公开(公告)号：KR100818215B1

公开(公告)日：2008-04-01

申请号：KR1020060099049

申请日：2006-10-11

Applicant: 재단법인서울대학교산학협력재단

Inventor： 강경선

IPC: C12N5/071 ,  C12N5/02

CPC classification number: C12N5/0636 ,  C12N5/0647 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/26 ,  C12N2506/11

Abstract: A method for preparing a T-cell progenitor from a CD34 positive stem cell is provided to control the differentiation direction of a hematopoietic precursor in an STF(stem cell factor, Thrombopoietin, Flk-2/Flt3 ligand) medium, proliferate the T-cell progenitor in large scale and be useful for cell therapy relating to AIDS, cancer and auto-immune diseases. A method for preparing a T-cell progenitor from a CD34 positive stem cell comprises the steps of: (a) isolating CD34 positive stem cells derived from blood selected from the group consisting of human peripheral blood, bone marrow and cord blood; and (b) culturing and differentiating the isolated CD34 positive stem cells in a medium containing at least one cytokine selected from the group consisting of thrombopoietin(TPO), stem cell factor(SCF) and flk-2/flt3 ligand(FL) and not including thymic organ to obtain the T-cell progenitor showing negative immunological characteristic on CD2 and positive immunological characteristic on CD4, wherein the medium is an STF(stem cell factor, Thrombopoietin, Flk-2/Flt3 ligand) medium.

Abstract translation: 提供了一种从CD34阳性干细胞制备T细胞祖细胞的方法，以控制STF（干细胞因子，血小板生成素，Flk-2 / Flt3配体）培养基中造血前体的分化方向，增殖T细胞 大量的祖细胞，可用于与艾滋病，癌症和自身免疫疾病有关的细胞治疗。 从CD34阳性干细胞制备T细胞祖细胞的方法包括以下步骤：（a）分离源自选自人外周血，骨髓和脐带血的血液的CD34阳性干细胞; （b）在含有至少一种选自血小板生成素（TPO），干细胞因子（SCF）和flk-2 / flt3配体（FL）的细胞因子的培养基中培养和分化分离的CD34阳性干细胞，而不是 包括胸腺器官以获得在CD2上显示出阴性免疫学特征的CD4细胞祖细胞和CD4上的阳性免疫特征，其中培养基是STF（干细胞因子，血小板生成素，Flk-2 / Flt3配体）培养基。

公开(公告)号：KR100818214B1

公开(公告)日：2008-04-01

申请号：KR1020060095990

申请日：2006-09-29

Applicant: 재단법인서울대학교산학협력재단

Inventor： 강경선

IPC: A61K35/50 ,  C12N5/073

CPC classification number: A61K35/50 ,  C12N5/0605 ,  C12N2502/025

Abstract: A multipotent stem cell derived from decidua or amnion isolated from human term placenta is provided to express both Oct4 and Cripto-1, be differentiated into mesenchymal stem cells, epithelial stem cells and neurons, thereby being applicable as a cell therapeutic agent due to excellent proliferation rate and being useful as a cell therapeutic agent of brain diseases such as Alzheimer's disease, Parkinson's disease, brain and spinal cord injury, and stroke. A method for preparing an adult stem cell comprises a step of culturing a pellet derived from amnion or decidua of human term placenta in a medium containing NAC(N-acetyl-L-cysteine) and then recovering the culture material, wherein the adult stem cell shows positive immunological characteristic on both Oct4 and Cripto-1 and has the ability of being differentiated into cells derived from endoderm, mesoderm and ectoderm and the adult stem cell derived from the amnion shows positive immunological characteristics on CD44, CD49b, CD73, CD90, CD24 and CD29 and negative immunological characteristics on CD4, CD33, CD34, CD45, CD62p, CD133, CD135 and HLA-DR. Further, the medium containing NAC(N-acetyl-L-cysteine) is a Keratinocyte-SFM(Serum-Free Medium) containing additionally an FBS(Fetal Bovine Serum), an ascorbic acid, a calcium, an rEGF(epidermal growth factor), a BPE(1,2-Bis (4-Pyridyl)Ethane), an insulin and a hydrocortisone.

Abstract translation: 提供衍生自从人类胎盘分离的蜕膜或羊膜的多能干细胞以表达Oct4和Cripto-1，被分化为间充质干细胞，上皮干细胞和神经元，因此由于优异的增殖而适用于细胞治疗剂 并且可用作脑疾病如阿尔茨海默病，帕金森病，脑和脊髓损伤以及中风的细胞治疗剂。 用于制备成体干细胞的方法包括在含有NAC（N-乙酰基-L-半胱氨酸）的培养基中培养源自人类胎盘的羊膜或蜕膜的颗粒的步骤，然后回收培养物质，其中成体干细胞 在Oct4和Cripto-1上显示出阳性免疫学特征，并且具有分化为源自内胚层，中胚层和外胚层的细胞的能力，并且源自羊膜的成体干细胞在CD44，CD49b，CD73，CD90，CD24上显示出阳性免疫学特征 和CD4，CD33，CD34，CD45，CD62p，CD133，CD135和HLA-DR上的CD29和阴性免疫学特征。 此外，含有NAC（N-乙酰基-L-半胱氨酸）的培养基是另外含有FBS（胎牛血清），抗坏血酸，钙，rEGF（表皮生长因子）的角质细胞-SFM（无血清培养基） ，BPE（1,2-双（4-吡啶基）乙烷），胰岛素和氢化可的松。

公开(公告)号：KR1020080028035A

公开(公告)日：2008-03-31

申请号：KR1020060093313

申请日：2006-09-26

Applicant: 삼성디스플레이 주식회사 ,  재단법인서울대학교산학협력재단

Inventor： 이신두 ,  김연태

IPC: G02F1/1337

CPC classification number: G02F1/133707 ,  G02F1/133711 ,  G02F2001/133776

Abstract: A display substrate and a manufacturing method thereof are provided to improve a viewing angle by a fine pattern and maintain the thickness of a liquid crystal layer uniformly by a cell gap maintaining pattern, thereby improving display quality. A base substrate(610) includes a plurality of pixel areas. A polymer layer is formed on the base substrate and includes a fine pattern(632) and a cell gap holding pattern(634). The fine pattern aligns the liquid crystal molecules of a liquid crystal layer. The cell gap holding pattern holds the cell gap of the liquid crystal layer. The pixel areas are divided by gate lines on an array layer formed between the base substrate and the polymer layer and source lines crossing the gate lines.

Abstract translation: 提供显示基板及其制造方法以通过精细图案改善视角，并通过单元间隙保持图案来均匀地保持液晶层的厚度，从而提高显示质量。 基底（610）包括多个像素区域。 聚合物层形成在基底基板上，并且包括精细图案（632）和单元间隙保持图案（634）。 精细图案使液晶层的液晶分子对准。 单元间隙保持图案保持液晶层的单元间隙。 像素区域由形成在基底基板和聚合物层之间的阵列层上的栅极线以及与栅极线交叉的源极线分隔开。

公开(公告)号：KR1020080027716A

公开(公告)日：2008-03-28

申请号：KR1020070061142

申请日：2007-06-21

Applicant: 삼성전자주식회사 ,  중앙대학교 산학협력단 ,  재단법인서울대학교산학협력재단

Inventor： 곽호영 ,  심일운 ,  변기택 ,  이승수

IPC: B82B3/00 ,  B82B1/00 ,  B82Y40/00

Abstract: A preparation method of layered nano structures and layered nano structures prepared thereby are provided to obtain homogeneous nano structure at lower temperature in a short time by coating nano raw material on nano support in the presence of multibubble sonoluminescence. A preparation method of layered nano structures comprises steps of coating nano raw material on nano support in the presence of multibubble sonoluminescence. The nano support is metal oxide particle having diameter of at most 50nm, which is selected from TiO2, ZnO, ZrO, Al2O3, Fe2O3, Fe3O4, Ga2O3, SnO2, Sb2O3, SiO2, MnO2, NiO2 and mixtures thereof. The nano raw material is metal chalcogenide of metal sulfate, metal selenide or metal telluride, which is selected from a group consisting of CdS, ZnS, HgS, PbS, InS, AgS, CuS, CdSe, ZnSe, HgSe, PbSe, InSe, AgSe, CuSe, CdTe, CdTe, ZnTe, HgTe, PbTe, InTe, AgTe, CuTe and mixtures thereof. For the multibubble sonoluminescence, the frequency of the supersonic wave is maintained at 10-20kHz, the power is maintained at 110-220W, the pressure is maintained at 1-2 atm by feeding the reaction reservoir with noble gas, and the temperature is maintained at 20-70deg.C. The preparation method of layered nano structures is carried out in situ by mixing metal oxide, chalcogenide precursor and metal oxide resolved in a solvent in the reaction reservoir while performing supersonic wave reaction for 20-30 minutes.

Abstract translation: 提供了由此制备的层状纳米结构和层状纳米结构的制备方法，以便在多层声发光的存在下，通过在纳米支持体上涂覆纳米原料，在短时间内获得均匀的纳米结构。 层状纳米结构的制备方法包括在多层声发光的存在下在纳米支撑体上涂覆纳米原料的步骤。 纳米载体是直径最大为50nm的金属氧化物颗粒，其选自TiO 2，ZnO，ZrO，Al 2 O 3，Fe 2 O 3，Fe 3 O 4，Ga 2 O 3，SnO 2，Sb 2 O 3，SiO 2，MnO 2，NiO 2及其混合物。 纳米原料是选自CdS，ZnS，HgS，PbS，InS，AgS，CuS，CdSe，ZnSe，HgSe，PbSe，InSe，AgSe中的金属硫酸盐，金属硒化物或金属碲化物的金属硫族化物 CuSe，CdTe，CdTe，ZnTe，HgTe，PbTe，InTe，AgTe，CuTe及其混合物。 对于多声发声，超声波的频率保持在10-20kHz，功率保持在110-220W，通过向惰性气体供给反应容器，将压力保持在1-2atm，并保持温度 在20-70℃。 层状纳米结构的制备方法是通过在反应槽中混合金属氧化物，硫属元素前体和在溶剂中分解的金属氧化物，同时进行超声波反应20-30分钟进行的。

公开(公告)号：KR1020080027654A

公开(公告)日：2008-03-28

申请号：KR1020060093059

申请日：2006-09-25

Applicant: 재단법인서울대학교산학협력재단

Inventor： 김명수 ,  윤소희 ,  문정희

IPC: G01N27/62

Abstract: A mass spectrometer is provided to improve the resolving power of each spectrum by installing four pairs of deflectors outside ionization source so that the amount of PSD ions at a location where PD laser is irradiated is maximally removed. A mass spectrometer comprises an ionization source(10) subject to a delayed extraction. Ions passing through an ionization source tube reach an ion gate(30). A deflection system(20), including four bipolar deflectors, is interposed between the tube and the ion gate to remove PSD ions. A PD laser(40) is installed next to the ion gate to irradiate laser onto ions that have passed through the ion gate. A detector(60) detects the ions according to the mass thereof.

Abstract translation: 提供质谱仪以通过在电离源外部安装四对偏转器来提高每个光谱的分辨能力，从而最大限度地去除PD激光器照射位置处的PSD离子的量。 质谱仪包括经过延迟提取的电离源（10）。 通过电离源管的离子到达离子门（30）。 包括四个双极偏转器的偏转系统（20）被插入在管和离子门之间以去除PSD离子。 PD激光器（40）安装在离子门旁边以将激光照射到已经通过离子浇口的离子上。 检测器（60）根据其质量检测离子。

公开(公告)号：KR1020080027642A

公开(公告)日：2008-03-28

申请号：KR1020060093025

申请日：2006-09-25

Applicant: 재단법인서울대학교산학협력재단

Inventor： 차국헌 ,  이성훈 ,  배완기 ,  허혁

IPC: H01L21/20 ,  H01L33/22 ,  H01L33/04

CPC classification number: H01L29/127 ,  B82Y10/00 ,  B82Y30/00 ,  C01B19/002 ,  C01B19/007 ,  C01G9/08 ,  C01G11/00 ,  C01G11/02 ,  C01P2004/03 ,  C01P2004/04 ,  C01P2004/84 ,  C01P2006/40 ,  C09K11/02 ,  C09K11/565 ,  C09K11/883 ,  H01L21/02474 ,  H01L21/02477 ,  H01L21/0248 ,  H01L21/02557 ,  H01L21/0256 ,  H01L21/02562 ,  H01L21/02601 ,  H01L29/22 ,  Y10S438/962 ,  Y10S977/774

Abstract: A quantum dot having a gradient shell structure and a method of manufacturing the same are provided to form economically the same within a short period of time by using a reaction difference of a semiconductor precursor. A quantum dot has a shell structure of a chemical compound of a second to sixth groups based on a chemical compound of a second to fourth groups. The chemical compound of the second to sixth groups for forming a shell has a band gap larger than a band gap of the chemical compound of the second to sixth groups for forming a core. The shell of the chemical compound of the second to sixth groups has gradient concentration. A method of manufacturing the quantum dot includes a process for mixing and heating the chemical compounds of the second group for forming the shell and the core, a process for heating the mixture at the temperature of 100-350 ‹C, a process for mixing the chemical compounds of the six group for forming the shell and the core, and a process for forming a shell structure having a gradient at the temperature of 100-350 ‹C.

Abstract translation: 提供具有梯度壳结构的量子点及其制造方法，以通过使用半导体前体的反应差在短时间内经济地形成。 基于第二至第四组的化合物，量子点具有第二至第六组的化合物的壳结构。 用于形成壳的第二至第六组的化合物具有比用于形成芯的第二至第六组的化合物的带隙大的带隙。 第二至第六组化合物的壳体具有梯度浓度。 制造量子点的方法包括混合和加热用于形成壳和芯的第二组的化合物的方法，在100-350℃的温度下加热该混合物的方法， 用于形成壳和芯的六组的化合物，以及在100-350℃的温度下形成具有梯度的壳结构的方法。

公开(公告)号：KR100817429B1

公开(公告)日：2008-03-27

申请号：KR1020060099661

申请日：2006-10-13

Applicant: 재단법인서울대학교산학협력재단

Inventor： 김민균 ,  김정은 ,  이사미 ,  남백희

IPC: C12Q1/68

CPC classification number: C12Q1/6809 ,  C12Q2600/156

Abstract: A DNA polymorphism marker of a lettuce chloroplast is provided to identify lettuce cultivars by finding out the difference between a specific region of a total lettuce chloroplast genome sequence of Lactuca sativa L. cv. Green curled leaf and cultivars analyzed in Japan such as Lactuca sativa L. cv. Cisco or AY865287 and AY865171 deposited in an NCBI, thereby being usefully used for identifying Korean lettuce cultivars and breeding and developing high quality lettuce. A DNA polymorphism marker of a lettuce chloroplast is a sequence of a portion where a 28bp locating between 12064-12210 loci is inserted, the 12064-12210 loci being a region with length variation in a chloroplast genome sequence of the lettuce, and includes a sequence of SEQ ID : NO. 1. A method for identifying lettuce cultivars comprises the steps of: (a) determining a chloroplast genome sequence corresponding to an object lettuce cultivar; and (b) comparing the lettuce chloroplast DNA polymorphism marker with the chloroplast genome sequence corresponding to the object lettuce cultivar. Further, the lettuce is Lactuca sativa L..

Abstract translation: 提供了莴苣叶绿体的DNA多态性标记，通过发现莴苣莴苣叶绿体基因组序列的特定区域之间的差异来鉴定莴苣品种。 在日本分析的绿色卷叶和品种如莴苣Lactuca sativa L.cv。 思科或AY865287和AY865171存放在NCBI中，从而有效地用于识别韩国莴苣品种，并育种和开发高品质的莴苣。 莴苣叶绿体的DNA多态性标记是其中插入位于12064-12210个位点之间的28bp的部分的序列，12064-12210位点是莴苣叶绿体基因组序列中长度变化的区域，并且包括序列 SEQ ID NO： 1.一种鉴定莴苣品种的方法，包括以下步骤：（a）测定对应于莴苣品种的叶绿体基因组序列; 和（b）将莴苣叶绿体DNA多态性标记与对应于莴苣品种的叶绿体基因组序列进行比较。 此外，莴苣是Lactuca sativa L ..

公开(公告)号：KR1020080027046A

公开(公告)日：2008-03-26

申请号：KR1020060092463

申请日：2006-09-22

Applicant: 재단법인서울대학교산학협력재단

Inventor： 김명현 ,  임재용

IPC: G21C9/033 ,  G21C9/02

CPC classification number: Y02E30/35

Abstract: A floating-type nuclear reactor shutdown system is provided to drive a control rod assembly with only buoyancy by combining a high density of a coolant and a characteristic of the control rod assembly in a liquid metal cooling nuclear reactor. A floating-type nuclear reactor shutdown system is used in a liquid metal reactor and includes a control rod assembly. The control rod assembly includes a neutron absorption body(1) and at least one control rod. The neutron absorption body is placed on a lower part of the control rod assembly. At least one control rod is formed on an upper part of the neutron absorption body and has a dummy metal tube(2) composed of a metal tube including a lighter material than a coolant of the liquid metal reactor. In the normal driving, the control rod assembly is placed under a reactor core. In an emergency situation, the control rod assembly rises by buoyancy to control output of a nuclear reactor.

Abstract translation: 提供了一种浮式核反应堆关闭系统，通过在液体金属冷却核反应堆中组合高密度冷却剂和控制棒组件的特性来驱动具有浮力的控制杆组件。 在液态金属反应器中使用浮式核反应堆关闭系统，并包括控制棒组件。 控制棒组件包括中子吸收体（1）和至少一个控制杆。 中子吸收体放置在控制棒组件的下部。 至少一个控制杆形成在中子吸收体的上部，并具有由金属管构成的虚拟金属管（2），该金属管包括比液态金属反应器的冷却剂更轻的材料。 在正常驾驶中，将控制杆组件放置在反应堆芯下。 在紧急情况下，控制杆组件由浮力升高以控制核反应堆的输出。

公开(公告)号：KR100816470B1

公开(公告)日：2008-03-26

申请号：KR1020060086207

申请日：2006-09-07

Applicant: 재단법인서울대학교산학협력재단

Inventor： 한민구 ,  이재훈

IPC: G09G3/30 ,  G09G3/36 ,  G09G3/32 ,  G09G3/20

Abstract: 본 발명은 화소 내의 스위칭 트랜지스터의 누설전류로 인한 화질열화를 최소화하기 위한 표시장치의 화소구조 및 그 구동방법에 관한 것이다.
본 발명에 따른 표시장치의 화소구조는 n 번째 스캔신호에 의해 제어되며, 데이터 라인과 스캔 라인에 의해 정의되는 단위 화소를 선택하는 스위칭 트랜지스터를 구비하는 화소구조에 있어서, 소스-드레인 전류통로가 노드A에서 상기 스위칭 트랜지스터의 소스-드레인 전류통로에 접속되며, n-1 번째 스캔신호에 의해 제어되어 상기 스위칭 트랜지스터의 누설전류를 보상하기 위한 제어데이터신호를 상기 노드 A에 전달하는 누설전류 보상용 트랜지스터를 더 포함함을 특징으로 한다.
유기발광소자, 화소, 표시장치, 누설전류, 문턱전압

公开(公告)号：KR100816200B1

公开(公告)日：2008-03-24

申请号：KR1020070117940

申请日：2007-11-19

Applicant: 삼성전자주식회사 ,  중앙대학교 산학협력단 ,  재단법인서울대학교산학협력재단

Inventor： 장석규 ,  송기철 ,  김준수 ,  박상미 ,  안상두 ,  성재영

IPC: C07D417/04 ,  C07D413/04 ,  C07D401/04

Abstract: 본 발명은 신규한 8-히드록시퀴놀린 아세트아미드 화합물 및 그 제조방법에 관한 것으로, 구체적으로 본 발명은 수은 이온에 대한 검출감도가 매우 높아 선택적인 화학선량계로 사용가능한 신규한 8-히드록시퀴놀린 티오아미드 화합물의 중간체인 8-히드록시 퀴놀린 아세트아미드 화합물과 그 제조방법에 관한 것이다.
8-히드록시퀴놀린 아세트아미드, 8-히드록시퀴놀린 티오아미드