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公开(公告)号：DK0712293T3
公开(公告)日：2003-06-30
申请号：DK94919208
申请日：1994-05-20
Applicant: IMARX PHARMACEUTICAL CORP
Inventor： UNGER EVAN C , FRITZ THOMAS A , MATSUNAGA TERRY , RAMASWAMI VARADARAJAN , YELLOWHAIR DAVID , WU GUANLI
IPC: A61B8/00 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/48 , A61K49/00 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , A61K37/22 , B01J13/02
Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
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公开(公告)号：PT711127E
公开(公告)日：2003-04-30
申请号：PT94919184
申请日：1994-05-19
Applicant: IMARX PHARMACEUTICAL CORP
Inventor： UNGER EVAN C , FRITZ THOMAS A , MATSUNAGA TERRY , RAMASWAMI VARADARAJAN , YELLOWHAIR DAVID , WU GUANLI
IPC: A61B8/00 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/48 , A61K48/00 , A61K49/00 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , B01J13/02
Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
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公开(公告)号：RU2181998C2
公开(公告)日：2002-05-10
申请号：RU97118412
申请日：1996-03-27
Applicant: IMARX PHARMACEUTICAL CORP
Inventor： UNGER EVAN C
IPC: A61K9/133 , A61K8/14 , A61K8/70 , A61K9/127 , A61K41/00 , A61K47/30 , A61K47/48 , A61K49/00 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00
Abstract: medicine, methods of diagnosis. SUBSTANCE: invention describes compositions comprising lipid and substance promoting to stabilization of the composition distributed in an aqueous carrier. Stabilizing substance binds with lipid noncovalently and it is taken in amount that sufficient to cover lipid but it does not increased the viscosity value of the composition. Compositions are useful especially for using in diagnosis carrying out including ultrasonic diagnosis. Compositions can be presented as vesicular compositions, for example, compositions containing micelles and liposomes. The use of composition decreases probability of vessels occlusion. EFFECT: enhanced stability of compositions. 17 cl, 3 tbl
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公开(公告)号：GR3036877T3
公开(公告)日：2002-01-31
申请号：GR20010401740
申请日：2001-10-11
Applicant: IMARX PHARMACEUTICAL CORP
Inventor： UNGER EVAN C , WU GUANLI
IPC: A61B8/00 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/48 , A61K49/00 , A61K49/18 , A61K49/22 , A61Q19/00 , B01J13/02 , A61K37/22
Abstract: Contrast agents for ultrasonic imaging comprising gas filled liposomes prepared using vacuum drying gas instillation methods, and gas filled liposomes substantially devoid of liquid in the interior thereof, are described. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in ultrasonic imaging applications are also disclosed. Also described are diagnostic kits for ultrasonic imaging which include the subject contrast agents.
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公开(公告)号：AU715681B2
公开(公告)日：2000-02-10
申请号：AU5936096
申请日：1996-05-28
Applicant: IMARX PHARMACEUTICAL CORP
Inventor： UNGER EVAN C
Abstract: Stabilized compositions comprising, in combination with a gas, a fluorinated amphiphilic compound. The compositions are particularly suitable for use in diagnostic applications, including ultrasound. The compositions can take the form of vesicular compositions, such as micelles and liposomes.
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Patent Agency Ranking
公开(公告)号：BR9609343A
公开(公告)日：1999-12-28
申请号：BR9609343
申请日：1996-06-06
Applicant: IMARX PHARMACEUTICAL CORP
Inventor： UNGER EVAN C , MCCREERY THOMAS , YELLOWHAIR DAVID , BARRETTE TERRENCE R
IPC: A61K49/00 , A61B5/055 , A61B8/00 , A61J3/00 , A61K8/14 , A61K8/70 , A61K9/127 , A61K41/00 , A61K47/48 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , B01F3/04 , B01F11/00 , B01F15/00 , A61B5/00 , A61K9/133
Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3 DEG . The total length of travel around the figure-8 pattern is at least 0.7 cm.
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公开(公告)号：HK1013625A1
公开(公告)日：1999-09-03
申请号：HK98114978
申请日：1998-12-23
Applicant: IMARX PHARMACEUTICAL CORP
Inventor： UNGER EVAN C
IPC: A61B20060101 , A61K20060101 , B01J20060101 , A61K , A61B , B01J
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公开(公告)号：AT180170T
公开(公告)日：1999-06-15
申请号：AT91902857
申请日：1990-12-19
Applicant: IMARX PHARMACEUTICAL CORP
Inventor： UNGER EVAN C
IPC: A61B8/00 , A61K9/127 , A61K41/00 , A61K47/48 , A61K49/00 , A61K49/18 , A61K49/22 , B01J13/02 , B01J13/12 , A61B8/14
Abstract: The present invention relates to a method for synthesizing a liposome having encapsulated therein a gas comprising contacting the liposomes in the liquid medium with gas under elevated pressure. The liposomes so produced and are useful in ultrasonic imaging techniques.
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公开(公告)号：AU1390699A
公开(公告)日：1999-06-07
申请号：AU1390699
申请日：1998-11-11
Applicant: IMARX PHARMACEUTICAL CORP
Inventor： UNGER EVAN C , MCCREERY THOMAS , SADEWASSER DAVID
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公开(公告)号：AU696056B2
公开(公告)日：1998-08-27
申请号：AU6953794
申请日：1994-05-19
Applicant: IMARX PHARMACEUTICAL CORP
Inventor： UNGER EVAN C , FRITZ THOMAS A , MATSUNAGA TERRY , RAMASWAMI VARADARAJAN , YELLOWHAIR DAVID , WU GUANLI
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