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公开(公告)号：KR1020070111409A
公开(公告)日：2007-11-21
申请号：KR1020070095740
申请日：2007-09-20
Applicant: 강원대학교산학협력단
CPC classification number: A23L33/105 , A23V2200/302 , A23V2250/21
Abstract: A kaempferol compound isolated from a kenaf extract(Hibiscus cannabinus) is provided to be used as active components of functional food with antibacterial and antioxidant activity. A functional food contains 0.1 to 20% by weight of a kaempferol compound represented by the formula(1) as an effective component from a kenaf extract and an excipient. The kaempferol compound is prepared by the steps of: obtaining crude extract by extracting kenaf leaf with methanol; obtaining a water layer and organic layer by extracting the crude extract with a solvent selected from water, aliphatic alcohol, aqueous alcohol solutions, hexane, chloroform, ethyl acetate, benzene and butanol; obtaining active fractions by absorbing the water layer and organic layer into a first silica chromatography column and eluting a fraction while changing the ratio of toluene and acetone or acetone and methanol; obtaining active fractions by absorbing the active fractions into a second silica chromatography column and eluting a fraction while changing the ratio of water and methanol(10:0 to 5:5); subjecting the fractions to gel filter chromatography(Sephadex LH-20) with 40% methanol; and finally recrystallizing the purified fractions and purifying a single active compound by high speed liquid chromatography.
Abstract translation: 提供从洋麻提取物（木槿大麻）中分离出的山奈酚化合物作为具有抗菌和抗氧化活性的功能性食品的活性成分。 功能性食品含有0.1〜20重量％的由式（1）表示的山奈酚化合物作为来自洋麻提取物和赋形剂的有效成分。 山奈酚化合物通过以下步骤制备：通过用甲醇提取洋麻叶来获得粗提物; 通过使用选自水，脂族醇，醇溶液，己烷，氯仿，乙酸乙酯，苯和丁醇的溶剂提取粗提取物得到水层和有机层; 通过将水层和有机层吸收到第一硅胶色谱柱中并在改变甲苯和丙酮或丙酮和甲醇的比例的同时洗脱级分获得活性级分; 通过将活性级分吸收到第二硅胶色谱柱中并在改变水和甲醇的比例（10:0至5:5）的同时洗脱级分来获得活性级分; 用馏分进行凝胶过滤层析（Sephadex LH-20）与40％甲醇; 最后将纯化的级分重结晶，并通过高速液相色谱纯化单一活性化合物。
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Patent Agency Ranking
公开(公告)号：KR100815476B1
公开(公告)日：2008-03-20
申请号：KR1020060067626
申请日：2006-07-19
Applicant: 강원대학교산학협력단
IPC: A61K36/185 , A23L1/29
Abstract: 본 발명은 케나프 추출물과 이로부터 분리된 신규 캠프페롤 화합물 및 이의 용도에 관한 것으로서, 더욱 상세하게는 케나프(
Hibiscus cannabbinus L., Malvaceae) 추출물과 이로부터 분리된 신규 캠프페롤 화합물이 항균제, 항산화제 등으로 사용할 수 있는 새로운 용도 및 이를 케나프에서 얻는 제조방법에 관한 것으로서, 본 발명의 캠프페롤 화합물이 포함된 약학적 조성물 및 케나프 추출물은 상기 효능이 탁월하여 앞으로 그 이용이 크게 기대된다.
케나프(Hibiscus cannabbinus L., Malvaceae), 캠프페롤 화합물-
公开(公告)号：KR100789737B1
公开(公告)日：2008-01-02
申请号：KR1020060067602
申请日：2006-07-19
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 케나프 차 및 그의 제조방법에 관한 것으로, 더욱 상세하게는 케나프 잎이 플라보노이드, 무기질, 폴리페놀 성분 등의 활성성분을 다량 함유하고 있음을 확인하고 이를 건강차로 활용하고자 하며, 특히 케나프 잎을 일정 조건으로 열처리 및 원적외선 처리하는 경우 온수에 추출되는 활성성분이 녹차보다 높게 나타남을 확인한 케나프 차 및 그의 제조방법에 관한 것이다.
케나프(Hibiscus cannabbinus L., Malvaceae), 차, 원적외선, 녹차-
公开(公告)号：KR100835710B1
公开(公告)日：2008-06-09
申请号：KR1020070095740
申请日：2007-09-20
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 케나프 추출물과 이로부터 분리된 신규 캠프페롤 화합물 및 이의 식품으로서의 용도에 관한 것으로서, 더욱 상세하게는 케나프(
Hibiscus
cannabbinus L., Malvaceae) 추출물과 이로부터 분리된 신규 캠프페롤 화합물이 항균 및 항산화 활성을 나타냄을 밝히고, 이를 식품으로 적용하기 위한 새로운 용도에 관한 것이다.
케나프(Hibiscus cannabbinus L., Malvaceae), 캠프페롤 화합물-
公开(公告)号：KR1020070105812A
公开(公告)日：2007-10-31
申请号：KR1020060067626
申请日：2006-07-19
Applicant: 강원대학교산학협력단
IPC: A61K36/185 , A23L1/29
Abstract: An extract of Hibiscus cannabinus L.(Malvaceae) and a novel kaempferol compound isolated therefrom are provided to inhibit growth of microorganisms, oxidation and aging in the skin without side effects, so that they are useful in medicines, cosmetics and functional food for improving skin beauty. An extract of Hibiscus cannabinus L. having improved antimicrobial and antioxidizing effects is prepared by extracting Hibiscus cannabinus L. with a solvent selected from water, aliphatic alcohol or alcohol solution, hexane, chloroform and ethylacetate. A novel kaempferol compound represented by the formula(1) is isolated from the extract of Hibiscus cannabinus L. by extracting Hibiscus cannabinus L. with methanol, extracting the crude methanol extract with water, aliphatic alcohol, alcohol solution, hexane, chloroform or ethylacetate to obtain a water layer and an organic layer, and subjecting the water layer and organic layer to silica chromatography, gel filtration chromatography and HPLC(high performance liquid chromatography), sequentially.
Abstract translation: 提供木槿大麻提取物和从其中分离出的新型山奈酚化合物，以抑制微生物的生长，皮肤的氧化和老化，而不会有副作用，因此它们可用于改善皮肤的药物，化妆品和功能性食品 美丽。 通过用选自水，脂族醇或醇溶液，己烷，氯仿和乙酸乙酯的溶剂萃取木槿大麻制备具有改善的抗微生物和抗氧化作用的木槿提取物。 用甲醇提取木槿大麻，从木槿提取物中分离出由式（1）表示的新型山奈酚化合物，用水，脂肪醇，醇溶液，己烷，氯仿或乙酸乙酯提取粗甲醇提取物， 得到水层和有机层，依次将水层和有机层进行硅胶色谱，凝胶过滤色谱和HPLC（高效液相色谱）。
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公开(公告)号：KR1020070105811A
公开(公告)日：2007-10-31
申请号：KR1020060067602
申请日：2006-07-19
Applicant: 강원대학교산학협력단
Abstract: Healthy tea with kenaf leaves and a preparation method thereof are provided to facilitate the elution of active ingredients in extraction in hot water by treating the leaves with heat and far infrared ray in a fixed condition, thereby substituting the same for green tea. Healthy tea with kenaf leaves is prepared by the steps of: heating kenaf leaves at 60~100°C for 10~45min; and applying far infrared ray to the leaves at 1.6kw for 10~45min while keeping the temperature at 60~100°C. In the preparation process, large quantities of minerals and antioxidant ingredients are extracted from the kenaf leaves. The extract is especially rich in kaempferols as a polyphenol compound. In addition, the content of physiologically active ingredients in the kenaf leaves is higher than that in green tea leaves.
Abstract translation: 提供具有洋麻叶的健康茶及其制备方法，以便通过用固定状态的热和远红外线处理叶子以促进在热水中萃取中的活性成分的洗脱，从而将其替换为绿茶。 通过以下步骤制备具有红麻叶的健康茶：在60〜100℃下加热洋麻叶10〜45分钟; 并在1.6kw的条件下将远红外线应用10〜45min，同时保持温度在60〜100℃。 在制备过程中，从洋麻叶中提取大量的矿物质和抗氧化成分。 提取物特别富含作为多酚化合物的山奈酚。 此外，洋麻叶中生理活性成分的含量高于绿茶叶。
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