公开(公告)号：CL2018001862A1

公开(公告)日：2018-10-05

申请号：CL2018001862

申请日：2018-07-09

Applicant: SERVIER LAB

Inventor： GLOANEC PHILIPPE ,  SCHAFFNER ARNAUD-PIERRE ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  MENNECIER PHILIPPE ,  VALLEZ MARIE-ODILE

IPC: A61K31/675 ,  A61P9/00 ,  C07F9/6584

Abstract: COMPUESTOS DE FÓRMULA (I), EN LA QUE: AK1 REPRESENTA UNA CADENA ALQUILO, X REPRESENTA -(CH2)M-, -CH(R)-, -N(R)-, -CH2-N(R)-, –N(R)-CH2- O -CH2-N(R)-CH2-, M Y R SON TALES COMO SE HAN DEFINIDO EN LA DESCRIPCIÓN, R1 Y R2 REPRESENTAN CADA UNO H CUANDO X REPRESENTA -(CH2)M-, -CH(R)-, -N(R)-, -CH2-N(R)- O – N(R)-CH2-, O BIEN FORMAN JUNTOS UNA UNIÓN CUANDO X REPRESENTA -CH2-N(R)-CH2-, R3 REPRESENTA NH2, CY-NH2, CY-AK3-NH2 O PIPERIDIN-4-ILO, CY Y AK3 SON TALES COMO SE HAN DEFINIDO EN LA DESCRIPCIÓN, R4 Y R5, IDÉNTICOS O DIFERENTES, REPRESENTAN CADA UNO H O F, SUS ISÓMEROS ÓPTICOS, ASÍ COMO SUS SALES DE ADICIÓN A UN ÁCIDO FARMACÉUTICAMENTE ACEPTABLE. MEDICAMENTOS.

公开(公告)号：AU2017207003A2

公开(公告)日：2018-10-04

申请号：AU2017207003

申请日：2017-01-13

Applicant: SERVIER LAB

Inventor： GLOANEC PHILIPPE ,  SCHAFFNER ARNAUD-PIERRE ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  MENNECIER PHILIPPE ,  VALLEZ MARIE-ODILE

IPC: C07F9/6584 ,  A61K31/675 ,  A61P9/00

Abstract: Compounds of formula (I) in which: Ak

公开(公告)号：MA41798A

公开(公告)日：2018-01-24

申请号：MA41798

申请日：2017-01-13

Applicant: SERVIER LAB

Inventor： GLOANEC PHILIPPE ,  MENNECIER PHILIPPE ,  RUPIN ALAIN ,  SANSILVESTRI-MOREL PATRICIA ,  SCHAFFNER ARNAUD-PIERRE ,  VALLEZ MARIE-ODILE

IPC: A61K31/66 ,  A61K9/00 ,  A61K31/675 ,  A61K45/06 ,  C07F9/6568 ,  C07F9/6584

公开(公告)号：GEP20115342B

公开(公告)日：2011-12-12

申请号：GEAP2009011185

申请日：2009-03-25

Applicant: SERVIER LAB

Inventor： SANSILVESTRI-MOREL PATRICIA ,  WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  VERBEUREN TONY ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61K31/7012 ,  A61P9/10 ,  A61P9/12 ,  C07D407/12

Abstract: Compounds of the formula (I), (I) wherein R1, R2 and R3 have the values indicated in the claims; a method for its production and use thereof for prevention or treatment of chronic vein diseases.

公开(公告)号：HRP20110361T1

公开(公告)日：2011-06-30

申请号：HRP20110361

申请日：2011-05-16

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRAN OISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANÇOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61K31/7012 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07D407/12 ,  C07H15/26

Abstract: Diosmetin derivatives (I), are new. Diosmetin derivatives of formula (I), are new. R1-R3 : H or (2S,3S,4R,5S)-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid moiety. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Anticoagulant; Antiinflammatory; Vasotropic; Antidiabetic; Hypotensive; Antiarteriosclerotic; Analgesic; Antianginal; Anorectic; Cerebroprotective. MECHANISM OF ACTION : None given.

公开(公告)号：SI2107055T1

公开(公告)日：2011-05-31

申请号：SI200930019

申请日：2009-03-31

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/00 ,  A61K31/352 ,  A61K31/7012 ,  A61P9/00 ,  C07D407/00 ,  C07H15/00

公开(公告)号：DE602009000873D1

公开(公告)日：2011-04-28

申请号：DE602009000873

申请日：2009-03-31

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61K31/7012 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07D407/12 ,  C07H15/26

公开(公告)号：NZ575902A

公开(公告)日：2010-12-24

申请号：NZ57590209

申请日：2009-03-30

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: A61K31/35 ,  C07D311/30 ,  A61K31/352 ,  A61P9/00 ,  C07D407/12

Abstract: The disclosure relates to diosmetin compounds of formula (I), to a process for their preparation and to pharmaceutical compositions containing them, wherein the variables shown in formula (I) are as defined in the specification. These compounds are suitable for the treatment of a condition selected from venous diseases, post-thrombotic syndrome, vascular complications associated with diabetes, hypertension, atherosclerosis, inflammation, metabolic syndrome associated with obesity, vascular complications associated with obesity, angina pectoris, arteritis of the lower limbs or cerebral vascular accidents, chronic wounds including venous or mixed leg ulcers and diabetic foot, haemorrhoid attacks, pressure ulcers, and multiple sclerosis.

公开(公告)号：EA013078B1

公开(公告)日：2010-02-26

申请号：EA200701820

申请日：2006-02-28

Applicant: SERVIER LAB

Inventor： VERBEUREN TONY ,  RUPIN ALAIN ,  SANSILVESTRI-MOREL PATRICIA ,  VALLEZ MARIE-ODILE ,  BOUSSARD MARIE-FRANCOISE ,  WIERZBICKI MICHEL

IPC: A61K31/352 ,  A61P7/02

Abstract: Применениедиосметиновыхсоединенийв получениифармацевтическихкомпозиций, предназначенныхдляпрофилактикии/илилечениятромботическихпатологийи патологийс рискомтромбоза.

公开(公告)号：AU2009201068A1

公开(公告)日：2009-10-15

申请号：AU2009201068

申请日：2009-03-17

Applicant: SERVIER LAB

Inventor： RUPIN ALAIN ,  WIERZBICKI MICHEL ,  LEFOULON FRANCOIS ,  VERBEUREN TONY ,  BOUSSARD MARIE-FRANCOISE ,  SANSILVESTRI-MOREL PATRICIA ,  PAYSANT JEROME

IPC: C07D311/30 ,  A61K31/352 ,  A61P7/02 ,  A61P9/10 ,  C07D407/02 ,  C07D407/12 ,  C07D407/14

Abstract: Diosmetin derivatives (I), are new. Diosmetin derivatives of formula (I), are new. R1-R3 : H or (2S,3S,4R,5S)-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid moiety. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Anticoagulant; Antiinflammatory; Vasotropic; Antidiabetic; Hypotensive; Antiarteriosclerotic; Analgesic; Antianginal; Anorectic; Cerebroprotective. MECHANISM OF ACTION : None given.