公开(公告)号：JPS6227402A

公开(公告)日：1987-02-05

申请号：JP16349186

申请日：1986-07-11

Applicant: SANOFI SA ,  SCLAVO SPA

Inventor： MOORISU PUCHITOU ,  JIYAN SHIYOAI

IPC: C07H11/00 ,  A61K31/70 ,  A61K31/715 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C08B37/00 ,  C08B37/08 ,  C08B37/10 ,  C12N9/99

公开(公告)号：JPS61197601A

公开(公告)日：1986-09-01

申请号：JP24992385

申请日：1985-11-07

Applicant: SANOFI SA ,  SCLAVO SPA

Inventor： ARAN BAIYOORU ,  FURANSHISU BURAN ,  JIYAKURIINU RANSEN ,  JIYAN PIEERU MAFURAN ,  JIYAN MARII PEREIRO

IPC: C08B37/00 ,  A61K31/715 ,  A61P3/06 ,  A61P7/02 ,  C08B37/14

公开(公告)号：JPH09157293A

公开(公告)日：1997-06-17

申请号：JP16034896

申请日：1996-06-20

Applicant: SCLAVO SPA

Inventor： MARIAGURAAJIA PITSUZA ,  ANTONETSURA BARUTOROONI ,  RIINO RATSUPUOORI

IPC: A61K39/00 ,  A61K39/10 ,  A61P31/04 ,  C07H21/04 ,  C07K14/00 ,  C07K14/195 ,  C07K14/235 ,  C07K14/41 ,  C12N1/20 ,  C12N1/21 ,  C12N15/09 ,  C12P21/00 ,  C12P21/02 ,  C12R1/19

公开(公告)号：JPH04210924A

公开(公告)日：1992-08-03

申请号：JP1683291

申请日：1991-01-18

Applicant: SCLAVO SPA

Inventor： FUIRITSUPO RATSUTANTSUI ,  MAURITSUIO CHIEKETSUTEIN ,  RITSUKARUDO BUANNI

IPC: A61K9/00 ,  A61K9/20 ,  A61K38/23 ,  A61K47/26 ,  A61K47/36 ,  A61K47/38 ,  A61P3/00

Abstract: PURPOSE: To obtain a pharmaceutical composition capable of providing blood concentration having same level as blood concentration of calcitonin obtainable by conventional intramuscular administration by oral administration at same unit dosage form by homogenizing with a mixture of solid excipients. CONSTITUTION: Perbuccal or sublingual tablets for oral administration contain calcitonin homogenized with a mixture of solid excipients, preferably completely a soluble diluent (especially mannitol, lactose or saccharose), a disintegrator (especially starch, its derivative, micro-crystalline cellulose, its derivative, crospovidone, amberlite, alginic acid) and a lubricant (especially magnesium stearate, aluminum stearate, stearic acid, talc, high molecular weight ethylene glycol) or the above diluent and a binder (especially gum arabic, hydroxypropyl cellulose or hydroxypropylmethyl cellulose) and lubricant, e.g. eel calcitonin in an amount of 20-800I.U., preferably 50-500I.U. per tablet as an active ingredient.

公开(公告)号：JPH03190822A

公开(公告)日：1991-08-20

申请号：JP33701990

申请日：1990-11-30

Applicant: SCLAVO SPA

Inventor： KURISUTEIINA BEKERUTSUCHI ,  MAURO PETSURETSUTEI ,  SERUJIYO SUIRUBUESUTORI ,  RUKA PARENTE

IPC: A61K38/00 ,  A61K38/07 ,  A61P29/00 ,  C07K5/10

Abstract: PURPOSE: To obtain a pharmaceutical composition containing natural tuftsin or its analogue and capable of healing inflammation without exhibiting adverse effects. CONSTITUTION: This pharmaceutical composition comprises a compound of formula II (absolute configuration of carbon atom expressed by asterisk is L-configuration and absolute configuration of carbon atom of malonyl residue is L- or D-configuration) or a pharmaceutically permissible salt which is its base adduct or acid adduct. The compound is prepared in the dosage form suitable for oral or parenteral administration and the compound contains an active ingredient in an amount of 0.1-10mg per kg body weight even in any cases. The composition can heal even chronic inflammation by repeated administration or repeated coating, etc.

公开(公告)号：JPH03169825A

公开(公告)日：1991-07-23

申请号：JP11186590

申请日：1990-05-01

Applicant: SCLAVO SPA

Inventor： MARIAGURATSUIA PITSUTSUA ,  ANTONEERO KOBUATSUCHI ,  RINO RATSUPUOORI ,  RUCHIAANO NENCHIOONI

IPC: C12N1/20 ,  A61K39/00 ,  A61K39/10 ,  C07K14/235 ,  C12N15/00 ,  C12N15/01 ,  C12N15/09 ,  C12N15/31 ,  C12R1/01

Abstract: PURPOSE: To provide a new immunoactive pertussis toxin variant that has amino acid sequence in whose subunits a specific amino acid moiety is lost, or replaced with a different amino acid selected from natural amino acids, and has reduced toxicity or does not have toxicity. CONSTITUTION: This immunoactive pertussis toxin variant in which at least one of amino acid moieties in amino acid sequence of subunits, Glu 129, Asp 11, Trp 25, Arg 9, Phe 50, Asp 1, Arg 13, Tyr 130 Gly 86, Ile 88, Tyr 89, Tyr 8, Gly 44, Thr 53 and Gly 88, is lost or replaced with a different amino acid selected from natural amino acids, for example, PT-9K variant in which Glu 129 and Arg 9 is replaced with Gly and Lys, respectively, is obtained by treatment with formaldehyde in a quantity of 0.035-0.420w/v%. Thus obtained variant has reduced mitogenicity or hemagglutinative activity, or does not have such activity, and is stable at 37 deg.C.

公开(公告)号：JPH0338598A

公开(公告)日：1991-02-19

申请号：JP17040790

申请日：1990-06-29

Applicant: SCLAVO SPA

Inventor： SABIINA MARIOTSUCHI ,  ARESANDORO SHISUTO ,  RUCHIAANO NENCHIOONI ,  RUIJI BIIRA ,  ANTONEERO PETSUSHI

IPC: A61K38/22 ,  A61K38/00 ,  A61P11/14 ,  A61P37/00 ,  C07K1/06 ,  C07K5/02 ,  C07K5/08 ,  C07K7/02

公开(公告)号：JPH0215827B2

公开(公告)日：1990-04-13

申请号：JP5574878

申请日：1978-05-12

Applicant: ISUCHI* SHEROTERAPIKO E BATSUCHINOJENO TOSUKANO SCLAVO SPA

Inventor： FURANCHESUKO KOKOORA ,  PAORO TARURI ,  PAORO NEERI

IPC: G01N33/543 ,  G01N33/53 ,  G01N33/58 ,  G01N33/60 ,  G01N33/76 ,  G21H5/02

公开(公告)号：JPH0265784A

公开(公告)日：1990-03-06

申请号：JP8715989

申请日：1989-04-07

Applicant: SCLAVO SPA

Inventor： ROI GUROSU ,  RIINO RATSUPUORI

IPC: C12N15/09 ,  C12N1/21 ,  C12N15/74 ,  C12P21/00 ,  C12R1/01 ,  C12R1/19

公开(公告)号：JPH027429B2

公开(公告)日：1990-02-19

申请号：JP19778781

申请日：1981-12-10

Applicant: ISUCHI* SHEROTERAPIKO E BATSUCHINOJENO TOSUKANO SCLAVO SPA

Inventor： ARESANDORO TABATSUKO ,  PAORO TARURI ,  PAORO NERI

IPC: G01N33/90