公开(公告)号：NO930200D0

公开(公告)日：1993-01-21

申请号：NO930200

申请日：1993-01-21

Applicant: HOECHST AG

Inventor： UHLMANN EUGEN ,  PEYMAN ANUSCHIRWAN ,  O'MALLEY GERARD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN

IPC: A61K31/70 ,  A61K31/7125 ,  A61K48/00 ,  A61P31/12 ,  A61P35/00 ,  C07F9/24 ,  C07F9/44 ,  C07H21/00 ,  C07H21/04 ,  C12Q1/68 ,  C07H

Abstract: Oligonucleotide analogs (I) and their physiologically tolerable salts. Oligonucleotide analogs and their physiologically tolerable salts of formula (I) are new. R = H, a substituent or -P(=W)ZZ'; R = H, OH, 1-18C alkoxy, halo, azido or amino; B = nucleotide base residue; A = oxy or methylene; d, e, f = 0-50; i = 1-10; r = 0 or 1; W = oxo, selenoxo or thioxo; V = oxy, sulfandiyl or imino; Y = oxy, sulfandiyl, imino or methylene; Y' = oxy, sulfandiyl, imino, (CH2)m or V(CH2)m; m = 1-18; X = OH or SH; U, R , R = substituents; p = 1-100; q = 0-18; R = H or functional group; Sp = a (3',5'-) spacer group of formula (i); g, g' = 0 or 1; h = 0-10; G = 1-12C alkylene (optionally substituted), (6-14C)aryldi-(1-8C)alkylene, 6-18C arylene, (CH2CH2V) alpha CH2CH2, (CH2V) alpha CH2, -(G-Y-P(=W)(U)-Y'-) beta or a group of formula (ii); alpha = 1-11; beta = 1-6; Z, Z' = OH, (seleno)thio or a substituent; provided that r is 0 when V is Y' and is 1 if i is greater than 1. Positions of R and the adjacent phosphoryl residue can be reversed; each nucleoside had D- or L-configuration and each B has alpha or beta configuration. Independent claims are also included for: (1) a method for producing (I); (2) the phosphitylation reagent of formula DMTr-X'-G'-Y''-P(U')(NR R ); and (3) a pharmaceutical composition containing at least one compound (I) and optionally auxiliary, carrier and/or other active agents. R , R = 1-12C alkyl or together form a 5-6 membered ring; DMTr = dimethoxytrityl; X', Y'' = oxy or sulfandiyl; U' = 1-4C alkyl or protected OH; G' = (CH2CH2O) alpha CH2CH2 or CH2CH(OR')CH2; and R' = 1-18C alkyl, 6-14C aryl or 6-14C aryl(1-8C) alkyl.

公开(公告)号：IE921187A1

公开(公告)日：1992-10-21

申请号：IE921187

申请日：1992-04-14

Applicant: HOECHST AG

Inventor： BILLHARDT UTA-MARIA ,  ROSNER MANFRED ,  RIEB GUNTHER ,  WINKLER IRVIN ,  BENDER RUDOLF

IPC: A61K31/495 ,  A61K20060101 ,  A61K31/535 ,  A61K31/54 ,  A61P31/12 ,  A61P31/16 ,  A61P31/18 ,  C07D20060101 ,  C07D241/38 ,  C07D241/40 ,  C07D241/44 ,  C07D241/52 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D471/04 ,  C07D487/04 ,  C07D241/00 ,  C07D401/00 ,  C07D403/00 ,  C07D405/00 ,  C07D409/00 ,  C07D487/00

Abstract: Compounds of the formula I or Ia in which n and the substituents R - R and also X have the same meaning, have antiviral activity.

公开(公告)号：NZ225611A

公开(公告)日：1991-09-25

申请号：NZ22561188

申请日：1988-07-29

Applicant: HOECHST AG

Inventor： SCHRINNER ELMAR ,  WINKLER IRVIN ,  MEICHSNER CHRISTOPH ,  HELSBERG MATTHIAS

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/52 ,  A61K31/70 ,  A61K31/715 ,  A61P31/12 ,  C07D20060101 ,  C07D473/04 ,  C08B20060101 ,  C08B37/00 ,  A61K31/72 ,  A61K31/735

Abstract: The preparation contains or consists of… a) at least one sulphated polysaccharide and… b) at least one xanthine derivative. The preparation is suitable for the control and prophylaxis of viral diseases, especially those caused by retroviruses.

公开(公告)号：HUT56111A

公开(公告)日：1991-07-29

申请号：HU841290

申请日：1990-12-21

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIWAN ,  UHLMANN EUGEN ,  WINKLER IRVIN ,  HELSBERG MATTHIAS ,  MEICHSNER CHRISTOPH

IPC: A61K31/66 ,  A61K31/662 ,  A61K31/675 ,  A61K31/685 ,  A61P31/12 ,  A61P31/18 ,  C07F9/38 ,  C07F9/40 ,  C07F9/58 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/6558 ,  C07F9/6571

Abstract: The compound of the formula I in which R represents an aldehyde group or a group which can be converted into an aldehyde, R and R represent alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, hydrogen, sodium, potassium, calcium, magnesium, aluminium, lithium, ammonium or triethylammonium or R and R together form a cyclic diester, R and R represent alkyl, alkenyl, alkynyl, cycloalkyl, hydrogen, alkoxy or halogen, R and R represent alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, alkoxy, phenyl, cyanide, hydroxyl or hydrogen, X, Y or Z represent oxygen or sulphur, or prodrug forms of the compound of the formula I can be used for treatment of diseases caused by viruses. The preparation of these compounds and pharmaceutical preparations which contain them and also their use are described.

公开(公告)号：CA2032772A1

公开(公告)日：1991-06-22

申请号：CA2032772

申请日：1990-12-20

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN ,  UHLMANN EUGEN ,  WINKLER IRVIN ,  HELSBERG MATTHIAS ,  MEICHSNER CHRISTOPH

IPC: A61K31/66 ,  A61K31/662 ,  A61K31/675 ,  A61K31/685 ,  A61P31/12 ,  A61P31/18 ,  C07F9/38 ,  C07F9/40 ,  C07F9/58 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/6558 ,  C07F9/6571 ,  C07F9/547

Abstract: 2-Formylbenzylphosphonic acid derivatives, their prepar- ation and their use for the treatment of diseases caused by viruses The compound of the formula I in which R is an aldehyde group or a group which can be converted into an aldehyde, R1 and R2 are alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, hydrogen, sodium, potas- sium, calcium, magnesium, aluminum, lithium, ammonium or triethylammonium, or R1 and R2 together form a cyclic diester, R3 and R4 are alkyl, alkenyl, alkynyl, cycloalkyl, hydro- gen, alkoxy or halogen, R5 and R8 are alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, alkoxy, phenyl, cyanide, hydroxyl or hydrogen, and X, Y or Z are oxygen or sulfur, or prodrug forms of the compound of the formula I can be used for the treatment of diseases caused by viruses. The preparation of these compounds and pharmaceutical preparations containing them and their use is described.

公开(公告)号：PT92573A

公开(公告)日：1990-06-29

申请号：PT9257389

申请日：1989-12-14

Applicant: HOECHST AG

Inventor： MEICHSNER CHRISTOPH ,  WINKLER IRVIN ,  ROSNER MANFRED

IPC: A61K31/435 ,  A61K31/41 ,  A61K31/44 ,  A61K31/505 ,  A61K31/52 ,  A61K31/70 ,  A61K31/715 ,  A61P31/12

公开(公告)号：DK638889A

公开(公告)日：1990-06-17

申请号：DK638889

申请日：1989-12-15

Applicant: HOECHST AG

Inventor： ROESNER MANFRED ,  WINKLER IRVIN ,  MEICHSNER CHRISTOPH

IPC: A61K31/435 ,  A61K31/41 ,  A61K31/44 ,  A61K31/505 ,  A61K31/52 ,  A61K31/70 ,  A61K31/715 ,  A61P31/12

公开(公告)号：PT91103A

公开(公告)日：1990-02-08

申请号：PT9110389

申请日：1989-07-07

Applicant: HOECHST AG

Inventor： SCHRINNER ELMAR ,  MEICHSNER CHRISTOPH ,  WINKLER IRVIN ,  HELSBERG MATTHIAS ,  KLOSA JOSEF ,  HANS-KROGER

IPC: A61K31/52 ,  A61P31/12 ,  C07D473/38

公开(公告)号：DK638889D0

公开(公告)日：1989-12-15

申请号：DK638889

申请日：1989-12-15

Applicant: HOECHST AG

Inventor： ROESNER MANFRED ,  WINKLER IRVIN ,  MEICHSNER CHRISTOPH

IPC: A61K31/435 ,  A61K31/41 ,  A61K31/44 ,  A61K31/505 ,  A61K31/52 ,  A61K31/70 ,  A61K31/715 ,  A61P31/12

公开(公告)号：ZA8900189B

公开(公告)日：1989-09-27

申请号：ZA8900189

申请日：1989-01-10

Applicant: HOECHST AG

Inventor： ZEECK AXEL ,  AXEL ZEECK ,  STEINHOFF ILSEMARIE ,  ILSEMARIE STEINHOFF ,  HAMMANN PETER ,  PETER HAMMANN ,  GRABLEY SUSANNE ,  SUSANNE GRABLEY ,  VOELSKOW HARTMUT ,  HARTMUT VOELSKOW ,  WINKLER IRVIN ,  IRVIN WINKLER ,  SEIBERT GERHARD ,  GERHARD SEIBERT

IPC: A61K20060101 ,  C07D20060101 ,  C07D ,  A61K