公开(公告)号：HK1006537A1

公开(公告)日：1999-03-05

申请号：HK98105569

申请日：1998-06-17

Applicant: SOLVAY PHARM GMBH

Inventor： EECKHOUT CHRISTIAN ,  PREUSCHOFF ULF ,  DAVID SAMUEL

IPC: A61K31/4184 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/437 ,  A61K31/44 ,  A61K31/47 ,  A61P1/00 ,  A61P1/14 ,  C07D233/96 ,  C07D403/06 ,  A61K

Abstract: Use of imidazol-1-yl compounds of the general formula I I wherein R1 denotes lower alkyl or hydrogen; m represents 2 or 3, and n represents 2 or 3; or a physiologically acceptable acid addition salt thereof for treating functional disturbances of the lower intestinal tract in larger mammals and humans associated with increased pain sensitivity and/or anomalies in stool passage in the colon region.

公开(公告)号：CA2245926A1

公开(公告)日：1999-02-27

申请号：CA2245926

申请日：1998-08-26

Applicant: SOLVAY PHARM GMBH

Inventor： PECK MICHAEL ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  ZIEGLER DIETER ,  DAVID SAMUEL ,  BRUECKNER REINHARD ,  ANTEL JOCHEN

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08 ,  C07D405/00

Abstract: Neurokinin-antagonistic compounds corresponding to formula I: in which R1 is hydrogen or lower alkyl, R2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and R3 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, or R2 and R3 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring, R4 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and R5 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, or R4 and R5 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring, R6 is lower alkyl, halogen or trifluoromethyl, R7 is lower alkyl, halogen or trifluoromethyl, A is a -(CH2) n- group in which n represents an integer from 1 to 3, or an -NH-(CH2) m - group in which m represents an integer from 2 to 3, and B is an alkylene chain with 1 to 3 carbon atoms optionally substituted by lower alkyl, and physiologically acceptable salts thereof and processes for the preparation of these compounds.

公开(公告)号：CA2403139C

公开(公告)日：2011-02-22

申请号：CA2403139

申请日：2002-09-13

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  PREUSCHOFF ULF ,  ANTEL JOCHEN ,  DAVID SAMUEL ,  SANN HOLGER ,  BRUECKNER REINHARD ,  REICHE DANIA ,  EECKOUT CHRISTIAN

IPC: C07D295/12 ,  C07D409/06 ,  A61K31/341 ,  A61K31/381 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/08 ,  C07D241/04 ,  C07D295/08 ,  C07D295/084 ,  C07D295/092 ,  C07D307/52 ,  C07D333/20 ,  C07D407/02 ,  C07D407/04 ,  C07D407/06 ,  C07D409/02

Abstract: Novel 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]--piperazine compounds which are antagonistic to tachykinin receptors, of the general formula I, (see formula I) wherein R6, R7, A and Z have the meanings given in the description, and medicaments containing these compounds are described. Furthermore, a process for the preparation of the novel compounds and intermediate products of this process are described.

公开(公告)号：PL201165B1

公开(公告)日：2009-03-31

申请号：PL36351801

申请日：2001-07-12

Applicant: SOLVAY PHARM GMBH

Inventor： HEBEBRAND JOHANNES ,  ANTEL JOCHEN ,  PREUSCHOFF ULF ,  DAVID SAMUEL ,  SANN HOLGER ,  WESKE MICHAEL

IPC: A61P3/04 ,  G01N33/50 ,  A61K45/00 ,  A61P1/00 ,  C12Q1/02 ,  C12Q1/527 ,  G01N33/15

公开(公告)号：PL193724B1

公开(公告)日：2007-03-30

申请号：PL32822198

申请日：1998-08-26

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUECKNER REINHARD ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM

IPC: C07D403/06 ,  A61K31/495 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/00 ,  C07D209/14 ,  C07D241/00

公开(公告)号：NO20063138A

公开(公告)日：2006-09-06

申请号：NO20063138

申请日：2006-07-06

Applicant: SOLVAY PHARM GMBH

Inventor： MENTZEL MATTHIAS ,  REICHE DANIA B ,  BRUCKNER REINHARD ,  DAVID SAMUEL ,  STEEN BARTHOLOMEUS J VAN ,  SCHON UWE ,  JASSERAND DANIEL ,  PREUSCHOFF ULF

IPC: C07D471/10 ,  A61K31/4747 ,  C07D487/08

CPC classification number: C07D471/10

公开(公告)号：AT310732T

公开(公告)日：2005-12-15

申请号：AT98115651

申请日：1998-08-20

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUECKNER REINHARD ,  ZIEGLER DIETER ,  EECKOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08

Abstract: 1-Benzoyl-4-aminoacyl-7-phenyl-1,4-diazepine derivatives (I) are new. Also new are four classes of intermediates. 1,4-Diazepine derivatives of formula (I) and their acid addition salts are new. Ph1 = phenyl substituted by R2 and R3; Ph2 = phenyl substituted by R4 and R5; Ph3 = 3-(R6)-5-(R7)-phenyl; R1 = H or alkyl; R2-R5 = H, alkyl, alkoxy, halo or CF3; or R2+R3 or R4+R5 on adjacent C = 1-2C alkylenedioxy; R6,R7 = alkyl, halo or CF3; A = (CH2)n or NH(CH2)m; n = 1-3; m = 2 or 3; and B = 1-3C alkylene chain (optionally substituted by alkyl).

公开(公告)号：PT1293506E

公开(公告)日：2005-11-30

申请号：PT02020115

申请日：2002-09-07

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  EECKHOUT CHRISTIAN ,  BRUCKNER REINHARD ,  ANTEL JOCHEN ,  SANN HOLGER ,  PREUSCHOFF ULF ,  DAVID SAMUEL ,  REICHE DANIA

IPC: C07D295/12 ,  A61K31/341 ,  A61K31/381 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/08 ,  C07D295/08 ,  C07D295/084 ,  C07D295/092 ,  C07D307/52 ,  C07D333/20 ,  C07D407/04 ,  C07D407/06 ,  C07D409/06 ,  C07D295/92

公开(公告)号：NZ523960A

公开(公告)日：2004-12-24

申请号：NZ52396001

申请日：2001-07-12

Applicant: SOLVAY PHARM GMBH

Inventor： ANTEL JOCHEN ,  PREUSCHOFF ULF ,  DAVID SAMUEL ,  WESKE MICHAEL ,  HEBEBRAND JOHANNES

IPC: G01N33/50 ,  A61K45/00 ,  A61P1/00 ,  A61P3/04 ,  C12Q1/02 ,  C12Q1/527 ,  G01N33/15

Abstract: Compounds for the treatment and/or prevention of obesity are selected on the basis of their capability to inhibit de novo lipogenesis in mammals. An independent claim is also included for the use of compounds which are capable of inhibiting de novo lipogenesis in mammals and which have no anticonvulsant activity for the production of a medicament for the treatment and/or prevention of obesity. - ACTIVITY : Anorectic. - MECHANISM OF ACTION : Lipogenesis inhibitor; Carboanhydrase inhibitor. No biological data given.

公开(公告)号：ZA200300444B

公开(公告)日：2004-04-16

申请号：ZA200300444

申请日：2003-01-16

Applicant: SOLVAY PHARM GMBH

Inventor： JOHANNES HEBEBRAND ,  ULF ANTEL JOCHEN PREUSCHOFF ,  DAVID SAMUEL ,  SANN HOLGER ,  WESKE MICHAEL

IPC: F16D27/112 ,  A61P ,  G01N