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1.发明专利
公开(公告)号：AU8976791A
公开(公告)日：1992-06-18
申请号：AU8976791
申请日：1991-12-13
Applicant: HOECHST AG
Inventor： ZEECK AXEL , BREIDING-MACK SABINE , GOHRT AXEL , GRABLEY SUSANNE , GRANZER ERNOLD , HUTTER KLAUS , THIERICKE RALF , WINK JOACHIM
IPC: A61K31/35 , A61K31/352 , A61P3/06 , C07D311/74 , C07D493/08 , C07H19/01 , C12P17/06 , C12P19/02 , C12P19/44 , C12R1/77 , A61K31/335 , C12N1/14
Abstract: It is possible with the aid of a Fusarium strain to prepare metabolites of the following formula I in which R is hydrogen or hydroxyl, R is hydroxyl or an oxo group, R is methoxy or hydroxyl or, together with R , forms an ether bridge and R is hydrogen or hydroxyl, R is hydrogen or, together with R , represents an additional bond and R is hydrogen or, together with R , is an additional bond. The metabolites are to be used, in particular, for inhibiting cholesterol biosynthesis.
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公开(公告)号：FI915024A
公开(公告)日：1992-04-27
申请号：FI915024
申请日：1991-10-24
Applicant: HOECHST AG
Inventor： ZEECK AXEL , PHILIPPS SIEGRID , GRABLEY SUSANNE , GRANZER ERNOLD , HUETTER KLAUS , THIERICKE RALF , WINK JOACHIM
IPC: A61K31/34 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , C07D407/06 , C07H17/04 , C07H17/08 , C12N1/20 , C12P17/08 , C12P19/60 , C12P19/62 , C12R1/465 , C12R1/625 , C12P
Abstract: Macrolactones of the formula I with pharmacological action can be prepared with the aid of Streptoverticillium and Streptomyces strains in which R is hydrogen or the group
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公开(公告)号：PT85597B
公开(公告)日：1989-11-16
申请号：PT8559787
申请日：1987-08-27
Applicant: HOECHST AG
Inventor： ZEECK AXEL , CIESIOLKA THOMAS , ZAEHNER HANS , DRAUTZ HANNELORE
IPC: C07H15/252 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P35/00 , C07H15/244
Abstract: The O-acyl derivatives of urdamycin A exhibit an antibiotic or antitumoral activity.
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公开(公告)号：ZA8900189B
公开(公告)日：1989-09-27
申请号：ZA8900189
申请日：1989-01-10
Applicant: HOECHST AG
Inventor： ZEECK AXEL , AXEL ZEECK , STEINHOFF ILSEMARIE , ILSEMARIE STEINHOFF , HAMMANN PETER , PETER HAMMANN , GRABLEY SUSANNE , SUSANNE GRABLEY , VOELSKOW HARTMUT , HARTMUT VOELSKOW , WINKLER IRVIN , IRVIN WINKLER , SEIBERT GERHARD , GERHARD SEIBERT
IPC: A61K20060101 , C07D20060101 , C07D , A61K
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公开(公告)号：DK447787A
公开(公告)日：1988-02-29
申请号：DK447787
申请日：1987-08-27
Applicant: HOECHST AG
Inventor： ZEECK AXEL , CIESIOLKA THOMAS , ZAEHNER HANS , DRAUTZ HANNELORE
IPC: C07H15/252 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P35/00 , C07H15/244 , C07H15/24
Abstract: The O-acyl derivatives of urdamycin A exhibit an antibiotic or antitumoral activity.
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Patent Agency Ranking6.发明专利
公开(公告)号：CA2057651A1
公开(公告)日：1992-06-16
申请号：CA2057651
申请日：1991-12-13
Applicant: HOECHST AG
Inventor： ZEECK AXEL , BREIDING-MACK SABINE , COEHRT AXEL , GRABLEY SUSANNE , GRANZER ERNOLD , HUETTER KLAUS , THIERICKE RALF , WINK JOACHIM
IPC: A61K31/35 , A61K31/352 , A61P3/06 , C07D311/74 , C07D493/08 , C07H19/01 , C12P17/06 , C12P19/02 , C12P19/44 , C12R1/77 , C12N1/14
Abstract: HOE 90/F 372 of the disclosure Agistatins, novel metabolites from Fusarium sp., a process for their preparation, and their use With the aid of a Fusaxium strain, it is possible to produce novel metabolites of the formula I below in which R1 is hydrogen or hydroxyl, R2 is hydroxyl or an oxo group, R3 is methoxy or hydroxyl or, together with R1, forms an ether bridge, and R4 is hydrogen or hydroxyl, R5 is hydrogen or, together with R4, is an additional bond, and R6 is hydrogen or, together with R3, is an additional bond. In particular, the metabolites are to be employed for inhibiting cholesterol biosynthesis.
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公开(公告)号：PT85598B
公开(公告)日：1989-11-30
申请号：PT8559887
申请日：1987-08-27
Applicant: HOECHST AG
Inventor： ZEECK AXEL , CIESIOLKA THOMAS , ROHR JUERGEN , ZAEHNER HANS , DRAUTZ HANNELORE
IPC: A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7042 , A61K31/7048 , A61P35/00 , C07H15/24 , C07H15/244 , C07H17/04 , C12P19/56 , C12R1/54
Abstract: A new substance, urdamycin G, has been found which, like its O-acyl derivatives, exhibits an antibiotic or antitumoral activity.
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公开(公告)号：AU589145B2
公开(公告)日：1989-10-05
申请号：AU4997585
申请日：1985-11-15
Applicant: HOECHST AG
Inventor： ZEECK AXEL , ROHR JURGEN , ZAHNER HANS , DRAUTZ HANNELORE , SHELDRICK GEORGE M , JONES PETER G , PAULUS ERICH F
IPC: C07D309/10 , A61K31/35 , A61K31/351 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P35/00 , C07H15/24 , C07H15/244 , C07H17/04 , C12P19/56 , C12R1/54 , C12N1/20 , A61K31/71 , C12P19/60
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公开(公告)号：ZA89189B
公开(公告)日：1989-09-27
申请号：ZA89189
申请日：1989-01-10
Applicant: HOECHST AG
Inventor： ZEECK AXEL , AXEL ZEECK , STEINHOFF ILSEMARIE , ILSEMARIE STEINHOFF , HAMMANN PETER , PETER HAMMANN , GRABLEY SUSANNE , SUSANNE GRABLEY , VOELSKOW HARTMUT , HARTMUT VOELSKOW , WINKLER IRVIN , IRVIN WINKLER , SEIBERT GERHARD , GERHARD SEIBERT
IPC: A61K20060101 , C07D20060101 , C07D , A61K
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公开(公告)号：DK11489A
公开(公告)日：1989-07-13
申请号：DK11489
申请日：1989-01-11
Applicant: HOECHST AG
Inventor： ZEECK AXEL , STEINHOFF ILSEMARIE , HAMMANN PETER , GRABLEY SUSANNE , VOELSKOW HARTMUT , WINKLER IRVIN , SEIBERT GERHARD
IPC: C07D493/10 , A61K31/35 , A61P31/04 , A61P31/12 , C07H19/01
Abstract: Nigericin derivatives of the formula I in which Z, R and R have the meanings given. The compounds of the formula I exhibit both antibacterial and antiviral activity.
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