公开(公告)号：WO1996033396A1

公开(公告)日：1996-10-24

申请号：PCT/US1996005520

申请日：1996-04-19

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  KIM, Young, Ran ,  KANTOR, Johanna

IPC: G01N01/30

CPC classification number: G01N33/80 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1477 ,  Y10S436/80 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/107497 ,  Y10T436/108331

Abstract: A method and reagent for the simultaneous or independent enumeration of reticulocytes in a whole blood sample, without the need to separately incubate the sample and reagent. The reagent contains a reticulocyte staining amount of an unsymmetrical cyanine dye, from about 40 mM to about 60 mM of a buffer selected from the group consisting of imidazole, Tris and Bis-Tris and a dye stabilizing amount of a non-ionic surfactant selected from the group consisting of N, N-bis[3-D-Glucon-amidopropyl] cholamide and a polyoxypropylene-polyoxyethylene block copolymer. The reagent has a pH from about 6.8 to about 7.2 and an osmolarity adjusted to about 280 to about 310 mOsm/l with a mono- or divalent alkali salt selected from the group consisting of NaCl, KCl, LiCl, CaCl2, MgCl2 and ZnCl2. The method utilizes the reagent in a no incubation process that also allows for the simultaneous determination of CBC as well as reticulocyte counts and maturity indices.

Abstract translation: 一种用于在全血样品中同时或独立计数网织红细胞的方法和试剂，而不需要分别培养样品和试剂。 该试剂含有网织红细胞染色量的不对称花青染料，约40mM至约60mM的选自咪唑，Tris和Bis-Tris的缓冲液和染料稳定量的非离子表面活性剂，其选自 由N，N-双[3-D-Glucon-amidopropyl]胆酰胺和聚氧丙烯 - 聚氧乙烯嵌段共聚物组成的组。 试剂的pH为约6.8至约7.2，渗透压调节至约280至约310mOsm / l，选自NaCl，KCl，LiCl，CaCl 2，MgCl 2和ZnCl 2的一价或二价碱金属盐。 该方法在无孵育过程中使用试剂，其也允许同时测定CBC以及网织红细胞计数和成熟度指数。

公开(公告)号：WO1996033196A1

公开(公告)日：1996-10-24

申请号：PCT/US1996004010

申请日：1996-03-25

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SHEPPARD, George, S. ,  DAVIDSON, Steven, K. ,  SUMMERS, James, B. ,  CARRERA, George, M., Jr.

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention provides compounds of formula (I) and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐，其为PAF的有效拮抗剂，可用于治疗PAF相关疾病，包括哮喘，休克，呼吸窘迫综合征，急性炎症，移植器官排斥反应，胃肠道 溃疡，过敏性皮肤疾病，延迟的细胞免疫，分娩，胎儿肺成熟和细胞分化。

公开(公告)号：WO1996031780A1

公开(公告)日：1996-10-10

申请号：PCT/US1996004469

申请日：1996-04-01

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ADAMCZYK, Maciej ,  BRATE, Elaine, M. ,  PERKOWITZ, Mary, M. ,  REGE, Sushil, D.

IPC: G01N33/94

CPC classification number: C07K16/44 ,  G01N33/533 ,  G01N33/9446 ,  Y10T436/10

Abstract: Immunoassay reagents, methods and test kits for the specific quantification of vancomycin in a test sample are disclosed. The reagent comprises antibodies prepared with immunogens of Figure 6 wherein P is an immunogenic carrier material and X is a linking moiety. Also described is the synthesis of labeled reagents of Figure 8 wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative, and X is a linking moiety.

Abstract translation: 公开了用于测试样品中万古霉素的特异性定量的免疫测定试剂，方法和测试试剂盒。 试剂包含用图6的免疫原制备的抗体，其中P是免疫原性载体材料，X是连接部分。 还描述了图8的标记试剂的合成，其中Q是可检测部分，优选荧光素或荧光素衍生物，X是连接部分。

公开(公告)号：WO1996031197A1

公开(公告)日：1996-10-10

申请号：PCT/US1996004513

申请日：1996-04-02

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  CHESKIN, Howard ,  HALE, Thomas, J. ,  VAN SCOIK, Kurt, G. ,  ZHOU, Ji

IPC: A61K09/48

CPC classification number: A61K9/4858 ,  A61K9/4866 ,  A61K31/19

Abstract: A controlled-release formulation comprising, in combination a therapeutically-effective dosage of drug which melts at low temperature and an additive selected from the group consisting of ethyl cellulose, methylcellulose, hydroxypropyl cellulose, polyacrylamide, ethylene vinyl acetate copolymer, polymethylmethacrylate, polyhydroxyethyl methacrylate and waxes, and the like, such that the additive and the drug form a homogeneous drug-additive composite with a 92-to-97 % weight/weight of said drug, wherein said drug is selected from the group consisting of: sodium hydrogen divalproex, ibuprofen, ramipril, dibenzyline, erythrityl tetranitrate, isosorbide dinitrate, methosuximide, ketoprofen, gemfibrozil, paroxetine hydrochloride, and trimipramine maleate.

Abstract translation: 一种控释制剂，其组合包含治疗有效剂量的在低温下熔化的药物和选自乙基纤维素，甲基纤维素，羟丙基纤维素，聚丙烯酰胺，乙烯乙酸乙烯酯共聚物，聚甲基丙烯酸甲酯，甲基丙烯酸聚羟乙酯和 蜡等，使得添加剂和药物形成具有92-97％重量/重量的所述药物的均匀药物 - 添加剂复合物，其中所述药物选自：氢二氢硬脂酸钠， 布洛芬，雷米普利，二苯地平，四硝酸赤藓酸酯，硝酸异山梨酯，甲氧嘧啶，酮洛芬，吉非贝齐，盐酸帕罗西汀和马来酸丙咪嗪。

公开(公告)号：WO1996028673A1

公开(公告)日：1996-09-19

申请号：PCT/US1996002506

申请日：1996-02-26

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ALCOCK, Alan, J.

IPC: F16K07/17

CPC classification number: G01N35/08 ,  F16K7/17 ,  G01N35/1097 ,  Y10T137/0318

Abstract: Embodiments described herein relate to a valve (10) and a method of use. In one embodiment, a first element (24) is operatively and removably positioned with respect to a first fluid conveying conduit (16) and a second fluid conveying conduit (18). The first element (24) is movable between a first position where no fluid communicates between the first fluid conveying conduit and the second fluid conveying conduit and a second position where fluid communicates between the first fluid conveying conduit and the second fluid conveying conduit. A second element (26) is operatively and removably engageable with the first element for maintaining operative position of the first element with respect to the first fluid conveying conduit and the second fluid conveying conduit. A third element (28) is operatively and removably engageable with the second element for maintaining engagement between the first element and the second element.

Abstract translation: 本文所述的实施例涉及阀（10）和使用方法。 在一个实施例中，第一元件（24）相对于第一流体输送导管（16）和第二流体输送导管（18）可操作地和可移除地定位。 第一元件（24）可在第一流体在第一流体输送管道和第二流体输送管道之间连通的第一位置和第二流体在第一流体输送管道与第二流体输送管道之间连通的第二位置之间移动。 第二元件（26）可操作地和可移除地与第一元件接合，用于保持第一元件相对于第一流体输送导管和第二流体输送导管的操作位置。 第三元件（28）可操作地和可移除地与第二元件接合，用于保持第一元件和第二元件之间的接合。

公开(公告)号：WO1996028089A1

公开(公告)日：1996-09-19

申请号：PCT/US1996001996

申请日：1996-02-15

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  McGAFFIGAN, Thomas, H.

IPC: A61B05/028

CPC classification number: A61M25/0012 ,  A61B5/028 ,  Y10T29/49083 ,  Y10T29/49865

Abstract: A heater (12) for a catheter (10) used in monitoring constant cardiac output is fabricated using a bifilar wire (21) coated with polyvinyl chloride (PVC) like that used for the catheter. The bifilar wire is coated with the PVC using a conventional extrusion technique, producing a coated lead (24, 32). The coated lead is wrapped around the exterior surface of the catheter, forming a helical coil. Heat is applied to the coated lead to melt the PVC coating, causing it to bond the lead to the catheter. The melted PVC also flows into gaps (23) or notches between adjacent coils of the lead, producing a relatively smooth outer surface for the heater when cooled.

Abstract translation: 用于监测恒定心输出量的用于导管（10）的加热器（12）使用涂覆有用于导管的聚氯乙烯（PVC）的双股线（21）来制造。 使用常规的挤出技术将双绞线用PVC涂覆，生产涂层引线（24,32）。 涂覆的导线缠绕在导管的外表面上，形成螺旋线圈。 对涂覆的铅施加热量以熔化PVC涂层，使其将导线粘合到导管上。 熔化的PVC还流入相邻线圈之间的间隙（23）或缺口，在冷却时产生相对平滑的加热器外表面。

公开(公告)号：WO1996028031A1

公开(公告)日：1996-09-19

申请号：PCT/US1996003376

申请日：1996-03-12

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  LIU, Chi-Li ,  STARNES, Robert, L. ,  MACMULLAN, Anita, M. ,  MANKER, Denise, C. ,  LUFBURROW, Patricia, A.

IPC: A01N63/02

CPC classification number: C12R1/075 ,  A01N43/60 ,  A01N63/02 ,  C12P17/12 ,  A01N63/00 ,  A01N2300/00

Abstract: The invention is related to a novel strain(s) of Bacillus thuringiensis in which essentially all of the pesticidal activity of said strain is in the supernatant of a fermentation of said strain. The strain produces a substance which has activity against an insect pest(s) of the order Coleoptera and which enhances the pesticidal activity of a Bacillus related pesticide. The invention further relates to pesticidal compositions comprising the substance and a pesticidal carrier, or the substance and a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties as well as methods of using the pesticidal compositions to control a pest.

Abstract translation: 本发明涉及一种苏云金芽孢杆菌的新菌株，其中所述菌株的所有杀虫活性基本上都在所述菌株的发酵上清液中。 该菌株产生一种具有抗鞘翅目昆虫害虫的活性的物质，其增强了与芽孢杆菌相关的农药的杀虫活性。 本发明还涉及包含该物质和杀虫载体的农药组合物，或该物质和一种与芽孢杆菌有关的农药，化学农药和/或具有杀虫性质的病毒以及使用该杀虫组合物来控制有害生物的方法。

公开(公告)号：WO1996027018A1

公开(公告)日：1996-09-06

申请号：PCT/US1996002866

申请日：1996-02-27

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MUKERJI, Pradip ,  THURMOND, Jennifer, Marie ,  HANSSON, Lennart ,  BAXTER, Jeffrey, Harris ,  HARDS, Robert, George

IPC: C12N15/67

CPC classification number: C12N9/12 ,  C07K14/4732 ,  C07K2319/02 ,  C12N15/62 ,  C12N15/64 ,  C12N15/67 ,  C12N15/70

Abstract: The present invention provides a plasmid containing a promoter sequence, a nucleotide sequence encoding an exogenous protein, and a nucleotide sequence encoding an enzyme capable of modifying the exogenous protein. In a specific embodiment of the invention the encoded exogenous protein is human beta -casein and the encoded enzyme is a human kinase capable of phosphorylating recombinant beta -casein in a bacterial system.

Abstract translation: 本发明提供含有启动子序列，编码外源蛋白质的核苷酸序列和编码能够修饰外源蛋白质的酶的核苷酸序列的质粒。 在本发明的具体实施方案中，编码的外源蛋白是人β-酪蛋白，编码的酶是能够在细菌系统中磷酸化重组β-酪蛋白的人激酶。

公开(公告)号：WO1996025997A1

公开(公告)日：1996-08-29

申请号：PCT/US1996000879

申请日：1996-01-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WANG, Jianjun ,  OSBORN, Douglas, D. ,  CORNELIUS, Billy, D. ,  HARP, Douglas, A.

IPC: B01D46/46

CPC classification number: G01N15/082

Abstract: A testing apparatus is disclosed which is useful for determining if air filters are providing clean/sterile air within acceptable aseptic processing and/or clean room operation acceptable contaminant levels. The advantage of the disclosed testing apparatus is that air filters may be tested "on-line" during a production process as opposed to the traditional testing methods which included removal of air filter for off-line testing. Less down-time is experienced using the disclosed testing system. A series of valves positioned at the outputs from the air filters, which allow communication with a particle counter, are controlled by a computer which sequentially activates the valves to test the contamination level of the air which passed through an air filter during the production process.

Abstract translation: 公开了一种测试装置，其用于确定空气过滤器是否在可接受的无菌处理和/或洁净室操作可接受的污染物水平内提供清洁/无菌空气。 所公开的测试装置的优点在于空气过滤器可以在生产过程中“在线”地进行测试，而不是传统的测试方法，包括去除用于离线测试的空气过滤器。 使用公开的测试系统减少停机时间。 位于空气过滤器的输出端的一系列阀，其允许与颗粒计数器通信，该计算机依次启动阀门，以测试在生产过程中通过空气过滤器的空气的污染水平。

公开(公告)号：WO1996023534A1

公开(公告)日：1996-08-08

申请号：PCT/US1995001363

申请日：1995-01-31

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  CARON, Lois, L. ,  DRIVAS, Nicolaos, A. ,  LASAITIS, Con, A. ,  RUDZENA, William, L.

IPC: A61M05/14

CPC classification number: A61M5/141 ,  Y10S128/12 ,  Y10S128/912 ,  Y10S604/905

Abstract: A solution administration apparatus for patient care, for use with an associated solution administration system, which apparatus includes a laser drilled orifice flow control device to provide a controlled, predetermined flow rate of solution to the patient. The apparatus includes a tubing set and a laser drilled orifice flow restrictor, formed in a body, and in fluid communication therewith, for use with an associated fluid supply container. The system provides a controlled, predetermined flow rate of solution to the patient which is independent of, and relatively constant over minor variations in solution supply pressure and viscosity.

Abstract translation: 一种用于患者护理的溶液施用装置，用于与相关联的溶液管理系统一起使用，该装置包括激光钻孔流量控制装置，以向患者提供受控的预定流速的溶液。 该设备包括管体组和激光钻孔节流器，其形成在主体中并与其流体连通，以与相关联的流体供应容器一起使用。 该系统为患者提供可控的，预定的溶液流速，其独立于溶液供应压力和粘度的微小变化且相对恒定。