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    BIOSENSOR WITH IMPROVED ANALYTE SPECIFICITY
    22.
    发明专利
    BIOSENSOR WITH IMPROVED ANALYTE SPECIFICITY 未知

    公开(公告)号：CA2719255C

    公开(公告)日：2016-05-03

    申请号：CA2719255

    申请日：2009-03-25

    Applicant: HOFFMANN LA ROCHE

    Inventor： WILSEY CHRISTOPHER D ,  GHOSHAL MITALI ,  WIEDER HERBERT

    IPC: C12Q1/00 ,  C12Q1/32 ,  G01N33/66

    Abstract: A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.

    Sistema de análisis para analizar una muestra líquida con un elemento de prueba analítico
    24.
    发明专利
    Sistema de análisis para analizar una muestra líquida con un elemento de prueba analítico 未知

    公开(公告)号：ES2403182T3

    公开(公告)日：2013-05-16

    申请号：ES05022049

    申请日：2005-10-10

    Applicant: HOFFMANN LA ROCHE

    Inventor： RIEBEL STEFAN ,  THOES BRUNO ROBERT ,  AUGSTEIN MANFRED ,  WIEDER HERBERT ,  BAINCZYK GREGOR

    IPC: G01N27/327

    Abstract: Sistema de análisis dotado de un sistema de conexión eléctrica para un elemento de prueba analítico (6), en elque el elemento de prueba (6) presenta, como mínimo, una superficie de contacto (16), caracterizado por - una corredera (2) desplazable dentro de un cuerpo envolvente (1) entre una posición inicial y una posiciónfinal, que comprende un espacio de alojamiento (5) con una abertura de entrada (7) para recibir el elementode prueba (6), estando el espacio de alojamiento (5) limitado por un tope (8), - como mínimo, un elemento de contacto (4) que está dispuesto de tal manera que, en la posición inicial de lacorredera (2), está distanciado de la superficie de contacto (16) de un elemento de prueba (6) introducidoen el espacio de alojamiento (5) y porque es desplazado hacia la superficie de contacto (16) mediante eldesplazamiento de la corredera (2) de la posición inicial a la posición final y es presionado contra lasuperficie de contacto (16), y - un circuito de evaluación electroquímico que está conectado eléctricamente con el elemento de contacto(4), como mínimo, en la posición final de la corredera (2).

    TEST DEVICE FOR DETERMINING AN ANALYTE CONCENTRATION
    25.
    发明专利
    TEST DEVICE FOR DETERMINING AN ANALYTE CONCENTRATION 未知

    公开(公告)号：CA2606715C

    公开(公告)日：2012-10-09

    申请号：CA2606715

    申请日：2006-06-14

    Applicant: HOFFMANN LA ROCHE

    Inventor： BAINCZYK GREGOR ,  WIEDER HERBERT ,  EISELE THOMAS

    IPC: G01N33/487 ,  B01L99/00

    Abstract: A test device (110) for determining at least one analyte concentration in a sample by means of at least one test element (136) is proposed. The test device (110) can be used particularly for glucose measurement, in particular blood glucose measurement, cholesterol measurement and/or coagulation measurement. The test device according to the invention comprises a housing (112) with a closed state and an opened state, and a storage device (134) for receiving at least one test element (136). The at least one test element (136) is designed as a strip-shaped test element (136), and the storage device (134) comprises a magazine (134), preferably an exchangeable magazine (134). The magazine (134) comprises a large number of cavities (135), and the strip-shaped test elements (136) are received substantially parallel to one another in said cavities (135). A measuring device, with at least one measurement position, and a dispensing device (140, 160) are also provided. The dispensing device (140, 160) comprises means (140, 166) for conveying the at least one test element (136) from at least one storage position of the storage device (134) during opening of the housing (112).

    MEASURING SYSTEM FOR IN VIVO MONITORING OF AN ANALYTE CONCENTRATION AND METHOD FOR DETECTING MALFUNCTIONS OF SUCH A MEASURING SYSTEM
    26.
    发明专利
    MEASURING SYSTEM FOR IN VIVO MONITORING OF AN ANALYTE CONCENTRATION AND METHOD FOR DETECTING MALFUNCTIONS OF SUCH A MEASURING SYSTEM 未知

    公开(公告)号：CA2639143A1

    公开(公告)日：2009-03-01

    申请号：CA2639143

    申请日：2008-08-26

    Applicant: HOFFMANN LA ROCHE

    Inventor： MARQUANT MICHAEL ,  WIEDER HERBERT

    IPC: A61B5/145 ,  A61B5/05

    Abstract: The invention relates to a measuring system for in vivo monitoring of an analyte concentration having an electrode system comprising a work electrode (1), a reference electrode (2) and a counter electrode (3) and a potentiostat (4) for adjusti ng a difference of potential between the electric potential of the work electrode (1) and th e electric potential of the reference electrode (2) to a specified value and f or detecting the current flow between the work electrode (1) and the counter electrode (3 ), the potentiostat (4) comprising a work electrode terminal (15) for connection to the work electrode (1), a reference electrode terminal (19) for connection to the reference electrode (2) and a counter electrode terminal (16) for connection to the counter electrode (3). According to the invention there is provided an evaluation un it (9) which monitors the electric potential (U CE) of the counter electrode (3) an d which generates a malfunction signal when said potential comes to lie outside a specified reference range. The invention further relates to a method for detecting malfunctions of a measuring system for in vivo measurement of an analyte concentration using three electrodes (1, 2, 3), where the electric potential (U CE) between the work electrode (1) and the counter electrode(3) is monitored and evaluated according to the invention for detecting malfunctions of the measuring system.

    METHODS AND DEVICES FOR PERFORMING AN ANALYTICAL MEASUREMENT
    27.
    发明专利
    METHODS AND DEVICES FOR PERFORMING AN ANALYTICAL MEASUREMENT 未知

    公开(公告)号：CA3116094A1

    公开(公告)日：2020-05-14

    申请号：CA3116094

    申请日：2019-10-28

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERG MAX ,  HAILER FREDRIK ,  LIMBURG BERND ,  MELCHINGER CHRISTIAN ,  SIEFFERT DANIEL ,  WIEDER HERBERT ,  WETZEL SIMON ,  GUERMAZI ZIED

    IPC: G16H50/00 ,  A61B5/15

    Abstract: A method of evaluating the suitability of a mobile device (112) for performing an analytical measurement based on a color formation reaction, a method of calibrating a mobile device (112) for performing an analytical measurement based on a color formation reaction and a method of performing an analytical measurement based on a color formation reaction in an optical test strip (120) by using a mobile device (112) are disclosed. Further disclosed are a suitability computer program, a calibration computer program and a measurement computer program as well as a mobile device (112) and a kit(110). The method of evaluating the suitability of a mobile device (112) for performing an analytical measurement based on a color formation reaction comprises: a) evaluating the capability of the mobile device (112) to have one or more relevant settings of the mobile device (112) controlled by a user's software running on the mobile device (112), the relevant settings pertaining to image raw data processing steps to be carried out by the mobile device (112), wherein the relevant settings include at least one of a color space transformation (132)and a tone mapping transformation (136); b) if the evaluation in step a) indicates that the mobile device (112) is capable of having the one or more relevant settings controlled by the user's software, providing at least one item of control information, the at least one item of control information indicating that the mobile device (112) is suitable for performing the analytical measurement; and c) if the evaluation in step a) indicates that the mobile device (112) is not capable of having the one or more relevant settings controlled by the user's software, providing at least one item of control information, the at least one item of control information indicating that the mobile device (112) is unsuitable for performing the analytical measurement.

    30.
    发明专利
    未知

    公开(公告)号：AT550650T

    公开(公告)日：2012-04-15

    申请号：AT05813728

    申请日：2005-11-24

    Applicant: HOFFMANN LA ROCHE

    Inventor： BAINCZYK GREGOR ,  MARQUANT MICHAEL ,  WIEDER HERBERT

    IPC: G01N33/487

    Abstract: The connecting device has a tightener for stretching the lancet systems connected with the modules and operating device for activating the stripes. A data exchange device is used to exchange the load information of the test stripes between the modules and has a transponder arranged in the magazine module (110) and a transponder reader arranged in the diagnostic module (112). Erasable programmable read only memory is arranged in the magazine module with vertical gripping section. The exchange and connecting devices are connected by electrical contact. Clamping carriages of the tightener is connected with feeder system. The magazine module exhibits test electrode connected with the diagnostic module and pile magazine for the stripes. Desiccant is brought into the magazine module for decreasing the air humidity. Independent claims are also included for: (1) magazine module; and (2) process for serving a diagnostic system.

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