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公开(公告)号：WO1992022802A1
公开(公告)日：1992-12-23
申请号：PCT/US1992005103
申请日：1992-06-12
Applicant: ABBOTT LABORATORIES , CHOW, Herbert, S. , WILSON, Thomas, J. , ALSBERG, Keith, D. , McCOY, Jimmy, D. , SEBESTA, Esward, E.
Inventor： ABBOTT LABORATORIES
IPC: G01N21/03
CPC classification number: G01N35/109 , B01L3/0262 , B01L3/5085 , G01N15/1468 , G01N21/82 , G01N35/0095 , G01N35/0098 , G01N35/028 , G01N35/1004 , G01N2035/042 , G01N2035/0425 , G01N2035/0491 , G01N2035/1018 , G01N2035/1025 , G01N2035/1034 , G01N2201/0446 , G01N2201/0461 , G01N2201/0492 , G02B7/28 , Y10T137/7306 , Y10T436/115831
Abstract: A reaction cartridge (10) for an automatic analysis apparatus having a plurality of reaction wells (16) having different reagents disposed thereon, at least one sample well (11a, 11b), a well (12) containing magnetically separable particles for binding the sample, a fluorophore containing well (13), and a wash area (15) for washing a probe.
Abstract translation: 一种用于自动分析装置的反应盒（10），具有设置在其上的具有不同试剂的多个反应孔（16），至少一个样品阱（11a，11b），含有用于结合样品的可磁分离颗粒的孔（12） ，含有荧光团（13）的荧光团和用于洗涤探针的洗涤区域（15）。
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公开(公告)号：WO1992022801A1
公开(公告)日：1992-12-23
申请号：PCT/US1992005028
申请日：1992-06-11
Applicant: ABBOTT LABORATORIES , CHOW, Herbert, S. , WILSON, Thomas, J. , WROBLEWSKI, Mieczyslaw , KOTLARIK, John, J. , ALSBERG, Keith, D. , McCOY, Jimmy, D. , LADD, Jimmy, L. , CORBETT, Kevin, M.
Inventor： ABBOTT LABORATORIES
IPC: G01N21/01
CPC classification number: G01N35/109 , B01L3/0262 , B01L3/5085 , G01N15/1468 , G01N21/82 , G01N35/0095 , G01N35/0098 , G01N35/028 , G01N35/1004 , G01N2035/042 , G01N2035/0425 , G01N2035/0491 , G01N2035/1018 , G01N2035/1025 , G01N2035/1034 , G01N2201/0446 , G01N2201/0461 , G01N2201/0492 , G02B7/28 , Y10T137/7306 , Y10T436/115831
Abstract: An apparatus is provided for moving a reaction cartridge (10) to different processing areas (36, 38, 42) of the apparatus. Robots (34, 40) for moving the reaction cartridge to the various areas (30, 32, 36, 38, 42, 46) of the apparatus. An image forming device (42) is provided to detect images which indicate whether specific reactions have occurred in reaction wells (16) of the reaction cartridge (10). The apparatus also includes a mechanism (36) for aspirating and dispensing liquids which includes a liquid level detecting mechanism (70, 72, 74, 76, 78, 80, 82, 84). The device further includes a microprocessor and logic (44) for controlling the apparatus operation and analyzing the information received from the image forming device (42) to generate a visual indication of assay results.
Abstract translation: 提供了一种用于将反应盒（10）移动到设备的不同处理区域（36,38,42）的装置。 用于将反应盒移动到设备的各个区域（30,32,36,38,42,46）的机器人（34,40）。 提供图像形成装置（42）以检测指示反应盒（10）的反应孔（16）中是否发生特定反应的图像。 该装置还包括用于吸入和分配液体的机构（36），该机构包括液面检测机构（70,72,74,76,78,80,82,84）。 该装置还包括微处理器和逻辑（44），用于控制装置操作并分析从图像形成装置（42）接收的信息以产生测定结果的视觉指示。
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公开(公告)号：EP1955101A1
公开(公告)日：2008-08-13
申请号：EP06819303.6
申请日：2006-11-07
Applicant: INNOPSYS
Inventor： BEC, Daniel , PAVEAU, Vincent , LE BRUN,Stéphane
CPC classification number: G01N21/6452 , G01N21/6458 , G01N2201/0438 , G01N2201/0492 , G01N2201/101 , G02B21/0076
Abstract: A device for analysing a specimen by fluorescence comprises a confocal microscope, illumination means capable of emitting a light beam that converges, by means of an objective, on a focal spot, means for successively positioning the focal spot at various points on the specimen (21) during analysis. The confocal microscope includes an objective mounted on a movable rapid-scan carriage driven in a reciprocating linear movement along a transverse direction by a rotating motor by means of a device of the connecting rod type. The specimen (21) is placed on a movable support (20) driven in a longitudinal movement and is able to move along the axis of the objective of the microscope in order to position the specimen relative to the focal spot. The excitation light spectrum is spread over the surface of the specimen (21) in such a way that the excitation light reflected by the specimen and corresponding to the wavelengths close to fluorescence converge on points that are sufficiently distant from a diaphragm positioned in front of a device for measuring the fluorescence.
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公开(公告)号：EP0588931A1
公开(公告)日：1994-03-30
申请号：EP92913497.0
申请日：1992-06-11
Applicant: ABBOTT LABORATORIES
Inventor： CHOW, Herbert, S. , WILSON, Thomas, J. , WROBLEWSKI, Mieczyslaw , KOTLARIK, John, J. , ALSBERG, Keith, D. , McCOY, Jimmy, D. , LADD, Jimmy, L. , CORBETT, Kevin, M.
CPC classification number: G01N35/109 , B01L3/0262 , B01L3/5085 , G01N15/1468 , G01N21/82 , G01N35/0095 , G01N35/0098 , G01N35/028 , G01N35/1004 , G01N2035/042 , G01N2035/0425 , G01N2035/0491 , G01N2035/1018 , G01N2035/1025 , G01N2035/1034 , G01N2201/0446 , G01N2201/0461 , G01N2201/0492 , G02B7/28 , Y10T137/7306 , Y10T436/115831
Abstract: Appareil assurant le transfert d'une cartouche de réaction (10) vers différentes zones de traitement (36, 38, 42). Des dispositifs automatiques (34, 40) assurent le transfert de la cartouche de réaction vers différentes zones de l'appareil (30, 32, 36, 38, 42, 46). Un dispositif de formation d'image (42) détecte des images indiquant si telle réaction s'est produite dans tel puits de réaction (16) de la cartouche de réaction (10). L'appareil comporte également un dispositif (36) d'aspiration et de distribution des liquides assorti d'un sytème de détection du niveau de liquide (70, 72, 74, 76, 78, 80, 82, 84). L'appareil comporte en outre un micro-processeur et une logique (44) de contrôle de fonctionnement et d'analyse des informations reçues du dispositif de formation d'image (42) afin de produire une indication visuelle des résultats des analyses.
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公开(公告)号：EP0251281A3
公开(公告)日：1989-11-02
申请号：EP87109342.3
申请日：1987-06-29
Applicant: HITACHI, LTD.
Inventor： Sakuraba, Shinichi , Matsushita, Hajime , Kurimura, Masaaki
CPC classification number: G06K9/00127 , G01N1/30 , G01N15/1468 , G01N21/25 , G01N2201/0492
Abstract: A stain discriminating apparatus in which light rays having at least one light component having a wavelength in a predetermined range is projected to a cell sample (2) to discriminate the staining method by which the cell sample has been stained on the basis of the light intensity of the light component transmitted through the sample and having the wavelength (530 nm) in the predetermined range. An automatic cell sample classifying apparatus in which a plurality of cell sample slides (2) are sequentially fed to the stain discriminating apparatus (6) to determine the staining method by which the cell samples have been stained, respectively. One of the examination/classification programs previously stored in a memory (82) is read out according to the staining method as discriminated and the cell samples are processed in accordance with the program as read out.
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Patent Agency Ranking
公开(公告)号：WO2011025582A1
公开(公告)日：2011-03-03
申请号：PCT/US2010/040208
申请日：2010-06-28
Applicant: CELLOMICS, INC. , SALISBURY, Richard, C. , VANDENBERG, Dirk, John , IPPOLITO, Kim, Anthony
CPC classification number: G01N21/276 , G01N21/278 , G01N21/6452 , G01N21/6458 , G01N2201/0492 , G02B21/32
Abstract: A stage assembly, an imaging system that uses the stage assembly, and methods for using the stage assembly in a high content screening system. The stage assembly includes a stage having a top surface and an opposing bottom surface and an opening extending between the top and bottom surfaces to receive a specimen plate. The stage assembly also includes a calibration sample bay formed in the stage. A calibration sample can also be secured within the calibration sample bay.
Abstract translation: 舞台组件，使用舞台组件的成像系统，以及在高含量的筛选系统中使用舞台组件的方法。 舞台组件包括具有顶表面和相对的底表面的台阶以及在顶表面和底表面之间延伸以接收标本板的开口。 舞台组件还包括形成在舞台中的校准样品室。 也可以在校准样品室内固定校准样品。
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公开(公告)号：WO2007054495A1
公开(公告)日：2007-05-18
申请号：PCT/EP2006/068184
申请日：2006-11-07
Applicant: INNOPSYS , BEC, Daniel , PAVEAU, Vincent , LE BRUN, Stéphane
Inventor： BEC, Daniel , PAVEAU, Vincent , LE BRUN, Stéphane
CPC classification number: G01N21/6452 , G01N21/6458 , G01N2201/0438 , G01N2201/0492 , G01N2201/101 , G02B21/0076
Abstract: Un dispositif d'analyse d'un échantillon par fluorescence comporte un microscope confocal, des moyens d'illumination aptes à émettre un faisceau lumineux convergeant au moyen d'un objectif en un point de focalisation, des moyens pour positionner successivement le point de focalisation en différents points de l'échantillon (21 ) en cours d'analyse. Le microscope confocal comporte un objectif monté sur un chariot mobile de balayage rapide entraîné dans un mouvement linéaire alternatif suivant une direction transversale par un moteur rotatif au moyen d'un dispositif de type bielle manivelle. L'échantillon (21 ) est placé sur un support mobile (20) entraîné suivant un déplacement longitudinal et est mobile suivant l'axe de l'objectif du microscope pour assurer le positionnement de l'échantillon par rapport au point focal. Le spectre de la lumière d'excitation est étalé à la surface de l'échantillon (21 ) de telle sorte que la lumière d'excitation réfléchie par l'échantillon et correspondant à des longueurs d'onde proche de la fluorescence converge en des points suffisamment distants d'un sténopé positionné devant un capteur de mesure de la fluorescence.
Abstract translation: 用于通过荧光分析样品的装置包括共聚焦显微镜，能够发射通过物镜会聚在焦点上的光束的照明装置，用于将焦点连续地定位在样本（21）上的各个点处的装置 ）。 共焦显微镜包括安装在可移动的快速扫描托架上的物镜，该托架通过连杆型的装置沿着横向由旋转马达沿往复运动的线性运动驱动。 样本（21）被放置在可纵向运动的可移动支撑件（20）上，并且能够沿着显微镜的物镜的轴线移动，以便使样本相对于焦斑定位。 激发光谱以试样（21）的表面扩散，使得被试样反射并对应于接近荧光的波长的激发光会聚在距离位于 用于测量荧光的装置。
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公开(公告)号：WO1992022879A1
公开(公告)日：1992-12-23
申请号：PCT/US1992005027
申请日：1992-06-11
Applicant: ABBOTT LABORATORIES , CORBETT, Kevin, M. , LADD, Jimmy, L.
Inventor： ABBOTT LABORATORIES
IPC: G06K09/00
CPC classification number: G01N35/109 , B01L3/0262 , B01L3/5085 , G01N15/1468 , G01N21/82 , G01N35/0095 , G01N35/0098 , G01N35/028 , G01N35/1004 , G01N2035/042 , G01N2035/0425 , G01N2035/0491 , G01N2035/1018 , G01N2035/1025 , G01N2035/1034 , G01N2201/0446 , G01N2201/0461 , G01N2201/0492 , G02B7/28 , Y10T137/7306 , Y10T436/115831
Abstract: A method is provided for auto-positioning auto-focusing reaction wells for optically imaging purposes within a programmable random access automated apparatus for performing assays wherein the apparatus includes a reaction cartridge (10) having a plurality of reaction wells requiring precision location of the reaction wells (16) within an image allowing accurate transfer of the optical images to a logic system for analyzing the optical information. The optical imaging system (185) provides a generated visual indication of the results of the assays being performed. A micro processor is provided to assist in the operation of the apparatus as well as the imaging processing.
Abstract translation: 提供了一种用于自动定位自动聚焦反应孔以在用于进行测定的可编程随机存取自动化装置中的光学成像目的的自动定位反应井，其中所述装置包括具有多个反应孔的反应筒（10），其需要精确定位反应井 （16），允许将光学图像准确地传送到用于分析光学信息的逻辑系统。 光学成像系统（185）提供所进行的测定结果的生成视觉指示。 提供微处理器以帮助设备的操作以及成像处理。
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公开(公告)号：EP0588972A4
公开(公告)日：1994-09-14
申请号：EP92914654
申请日：1992-06-11
Applicant: ABBOTT LAB
Inventor： CORBETT KEVIN M , LADD JIMMY L
IPC: G01N21/17 , B01L3/00 , B01L3/02 , G01N15/14 , G01N21/82 , G01N33/48 , G01N33/483 , G01N33/543 , G01N33/80 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , G02B7/28 , G06T1/00 , G06K9/00
CPC classification number: G01N35/109 , B01L3/0262 , B01L3/5085 , G01N15/1468 , G01N21/82 , G01N35/0095 , G01N35/0098 , G01N35/028 , G01N35/1004 , G01N2035/042 , G01N2035/0425 , G01N2035/0491 , G01N2035/1018 , G01N2035/1025 , G01N2035/1034 , G01N2201/0446 , G01N2201/0461 , G01N2201/0492 , G02B7/28 , Y10T137/7306 , Y10T436/115831
Abstract: A method is provided for auto-positioning auto-focusing reaction wells for optically imaging purposes within a programmable random access automated apparatus for performing assays wherein the apparatus includes a reaction cartridge (10) having a plurality of reaction wells requiring precision location of the reaction wells (16) within an image allowing accurate transfer of the optical images to a logic system for analyzing the optical information. The optical imaging system (185) provides a generated visual indication of the results of the assays being performed. A micro processor is provided to assist in the operation of the apparatus as well as the imaging processing.
Abstract translation: 提供了一种装置，其包括具有多个反应孔的反应筒，反应孔具有设置在其上的不同试剂，至少一个适于接收样品的孔，含有适于结合样品的颗粒的孔，并具有与样品分离的能力 不结合分离颗粒的细胞和适于结合样品中特定类型的细胞的至少一种荧光团和适于洗涤探针的洗涤区域。 提供图像形成装置以检测指示每个反应孔中是否发生特定反应的图像。 该装置还包括用于分配和抽吸液体的机构，包括用于检测液位的机构。 该装置还包括用于分析从图像检测装置接收的信息并处理信息以生成正在执行的测定结果的视觉指示的逻辑。 提供微处理器以帮助设备的操作以及图像处理。
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公开(公告)号：EP0588969A4
公开(公告)日：1994-08-17
申请号：EP92914552
申请日：1992-06-12
Applicant: ABBOTT LAB
Inventor： KOTLARIK JOHN J , WROBLEWSKI MIECZYSLAW
IPC: G01N21/17 , B01L3/00 , B01L3/02 , G01N15/14 , G01N21/82 , G01N33/48 , G01N33/483 , G01N33/543 , G01N33/80 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , G02B7/28 , G06T1/00 , G06K9/00
CPC classification number: G01N35/109 , B01L3/0262 , B01L3/5085 , G01N15/1468 , G01N21/82 , G01N35/0095 , G01N35/0098 , G01N35/028 , G01N35/1004 , G01N2035/042 , G01N2035/0425 , G01N2035/0491 , G01N2035/1018 , G01N2035/1025 , G01N2035/1034 , G01N2201/0446 , G01N2201/0461 , G01N2201/0492 , G02B7/28 , Y10T137/7306 , Y10T436/115831
Abstract: A method for agglutination detection using optical imaging of reaction wells containing agglutination objects in a programmable random access automated apparatus for perforing agglutination assays is provided. An image of the agglutination objects in the reaction wells is taken with analyzation of the intensity values and transitions through relative portions of the image and background which provides intensity values suitable for classifying. The method utilizes slope information from a derivative (Fig. 34 A-E, second row) rather than absolute intensities, thus allowing scoring algorithm based on slope total information. The agglutination detection method uses a CCD camera to take an image at each well (Fig. 34 A-E, first row) of a multiple well cartridge, thus providing information suitable for analyzing from the image detection apparatus, the apparatus processes the information to generate a visual indication of the results of the assays being performed. A micro-processor is provided to assist in the operation of the apparatus as well as the image processing data collection and analysis.
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