公开(公告)号：BRPI0407954A

公开(公告)日：2006-03-07

申请号：BRPI0407954

申请日：2004-03-17

Applicant: KANEKA CORP

Inventor： TANAKA TATSUYOSHI ,  SUGAWARA MASANOBU ,  MAEDA HIROFUMI ,  NISHIYAMA AKIRA ,  YASOHARA YOSHIHIKO ,  NAGASHIMA NOBUO

IPC: C07C231/02 ,  C07C231/10 ,  C07C231/18 ,  C07C235/16 ,  C07C237/06 ,  C07C237/52 ,  C07C303/28 ,  C07C309/66 ,  C07C309/73 ,  C07D205/08 ,  C07C269/06 ,  C07C269/04 ,  C07C271/64 ,  C07C303/44

公开(公告)号：ES2234802T3

公开(公告)日：2005-07-01

申请号：ES01902737

申请日：2001-02-02

Applicant: KANEKA CORP

Inventor： SAKA YASUHIRO ,  HONDA TATSUYA ,  NAGASHIMA NOBUO

IPC: C07D205/04

Abstract: Procedimiento para la producción del ácido azetidin-2-carboxílico ópticamente activo de fórmula general (2): en la fórmula, * indica un átomo de carbono asimétrico, que comprende ciclar un ácido 4-amino-2- halogenobutírico ópticamente activo de fórmula general (1): en la fórmula, X representa un átomo de halógeno y * indica un átomo de carbono asimétrico, en presencia de un óxido de un metal alcalinotérreo, hidróxido de magnesio o una amina orgánica.

公开(公告)号：DE60008334T2

公开(公告)日：2004-11-25

申请号：DE60008334

申请日：2000-04-14

Applicant: KANEKA CORP

Inventor： KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  NAGASHIMA NOBUO ,  SAKA YASUHIRO ,  HONDA TATSUYA ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C29/147 ,  C07C31/42 ,  C07D307/20

Abstract: The application is concerned with a process for producing a 3-hydroxytetrahydrofuran of the formula (3): by cyclizing a 4-halo-1,3-butanediol of the general formula (2): wherein X represents a halogen atom in an aqueous solution, which comprises carrying out the cyclization reaction under weakly acidic to neutral conditions. Furthermore several methods are disclosed for the isolution of highly pure 3-hydroxytetrahydrofuran.

公开(公告)号：AU9228201A

公开(公告)日：2002-04-08

申请号：AU9228201

申请日：2001-09-28

Applicant: KANEKA CORP

Inventor： HONDA TATSUYA ,  NAGASHIMA NOBUO

IPC: C07D307/33 ,  C07D315/00

公开(公告)号：NO20015042D0

公开(公告)日：2001-10-16

申请号：NO20015042

申请日：2001-10-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  G01N

Abstract: An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.

公开(公告)号：DE60108355T2

公开(公告)日：2005-06-16

申请号：DE60108355

申请日：2001-02-02

Applicant: KANEKA CORP

Inventor： SAKA YASUHIRO ,  HONDA TATSUYA ,  NAGASHIMA NOBUO

IPC: C07D205/04

公开(公告)号：AU2003289020A1

公开(公告)日：2004-07-29

申请号：AU2003289020

申请日：2003-12-10

Applicant: KANEKA CORP

Inventor： OHISHI TAKAHIRO ,  MORI KOHEI ,  KINOSHITA KOICHI ,  MAEHARA KATSUJI ,  KAWASAKI HIROAKI ,  NAGASHIMA NOBUO ,  FUSE YOSHIHIDE

IPC: C07C319/14 ,  C07C323/56 ,  C07D407/06 ,  C07D317/60 ,  C07D305/12

Abstract: The present invention provides a process for simply producing an optically active 2-thiomethyl-3-phenylpropionic acid derivative useful as an intermediate for medicines from inexpensive raw materials. An optically active 2-hydroxymethyl-3-phenylpropionic acid ester derivative which can be relatively easily obtained by asymmetric reduction reaction with an enzyme is cyclized to an optically active P-lactone derivative which is then reacted with a sulfur compound to produce an optically active 2-thiomethyl-3-phenylpropionic acid derivative in high yield.

公开(公告)号：AT259794T

公开(公告)日：2004-03-15

申请号：AT00915524

申请日：2000-04-14

Applicant: KANEKA CORP

Inventor： KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  NAGASHIMA NOBUO ,  SAKA YASUHIRO ,  HONDA TATSUYA ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C29/147 ,  C07C31/42 ,  C07D307/20

Abstract: The application is concerned with a process for producing a 3-hydroxytetrahydrofuran of the formula (3): by cyclizing a 4-halo-1,3-butanediol of the general formula (2): wherein X represents a halogen atom in an aqueous solution, which comprises carrying out the cyclization reaction under weakly acidic to neutral conditions. Furthermore several methods are disclosed for the isolution of highly pure 3-hydroxytetrahydrofuran.

公开(公告)号：AU2003244235A1

公开(公告)日：2004-01-19

申请号：AU2003244235

申请日：2003-06-17

Applicant: KANEKA CORP

Inventor： MATOHARA KUMI ,  NAGASHIMA NOBUO

IPC: C07D301/26 ,  C07D303/36 ,  C07D327/10

Abstract: The present invention provides an industrial process for effectively and advantageously preparing optically active 1-substituted amino-2,3-epoxypropanes useful as intermediates for preparing agricultural chemicals and medical products from optically active 1-substituted amino-2,3-propanediols used as raw materials. The present invention also provides useful intermediates. Specifically, an optically active 1-substituted amino-2,3-propanediol (1) is reacted with an orthoacid ester (2) or thionyl chloride (3) to produce a cyclic optically active compound (4), and then a compound (5) containing a halogen atom is prepared by reaction with a ring-opening reaction agent having an ability to introduce a halogen atom X. Finally, an optical active 1-substituted amino-2,3-epoxypropane is prepared by ring-closure reaction in the presence of a base.

公开(公告)号：PL350362A1

公开(公告)日：2002-12-02

申请号：PL35036201

申请日：2001-02-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  C07C227/04 ,  C07B53/00

Abstract: An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.