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公开(公告)号：EP0588969A4
公开(公告)日：1994-08-17
申请号：EP92914552
申请日：1992-06-12
Applicant: ABBOTT LAB
Inventor： KOTLARIK JOHN J , WROBLEWSKI MIECZYSLAW
IPC: G01N21/17 , B01L3/00 , B01L3/02 , G01N15/14 , G01N21/82 , G01N33/48 , G01N33/483 , G01N33/543 , G01N33/80 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , G02B7/28 , G06T1/00 , G06K9/00
CPC classification number: G01N35/109 , B01L3/0262 , B01L3/5085 , G01N15/1468 , G01N21/82 , G01N35/0095 , G01N35/0098 , G01N35/028 , G01N35/1004 , G01N2035/042 , G01N2035/0425 , G01N2035/0491 , G01N2035/1018 , G01N2035/1025 , G01N2035/1034 , G01N2201/0446 , G01N2201/0461 , G01N2201/0492 , G02B7/28 , Y10T137/7306 , Y10T436/115831
Abstract: A method for agglutination detection using optical imaging of reaction wells containing agglutination objects in a programmable random access automated apparatus for perforing agglutination assays is provided. An image of the agglutination objects in the reaction wells is taken with analyzation of the intensity values and transitions through relative portions of the image and background which provides intensity values suitable for classifying. The method utilizes slope information from a derivative (Fig. 34 A-E, second row) rather than absolute intensities, thus allowing scoring algorithm based on slope total information. The agglutination detection method uses a CCD camera to take an image at each well (Fig. 34 A-E, first row) of a multiple well cartridge, thus providing information suitable for analyzing from the image detection apparatus, the apparatus processes the information to generate a visual indication of the results of the assays being performed. A micro-processor is provided to assist in the operation of the apparatus as well as the image processing data collection and analysis.
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公开(公告)号：EP0588968A4
公开(公告)日：1994-06-22
申请号：EP92914538
申请日：1992-06-12
Applicant: ABBOTT LAB
Inventor： WHITE DAVID A , WROBLEWSKI MIECZYSLAW , KOTLARIK JOHN J
IPC: G01N21/17 , B01L3/00 , B01L3/02 , G01N15/14 , G01N21/82 , G01N33/48 , G01N33/483 , G01N33/543 , G01N33/80 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , G02B7/28 , G06T1/00 , G01N21/01
CPC classification number: G01N35/109 , B01L3/0262 , B01L3/5085 , G01N15/1468 , G01N21/82 , G01N35/0095 , G01N35/0098 , G01N35/028 , G01N35/1004 , G01N2035/042 , G01N2035/0425 , G01N2035/0491 , G01N2035/1018 , G01N2035/1025 , G01N2035/1034 , G01N2201/0446 , G01N2201/0461 , G01N2201/0492 , G02B7/28 , Y10T137/7306 , Y10T436/115831
Abstract: A liquid dispensing mechanism (34) is provided which includes a dispensing probe having a tip (70) for dispensing liquid, a pump for collectively discharging fluid from the probe tip (70) in measured quantities such as droplets. The dispensing probe has the capability to detect droplet formation and droplet separation from the probe (70) through use of a radio-frequency signal (74, 76) to the probe tip (70) and a conductive element (72) connected to amplifying and analyzing circuitry (78, 80, 82, 84) disposed below the dispensing probe (70) and a reaction well (16) which contains a receiving fluid. The conductive element (72) also detects when the probe has been inserted into the receiving fluid.
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公开(公告)号：EP0588931A4
公开(公告)日：1994-06-22
申请号：EP92913497
申请日：1992-06-11
Applicant: ABBOTT LAB
Inventor： CHOW HERBERT S , WILSON THOMAS J , WROBLEWSKI MIECZYSLAW , KOTLARIK JOHN J , ALSBERG KEITH D , MCCOY JIMMY D , LADD JIMMY L , CORBETT KEVIN M
IPC: G01N21/17 , B01L3/00 , B01L3/02 , G01N15/14 , G01N21/82 , G01N33/48 , G01N33/483 , G01N33/543 , G01N33/80 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , G02B7/28 , G06T1/00 , G01N21/01
CPC classification number: G01N35/109 , B01L3/0262 , B01L3/5085 , G01N15/1468 , G01N21/82 , G01N35/0095 , G01N35/0098 , G01N35/028 , G01N35/1004 , G01N2035/042 , G01N2035/0425 , G01N2035/0491 , G01N2035/1018 , G01N2035/1025 , G01N2035/1034 , G01N2201/0446 , G01N2201/0461 , G01N2201/0492 , G02B7/28 , Y10T137/7306 , Y10T436/115831
Abstract: An apparatus is provided for moving a reaction cartridge (10) to different processing areas (36, 38, 42) of the apparatus. Robots (34, 40) for moving the reaction cartridge to the various areas (30, 32, 36, 38, 42, 46) of the apparatus. An image forming device (42) is provided to detect images which indicate whether specific reactions have occurred in reaction wells (16) of the reaction cartridge (10). The apparatus also includes a mechanism (36) for aspirating and dispensing liquids which includes a liquid level detecting mechanism (70, 72, 74, 76, 78, 80, 82, 84). The device further includes a microprocessor and logic (44) for controlling the apparatus operation and analyzing the information received from the image forming device (42) to generate a visual indication of assay results.
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公开(公告)号：CA2173862C
公开(公告)日：2006-10-31
申请号：CA2173862
申请日：1994-09-28
Applicant: ABBOTT LAB
Inventor： ZAUN PETER , BOUMA STANLEY R , GORDON JULIAN , KOTLARIK JOHN J , SOLOMON NATALIE A
IPC: G01N1/00 , B01L3/00 , B01L7/00 , B01L99/00 , C12M1/40 , C12N15/09 , C12P19/34 , C12Q1/68 , G01N35/00 , G01N35/10
Abstract: Methods, devices, apparatus and kits for amplifying and detecting nucleic acid are provided. The apparatus is a one or two-tier thermal cycling device (16) that operates in conjunction with a reaction/detection unit (20). A sample (38) is loaded into a reaction chamber (30) of the device which is then mated with a detection chamber (32) to form the reaction/detection unit. A first heating element (90) of the thermal cycling apparatus applies a desired temperature to the reaction/detection device to amplify target nucleic acid in the sample. The reaction mixture is then transferred to the detection chamber by the second heating element (92) and amplified target nucleic acid is immobilized on a support in the detection chamber. Microprocessor control controls the heat applied by the second element independently of the heat applied by the first element. A detection system associated with the apparatus detects and analyzes the immobilized amplified nucleic acid target. Images are captured and digitized and subjected to statistical analysis to improve the accuracy of the method.
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公开(公告)号：AU8073294A
公开(公告)日：1995-05-08
申请号：AU8073294
申请日：1994-09-28
Applicant: ABBOTT LAB
Inventor： ZAUN PETER , BOUMA STANLEY R , GORDON JULIAN , KOTLARIK JOHN J , SOLOMON NATALIE A
Abstract: Methods, devices, apparatus and kits for amplifying and detecting nucleic acid are provided. The apparatus is a one or two-tier thermal cycling device that operates in conjunction with a reaction/detection unit. A sample is loaded into a reaction chamber of the device which is then mated with a detection chamber to form the reaction/detection unit. A first heating element of the thermal cycling apparatus applies a desired temperature to the reaction/detection device to amplify target nucleic acid in the sample. The reaction mixture is then transferred to the detection chamber by the second heating element and amplified target nucleic acid is immobilized on a support in the detection chamber. Microprocessor control controls the heat applied by the second element independently of the heat applied by the first element. A detection system associated with the apparatus detects and analyzes the immobilized amplified nucleic acid target. Images are captured and digitized and subjected to statistical analysis to improve the accuracy of the method.
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Patent Agency Ranking
公开(公告)号：CA2306728A1
公开(公告)日：1999-04-29
申请号：CA2306728
申请日：1998-10-20
Applicant: ABBOTT LAB
Inventor： LOOMIS NEIL W , BOJAN PETE M , GRACE JOHN P , NOONAN KRISTIN , SCHAPIRA THOMAS G , LOWERY MICHAEL G , KOTLARIK JOHN J , SCHMIDT DANIEL D , TUNG-MING HUANG , POPE MARK R , HILTIBRAN GLEN , WONG SIE TING , CUNNINGHAM DAVID DEAN , TARKOWSKI BRIAN JOSEPH
IPC: A61B10/02 , A61B5/15 , A61B10/00 , A61B17/132
Abstract: The present invention involves apparatus and methods for use in collecting bodily fluids, such as interstitial fluids, from the epidermal layer of an animal. A preferred apparatus includes a pressure head and, optionally, a holder therefor for supplying a positive pressure to the head. The methods include the application of a positive pressure to the area surrounding an epidermal site from which stratum corneum has been breached, such as by laser ablation, to cause bodily fluids, such as interstitial fluids, to exude from the site and collecting the fluids exuding therefrom.
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公开(公告)号：AU7960494A
公开(公告)日：1995-05-08
申请号：AU7960494
申请日：1994-09-28
Applicant: ABBOTT LAB
Inventor： GORDON JULIAN , KOTLARIK JOHN J , STIMPSON DONALD I , HOIJER JOANELL V
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公开(公告)号：ES2196034T3
公开(公告)日：2003-12-16
申请号：ES94930509
申请日：1994-09-28
Applicant: ABBOTT LAB
Inventor： GORDON JULIAN , KOTLARIK JOHN J , STIMPSON DONALD I , HOIJER JOANELL V
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公开(公告)号：AT236400T
公开(公告)日：2003-04-15
申请号：AT94930509
申请日：1994-09-28
Applicant: ABBOTT LAB
Inventor： GORDON JULIAN , KOTLARIK JOHN J , STIMPSON DONALD I , HOIJER JOANELL V
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公开(公告)号：ES2123162T3
公开(公告)日：1999-01-01
申请号：ES94931783
申请日：1994-09-28
Applicant: ABBOTT LAB
Inventor： ZAUN PETER , BOUMA STANLEY R , GORDON JULIAN , KOTLARIK JOHN J , SOLOMON NATALIE A
Abstract: Methods, devices, apparatus and kits for amplifying and detecting nucleic acid are provided. The apparatus is a one or two-tier thermal cycling device that operates in conjunction with a reaction/detection unit. A sample is loaded into a reaction chamber of the device which is then mated with a detection chamber to form the reaction/detection unit. A first heating element of the thermal cycling apparatus applies a desired temperature to the reaction/detection device to amplify target nucleic acid in the sample. The reaction mixture is then transferred to the detection chamber by the second heating element and amplified target nucleic acid is immobilized on a support in the detection chamber. Microprocessor control controls the heat applied by the second element independently of the heat applied by the first element. A detection system associated with the apparatus detects and analyzes the immobilized amplified nucleic acid target. Images are captured and digitized and subjected to statistical analysis to improve the accuracy of the method.
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