公开(公告)号：JPS6440498A

公开(公告)日：1989-02-10

申请号：JP19629687

申请日：1987-08-07

Applicant: TOSOH CORP

Inventor： KURAUCHI YASUHIRO ,  AKAZAWA MICHIHIRO ,  HARADA TSUNEO ,  KOYAMA KIYOTAKA ,  TOKUDA AKIRA

IPC: C07K5/037 ,  B01D61/00 ,  B01D61/44 ,  B01D61/54 ,  C07K1/00 ,  C07K1/14 ,  C07K1/24 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075 ,  C08J5/22 ,  C09K5/06 ,  C25B3/00

Abstract: PURPOSE:To purify the titled compound in high efficiency, suppressing the decomposition of the compound, by supplying an aqueous solution of a dipeptide ester containing an inorganic acid into a middle chamber of an electrolytic cell partitioned with anion exchange membranes, charging a base and an electrolyte to a cathode chamber and an anode chamber, respectively, and transferring the inorganic acid from the middle chamber to the anode chamber. CONSTITUTION:An aqueous solution of a dipeptide ester (e.g. alpha-aspartyl-L-phenylalanine methyl ester) containing an inorganic acid is supplied to a middle chamber 7 between anion exchange chambers 2, 3 of an electrolytic cell 1 partitioned with plural anion exchange membranes 2, 3. The cathode chamber 8 and the anode chamber 6 are supplied with an aqueous solution containing a basic substance and an aqueous solution of an electrolyte, respectively. A potential is applied between the anode 4 and the cathode 5 to transfer hydroxyl ion from the cathode chamber 8 through the anion exchange membrane 3 into the middle chamber 7 to neutralize the aqueous solution of dipeptide ester containing inorganic acid and, at the same time, the anion of the inorganic acid in the aqueous solution is transferred through the anion exchange membrane 2 into the anode chamber 6 to obtain the objective compound in purified state.

公开(公告)号：JP2013128901A

公开(公告)日：2013-07-04

申请号：JP2011281383

申请日：2011-12-22

Applicant: Tosoh Corp ,  東ソー株式会社

Inventor： KAWABE TADASHI ,  HARADA TSUNEO

IPC: B01J23/78

Abstract: PROBLEM TO BE SOLVED: To provide a molded product of a hydrogenation catalyst composition, having a sufficient strength and a crushing strength of at least 4.5 Kg, in association with the molded product of a hydrogenation catalyst composition comprising copper and calcium silicate even without containing clay, organic substances and the like; and to provide a method for producing the same.SOLUTION: A copper compound is added to a calcium silicate slurry to form a slurry carrying copper, and the slurry is filtered. The filtered cake is dried to give a catalytic composition, and using the composition, after mixing with water, the molding is performed.

Abstract translation: 要解决的问题：提供一种氢化催化剂组合物的模制产品，其具有足够的强度和抗碎强度至少为4.5Kg，与包含铜和硅酸钙的加氢催化剂组合物的模制产品相结合，甚至不含粘土 ，有机物质等; 并提供其制造方法。解决方案：将铜化合物加入到硅酸钙浆料中以形成携带铜的浆料，并将浆料过滤。 将滤饼干燥，得到催化剂组合物，并使用该组合物，在与水混合后进行成型。

公开(公告)号：JP2013103192A

公开(公告)日：2013-05-30

申请号：JP2011249752

申请日：2011-11-15

Applicant: Tosoh Corp ,  東ソー株式会社

Inventor： KAWABE TADASHI ,  HARADA TSUNEO ,  SHIRAISHI CHIKARA

IPC: B01J23/78 ,  B01J37/04 ,  C07B61/00 ,  C07C209/36 ,  C07C211/46

CPC classification number: Y02P20/52

Abstract: PROBLEM TO BE SOLVED: To provide a method of manufacturing a hydrogenation catalyst, simpler and more efficient than a coprecipitation method, in the method of manufacturing the hydrogenation catalyst comprising copper and calcium silicate.SOLUTION: Silica, a calcium compound, water, ammonia, and a copper compound are added and kneaded simultaneously or sequentially, wherein an ammonia addition amount is 30-65 wt.% with respect to the copper in the copper compound. A hydrogenation catalyst precursor obtained by drying and then firing the resultant paste at a temperature of 300-600°C is subjected to reduction treatment.

Abstract translation: 要解决的问题：提供一种制造氢化催化剂的方法，比制备包含铜和硅酸钙的氢化催化剂的方法中的共沉淀法更简单和更有效。 溶液：同时或依次加入二氧化硅，钙化合物，水，氨和铜化合物，其中氨加入量相对于铜化合物中的铜为30-65重量％。 通过在300〜600℃的温度下干燥然后烧结所得糊料得到的氢化催化剂前体进行还原处理。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2011147934A

公开(公告)日：2011-08-04

申请号：JP2010288883

申请日：2010-12-24

Applicant: Tosoh Corp ,  東ソー株式会社

Inventor： HARADA TSUNEO ,  KAWABE TADASHI

IPC: B01J23/78 ,  B01J35/10 ,  B01J37/18 ,  C07B61/00 ,  C07C209/36 ,  C07C211/46

CPC classification number: Y02P20/52

Abstract: PROBLEM TO BE SOLVED: To provide a catalyst free of a risk of contaminating the environment and of a risk of a health hazard thanks to the absence of an oxide of chromium unlike a prior art copper/chromium-oxide, and moreover exhibiting activity, selectivity and durability equal to or higher than those of a prior art copper/chromium-oxide catalyst. SOLUTION: The hydrogenation catalyst comprising copper and calcium silicate as its main components, is characterized in that copper is contained in an amount of 20 to 60 wt.%, and the molar ratio of calcium oxide (CaO) to silicon oxide (SiO 2 ) in calcium silicate is in a range of 0.1 to 0.7. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：由于不像现有技术的铜/铬氧化物那样，由于不存在铬的氧化物而提供没有污染环境和健康危害的风险的催化剂，而且还显示出 活性，选择性和耐久性等于或高于现有技术的铜/铬 - 氧化物催化剂。 解决方案：包含铜和硅酸钙作为其主要成分的氢化催化剂的特征在于铜的含量为20至60重量％，氧化钙（CaO）与氧化硅的摩尔比（ SiO 2在硅酸钙中的含量为0.1〜0.7的范围。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JPH02270894A

公开(公告)日：1990-11-05

申请号：JP9185989

申请日：1989-04-13

Applicant: TOSOH CORP

Inventor： DOI MASAHARU ,  SAKAMOTO KENJI ,  HARADA TSUNEO ,  MORI TAKASHI

IPC: B01D61/44 ,  C07K1/14 ,  C07K5/06 ,  C07K5/075 ,  C25B3/00

Abstract: PURPOSE:To accomplish the title purification in an efficient, simple manner without lowering the yield by feeding a specific intermediate chamber with an aqueous solution of a dipeptide ester containing organic acids followed by energization to remove the organic acids. CONSTITUTION:(B) An aqueous solution of a dipeptide ester containing (A) organic acids is fed into an intermediate chamber partitioned from the other chambers of an electrolytic cell with a cation exchange membrane and an anion exchange one each made up of at least two layers differing in ion exchange capacity from each other, and an energization is made from electrodes set out of the intermediate chamber to remove the component A out of the intermediate chamber through the ion exchange membranes, thus accomplishing the purification of the component B. It is preferable that the component B be an aqueous solution of alpha-L-aspartyl-L-phenylalanine methyl ester and the pH of the aqueous solution 4.0-7.0.

公开(公告)号：JPH01111894A

公开(公告)日：1989-04-28

申请号：JP26804987

申请日：1987-10-26

Applicant: TOSOH CORP

Inventor： HARADA TSUNEO ,  FUKUDA KENICHI ,  SHIMIZU HIROSHI ,  TOKUDA AKIRA ,  KOYAMA KIYOTAKA

IPC: C07K1/14 ,  C07K1/24 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075 ,  C25B3/00 ,  C25B9/00 ,  C25B9/08 ,  C25D3/00

Abstract: PURPOSE:To efficiently remove org. acids with an anion-exchange membrane by supplying an aq. soln. of dipeptide ester(APM) contg. the org. acids into the intermediate chamber of an electrolytic cell, and electrolytically purifying the APM. CONSTITUTION:An aq. alpha-APM soln. contg. org. acids is supplied into the central section 7 of the electrolytic cell enclosed with an anion-exchange membrane 3 and a cation-exchange membrane 2 or plural anion-exchange membranes. When electrolysis is started, gaseous H2 is generated from a cathode 4, and gaseous chlorine is generated from an anode 5. The anions of the 1,3-benzyl-6- carboxymethyl-2,5-diketopiperazine(DKP), alpha-L-aspartyl-L-phenylalanine(AP), etc., are moved to an anode chamber 8 from the intermediate chamber 7, or the central chamber 7, through the anion-exchange membrane 3. The cations are moved to a cathode chamber 6. As a result, the inorg. ion and org. ion are efficiently removed.

公开(公告)号：JPS6463565A

公开(公告)日：1989-03-09

申请号：JP22049987

申请日：1987-09-04

Applicant: TOSOH CORP

Inventor： HARADA TSUNEO ,  TOKUDA AKIRA ,  KOYAMA KIYOTAKA

IPC: C07C271/54 ,  C07C67/00 ,  C07C239/00 ,  C07C269/04 ,  C07C271/22

Abstract: PURPOSE:To obtain the title compound of reduced impurities from benzyl chloroformate and L-aspartic acid, by allowing the title compound or its salt to exist beforehand in the reaction system at the start to facilitate the control of the reaction. CONSTITUTION:When N-benzyloxycarbonyl-L-aspartic acid (Z-Asp) is prepared from benzyl chloroformate (Z-Cl) and L-aspartic acid (Asp), Z-Asp or its salt is allowed to exist beforehand in the reaction system at the start of the reaction in an amount of 0.5-50mol.% based on L-Asp, and the reaction mixture is kept at 0-60 deg.C, 9.5-13.5pH to facilitate the reaction control to give Z-Asp of reduced impurities, which is used as a starting substance of alpha-L-aspartyl-L- phenylalanine methyl ester (artificial sweetener).

公开(公告)号：JPH05286994A

公开(公告)日：1993-11-02

申请号：JP11846492

申请日：1992-04-13

Applicant: TOSOH CORP

Inventor： WAKAMATSU HIDETOSHI ,  HARADA TSUNEO ,  KUNISAWA YUKIO ,  KOYAMA KIYOTAKA

IPC: A23L27/30 ,  C07K1/14 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075

Abstract: PURPOSE:To crystallize a crystal of the subject compound having good filtrating property and dehydrating property by continuously feeding a hot water solution containing alpha-L-aspartyl-L-phenylalanine methyl ester to a crystallizing tank cooled to a temperature or below at which the compound is dissolved. CONSTITUTION:Whenalpha-L-aspartyl-L-phenylalanine methyl ester (A2PM) is crystallized from a hot water solution containing alpha-L-aspartyl-L-phenylalanine methyl ester by cooling, the crystallization of A2PM is carried out by continuously feeding a hot water solution in which the content of L-aspartyl-Laspartyl-L- phenylalanine methyl ester (A2PM) is 0.6% smaller than the of alpha-L-spartyl-L- phenylalanine methyl ester to a crystallizing tank cooled to a temperature or below at which alpha-L-aspartyl-L-phenylalanine methyl ester is dissolved and simultaneously continuously drawing out the produced slurry from the crystallizing tank.

公开(公告)号：JPH03106899A

公开(公告)日：1991-05-07

申请号：JP24081989

申请日：1989-09-19

Applicant: TOSOH CORP

Inventor： HARADA TSUNEO ,  WAKAMATSU HIDETOSHI ,  KUNISAWA YUKIO ,  KOYAMA KIYOTAKA

IPC: C07K1/14 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075

Abstract: PURPOSE:To prepare crystals free from impurities and having good filterability and dehydrating ability by continuously feeding a hot aqueous solution of aspartylphenylalanine methyl ester into a crystallization tank cooled to a specific temperature and subsequently separating the produced slurry to remove impurities. CONSTITUTION:A hot aqueous solution (preferably 30-80 deg.C) of alpha-L-aspartyl-L- phenylalanine methyl ester containing

公开(公告)号：JPH02174796A

公开(公告)日：1990-07-06

申请号：JP32764988

申请日：1988-12-27

Applicant: TOSOH CORP

Inventor： SAKAMOTO KENJI ,  HARADA TSUNEO ,  DOI MASAHARU ,  MORI TAKASHI

IPC: B01D61/44 ,  C07K1/14 ,  C07K5/06 ,  C07K5/075

Abstract: PURPOSE:To purify an aqueous solution of a dipeptide ester containing organic acids by supplying the solution to a treating chamber separated by an anion exchange membrane and a cation exchange membrane and treating under a specific condition, thereby easily removing the impurity organic acids in high efficiency. CONSTITUTION:An aqueous solution of a dipeptide ester containing organic acids as impurities is supplied to a treating chamber separated from the other chambers of an electrolytic cell with an anion exchange membrane and a cation exchange membrane at a linear flow rate of 5.0-50cm/sec and electrified with electrodes placed outside of the treating chamber to remove the organic acids from the treating chamber through the ion exchange membrane. Preferably, the aqueous solution of dipeptide ester is alpha-L-aspartyl-L-phenylalanine methyl ester solution and its pH is 4.0-7.0.