公开(公告)号：AT259794T

公开(公告)日：2004-03-15

申请号：AT00915524

申请日：2000-04-14

Applicant: KANEKA CORP

Inventor： KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  NAGASHIMA NOBUO ,  SAKA YASUHIRO ,  HONDA TATSUYA ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C29/147 ,  C07C31/42 ,  C07D307/20

Abstract: The application is concerned with a process for producing a 3-hydroxytetrahydrofuran of the formula (3): by cyclizing a 4-halo-1,3-butanediol of the general formula (2): wherein X represents a halogen atom in an aqueous solution, which comprises carrying out the cyclization reaction under weakly acidic to neutral conditions. Furthermore several methods are disclosed for the isolution of highly pure 3-hydroxytetrahydrofuran.

公开(公告)号：PL350362A1

公开(公告)日：2002-12-02

申请号：PL35036201

申请日：2001-02-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  C07C227/04 ,  C07B53/00

Abstract: An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.

公开(公告)号：CA2369678A1

公开(公告)日：2001-08-23

申请号：CA2369678

申请日：2001-02-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  KINOSHITA KOICHI ,  TAKEDA TOSHIHIRO ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI ,  OKURO KAZUMI ,  INOUE KENJI ,  MOROSHIMA TADASHI ,  NAGASHIMA NOBUO ,  SAKA YASUHIRO

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  C07B53/00 ,  C07C227/04

Abstract: An optically active amino acid derivative is prepared either by subjecting a n optically active 3-haloalanine derivative (1) to N-protection followed by cyclization or cyclization followed by N-protection to prepare an optically active aziridinecarboxylic acid derivative (3) whose imino group is protecte d with 2- and/or 4-nitrated benzenesulfonyl and treating this derivative (3) with an organometallic reagent or by subjecting an optically active 3- haloalanine derivative to N-protection to obtain an optically active 3- haloalanine derivative (4) whose amino group is protected with 2- and/or 4- nitrated benzenesulfonyl and treating this derivative (4) with an organometallic reagent. According to such processes, natural and nonnatural optically active amino acids can be prepared from inexpensive raw materials through simple and easy operation. In said derivatives, X is halogen; R1 and R2 are each hydrogen or the like; * represents an asymmetric carbon atom; an d P1 is 2- and/ or 4- nitrated benzenesulfonyl.

公开(公告)号：AU3056901A

公开(公告)日：2001-08-14

申请号：AU3056901

申请日：2001-02-02

Applicant: KANEKA CORP

Inventor： SAKA YASUHIRO ,  HONDA TATSUYA ,  NAGASHIMA NOBUO

IPC: C07D205/04

公开(公告)号：AU3678700A

公开(公告)日：2000-11-02

申请号：AU3678700

申请日：2000-04-14

Applicant: KANEKA CORP

Inventor： KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  NAGASHIMA NOBUO ,  SAKA YASUHIRO ,  HONDA TATSUYA ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C29/147 ,  C07C31/42 ,  C07D307/20

Abstract: The application is concerned with a process for producing a 3-hydroxytetrahydrofuran of the formula (3): by cyclizing a 4-halo-1,3-butanediol of the general formula (2): wherein X represents a halogen atom in an aqueous solution, which comprises carrying out the cyclization reaction under weakly acidic to neutral conditions. Furthermore several methods are disclosed for the isolution of highly pure 3-hydroxytetrahydrofuran.

公开(公告)号：EP2050738A4

公开(公告)日：2010-09-22

申请号：EP07743261

申请日：2007-05-14

Applicant: KANEKA CORP

Inventor： SAKA YASUHIRO ,  FUJII AKIO ,  OKURO KAZUMI ,  MITSUDA MASARU

IPC: C07D233/32 ,  C07B61/00 ,  C07C227/22 ,  C07C229/08 ,  C07C229/22 ,  C07C229/36

CPC classification number: C07D233/32 ,  C07C227/22 ,  C07C231/10 ,  C07C229/14 ,  C07C229/22 ,  C07C229/36 ,  C07C237/06

公开(公告)号：EP2351762A4

公开(公告)日：2012-07-18

申请号：EP09821993

申请日：2009-10-19

Applicant: KANEKA CORP

Inventor： SAKA YASUHIRO ,  NISHIYAMA AKIRA

IPC: C07F9/6512 ,  C07D405/06

CPC classification number: C07F9/65122 ,  C07D405/06

公开(公告)号：EP1179530A4

公开(公告)日：2005-07-27

申请号：EP01904517

申请日：2001-02-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  C07B53/00 ,  C07C227/04

CPC classification number: C07D203/08 ,  C07B2200/07 ,  C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/30 ,  C07C303/36 ,  C07D203/20 ,  C07D203/24 ,  C07C311/19 ,  C07C229/26

Abstract: An optically active amino acid derivative is prepared either by subjecting an optically active 3-haloalanine derivative (1) to N-protection followed by cyclization or cyclization followed by N-protection to prepare an optically active aziridinecarboxylic acid derivative (3) whose imino group is protected with 2- and/or 4-nitrated benzenesulfonyl and treating this derivative (3) with an organometallic reagent or by subjecting an optically active 3-haloalanine derivative to N-protection to obtain an optically active 3-haloalanine derivative (4) whose amino group is protected with 2- and/or 4-nitrated benzenesulfonyl and treating this derivative (4) with an organometallic reagent. According to such processes, natural and nonnatural optically active amino acids can be prepared from inexpensive raw materials through simple and easy operation. In said derivatives, X is halogen; R?1 and R2¿ are each hydrogen or the like; * represents an asymmetric carbon atom; and P1 is 2- and/ or 4- nitrated benzenesulfonyl.

公开(公告)号：EP1253140A4

公开(公告)日：2003-03-26

申请号：EP01902737

申请日：2001-02-02

Applicant: KANEKA CORP

Inventor： SAKA YASUHIRO ,  HONDA TATSUYA ,  NAGASHIMA NOBUO

IPC: C07D205/04

CPC classification number: C07D205/04

Abstract: A process for preparing optically active azetidine -2-carboxylic acid efficiently, easily, simply, and industrially advantageously by cyclizing an optically active 4-amino- 2-halogenobutyric acid in an optical yield of as high as 90 % or above. Specifically, a process for preparing optically active azetidine-2-carboxylic acid of formula (2) (wherein * represents an asymmetric carbon atom) by cyclizing an optically active 4-amino-2-halogenobutyric acid of the general formula (1) (wherein X is halogeno and * represents an asymmetric carbon atom) in the presence of an alkaline earth metal oxide, an alkaline earth metal hydroxide except barium hydroxide, or an organic amine.

公开(公告)号：JP2010100651A

公开(公告)日：2010-05-06

申请号：JP2010015834

申请日：2010-01-27

Applicant: Kaneka Corp ,  株式会社カネカ

Inventor： KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  YANAGIDA YOSHIBUMI ,  NAGASHIMA NOBUO ,  SAKA YASUHIRO ,  HONDA TATSUYA ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07D307/20

Abstract: PROBLEM TO BE SOLVED: To provide high-purity 3-hydroxytetrahydrofuran in a high yield easily and simply by an industrially advantageous process.
SOLUTION: The process includes: reducing a 4-halo-3-hydroxybutyric acid ester with a boron hydride compound and/or an aluminum hydride compound in an organic solvent immiscible with water; treating the reaction mixture with an acid and water to convert it into the corresponding 4-halo-1, 3-butanediol and at the same time obtaining an aqueous solution containing the compound; carrying out the cyclization reaction in the aqueous solution; extracting the resulting 3-hydroxytetrahydrofuran from the aqueous solution using an organic solvent immiscible with water; and isolating the 3-hydroxytetrahydrofuran by concentration and/or distillation of the solution obtained.
COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 待解决的问题：通过工业上有利的方法容易且简单地提供高产率的高纯度3-羟基四氢呋喃。 解决方案：该方法包括：用氢化硼化合物和/或氢化铝化合物在与水不混溶的有机溶剂中还原4-卤-3-羟基丁酸酯; 用酸和水处理反应混合物，将其转化成相应的4-卤代-1,3-丁二醇，同时得到含有该化合物的水溶液; 在水溶液中进行环化反应; 使用与水不混溶的有机溶剂从水溶液中萃取所得3-羟基四氢呋喃; 并通过所得溶液的浓缩和/或蒸馏分离3-羟基四氢呋喃。 版权所有（C）2010，JPO＆INPIT