01-31

申请号：SE7608546

申请日：1976-07-29

Applicant: HOECHST AG

Inventor： MCFADDEN A R ,  AULTZ D E

IPC: A61K31/55 ,  A61P25/04 ,  A61P29/00 ,  C07D313/12

CPC classification number: C07D313/12

公开(公告)号：NO743203L

公开(公告)日：1975-04-01

申请号：NO743203

申请日：1974-09-05

Applicant: HOECHST AG

Inventor： HELSLEY G C ,  MCFADDEN A R ,  HOFFMANN D

IPC: C07C59/70 ,  C07C65/24 ,  C07D313/12 ,  C07D

Abstract: 6,11-Dihydrodibenz[b,e]oxepin-acetic acids and derivatives having the general formula are prepared by multi-step sequences. X is C=O, CHCl, CHBr, CH2 or CHOR4; Y is alkyl or alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; n is 0, 1, 2 or 3; Z is COOR5, CH2OR5, CONR25 or CONHOR5; and R1-R5 are hydrogen or alkyl of 1 to 4 carbon atoms. These compounds and the physiologically tolerable salts thereof are useful as antiinflammatory and analgesic agents.

公开(公告)号：SE7411156A

公开(公告)日：1975-03-07

申请号：SE7411156

申请日：1974-09-04

Applicant: HOECHST AG

Inventor： HELSLEY G C ,  MCFADDEN A R ,  HOFFMANN D

IPC: C07C59/70 ,  C07C65/24 ,  C07D313/12 ,  C07D9/00

CPC classification number: C07D313/12 ,  C07C59/70 ,  C07C65/24

公开(公告)号：FI258374A

公开(公告)日：1975-03-07

申请号：FI258374

申请日：1974-09-04

Applicant: HOECHST AG

Inventor： HELSLEY G C ,  MCFADDEN A R ,  HOFFMANN D

IPC: C07C59/70 ,  C07C65/24 ,  C07D313/12 ,  C07D

Abstract: 6,11-Dihydrodibenz[b,e]oxepin-acetic acids and derivatives having the general formula are prepared by multi-step sequences. X is C=O, CHCl, CHBr, CH2 or CHOR4; Y is alkyl or alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; n is 0, 1, 2 or 3; Z is COOR5, CH2OR5, CONR25 or CONHOR5; and R1-R5 are hydrogen or alkyl of 1 to 4 carbon atoms. These compounds and the physiologically tolerable salts thereof are useful as antiinflammatory and analgesic agents.