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公开(公告)号：DE3932817A1
公开(公告)日：1991-04-11
申请号：DE3932817
申请日：1989-09-30
Applicant: HOECHST AG
Inventor： KLEEMANN HEINZ-WERNER DR , URBACH HANSJOERG DR , WAGNER ADALBERT DR , RUPPERT DIETER DR , LINZ WOLFGANG DR , KRAMER WERNER DR DR
IPC: C07D233/54 , C07D401/12 , C07D403/12 , C07D409/12 , C07K5/065 , C07K5/078
Abstract: Peptide polyhydroxyalkylamides of formula (I) and their salts are new; where A = R1R6N-CHR5-CO-, R1R7CH-CHR5-CO- or R1O-CHR5-CO-; R1 = R'1 or R'1W; R'1 = (a) 3-8C cycloalkyl, CONH2, OCH2COOH, NH2, etc. (b) H, OH or 1-4C alkoxy, (c) 1-18C alkyl, quanidino, phenyl(1-4C)alkoxy, etc. (d) 6-14C aryl, (6-14C)aryl(1-4C)alkyl, etc. (e) Het or Het(1-4C)alkyl, where Het is an opt. benzo-fused 5- to 7-membered heterocyclic ring contg. 1 or 2 of N, O, S, No, etc. (f) NR8R9; Het or Het(1-4C)alkyl, or NR8R9 is a mono- or bicyclic 5- to 12-membered ring system opt. contg. 1 or 2 more N atoms, an S atom or an O atom, opt. substd. by 1-4C alkyl; W = CO, CS, OSO, SO2, SO, NHSO2, NHCO, CHOH or NOH; n = 2-10.
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公开(公告)号：DE3839559A1
公开(公告)日：1990-05-31
申请号：DE3839559
申请日：1988-11-24
Applicant: HOECHST AG
Inventor： HENNING RAINER DR , URBACH HANSJOERG DR , RUPPERT DIETER DR , SCHOELKENS BERNWARD DR
IPC: C07D213/40 , A61K31/415 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K38/00 , A61K38/55 , A61P9/12 , C07D233/64 , C07D401/12 , C07D409/12 , C07K5/02 , C07K5/06 , C07K5/065 , C07K14/81
Abstract: The invention relates to compounds of the formula I in which A is a radical of the formula II in which E is a CH2 group or a radical NR , G is a radical from the group comprising S, SO, SO2, O, CO, CS or a direct bond, B is an amino acid, D is a heterocycle, and R , R , R , R , R , R and R are defined in the description, and the salts thereof. The invention also relates to a process for preparing the compounds of the formula I and to the use thereof as medicines.
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公开(公告)号：DE3839128A1
公开(公告)日：1990-05-31
申请号：DE3839128
申请日：1988-11-19
Applicant: HOECHST AG
Inventor： RUEGER WOLFGANG DR , URBACH HANSJOERG DR , RUPPERT DIETER DR , SCHOELKENS BERNWARD DR
Abstract: The invention relates to compounds of the formula I in which A denotes the radical of a natural or synthetic amino acid, B denotes the radical of a natural or synthetic amino acid, D denotes a group from the series comprising -CH2-SOx- and -CH2-NH- E is absent or denotes a group from the series comprising -(CH2)1-3-, -CHF-, -CF2-, -CH2-SOy-, X is absent or denotes a group from the series comprising and Y and R to R are defined as indicated in the description, and to a process for their preparation, agents containing them and their use.
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公开(公告)号：DE3836911A1
公开(公告)日：1989-05-24
申请号：DE3836911
申请日：1988-10-29
Applicant: HOECHST AG
Inventor： KLEEMANN HEINZ-WERNER DR , URBACH HANSJOERG DR , RUPPERT DIETER DR , SCHOELKENS BERNWARD DR
Abstract: The invention relates to compounds of the formula I in which A is one of the radicals of the formulae or A is absent or is a radical of the formula R , R and R are defined as in the description, and X and Y are, independently of one another, -O- or -NR , and their salts. Also described are a process for the preparation of the compounds of the formula I, corresponding pharmaceutical products and their use as medicines as well as intermediates for the preparation of these compounds.
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公开(公告)号：DE3610593A1
公开(公告)日：1987-10-01
申请号：DE3610593
申请日：1986-03-29
Applicant: HOECHST AG
Inventor： WEGMANN HELMUT DR , WAGNER ADALBERT DR , KLEEMANN HEINZ-WERNER DR , RUPPERT DIETER DR
IPC: C07K14/81 , A61K31/165 , A61K31/18 , A61K31/195 , A61K31/215 , A61K31/22 , A61K31/235 , A61K31/255 , A61K31/27 , A61P9/12 , A61P43/00 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C237/06 , C07C237/12 , C07C237/20 , C07C237/22 , C07C239/00 , C07C301/00 , C07C303/30 , C07C303/36 , C07C309/76 , C07C311/37 , C07C313/00 , C07C317/48 , C07C317/50 , C07C323/41 , C07D213/38 , C07D233/54 , C07D233/61 , C07D233/64 , C07D521/00 , C07K1/113 , C07K5/02 , C07K5/06 , A61K37/64 , C07D213/40
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Patent Agency Ranking
公开(公告)号：CZ9004711A3
公开(公告)日：2000-08-16
申请号：CZ471190
申请日：1990-09-27
Applicant: HOECHST AG
Inventor： BUDT KARL-HEINZ DR , STOWASSER BERND DR , RUPPERT DIETER DR , MEICHSNER CHRISTOPH DR , PAESSENS ARNOLD DR , HANSEN JUTTA DR , KNOLLE JOCHEN DR
IPC: A61K38/55 , A61K31/13 , A61K31/16 , A61K31/27 , A61K38/00 , A61K38/04 , A61P31/12 , C07C211/20 , C07C211/27 , C07C215/18 , C07C237/10 , C07C237/22 , C07C271/10 , C07C271/20 , C07C271/22 , C07C317/28 , C07C317/44 , C07C323/58 , C07C323/60 , C07D211/58 , C07D211/96 , C07D213/34 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/70 , C07D213/89 , C07D215/48 , C07D217/26 , C07D317/50 , C07D333/22 , C07D333/24 , C07D521/00 , C07F7/18 , C07K1/113 , C07K5/00 , C07K5/06 , C07K5/065 , C07K5/072 , C07K5/078 , C07K5/08 , C07K5/083 , C07K5/10 , C07K7/06 , C07K9/00 , C07K14/81
CPC classification number: C07D213/40 , A61K38/00 , C07C211/20 , C07C211/27 , C07C215/18 , C07C237/10 , C07C237/22 , C07C271/20 , C07C271/22 , C07C317/28 , C07C317/44 , C07C323/58 , C07C323/60 , C07C2601/14 , C07D211/58 , C07D211/96 , C07D213/34 , C07D213/50 , C07D213/56 , C07D213/70 , C07D213/89 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D249/08 , C07D317/50 , C07D333/22 , C07D333/24 , C07F7/1852 , C07K5/00 , C07K5/06026 , C07K5/06043 , C07K5/0606 , C07K5/06078 , C07K5/06095 , C07K5/06104 , C07K5/06139 , C07K5/06156 , C07K5/081 , C07K9/001
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公开(公告)号：CZ471190A3
公开(公告)日：2000-08-16
申请号：CZ471190
申请日：1990-09-27
Applicant: HOECHST AG
Inventor： BUDT KARL-HEINZ DR , STOWASSER BERND DR , RUPPERT DIETER DR , MEICHSNER CHRISTOPH DR , PAESSENS ARNOLD DR , HANSEN JUTTA DR , KNOLLE JOCHEN DR
IPC: A61K38/55 , A61K31/13 , A61K31/16 , A61K31/27 , A61K38/00 , A61K38/04 , A61P31/12 , C07C211/20 , C07C211/27 , C07C215/18 , C07C237/10 , C07C237/22 , C07C271/10 , C07C271/20 , C07C271/22 , C07C317/28 , C07C317/44 , C07C323/58 , C07C323/60 , C07D211/58 , C07D211/96 , C07D213/34 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/70 , C07D213/89 , C07D215/48 , C07D217/26 , C07D317/50 , C07D333/22 , C07D333/24 , C07D521/00 , C07F7/18 , C07K1/113 , C07K5/00 , C07K5/06 , C07K5/065 , C07K5/072 , C07K5/078 , C07K5/08 , C07K5/083 , C07K5/10 , C07K7/06 , C07K9/00 , C07K14/81
Abstract: The present invention relates to a compound of the formula I in which A, Y, R , R , R , R , R , l, m and the corresponding radicals with are defined as indicated in the description, a process for the preparation thereof, and the use thereof for inhibiting retroviral proteases.
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公开(公告)号：AT104678T
公开(公告)日：1994-05-15
申请号：AT89121499
申请日：1989-11-21
Applicant: HOECHST AG
Inventor： HENNING RAINER DR , URBACH HANSJOERG DR , RUPPERT DIETER DR , SCHOELKENS BERNWARD DR
IPC: C07D213/40 , A61K31/415 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K38/00 , A61K38/55 , A61P9/12 , C07D233/64 , C07D401/12 , C07D409/12 , C07K5/02 , C07K5/06 , C07K5/065 , C07K14/81 , A61K37/64
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公开(公告)号：AT100463T
公开(公告)日：1994-02-15
申请号：AT90113712
申请日：1990-07-18
Applicant: HOECHST AG
Inventor： KLEEMANN HEINZ-WERNER DR , URBACH HANSJOERG DR , WAGNER ADALBERT DR , RUPPERT DIETER DR , LINZ WOLFGANG DR , KRAMER WERNER DR DR
IPC: C12N9/99 , A61K31/38 , A61K31/381 , A61K31/415 , A61K31/445 , A61K31/535 , A61K38/55 , A61P9/12 , C07C237/08 , C07C237/22 , C07D211/26 , C07D211/58 , C07D233/54 , C07D233/64 , C07D295/20 , C07D333/24 , C07D401/12 , C07D403/12 , C07D409/12 , C07D521/00 , C07K1/113 , C07K5/06 , C07K5/065 , C07K5/078 , C07K14/81
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公开(公告)号：AT97912T
公开(公告)日：1993-12-15
申请号：AT87110847
申请日：1987-07-27
Applicant: HOECHST AG
Inventor： WAGNER ADALBERT DR , KLEEMANN HEINZ-WERNER DR , RUPPERT DIETER DR , SCHOELKENS BERNWARD DR
IPC: A61K31/415 , C07D233/64 , C07K1/00 , C07K5/02 , C07K5/06 , A61K37/64
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