公开(公告)号：BRPI0407954A

公开(公告)日：2006-03-07

申请号：BRPI0407954

申请日：2004-03-17

Applicant: KANEKA CORP

Inventor： TANAKA TATSUYOSHI ,  SUGAWARA MASANOBU ,  MAEDA HIROFUMI ,  NISHIYAMA AKIRA ,  YASOHARA YOSHIHIKO ,  NAGASHIMA NOBUO

IPC: C07C231/02 ,  C07C231/10 ,  C07C231/18 ,  C07C235/16 ,  C07C237/06 ,  C07C237/52 ,  C07C303/28 ,  C07C309/66 ,  C07C309/73 ,  C07D205/08 ,  C07C269/06 ,  C07C269/04 ,  C07C271/64 ,  C07C303/44

公开(公告)号：CA2464446A1

公开(公告)日：2003-05-15

申请号：CA2464446

申请日：2002-10-24

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  INOUE KENJI

IPC: C07C67/29 ,  C07C67/31 ,  C07C69/675 ,  C07C69/78

Abstract: A process for producing an optically active 3,5-dihydroxyhexanoic acid derivative by stereoselectively reducing an optically active 3-oxo-5- hydroxyhexanoic acid derivative. It necessitates neither an ultralow- temperature reactor nor an incubator and is a simple and economical process in which protection of the 5-position hydroxy is unnecessary. Hydrogen, which i s extremely inexpensive, is used as a reducing agent to asymmetrically hydrogenate an optically active 3-oxo-5-hydroxyhexanoic acid derivative by t he catalytic action of a ruthenium/optically active phosphine complex, especial ly an RuBr2BINAP complex prepared from 2,2'-bisdiarylphosphino-1,1'-binaphthyl (BINAP) and a ruthenium complex, to thereby produce an optically active 3,5- dihydroxyhexanoic acid derivative.

公开(公告)号：NO20015042D0

公开(公告)日：2001-10-16

申请号：NO20015042

申请日：2001-10-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  G01N

Abstract: An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.

公开(公告)号：DE60225825T2

公开(公告)日：2009-04-16

申请号：DE60225825

申请日：2002-10-24

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  INOUE KENJI

IPC: C07C69/675 ,  C07C67/29 ,  C07C67/31 ,  C07C69/78

Abstract: A method for producing an optically active 3,5-dihydroxyhexanoic acid derivative by stereoselectively reducing an optically active 3-oxo-5-hydroxyhexanoic acid derivative is provided. The method, which requires neither an ultralow-temperature reactor, an incubator, nor protection of the 5-position hydroxy group, is simple and economical. An optically active 3,5-dihydroxyhexanoic acid derivative is produced by asymmetrical hydrogenation of an optically active 3-oxo-5-hydroxyhexanoic acid derivative catalyzed by an RuBr2BINAP complex prepared from a ruthenium complex and a ruthenium-optically active phosphine complex, i.e., 2,2'-bisdiarylphosphino-1,1'-binaphthyl (BINAP), while using extremely inexpensive hydrogen as the reductant.

公开(公告)号：PL350362A1

公开(公告)日：2002-12-02

申请号：PL35036201

申请日：2001-02-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  C07C227/04 ,  C07B53/00

Abstract: An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.

公开(公告)号：CA2369678A1

公开(公告)日：2001-08-23

申请号：CA2369678

申请日：2001-02-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  KINOSHITA KOICHI ,  TAKEDA TOSHIHIRO ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI ,  OKURO KAZUMI ,  INOUE KENJI ,  MOROSHIMA TADASHI ,  NAGASHIMA NOBUO ,  SAKA YASUHIRO

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  C07B53/00 ,  C07C227/04

Abstract: An optically active amino acid derivative is prepared either by subjecting a n optically active 3-haloalanine derivative (1) to N-protection followed by cyclization or cyclization followed by N-protection to prepare an optically active aziridinecarboxylic acid derivative (3) whose imino group is protecte d with 2- and/or 4-nitrated benzenesulfonyl and treating this derivative (3) with an organometallic reagent or by subjecting an optically active 3- haloalanine derivative to N-protection to obtain an optically active 3- haloalanine derivative (4) whose amino group is protected with 2- and/or 4- nitrated benzenesulfonyl and treating this derivative (4) with an organometallic reagent. According to such processes, natural and nonnatural optically active amino acids can be prepared from inexpensive raw materials through simple and easy operation. In said derivatives, X is halogen; R1 and R2 are each hydrogen or the like; * represents an asymmetric carbon atom; an d P1 is 2- and/ or 4- nitrated benzenesulfonyl.

公开(公告)号：CA2515789A1

公开(公告)日：2004-09-30

申请号：CA2515789

申请日：2004-03-17

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  YASOHARA YOSHIHIKO ,  NISHIYAMA AKIRA ,  MAEDA HIROFUMI ,  TANAKA TATSUYOSHI ,  NAGASHIMA NOBUO

IPC: C07C231/02 ,  C07C231/10 ,  C07C231/18 ,  C07C235/16 ,  C07C237/06 ,  C07C237/52 ,  C07C303/28 ,  C07C309/66 ,  C07C309/73 ,  C07D205/08 ,  C07C269/06 ,  C07C269/04 ,  C07C271/64 ,  C07C303/44

公开(公告)号：AU2003261774A1

公开(公告)日：2004-03-29

申请号：AU2003261774

申请日：2003-08-27

Applicant: KANEKA CORP

Inventor： IZUMIDA MASASHI ,  HONDA TATSUYA ,  MORI KOUHEI ,  YANAGISAWA SATOHIRO ,  INOUE KENJI ,  OHISHI TAKAHIRO ,  NANBA HIROKAZU ,  SUGAWARA MASANOBU

IPC: C07C319/06 ,  C07C319/14 ,  C07C323/58 ,  C07C327/34 ,  C07D233/76 ,  C12P17/10 ,  C12P41/00 ,  C12P17/14 ,  C07B53/00 ,  C07B61/00

Abstract: A process for easily producing an L- alpha -methylcysteine derivative or its salt, which is useful as a drug intermediate, from a cheap easily procurable raw material through an enzymatic D-stereoselective hydrolysis of racemic 5-halomethyl-5-methyl-hydantoin. L- alpha -methylcysteine derivative or its salt is produced by converting racemic 5-halomethyl-5-methylhydantoin to L-5-halomethyl-5-methylhydantoin through an enzymatic D-stereoselective hydrolysis, reacting the L-5-halomethyl-5-methylhydantoin with a sulfurizing agent into L-5-methyl-5-thiomethylhydantoin and hydrolyzing the L-5-methyl-5-thiomethylhydantoin.

公开(公告)号：AU2003242072A1

公开(公告)日：2003-12-31

申请号：AU2003242072

申请日：2003-06-05

Applicant: KANEKA CORP

Inventor： OHISHI TAKAHIRO ,  NANBA HIROKAZU ,  SUGAWARA MASANOBU ,  IZUMIDA MASASHI ,  HONDA TATSUYA ,  MORI KOHEI ,  YANAGISAWA SATOHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI

IPC: C07C319/06 ,  C07C323/58 ,  C07D233/76 ,  C12P13/12 ,  C12P17/04 ,  C12P17/10 ,  C12P41/00 ,  C07C319/02 ,  C07C319/14

Abstract: The present invention relates to a racemic N-carbamoyl-±-methylcysteine derivative represented by formula (1) or its salts: (wherein R 1 represents a substituted or unsubstituted alkyl group having 1 to 20 carbon atoms, a substituted or unsubstituted aralkyl group having 7 to 20 carbon atoms, or a substituted or unsubstituted aryl group having 6 to 20 carbon atoms).

公开(公告)号：AU2003211264A1

公开(公告)日：2003-09-09

申请号：AU2003211264

申请日：2003-02-24

Applicant: KANEKA CORP

Inventor： TAOKA NAOAKI ,  SUGAWARA MASANOBU ,  YASOHARA YOSHIHIKO

IPC: C07B53/00 ,  C07B61/00 ,  C07C29/145 ,  C07C31/42 ,  C07C45/00 ,  C07C45/30 ,  C07C45/81 ,  C07C49/173 ,  C07D319/12