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    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF
    21.
    发明专利
    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF 未知

    公开(公告)号：CA2856216C

    公开(公告)日：2021-01-12

    申请号：CA2856216

    申请日：2012-11-09

    Applicant: UCB PHARMA SA

    Inventor： ADAMS RALPH ,  BHATTA PALLAVI ,  HEYWOOD SAM PHILIP ,  HUMPHREYS DAVID PAUL

    IPC: C07K16/18 ,  C07K16/28 ,  C07K16/46

    Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.

    proteína de fusão de anticorpo multivalente, e, ligação de albumina
    22.
    发明专利
    proteína de fusão de anticorpo multivalente, e, ligação de albumina 未知

    公开(公告)号：BR112012006492A2

    公开(公告)日：2016-11-22

    申请号：BR112012006492

    申请日：2010-09-24

    Applicant: UCB PHARMA SA

    Inventor： HANCOCK LAURA ,  ADAMS RALPH ,  HEYWOOD SAM PHILIP

    IPC: C07K16/24 ,  C07K16/18 ,  C07K16/28 ,  C07K16/46

    Abstract: proteína de fusão de anticorpo multivalente, e, ligação de albumina. uma proteína de fusão de anticorpo multivalente que compreende uma porçaõ de imunoglobina, por exemplo um fragmento de fab ou fab', com uma primeira especificidade para um antígeno de interesse, e compreende ainda dois anticorpos de domínio único (dab) com especificoidade para um segundo antígeno de interesse que são par vh/vl, em que os dois anticorpos de domínio único são ligados por uma ligação de dissulfeto. também são fornecidas proteínas de fusão de anticorpo de especificidade dual particulares e outros fragmentos de anticorpo que são estabilizados por uma ligação de dissulfeto.

    ПОЛИВАЛЕНТНЫЕ АНТИТЕЛА
    23.
    发明专利
    ПОЛИВАЛЕНТНЫЕ АНТИТЕЛА 未知

    公开(公告)号：EA023053B1

    公开(公告)日：2016-04-29

    申请号：EA201200725

    申请日：2010-11-17

    Applicant: UCB PHARMA SA

    Inventor： HUMPHREYS DAVID PAUL ,  HEYWOOD SAM PHILIP ,  LAWSON ALASTAIR DAVID GRIFFITHS

    IPC: C07K16/00 ,  C07K19/00

    Abstract: Визобретенииописангибридныйбелокполивалентногоантитела, включающийтяжелуюцепь, содержащуюпоследовательнос N-концавариабельныйдоменноминально V1, область C1 идополнительныйвариабельныйдоменноминально V2, легкуюцепь, включающуюпоследовательнос N-концавариабельныйдоменноминально V1, домен CL ивариабельныйдоменноминально V2, причемуказанныетяжелуюи легкуюцепивыравниваютдляобеспеченияпервогосайтасвязывания, сформированногопервойвариабельнойдоменнойпарой V1 и V1, ивторогосайтасвязывания, сформированноговторойвариабельнойдоменнойпарой V2 и V2, причемимеетсядисульфиднаясвязьвнутривариабельнойдоменнойпары, формирующейсайтсвязывания, иуказанныйгибридныйбелокконъюгированс полимеромПЭГ.

    DISULFIDE STABILISED MULTIVALENT ANTIBODIES
    27.
    发明专利
    DISULFIDE STABILISED MULTIVALENT ANTIBODIES 未知

    公开(公告)号：CA2773286A1

    公开(公告)日：2011-03-31

    申请号：CA2773286

    申请日：2010-09-24

    Applicant: UCB PHARMA SA

    Inventor： ADAMS RALPH ,  HANCOCK LAURA ,  HEYWOOD SAM PHILIP

    IPC: C07K16/46 ,  C07K16/18 ,  C07K16/24 ,  C07K16/28

    Abstract: A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab' fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest which are a VH/VL pair, wherein the two single domain antibodies are linked by a disulfide bond. Also provided are particular dual specificity antibody fusion proteins and other antibody fragments which are stabilised by a disulfide bond.

    Modified antibody fragments
    29.
    发明专利
    Modified antibody fragments 未知

    公开(公告)号：AU2004253747A1

    公开(公告)日：2005-01-13

    申请号：AU2004253747

    申请日：2004-07-01

    Applicant: UCB PHARMA SA

    Inventor： HUMPHREYS DAVID PAUL ,  HEYWOOD SAM PHILIP

    IPC: C07K16/00 ,  A61K39/395

    Abstract: The present invention relates to a new class of antibody fragments including antibody Fab and Fab' fragments in which the heavy chain is not covalently bonded to the light chain and two or more effector molecules are attached to the fragment, of which at least one of said molecules is attached to a cysteine in the heavy or light chain constant region.

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