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    METHODS AND COMPOSITIONS ASSOCIATED WITH ADMINISTRATION OF AN EXTRACT OF GANODERMA LUCIDUM
    293.
    发明申请
    METHODS AND COMPOSITIONS ASSOCIATED WITH ADMINISTRATION OF AN EXTRACT OF GANODERMA LUCIDUM 审中-公开
    与甘草提取物相关的方法和组合物

    公开(公告)号：WO2006044616A3

    公开(公告)日：2006-08-24

    申请号：PCT/US2005036961

    申请日：2005-10-14

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  HSU HSIEN-YEH ,  HUA KUO-FENG ,  LIN CHUN-HUNG ,  HSU JASON ,  CHEN SHUI-TEIN ,  LIN KUO-I ,  YANG WEN-BIN ,  YU JOHN ,  YU ALICE

    Inventor： WONG CHI-HUEY ,  HSU HSIEN-YEH ,  HUA KUO-FENG ,  LIN CHUN-HUNG ,  HSU JASON ,  CHEN SHUI-TEIN ,  LIN KUO-I ,  YANG WEN-BIN ,  YU JOHN ,  YU ALICE

    IPC: A01N65/00

    CPC classification number: A61K36/074

    Abstract: A fucose-containing glycoprotein fraction obtainable from an extract of Ganoderma Lucidum Reishi, compositions comprising the fuconse-containing glycoprotein fraction, a method to mediate immunomodulating events associated with IL-1 gene expression, a method to stimulate the expression of an inflammatory cytokine, a method to modulate protein kinase pathways associated with inflammatory cytokine Interleukin 1, a method to induce a TLR mediated event; a method to modulate differentiation of a mononuclear cell, a method to enhance cytotoxicity of an NK cell against an NK-sensitive tumor cell, a method to activate the expression of cytokines, a method to induce Blimp-1 expression in a mouse splenic B cell or human B cell, human mature splenocytes or dendritic cell, a method to inhibit LPS induced nitric oxide production in macrophages, a method to activate spleen cells proliferation, and a method to modify the proteome of a spleen cell.

    Abstract translation: 从灵芝提取物获得的含岩藻糖的糖蛋白部分，包含含有蛋白质的糖蛋白部分的组合物，介导与IL-1基因表达相关的免疫调节事件的方法，刺激炎性细胞因子的表达的方法 调节与炎症细胞因子相关的蛋白激酶途径白细胞介素1的方法，诱导TLR介导的事件的方法; 调节单核细胞分化的方法，增强NK细胞对NK敏感性肿瘤细胞的细胞毒性的方法，激活细胞因子表达的方法，在小鼠脾B细胞中诱导Blimp-1表达的方法 或人B细胞，人成熟脾细胞或树突状细胞，抑制巨噬细胞中LPS诱导的一氧化氮产生的方法，活化脾细胞增殖的方法以及修饰脾细胞的蛋白质组的方法。

    PLASMA APPARATUS AND METHODS FOR CRACKING A GAS
    296.
    发明专利
    PLASMA APPARATUS AND METHODS FOR CRACKING A GAS 未知

    公开(公告)号：AU2023311999A1

    公开(公告)日：2025-02-06

    申请号：AU2023311999

    申请日：2023-07-21

    Applicant: ACADEMIA SINICA

    Inventor： CHOU MEI-YIN ,  LIAO JAMES ,  CHEN YANG-YUAN ,  OU MIN-NAN ,  WU SHAN-LUO

    IPC: H05H1/24 ,  H01J37/32 ,  H05H1/34

    Abstract: The present disclosure relates to a plasma apparatus and a method. The plasma apparatus comprises an inner electrode and an outer electrode. The inner electrode comprises a wall defining a first cavity, and an opening of the first cavity is configured to receive a first gas. The outer electrode surrounds the inner electrode. The inner electrode has a through-hole extending through the wall of the inner electrode, such that the first cavity is in fluid communication with a plasma generation region between the inner electrode and the outer electrode via the through-hole. The inner electrode is rotatable about a first axis of rotation, and the first axis of rotation extends through the first cavity. In particular, some embodiments of the present disclosure relate to a plasma apparatus and a method for cracking a gas.

    PDIA4 inhibitors and use thereof for inhibiting ß-cell pathogenesis and treating diabetes
    299.
    发明专利
    PDIA4 inhibitors and use thereof for inhibiting ß-cell pathogenesis and treating diabetes 未知

    公开(公告)号：AU2020397821A1

    公开(公告)日：2022-06-23

    申请号：AU2020397821

    申请日：2020-11-15

    Applicant: ACADEMIA SINICA

    Inventor： YANG WEN-CHIN ,  TSAI KENG-CHANG

    IPC: A61K31/7028 ,  A61K45/06 ,  G01N33/68

    Abstract: Disulfide-Isomerase A4 (PDIA4) inhibitors and use thereof for inhibiting pancreatic β-cell pathogenesis and treating diabetes are disclosed. Drug candidates that inhibit PDIA4 with IC50 values ranging from 4 μM to 300 nM are identified. The compounds are highly active in augmenting insulin secretion from pancreatic β-cells. The representative compound No. 8 (4,5-dimethoxy-2-propiolamidobenzoic acid), alone or in combination with metformin, is effective in preserving pancreatic β-cell function, treating and/or reversing, returning blood glucose concentration to a normal level in a diabetic.

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