公开(公告)号：WO1991010892A1

公开(公告)日：1991-07-25

申请号：PCT/US1991000029

申请日：1991-01-10

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  PURDIE, Neil

IPC: G01N21/00

CPC classification number: G01N33/743 ,  G01N21/19 ,  G01N21/75 ,  G01N21/78 ,  G01N33/92

Abstract: The present invention is concerned with the use of spectrophotometric methods, including the use of convention spectroscopic absorption or circular dichroism for clinical chemistry detection methods. More specifically, with the use of such spectrophotometric methods in the measurement of cholesterol levels and direct measurement of cholesterol subfractions in clinical samples, and in the measurement of lipoprotein levels in a clinical test sample, as well as in the detection of anabolic steroids and other steroid products. The invention is also concerned with providing certain CD and conventional spectrophotometric apparatus useful in each of the aforesaid chemical methods.

Abstract translation: 本发明涉及使用分光光度法，包括使用常规的光谱吸收或圆二色性用于临床化学检测方法。 更具体地说，通过使用这种分光光度法测定胆固醇水平并直接测量临床样品中的胆固醇亚组分，以及临床测试样品中脂蛋白水平的测量，以及合成代谢类固醇和其他 类固醇产品。 本发明还涉及提供在上述各种化学方法中有用的某些CD和常规分光光度计。

公开(公告)号：WO1991008310A1

公开(公告)日：1991-06-13

申请号：PCT/US1990006887

申请日：1990-11-26

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  PIENIAZEK, Norman, J. ,  SLEMENDA, Susan, B. ,  PIENIAZEK, Danuta ,  VELARDE, Jorge ,  LUFTIG, Ronald, B.

IPC: C12Q01/70

CPC classification number: C07K14/005 ,  A61K38/00 ,  C12N2710/10322

Abstract: The present invention relates to DNA and proteins of human Adenovirus Type 41 and their use in detection of said virus. More specifically, the present invention relates to the isolation of a 41.4 kd short fiber protein and a 60.6 kd long fiber protein of Adenovirus Type 41 (Ad41), as well as protein derived from the Ad41 E3 region, thereby providing virus-derived antigens and active derivatives and parts thereof, useful in the development of diagnostic assays, DNA probes and vaccines for said virus or other related viruses belonging to the human enteric family.

Abstract translation: 本发明涉及人腺病毒41型的DNA和蛋白质及其在检测所述病毒中的用途。 更具体地说，本发明涉及分离41.4kd的短纤维蛋白质和61.6型的Adenovirus 41型（Ad41）的长纤维蛋白质，以及衍生自Ad41 E3区域的蛋白质，从而提供病毒衍生的抗原和 活性衍生物及其部分，可用于开发用于所述病毒或属于人肠系氏病的其它相关病毒的诊断测定，DNA探针和疫苗。

公开(公告)号：WO1991008190A1

公开(公告)日：1991-06-13

申请号：PCT/US1990007083

申请日：1990-12-04

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  CARPINO, Louis, A. ,  WU, An-Chuu

IPC: C07C53/44

CPC classification number: C07D405/12 ,  C07C43/168 ,  C07C61/29 ,  C07C2603/18 ,  C07C2603/24 ,  C07D311/82 ,  C07F7/0805 ,  C07F7/081 ,  C07K1/063 ,  C07K1/064 ,  Y02P20/55

Abstract: This invention relates to compounds of the formula a compound of the formula wherein X is O, CR7R8, S or NR9 wherein R7 and R8 are independently hydrogen, or lower alkyl, and R9 is lower alkyl; n is 0 or 1; R1 and R2 are independently hydrogen, lower alkyl, monoorganosilyl, diorganosilyl, triorganosilyl, halogen, aryl, or nitro; R3 is hydrogen, lower alkyl, monoorganosilyl, diorganosilyl, triorganosilyl, halogen, 9-fluorenylalkyl, cycloalkyl, aryl or aralkyl; R4 and R5 are independently hydrogen, lower alkyl, or aryl or one of R4 and R5 is 9-fluorenyl; R6 is H or COZ wherein Z is an amino acid, a peptide residue or a leaving group; and with the provisos that when n is 0 and R3 is hydrogen, R1 and R2 are not hydrogen, halogen or nitro; that when n is 0 and R3 is lower alkyl, R1 and R2 are not hydrogen; and that when X is O or CR7R8 wherein R7 and R8 are H, that R1, R2, R3, R4, R5, and R6 are not all simultaneously H. The compounds of the present invention are useful in peptide synthesis as blocking or protecting groups for reactive groups. The present invention is also directed to a method of protecting a reactive group of an organic molecule during a reaction which modifies a portion of the molecule other than the protected group.

公开(公告)号：WO1991006894A1

公开(公告)日：1991-05-16

申请号：PCT/US1990006013

申请日：1990-10-18

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  HILL, Steven, C. ,  PATEL, Ramesh, C. ,  BARKER, Delmar, L. ,  BAKER, Kim, A. ,  STUMPF, Joseph, G. ,  JACOB, Jeffery, E. ,  CREANGE, John, E.

IPC: G03C05/00

CPC classification number: B82Y5/00 ,  A61K8/025 ,  A61K2800/413 ,  A61K2800/63 ,  A61Q17/04 ,  C02F1/32 ,  C02F1/725 ,  C02F2305/10 ,  G03C5/58

Abstract: Methods and apparatus provided with selected nanoparticles that exhibit the plasmon resonance effect to enhance photoprocesses. In a first embodiment, such nanoparticles are used in a method of forming an integrated circuit; and in additional embodiments, the nanoparticles are used to increase the catalytic effect of a metal catalyst to increase the rate at which molecules absorb light, to accelerate the reduction of carbon dioxide to formic acid, to accelerate the decomposition of pollutants, and to accelerate the reaction of two reactants to produce a fuel. Additional embodiments utilize the plasmon resonance effect to enhance the effect of solar energy on a solar responsive electrode of a photochemical battery, and to inhibit the passage of ultraviolet light through a sunscreen. Also, in accordance with the present invention, nanoparticles that exhibit the plasmon resonance effect are used to improve a test for a solution for a bio-agent, and to develop fingerprints on a surface.

Abstract translation: 提供具有等离子体共振效应的选定纳米粒子的方法和装置以增强光刻处理。 在第一实施例中，这种纳米颗粒用于形成集成电路的方法; 并且在另外的实施方案中，纳米颗粒用于增加金属催化剂的催化作用以增加分子吸收光的速率，加速二氧化碳还原成甲酸，加速污染物的分解，并加速 两种反应物产生燃料的反应。 另外的实施例利用等离子体共振效应来增强太阳能对光化学电池的太阳能响应电极的影响，并且抑制紫外线通过防晒剂。 此外，根据本发明，使用表现出等离子共振效应的纳米颗粒来改善生物剂溶液的测试，并在表面上显影指纹。

公开(公告)号：WO1990008838A1

公开(公告)日：1990-08-09

申请号：PCT/US1990000182

申请日：1990-01-09

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  McLAUGHLIN, Larry, W.

IPC: C12Q01/68

CPC classification number: C07H21/00

Abstract: The present invention relates to DNA markers and, particularly, nucleic acid labeling techniques. More specifically, this invention contemplates a protocol which permits the covalent introduction of single or multiple fluorescent markers or other probes into DNA fragments and oligodeoxynucleotides. The instant technique, particularly employing multiple fluorescent markers, allows high sensitivity detection of nucleic acids (without the use of sophisticated detection devices) in the low femtomolar (10 mol) range and additionally permits the placement of markers and probes at specific locations within the macromolecule. The present invention can be used with high detection sensitivity for DNA sequencing and hybridization procedures including a host of diagnostic and therapeutic procedures. The present technique can be employed as a tool for the study of nucleic acid dynamics through recognition and evaluation of fluorescence energy transfer and electron spin resonance, and the study of structure, conformation and dynamics of biopolymers. Specific labeling procedures allow the introduction of a probe or other entity for the location of desired sequences or the delivery of the probe to a specific sequence. This process is fundamental to the emerging fields of DNA diagnostics and therapeutics.

Abstract translation: 本发明涉及DNA标记，特别是核酸标记技术。 更具体地，本发明考虑了允许将单个或多个荧光标记物或其他探针共价引入DNA片段和寡脱氧核苷酸的方案。 本技术，特别是使用多种荧光标记物，允许在低飞沫（10-15μm）范围内对核酸（不使用复杂的检测装置）进行高灵敏度检测，并且另外允许将标记物和探针放置在特定的 大分子内的位置。 本发明可以用于DNA测序和杂交程序的高检测灵敏度，包括许多诊断和治疗程序。 本技术可用作通过荧光能量转移和电子自旋共振的识别和评估以及生物聚合物的结构，构象和动力学研究来研究核酸动力学的工具。 特异性标记方法允许引入探针或其他实体用于所需序列的位置或将探针递送到特定序列。 这个过程是DNA诊断和治疗新兴领域的基础。

公开(公告)号：WO1989009815A1

公开(公告)日：1989-10-19

申请号：PCT/US1989001379

申请日：1989-04-04

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  SHAW, George, M. ,  HAHN, Beatrice, H. ,  KONG, Lilly, I. ,  LEE, Shei-Wen

IPC: C12N01/00

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/1045 ,  C12N7/00 ,  C12N2740/16021 ,  C12N2740/16122 ,  C12Q1/703

Abstract: The present invention relates to a novel virus, said virus belonging to the HIV-2 family of viruses. In particular, the invention relates to a retrovirus characterized by being antigenically more similar to, but genetically distinct from, HIV-2/ROD and SIVMAC than to HIV-1. More particularly, the present invention relates to the isolation and cultivation of HIV-2/ST thereby providing a source of said virus and its derivatives including virus-derived antigens and derivatives and parts thereof, useful in the development of diagnostic assays for said virus or other related viruses belonging to the HIV-2 family. Furthermore, the present invention is also directed to recombinant DNA molecules containing the entire HIV-2/ST provirus thereby providing a source of recombinant viral components useful in the development of said diagnostic assays for HIV-2 viruses. The present invention is also directed to antibodies specific to viral components and to different antibodies specific to the first antibodies, said antibodies are also useful in the development of diagnostic assays for HIV-2 viruses. The present invention also contemplates a method of the isolation of HIV-2/ST-type viruses.

Abstract translation: 本发明涉及一种新型病毒，所述病毒属于HIV-2病毒家族。 特别地，本发明涉及一种逆转录病毒，其特征在于与HIV-1相比，其在抗原上与HIV-2 / ROD和SIVMAC更相似，但在遗传上不同。 更具体地，本发明涉及HIV-2 / ST的分离和培养，从而提供所述病毒及其衍生物的来源，所述病毒及其衍生物包括病毒衍生抗原及其衍生物及其部分，可用于开发用于所述病毒的诊断测定或 属于HIV-2家族的其他相关病毒。 此外，本发明还涉及含有整个HIV-2 / ST原病毒的重组DNA分子，从而提供可用于开发用于HIV-2病毒的所述诊断测定的重组病毒组分的来源。 本发明还涉及针对病毒组分和针对第一抗体特异性的不同抗体的抗体，所述抗体也可用于开发用于HIV-2病毒的诊断测定。 本发明还考虑了分离HIV-2 / ST型病毒的方法。

公开(公告)号：WO1989005143A1

公开(公告)日：1989-06-15

申请号：PCT/US1987003251

申请日：1987-12-07

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  LUZZI, Louis, A. ,  LUZZI, Joyce, K.

IPC: A61K31/36

CPC classification number: A61K31/34

Abstract: A composition for skin disorders comprising dimethyl isosorbide. It has been found that dimethyl isosorbide has a dermal penetrating action which can effectively carry it to the source of a skin disorder and that it has antifungal, antiviral and antibacterial effects which make it effective in the treatment of a wide range of skin disorders.

Abstract translation: 一种包含二甲基异山梨醇的皮肤病组合物。 已经发现，二甲基异山梨醇具有皮肤渗透作用，其可以有效地将其带入皮肤病症的来源，并且其具有抗真菌，抗病毒和抗菌作用，使其在治疗各种皮肤病中有效。

公开(公告)号：WO1997043298A1

公开(公告)日：1997-11-20

申请号：PCT/US1997008307

申请日：1997-05-15

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  KOOL, Eric, T.

IPC: C07H19/00

CPC classification number: C07H21/00 ,  C07H7/04 ,  C07H15/20

Abstract: The present invention provides fluorescent nucleosides carrying polycyclic aromatic hydrocarbons such as anthracene, phenanthrene, pyrene, stilbene, tetracene or pentacene. The subject nucleosides may be synthesized using a C-glycosidic bond formation method employing organocadium or organozinc derivatives of the aromatic compounds and coupling with a 1- alpha -chlororibose or deoxyribose synthon. The alpha -anomers of the coupling reaction may be epimerized to the beta -anomers by acid-catalyzed equilibration. The fluorescent nucleosides act as a DNA or RNA base analogs and can be incorporated into nucleic acids. Resultant fluorescently tagged nucleic acids are useful as probes for target nucleic acids in tissues, solutions or immobilized on membranes.

Abstract translation: 本发明提供携带多环芳烃的荧光核苷，例如蒽，菲，芘，芪，并四苯或并五苯。 可以使用使用有机体或芳族化合物的有机锌衍生物的C-糖苷键形成方法并与1-α-半胱氨酸或脱氧核糖合成酶偶联来合成目标核苷。 偶联反应的α-异构体可以通过酸催化的平衡而差向异构化为β-异构体。 荧光核苷作为DNA或RNA碱基类似物，可以并入核酸。 得到的荧光标记核酸可用作组织，溶液中的靶核酸的探针或固定在膜上。

公开(公告)号：WO1997023787A1

公开(公告)日：1997-07-03

申请号：PCT/US1996014110

申请日：1996-09-03

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  GELBART, Daniel ,  LABERGE, Michel, G.

IPC: G01S17/66

CPC classification number: G01S17/66 ,  G01S1/70 ,  G01S3/784 ,  G01S3/787 ,  G01S5/16 ,  G01S17/74 ,  G01S17/875 ,  G01S17/88

Abstract: An apparatus and method for directing a light beam onto a moving article. The apparatus comprises first and second mirrors for directing the light beam in an adjustable direction, first and second motors connected to the first and second mirrors to move those mirrors, and a tracking system connected to the first and second motors to operate those motors to move the first and second mirrors to maintain the light beam directed at the article as the article moves. Preferably, the tracking system includes coarse and fine tracking subsystems. The coarse tracking subsystem is used to operate the motors to move the mirrors to direct the light beam approximately onto the article, and the fine tracking subsystem is used to operate the motors to operate the mirrors to direct the light beam substantially directly onto the article.

Abstract translation: 一种用于将光束引导到移动物品上的装置和方法。 该装置包括用于将光束引向可调节方向的第一和第二反射镜，连接到第一和第二反射镜以移动这些反射镜的第一和第二马达以及连接到第一和第二马达的跟踪系统以操作那些马达移动 第一和第二反射镜以在制品移动时保持指向物品的光束。 优选地，跟踪系统包括粗略和精细跟踪子系统。 粗跟踪子系统用于操作电动机以移动反射镜以将光束近似地引导到物品上，并且精细跟踪子系统用于操作电动机以操作镜子以将光束基本上直接引导到物品上。

公开(公告)号：WO1996040948A2

公开(公告)日：1996-12-19

申请号：PCT/US1996008503

申请日：1996-06-04

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  ROTH, Don, Allen ,  LANGLAND, Jeffrey, Olaf

IPC: C12N15/82

CPC classification number: C12N15/8509 ,  A01K2217/05 ,  A01K2267/02 ,  A01K2267/0337 ,  A61K38/00 ,  A61K48/00 ,  C07K14/005 ,  C12N15/8283 ,  C12N2710/24122 ,  C12N2720/12322

Abstract: The invention provides a method for imparting resistance in animals to viruses, and in plants to viruses and viroids, that express double-stranded RNA-like structures (dsRNAs). This method enables the binding of pathogenic dsRNAs during the infection process by expression of dsRNA-binding protein in transgenic animal and plant hosts, thus interrupting the infection cycle and inhibiting disease. The presence of a dsRNA-binding protein in a transgenic host renders the transgenic host resistant to the phenotypic symptoms of viral infection and/or decreased pathogen replication. Accordingly, the present invention provides a genetically engineered animal and plant, stably transformed to express a dsRNA-binding protein, such that the transgenic host displays resistance to virus and/or viroid challenge.

Abstract translation: 本发明提供了一种赋予动物对病毒和植物中表达双链RNA样结构（dsRNA）的病毒和类病毒的抗性的方法。 该方法能够在感染过程中通过在转基因动物和植物宿主中表达dsRNA结合蛋白来结合病原性dsRNA，从而中断感染周期并抑制疾病。 在转基因宿主中dsRNA结合蛋白的存在使转基因宿主对病毒感染的表型症状和/或病原体复制减少具有抗性。 因此，本发明提供了稳定转化以表达dsRNA结合蛋白的基因工程动物和植物，使得转基因宿主显示出对病毒和/或类病毒攻击的抗性。