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公开(公告)号：KR1020130027338A
公开(公告)日：2013-03-15
申请号：KR1020110090866
申请日：2011-09-07
Applicant: 강원대학교산학협력단
CPC classification number: C12N15/8218 , C07K14/415 , C12N9/1007 , C12N15/8243 , C12N15/8255 , C12N15/8265 , C12Y201/01068
Abstract: PURPOSE: COMT gene originated from Miscanthus sinensis and its use is provided to use for the yield increase controlling the anti oxidation activation of plants as the phenolic compound contents are controllable in the vector-transformed plant. CONSTITUTION: The method to control the phenolic compound content of plant comprises a step that controls the revelation of COMT gene by transforming recombinant vector in a plant cell which contains COMT [caffeic acid O-methyltransferase] gene originated from Miscanthus sineis; and a step that redifferentiates plants from the transformed plant cells. The phenolic compound content of plant is reduced by inhibiting the revelation of COMT gene. The phenolic compound contents of plant is increased by the overexpression of COMT gene. The phenolic compound of plant is flavonoid or lignine. The inhibition of COMT gene revelation is executed by transforming the plant with the recombinant plant vector in which COMT gene originated from Miscanthus sinensis is inserted in an anti-sense direction. The COMT gene is formed with a base rank of the rank number 1. The plant with reduced content of phenolic compound is produced by inhibiting the expression of COMT gene.
Abstract translation: 目的：COMT基因起源于芒草，其用途用于控制植物的抗氧化活化的产量增加，因为酚类化合物含量在载体转化植物中是可控的。 构成：控制植物酚类化合物含量的方法包括通过在含有源自芒草的COMT [咖啡酸O-甲基转移酶]基因的植物细胞中转化重组载体来控制COMT基因的启动的步骤; 以及将植物从转化的植物细胞重新分化的步骤。 通过抑制COMT基因的启示来减少植物的酚类化合物含量。 通过COMT基因的过表达，植物的酚类化合物含量增加。 植物的酚类化合物是类黄酮或木质素。 通过用来自中国芒草的COMT基因以反义方向插入的重组植物载体转化植物来进行COMT基因启动的抑制。 COMT基因形成为等级1的碱基级别。通过抑制COMT基因的表达产生酚类化合物含量降低的植物。
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公开(公告)号：KR1020120128226A
公开(公告)日：2012-11-27
申请号：KR1020110046038
申请日：2011-05-17
Applicant: 강원대학교산학협력단
IPC: A61K36/899 , A61P35/00
CPC classification number: A61K36/899 , A23L3/00 , A23L3/165 , A23L3/3454 , A23L3/3472 , A61K36/00 , A61K36/18 , A61K36/88
Abstract: PURPOSE: A pharmaceutical composition containing Sorghum bicolor extract for preventing or treating cancer is provided to be used in a pharmaceutical composition or functional foods. CONSTITUTION: A pharmaceutical composition for preventing or treating cancer contains Sorghum bicolor extract as an active ingredient. The extract is an hexane fraction, ethyl acetate fraction, butanol fraction, or water fraction which is prepared by fractioning Sorghum bicolor crude extract with hexane, ethyl acetate, butanol, and water.
Abstract translation: 目的：提供含有用于预防或治疗癌症的高粱双色提取物的药物组合物用于药物组合物或功能性食品中。 构成：用于预防或治疗癌症的药物组合物含有高粱双色提取物作为活性成分。 提取物是通过用己烷，乙酸乙酯，丁醇和水分离高粱双色粗提物制备的己烷级分，乙酸乙酯级分，丁醇级分或水级分。
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Patent Agency Ranking
公开(公告)号：KR1020110126362A
公开(公告)日：2011-11-23
申请号：KR1020100046006
申请日：2010-05-17
Applicant: 강원대학교산학협력단 , 삼성생약 주식회사 농업회사법인
Abstract: PURPOSE: A method for manufacturing distilled liquor using Hippophae rhamnoides L. is provided to ensure the flavor and taste of Hippophae rhamnoides L. and to improve preference. CONSTITUTION: A method for manufacturing distilled liquor using Hippophae rhamnoides L. comprises: a step of mixing steamed rice, modified nuruk, yeast, Hippophae rhamnoides L. leaves or extract thereof, and water to prepare a mixture; a step of fermenting the mixture at 20-30 degrees Celsius for 1-5 days to prepare crude liquor; a step of filtering residues from the crude liquor and maturing in a refrigerator for 1-5 days; and a step of distilling the matured liquor.
Abstract translation: 目的：提供使用沙棘沙门氏菌制造蒸馏酒的方法，以确保沙棘沙门氏菌的风味和味道，并改善偏好。 构成：使用沙棘制造蒸馏酒的方法包括：将蒸米，改良的育儿，酵母，沙棘叶或其提取物和水混合以制备混合物的步骤; 在20-30摄氏度下发酵混合物1-5天以制备粗液的步骤; 从粗液中过滤残留物并在冰箱中熟化1-5天的步骤; 以及蒸馏成熟酒的一个步骤。
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公开(公告)号：KR101007468B1
公开(公告)日：2011-01-12
申请号：KR1020080113386
申请日：2008-11-14
Applicant: (주)아모레퍼시픽 , 강원대학교산학협력단
Abstract: 본 발명은 유효성분으로서 양마(Hibiscus cannabinus) 추출물을 함유하는 피부 미백용 외용제 조성물에 관한 것이다. 보다 상세하게는 양마(Hibiscus cannabinus) 추출물을 함유함으로써 피부에 대한 부작용 없이 안전하게 사용할 수 있을 뿐만 아니라 멜라닌 생성을 억제하여 색소 침착을 저해하는 효과가 뛰어나 기미 또는 주근깨 개선 및 피부 미백 효과가 우수한 피부 미백용 외용제 조성물에 관한 것이다.
양마, 케나프, 미백, 외용제 조성물-
公开(公告)号：KR1020080111299A
公开(公告)日：2008-12-23
申请号：KR1020070059510
申请日：2007-06-18
Applicant: (주)아모레퍼시픽 , 강원대학교산학협력단
CPC classification number: A61K8/97 , A61K36/185 , A61Q19/00 , A61Q19/02 , A61Q19/10 , Y10S514/844 , Y10S514/846
Abstract: A whitening composition for external applications to the skin, containing kaempferol-3,7-o-alpha-l-dirhamnopyranoside is provided to suppress melanogenesis and to ensure excellent anti-freckles and skin whitening effect. A whitening composition for external applications to the skin comprises a kaempferol -3,7-O-alpha-L-di rhamnopyranoside as an active ingredient. The kaempferol-3,7-O- alpha-L-di rhamnopyranoside is derived from the kenaf. The kaempferol-3,7-O- alpha-L-di rhamnopyranoside is contained in an amount of 0.001~20.0 weight based on the total weight of the composition.
Abstract translation: 提供含有山奈酚-3,7-o-α-1-双嘧苯并吡喃糖苷外用于皮肤的美白组合物以抑制黑素生成，并确保优异的抗雀斑和美白效果。 用于外用于皮肤的美白组合物包含山奈酚-3,7-O-α-L-吡喃半乳糖苷作为活性成分。 山奈酚-3,7-O-α-L-吡喃半乳糖苷衍生自洋麻。 基于组合物的总重量，山奈酚-3,7-O-α-L-吡喃半乳糖苷的含量为0.001〜20.0重量％。
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公开(公告)号：KR1020070111409A
公开(公告)日：2007-11-21
申请号：KR1020070095740
申请日：2007-09-20
Applicant: 강원대학교산학협력단
CPC classification number: A23L33/105 , A23V2200/302 , A23V2250/21
Abstract: A kaempferol compound isolated from a kenaf extract(Hibiscus cannabinus) is provided to be used as active components of functional food with antibacterial and antioxidant activity. A functional food contains 0.1 to 20% by weight of a kaempferol compound represented by the formula(1) as an effective component from a kenaf extract and an excipient. The kaempferol compound is prepared by the steps of: obtaining crude extract by extracting kenaf leaf with methanol; obtaining a water layer and organic layer by extracting the crude extract with a solvent selected from water, aliphatic alcohol, aqueous alcohol solutions, hexane, chloroform, ethyl acetate, benzene and butanol; obtaining active fractions by absorbing the water layer and organic layer into a first silica chromatography column and eluting a fraction while changing the ratio of toluene and acetone or acetone and methanol; obtaining active fractions by absorbing the active fractions into a second silica chromatography column and eluting a fraction while changing the ratio of water and methanol(10:0 to 5:5); subjecting the fractions to gel filter chromatography(Sephadex LH-20) with 40% methanol; and finally recrystallizing the purified fractions and purifying a single active compound by high speed liquid chromatography.
Abstract translation: 提供从洋麻提取物（木槿大麻）中分离出的山奈酚化合物作为具有抗菌和抗氧化活性的功能性食品的活性成分。 功能性食品含有0.1〜20重量％的由式（1）表示的山奈酚化合物作为来自洋麻提取物和赋形剂的有效成分。 山奈酚化合物通过以下步骤制备：通过用甲醇提取洋麻叶来获得粗提物; 通过使用选自水，脂族醇，醇溶液，己烷，氯仿，乙酸乙酯，苯和丁醇的溶剂提取粗提取物得到水层和有机层; 通过将水层和有机层吸收到第一硅胶色谱柱中并在改变甲苯和丙酮或丙酮和甲醇的比例的同时洗脱级分获得活性级分; 通过将活性级分吸收到第二硅胶色谱柱中并在改变水和甲醇的比例（10:0至5:5）的同时洗脱级分来获得活性级分; 用馏分进行凝胶过滤层析（Sephadex LH-20）与40％甲醇; 最后将纯化的级分重结晶，并通过高速液相色谱纯化单一活性化合物。
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公开(公告)号：KR100738647B1
公开(公告)日：2007-07-11
申请号：KR1020050113631
申请日：2005-11-25
Applicant: 강원도 , 강원대학교산학협력단
Abstract: 본 발명은 다수의 식물바이러스 감염억제 활성을 나타내는 오배자 추출물을 포함하는 조성물에 관한 것으로, 토마토모자이크바이러스(ToMV), 오이모자이크바이러스(CMV), 고추마일드모틀바이러스(PMMoV), 쥬키니황반모자이크바이러스(ZYMV), 수박모자이크바이러스(WMV), 호박모자이크바이러스(WMV2), 감자바이러스 Y(PVY), 순무모자이크 바이러스 (TuMV), 오이녹반모자이크바이러스(CGMMV), 메론괴저반점바이러스(MNSV), 감자엽권바이러스(PLRV), 나리모자이크 바이러스(LMoV), 나리무병징바이러스(LSV), 오돈토그로솜링스포트바이러스(ORSV), 심비디움모자이크바이러스(CyMV) 등 RNA를 유전자로 가진 식물바이러스에 대하여 우수한 항바이러스 활성을 나타내는 오배자 추출물을 유효성분으로 함유하는 조성물에 관한 것이다.
본 발명에 따른 조성물은 천연물 유래의 물질로써 독성이 없으며, 다양한 식물바이러스에 대하여 탁월한 효과를 나타내므로, 식물바이러스 감염방제제로 유용하게 이용될 수 있다.
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