公开(公告)号：EP1184076B1

公开(公告)日：2010-04-21

申请号：EP00969995.0

申请日：2000-10-23

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu

IPC: B01J31/10 ,  B01J31/02 ,  C07B37/12 ,  C07C29/40 ,  C07C45/72 ,  C07C227/26 ,  B01J31/06 ,  B01J31/26

CPC classification number: B01J31/10 ,  B01J31/0227 ,  B01J31/1658 ,  B01J31/2226 ,  B01J31/4015 ,  B01J2231/326 ,  B01J2231/342 ,  B01J2231/343 ,  B01J2231/44 ,  B01J2531/35 ,  B01J2531/37 ,  B01J2531/38 ,  C07B37/02 ,  C07B2200/07 ,  C07C29/38 ,  C07C67/343 ,  C07C227/26 ,  C07C253/00 ,  C07C253/08 ,  C07C327/22 ,  C07C2601/14 ,  C07D263/38 ,  Y02P20/584 ,  C07C69/732 ,  C07C255/42 ,  C07C33/14 ,  C07C33/30

Abstract: A novel polymer-supported Lewis acid catalyst which has high activity in reactions in an aqueous medium, can be easily recovered, and is highly reusable. The catalyst comprises a polymer film and Lewis acid groups represented by general formula (I) MXn, wherein M represents a polyvalent element; X represents an anionic group, and n is an integer corresponding to the valence of M bonded to and supported on the film through SO3 or SO4 groups.

公开(公告)号：EP1359141B1

公开(公告)日：2007-11-07

申请号：EP02715709.8

申请日：2002-01-08

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu

IPC: C07C231/12 ,  C07C233/33 ,  C07C271/28 ,  C07C311/08 ,  C07C303/40 ,  C07B37/04 ,  C07B61/00

CPC classification number: C07C269/06 ,  C07C231/12 ,  C07C303/40 ,  C07C311/08 ,  C07C233/33 ,  C07C271/28

Abstract: An anilide is reacted with an acylating agent by using as a catalyst a tri(perfluoroalkane sulfonate) compound of any of the elements belonging to the groups 3 to 5 and the groups 13 to 15 in the periods 4 to 6 of the periodic and thus the acyl group in the benzene ring is bonded. Thus, ketoaniline derivatives which are useful as physiologically active compounds or intermediates in synthesizing the same are synthesized at a high reaction yield by the catalytic acylation.

公开(公告)号：EP1731501A1

公开(公告)日：2006-12-13

申请号：EP05720950.4

申请日：2005-03-10

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  AKIYAMA, Ryo

IPC: C07C231/12 ,  C07C231/10 ,  C07C233/47 ,  C07C233/82 ,  C07C275/18 ,  B01J31/06 ,  C07B61/00 ,  C08L25/02 ,  C08L29/10

CPC classification number: C08F212/08 ,  B01J31/06 ,  B01J2531/0211 ,  C07C231/12 ,  C07C273/1854 ,  C07C2601/14 ,  C08F8/42 ,  C08F12/22 ,  C08F12/26 ,  C08F212/14 ,  C07C233/47 ,  C07C233/84 ,  C07C275/18

Abstract: A novel method of an amidocarbonylation reaction among an aldehyde compound, an amide compound, and carbon monoxide, which comprises using a palladium-supporting crosslinked-polymer composition containing palladium clusters having a major-axis length of 20 nm or shorter to conduct the amidocarbonylation reaction. Thus, an N-acyl-α-amino acid can be more efficiently and selectively synthesized in a clean reaction system. Also provided is a catalyst for use in the method.

Abstract translation: 一种醛化合物，酰胺化合物和一氧化碳之间的酰胺基羰基化反应的新方法，包括使用含有长轴长度为20nm或更短的钯簇的钯负载交联聚合物组合物进行酰胺基羰基化反应 。 因此，N-酰基-α-氨基酸可以在清洁的反应体系中更有效地和选择性地合成。 还提供了用于该方法的催化剂。

公开(公告)号：EP1726577A1

公开(公告)日：2006-11-29

申请号：EP05704332.5

申请日：2005-01-26

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  MORI, Yuichiro ,  KITAMORI, Takehiko ,  UENO, Masaharu ,  OKAMOTO, Kuniaki

IPC: C07B35/02 ,  C07B41/12 ,  C07C15/12 ,  C07C15/18 ,  C07C13/28 ,  C07C5/03 ,  C07C5/08 ,  C07C45/62 ,  C07C49/213 ,  C07C49/403 ,  C07C29/17 ,  C07C33/20 ,  C07C67/00 ,  C07C69/618 ,  C07C211/46 ,  C07C209/36 ,  B01J31/28 ,  C07B61/00

CPC classification number: C07C5/03 ,  B01J19/0093 ,  B01J23/44 ,  B01J31/1633 ,  B01J35/0013 ,  B01J37/0219 ,  B01J2219/00831 ,  B01J2219/00835 ,  B01J2231/641 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/62 ,  B01J2531/64 ,  B01J2531/66 ,  B01J2531/72 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/825 ,  B01J2531/827 ,  C07C5/08 ,  C07C29/175 ,  C07C45/62 ,  C07C209/36 ,  C07C2601/14 ,  Y02P20/588 ,  C07C15/12 ,  C07C15/18 ,  C07C33/20 ,  C07C211/46

Abstract: A method of catalytic reaction uses a micro-reactor (1) with a metal catalyst (5) or a metal complex catalyst (5) as a solid phase supported on the inner wall (4c) of a channel (4), a solution (7) dissolving a reactant as a liquid phase and hydrogen (9) as a gas phase are flown through the channel (4) in pipe flow state, and the reaction of the solution (7) and the gas (9) accelerated by the metal catalyst (5) or the metal complex catalyst (5) is conducted by three phase catalytic reaction of solid - liquid - gas phases. The metal catalyst (5) or the metal complex catalyst (5) is incorporated in a polymer, and hydrogenation reaction by three phase catalytic reductive reaction of a substance to be reduced can be conducted in short time at good yield. For hydrogenation reaction of unsaturated organics, the rate of reaction and yield are high when palladium catalyst is used, and carbonylation reaction can be conducted if carbon monoxide is used instead of hydrogen.

公开(公告)号：EP1707559A1

公开(公告)日：2006-10-04

申请号：EP05704279.8

申请日：2005-01-24

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu

IPC: C07C231/12 ,  B01J31/22 ,  C07B53/00 ,  C07C233/47 ,  C07C269/06 ,  C07C271/22 ,  C07D207/273 ,  C07B61/00

CPC classification number: C07B53/00 ,  B01J31/1805 ,  B01J2231/341 ,  B01J2531/16 ,  C07B2200/07 ,  C07C231/18 ,  C07D207/273

Abstract: An asymmetric synthesis of amino acid compound that is useful as a starting material or synthetic intermediate for production of medicinal products, agrichemicals, perfumes, functional polymers, etc. There is provided a method of enanthio-selective nucleophilic addition reaction to imine compound being a method of nucleophilic addition reaction of enamide compound accompanied by amino formation to imino group (-CH=N-) of imine compound, characterized in that the reaction is performed in the presence of a chiral copper catalyst. Further, there is provided a novel method of synthesizing an amino acid compound, etc., to which the above is applied.

Abstract translation: 确实氨基酸化合物的不对称合成是作为起始材料是有用的或合成中间体生产医药产品，农用化学品，香料，功能性聚合物等的本发明提供enanthio选择性亲核加成反应来亚胺化合物的方法是一个方法 由氨基形成的陪同下，以亚氨基亚胺化合物的基团（-CH = N-）化合物的烯酰胺亲核加成反应的，在DASS特点死反应在手性铜催化剂的存在下进行。 此外，提供了一种合成的氨基酸化合物等的一种新颖的方法，向其中上述被应用。

公开(公告)号：EP1707556A1

公开(公告)日：2006-10-04

申请号：EP05704278.0

申请日：2005-01-24

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu

IPC: C07C67/343 ,  C07B61/00 ,  C07C69/738 ,  C07C269/04 ,  C07C271/22 ,  C07F7/18 ,  C07B53/00 ,  C07D307/32 ,  C07D207/18

CPC classification number: C07D207/18 ,  C07B2200/07 ,  C07C67/343 ,  C07C269/04 ,  C07C69/738 ,  C07C69/716

Abstract: A method of an enantioselective nucleophilic addition reaction to carbonyl, which enables an asymmetric synthesis of an optically active α-hydroxy-γ-keto acid ester, an optically active α-hydroxy-γ-amino acid ester, hydroxydiketone compounds, etc. being useful as a raw material or synthesis intermediate for producing a pharmaceutical preparation, an agricultural chemical, a fragrance, a functional polymer or the like. In this method, the nucleophilic addition reaction of enamide compound accompanied by hydroxyl (-OH) formation to carbonyl is carried out in the presence of a chiral catalyst with copper or nickel.

Abstract translation: 对羰基的对映选择性亲核加成反应的方法，其使得光学活性的±羟基-3-酮酸酯，光学活性的±羟基-3-氨基酸酯，羟基二酮化合物等的不对称合成是有用的 作为制备药物制剂，农药，香料，功能聚合物等的原料或合成中间体。 在这种方法中，伴随着羟基（-OH）形成羰基的烯酰胺化合物的亲核加成反应在具有铜或镍的手性催化剂的存在下进行。

公开(公告)号：EP1724275B1

公开(公告)日：2015-04-08

申请号：EP05720123.8

申请日：2005-03-07

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu

IPC: C07F9/38 ,  C07F9/40

CPC classification number: B01J31/1805 ,  B01J2531/16 ,  C07B53/00 ,  C07F9/3808 ,  C07F9/3882 ,  C07F9/4006 ,  C07F9/4056

公开(公告)号：EP1739104B1

公开(公告)日：2014-07-09

申请号：EP05720120.4

申请日：2005-03-07

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  OKAMOTO, Kuniaki ,  AKIYAMA, Ryo ,  OHNO, Keiji ,  INAGAKI, Yoshio

IPC: C08F212/08 ,  B01J35/00 ,  C07C67/343 ,  C07C69/618 ,  C07B61/00 ,  B01J31/16

CPC classification number: C07C67/31 ,  B01J31/069 ,  B01J31/165 ,  B01J2231/4261 ,  B01J2231/643 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  C07C17/14 ,  C07C45/68 ,  C07C49/796 ,  C07C67/343 ,  C08F212/08 ,  C08F212/14 ,  C07C22/04 ,  C07C69/732 ,  C07C69/618

公开(公告)号：EP1495806B1

公开(公告)日：2013-12-04

申请号：EP03710298.5

申请日：2003-03-11

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu

IPC: B01J31/38 ,  B01J29/06 ,  C07C227/12 ,  C07C229/34 ,  C07C327/22 ,  C07D307/52 ,  C07B61/00 ,  B01J29/70 ,  B01J31/16 ,  B01J31/40 ,  C07B53/00 ,  C07C227/32 ,  C07D307/54 ,  B01J31/22

CPC classification number: C07D307/54 ,  B01J29/061 ,  B01J29/7053 ,  B01J31/1616 ,  B01J31/223 ,  B01J31/4015 ,  B01J2229/186 ,  B01J2229/34 ,  B01J2231/346 ,  B01J2531/0266 ,  B01J2531/48 ,  B01J2540/22 ,  C07B53/00 ,  C07B2200/07 ,  C07C227/32 ,  C07C327/22 ,  Y02P20/584 ,  Y02P20/588 ,  C07C229/18 ,  C07C229/34

公开(公告)号：EP1707556B1

公开(公告)日：2013-05-08

申请号：EP05704278.0

申请日：2005-01-24

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu

IPC: C07C67/343 ,  C07B61/00 ,  C07C69/738 ,  C07C269/04 ,  C07C271/22 ,  C07F7/18 ,  C07B53/00 ,  C07D307/32 ,  C07D207/18

CPC classification number: C07D207/18 ,  C07B2200/07 ,  C07C67/343 ,  C07C269/04 ,  C07C69/738 ,  C07C69/716