公开(公告)号：CA3071001A1

公开(公告)日：2019-02-07

申请号：CA3071001

申请日：2018-08-01

Applicant: UNIV HEALTH NETWORK

Inventor： BRAY MARK ROBERT ,  MASON JACQUELINE M ,  MAK TAK W ,  FLETCHER GRAHAM

IPC: A61K31/519 ,  A61K39/395 ,  A61P35/00 ,  C07D487/04 ,  C07K16/18

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

公开(公告)号：CA2941697A1

公开(公告)日：2015-09-11

申请号：CA2941697

申请日：2015-03-06

Applicant: UNIV HEALTH NETWORK

Inventor： MAK TAK W

IPC: A61K39/395 ,  A61K38/17 ,  A61P35/00 ,  A61P37/00

Abstract: The present invention is directed to methods and compositions for modulating proteins involved in the immune response, specifically by modulating the expression and/or activity of the Toso protein. The present invention further provides methods and compositions for treatment of autoimmune disease and cancer by modulating the expression and/or activity of the Toso protein.

公开(公告)号：CA2941693A1

公开(公告)日：2015-09-11

申请号：CA2941693

申请日：2015-03-06

Applicant: UNIV HEALTH NETWORK

Inventor： BLASER HEIKO ,  MAK TAK W

IPC: C12Q1/68 ,  C04B20/00 ,  C04B30/00 ,  C12N15/09

Abstract: The present application is directed to methods and compositions for identifying target nucleic acids that are involved in cancer metastasis. The method comprises transfecting an immortalized cell line with one or more target cDNAs, said transfected cells further expressing a detectable reporter gene. The immortalized cell line lacks metastatic potential in absence of the transfected target cDNAs. Upon injection of said transfected cells into an animal, tumor cells are imaged, isolated and analyzed with respect to the presence of said target cDNAs thus identifying a gene(s) that modulates tumor metastasis.

公开(公告)号：CA2867444A1

公开(公告)日：2013-09-19

申请号：CA2867444

申请日：2013-03-14

Applicant: UNIV HEALTH NETWORK

Inventor： TUSCHE MICHAEL W ,  MAK TAK W ,  OHASHI PAMELA S ,  LANG PHILIPP ,  LANG KARL ,  BRENNER DIRK ,  LIN GLORIA

IPC: A61K38/17 ,  A61P3/10 ,  A61P19/02 ,  A61P37/00

Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.