公开(公告)号：JP2007033463A

公开(公告)日：2007-02-08

申请号：JP2006303580

申请日：2006-11-09

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： CLARK FREDERIC L ,  CLEMENS JOHN M ,  HANCE ROBERT B ,  HENDRICK KENDALL B ,  TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MCDOWELL DOUGLAS D ,  MERRIAM RICHARD A ,  MOORE LARRY W ,  OLEKSAK CARL M ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  RUMBAUGH WILLIAM D ,  SCHMIDT LINDA S ,  SCHRIER PAUL R ,  SMITH B JANE ,  SPRONK ADRIAN M ,  WALKER EDNA S ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ,  WALKER DONNY RAY ,  WATKINS WILLIAM E III ,  WINTER GARY E ,  WOHLFORD ROBERT A ,  CLIFT GILBERT ,  CLOONAN KEVIN M ,  MITCHELL JAMES E ,  STANTON ALYN K ,  YOST DAVID A ,  HILLS DAVID B

IPC: G01N33/483 ,  G01N35/02 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/77 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: PROBLEM TO BE SOLVED: To provide an automatic continuous random access analytical system having a device and a method capable of performing simultaneous assays in a plurality of liquid samples by using different assay methods respectively for allowing continuous random access and carrying out a plurality of different assays in the same sample or different samples during the same period and to provide a method for operating the automatic random access system capable of performing a plurality of assays in a plurality of liquid samples. SOLUTION: In this method, a plurality of various assays in the liquid samples are scheduled, and then, a unit dose disposable is generated without starting an assay reaction sequence, and a first liquid sample and an agent are transferred to a reaction vessel separately. Subsequently, the unit dose disposable is physically transferred to a treatment workstation, and in this way, the unit dose disposable agent and the sample are mixed together in incubation. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：提供一种具有装置和方法的自动连续随机存取分析系统，其能够通过分别使用不同的测定方法在多个液体样品中进行同时测定，以允许连续随机存取并执行多个 在同一时期内在相同样品或不同样品中的不同测定法，并提供一种操作能够在多个液体样品中进行多个测定的自动随机存取系统的方法。 解决方案：在该方法中，调整液体样品中的多种各种测定，然后生成单位剂量一次性，而不开始测定反应序列，并将第一液体样品和试剂转移至反应 船只分开。 随后，将单位剂量一次性物理转移到治疗工作站，并且以这种方式，将单位剂量一次性药剂和样品在孵育中混合在一起。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2006206597A

公开(公告)日：2006-08-10

申请号：JP2006052376

申请日：2006-02-28

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： STUK TIMOTHY L ,  KERDESKY FRANCIS A J ,  LIJEWSKI LINDA M ,  NORBECK DANIEL W ,  SCARPETTI DAVID ,  TIEN JIEN-HEH J ,  ALLEN MICHAEL S ,  LANGRIDGE DENTON C ,  MELCHER LAURA ,  RENO DANIEL S ,  SHAM HING LEUNG ,  ZHAO CHEN ,  HAIGHT ANTHONY R ,  LEANNA M ROBERT ,  MORTON HOWARD E ,  ROBBINS TIMOTHY A ,  SOWIN THOMAS J

IPC: C07C215/28 ,  C07B61/00 ,  C07C213/00 ,  C07C225/14 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/38 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14

CPC classification number: C07D221/14 ,  C07B2200/07 ,  C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C251/40 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07C215/08

Abstract: PROBLEM TO BE SOLVED: To provide a substituted 2,5-diamino-3-hydroxyhexane useful for producing HIV protease inhibitors, and to provide a method for producing the compound.
SOLUTION: The substituted 2,5-diamino-3-hydroxyhexane useful for producing HIV protease inhibitors is represented by general formula I.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 待解决的问题：提供可用于产生HIV蛋白酶抑制剂的取代的2,5-二氨基-3-羟基己烷，并提供一种生产该化合物的方法。 解决方案：用于生产HIV蛋白酶抑制剂的取代的2,5-二氨基-3-羟基己烷由通式I表示。（C）2006，JPO和NCIPI

公开(公告)号：JP2005321408A

公开(公告)日：2005-11-17

申请号：JP2005156926

申请日：2005-05-30

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： CLARK FREDERIC L ,  CLEMENS JOHN M ,  HANCE ROBERT B ,  HENDRICK KENDALL B ,  TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MCDOWELL DOUGLAS D ,  MERRIAM RICHARD A ,  MOORE LARRY W ,  OLEKSAK CARL M ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  RUMBAUGH WILLIAM D ,  SCHMIDT LINDA S ,  SCHRIER PAUL R ,  SMITH B JANE ,  SPRONK ADRIAN M ,  WALKER EDNA S ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ,  WALKER DONNY RAY ,  WATKINS WILLIAM E III ,  WINTER GARY E ,  WOHLFORD ROBERT A ,  CLIFT GILBERT ,  CLOONAN KEVIN M ,  MITCHELL JAMES E ,  STANTON ALYN K ,  YOST DAVID A ,  HILLS DAVID B

IPC: G01N33/483 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: PROBLEM TO BE SOLVED: To provide an automatic continuous random access analysis system that has an apparatus and a method for simultaneously executing a plurality of examinations of a liquid sample, by using each different examination method is capable of continuous random access, and executes a plurality of different examinations of the same sample or a different one during the same period, and to provide a method for operating the automatic random access system, for simultaneously executing a plurality of examinations to a plurality of liquid samples. SOLUTION: In the method, the diversified examinations of the plurality of liquid samples are scheduled, no examination reaction sequences are started after it; a unit dose disposable is generated, a first liquid sample and a reagent are transferred separately to a reaction bath; and the unit dose disposable is physically transferred to a treatment workstation, thus mixing the unit dose disposable reagent and the sample in incubation. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种具有同时执行液体样品的多次检查的装置和方法的自动连续随机存取分析系统，通过使用每种不同的检查方法能够连续随机存取，并且 在同一时间段内执行相同样本或不同检查的多个不同检查，并且提供一种用于操作自动随机存取系统的方法，用于同时对多个液体样本执行多次检查。 解决方案：在该方法中，调整多个液体样品的多样化检查，之后不开始检查反应序列; 产生单位剂量一次性，第一液体样品和试剂分别转移到反应浴中; 并且将单位剂量一次性物理转移到治疗工作站，从而在孵育期间混合单位剂量一次性试剂和样品。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2005300552A

公开(公告)日：2005-10-27

申请号：JP2005139663

申请日：2005-05-12

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： FIGARD STEVE D

IPC: G01N33/53 ,  G01N33/531 ,  G01N33/543 ,  G01N33/576

CPC classification number: G01N33/531 ,  G01N33/5306 ,  G01N33/54393 ,  G01N33/5767 ,  Y10S436/82 ,  Y10S436/826

Abstract: PROBLEM TO BE SOLVED: To provide a composition giving immune response stability to antigen and antibody at a raised temperature for a relatively long time. SOLUTION: An aqueous composition suitable for use when performing immunological procedures. The composition includes at least one biological buffer, dithiothreitol (alternatively referred to herein as "DTT"), and ethylene glycol. The composition can also include at least one biological detergent, at least one source of positive and negative counterions, e.g., salt, and at least one viscosity modifier, e.g., sugar. The buffer also can include at least one preservative, such as sodium azide. The pH of the composition preferably ranges from about 6.4 to 7.2. A kit containing the composition is also disclosed. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供在升高的温度下对抗原和抗体在相当长的时间内给予免疫应答稳定性的组合物。 解决方案：适合在进行免疫程序时使用的水性组合物。 组合物包括至少一种生物缓冲液，二硫苏糖醇（本文中称为“DTT”）和乙二醇。 组合物还可以包括至少一种生物洗涤剂，至少一种正和负抗衡离子源，例如盐，和至少一种粘度调节剂，例如糖。 缓冲液还可以包括至少一种防腐剂，例如叠氮化钠。 组合物的pH优选为约6.4至7.2。 还公开了含有该组合物的试剂盒。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2004346077A

公开(公告)日：2004-12-09

申请号：JP2004163024

申请日：2004-06-01

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： LIPARI JOHN ,  AL RAZZAK LAMAN A ,  GHOSH SOUMOJEET ,  GAO RONG ,  KAUL DILIP

IPC: A61K31/425 ,  A61K9/48 ,  A61K31/17 ,  A61K31/341 ,  A61K31/426 ,  A61K31/4433 ,  A61K31/45 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/513 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/55 ,  A61K31/551 ,  A61K31/635 ,  A61K38/05 ,  A61K38/55 ,  A61K45/08 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26 ,  A61K47/42 ,  A61K47/44 ,  A61P31/18 ,  A61P43/00

CPC classification number: A61K38/55 ,  A61K9/4858 ,  A61K31/341 ,  A61K31/426 ,  A61K31/4433 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/513 ,  A61K31/5375 ,  A61K31/551 ,  A61K38/05 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26 ,  A61K47/44

Abstract: PROBLEM TO BE SOLVED: To provide a liquid pharmaceutical composition for treatment of AIDS, having improved oral bioavailability for compounds which are inhibitors of HIV protease. SOLUTION: The liquid pharmaceutical composition comprises (a) the HIV protease inhibitor, (b) an organic solvent comprising a mixture of a long chain fatty acid and an alcohol, (c) a surfactant, wherein the liquid preparation is encapsulated in either hard gelatin capsules or soft elastic capsules (SEC). The HIV protease inhibitor is a combination of ritonavir and indinavir, saquinavir, VX-478, nelfinavir, etc., the organic solvent is oleic acid, ethanol, propylene glycol, and the surfactant is polyoxyl35 castor oil. COPYRIGHT: (C)2005,JPO&NCIPI

公开(公告)号：JP2004209243A

公开(公告)日：2004-07-29

申请号：JP2003424003

申请日：2003-12-22

Applicant: Abbott Lab Vascular Enterprises Ltd ,  アボット ラボラトリーズ バスキュラー エンタープライゼズ リミテッド

Inventor： QUINT BODO

IPC: A61F2/958 ,  A61M25/00

CPC classification number: A61M25/1036 ,  A61M25/0054 ,  A61M2025/1093

Abstract: PROBLEM TO BE SOLVED: To provide a catheter which has especially high flexibility in the distal end part and further stability sufficient for obtaining good pushing ability. SOLUTION: The invention relates to a catheter 1 comprising a catheter shaft 2. The catheter tip 7 of the shaft 2 is provided with a joint 9 made of a material 11 which is more flexible than the material of the catheter shaft 2. The joint 9 is disposed between the distal end 8 of the shaft 2 and the distal end 10 of the catheter tip 7. The distal end 10 consists of a material which is the same as the shaft 2 or harder than that of the shaft 2. COPYRIGHT: (C)2004,JPO&NCIPI

公开(公告)号：JP2004093563A

公开(公告)日：2004-03-25

申请号：JP2003286450

申请日：2003-08-05

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： DOWELL BARRY L ,  KING CAROL A ,  ALEXANDER DEBRA B ,  SMITH ALLAN H ,  O'MORCHOE SUSAN B

IPC: G01N33/53 ,  A61K39/395 ,  C07K16/18 ,  C07K19/00 ,  G01N33/543 ,  G01N33/566 ,  G01N33/574 ,  G01N33/68

CPC classification number: G01N33/689 ,  G01N33/57434 ,  G01N2333/811 ,  G01N2333/8121 ,  G01N2800/342 ,  Y10S435/962 ,  Y10S435/967 ,  Y10S435/975 ,  Y10S436/813

Abstract: PROBLEM TO BE SOLVED: To provide an immunoassary for prostatic specific antigen (PSA) in the field of a carcinoma immunoassary. SOLUTION: This immunoassary is for the prostate specific antigen (PSA). In this method, complexes similar to the complex of PSA usable as a calibrator or a control and α-antichymotrypsin (ACT) and polyclonal antibodies for the PSA are classified into those bonded to epitope masked by the bonding of the PSA to the ACT and those not bonded to the epitope. COPYRIGHT: (C)2004,JPO

公开(公告)号：JP2003177137A

公开(公告)日：2003-06-27

申请号：JP2002273035

申请日：2002-09-19

Applicant: ABBOTT LAB

Inventor： CLARK FREDERIC L ,  CLEMENS JOHN M ,  HANCE ROBERT B ,  HENDRICK KENDALL B ,  TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MCDOWELL DOUGLAS D ,  MERRIAM RICHARD A ,  MOORE LARRY W ,  OLEKSAK CARL M ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  RUMBAUGH WILLIAM D ,  SCHMIDT LINDA S ,  SCHRIER PAUL R ,  SMITH B JANE ,  SPRONK ADRIAN M ,  WALKER EDNA S ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ,  WALKER DONNY RAY ,  WATKINS WILLIAM E III ,  WINTER GARY E ,  WOHLFORD ROBERT A ,  CLIFT GILBERT ,  CLOONAN KEVIN M ,  MITCHELL JAMES E ,  STANTON ALYN K ,  YOST DAVID A ,  HILLS DAVID B

IPC: G01N33/483 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

Abstract: PROBLEM TO BE SOLVED: To provide an automatic continuous and random access analytical system having an apparatus and a method capable of simultaneously performing a plurality of assays of liquid samples by using different assay methods, capable of performing continuous and random access and performing a plurality of different assays to the same sample or to different samples during the same time, and a method for operating the automatic random access system capable of performing simultaneously a plurality of assays to a plurality of liquid samples. SOLUTION: In this method, various assays of the plurality of liquid samples are scheduled, and then a unit dose disposable is generated without starting an assay reaction sequence, and a first liquid sample and a reagent are transferred separately to a reaction vessel. Thereafter, the unit dose disposable is transferred physically to a treatment work station, and thereby the unit dose disposable is mixed with the sample at the incubation time. COPYRIGHT: (C)2003,JPO

公开(公告)号：JP2002250735A

公开(公告)日：2002-09-06

申请号：JP2002008960

申请日：2002-01-17

Applicant: ABBOTT LAB

Inventor： CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MITCHELL JAMES E ,  MOORE LARRY W ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH B JANE ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A ,  RUMBAUGH WILLIAM ,  WINTER GARY E ,  HANCE ROBERT B ,  STANTON ALYN K ,  OLEKSAK CARL M ,  WATKINS WILLIAM E III ,  VICKSTROM RICHARD L ,  CLOONAN KEVIN M ,  ROBERT A WOLFORD ,  HILLS DAVID B JR ,  SCHRIER PAUL R

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  G01N1/00 ,  G01N1/14 ,  G01N1/28 ,  G01N21/03 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G05D23/00 ,  H01J49/04 ,  H02P8/00 ,  H05B41/00

Abstract: PROBLEM TO BE SOLVED: To provide an automated continuous random access analytical system which has an apparatus and a method whereby a plurality of assays for a liquid sample can be carried out simultaneously with the use of different assay methods, providing a continuous random access, and moreover, carrying out a plurality of different assays to the same or different samples within the same period of time. SOLUTION: Various assays for a plurality of liquid samples are scheduled. Then, a disposable unit quantity is generated, and the first liquid sample 26 and a reagent 30 are separately moved to a reaction container 34 without starting an assay reaction sequence. Thereafter, the disposable unit quantity 34 is physically moved to a process work station. A mixture 34 of the disposable unit quantity of the reagent and the sample is obtained while being incubated.

公开(公告)号：JPH1154216A

公开(公告)日：1999-02-26

申请号：JP15350398

申请日：1998-04-24

Applicant: ABBOTT LAB

Inventor： L SCOTT FARLEY ,  DEAN T FARISH ,  RUSSELL D HEIBOON ,  KEVIN H JOHNSON ,  MICHAEL S NEILSON ,  STEVEN B SHANNON

IPC: H01R13/58 ,  H01R24/62 ,  H01R23/66

Abstract: PROBLEM TO BE SOLVED: To provide a connector that can positively connect a conductor to a jack, without depending on strict component tolerance by holding a flat cable fixedly in the passage of a housing, and bending the conductor exposed from the tip to fuse it to slots. SOLUTION: A flat cable with a conductor which is exposed from its terminal end is inserted in a passage 70 of a connector 40 from the opening of a first end part 72, and its insulator part is accommodated in the passage 70, while the conductor is led out of the opening of a second end part 74. A strain relief tab 110 provided at a housing top face 76 is turned horizontally via a hinge part 120, and the insulator part is pressed downward by its top part 123 for fixing and holding the cable onto a bottom face 78. The conductor is bent, curved upward along a support wall 98 of the second end part 74 and further is bent horizontally at a protrusive distal part 100, while being divided by an external divider wall 94 so as to be led to a recessed inner part 102. A conductor terminal part is fused to a plurality of slots engaged with a jack.