公开(公告)号：KR1020000048105A

公开(公告)日：2000-07-25

申请号：KR1019990057228

申请日：1999-12-13

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K9/107 ,  A61K9/10 ,  B82Y5/00

CPC classification number: A61Q19/007 ,  A61K8/06 ,  A61K8/4993 ,  A61K9/0048 ,  A61K9/1075 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q5/00 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/938 ,  Y10S514/941 ,  Y10S514/942

Abstract: PURPOSE: A nanoemulsion based on fatty esters of oxyethylated or non-oxylated sorbitan is provided, which is stable in preservation; maintains excellent transparency; has good cosmetic property; and contains a lot of oil. An use of the nanoemulsion in the fields of cosmetics, dermatology and/or ophthalmology is also provided. CONSTITUTION: A nanoemulsion based on fatty esters of oxyethylated or non-oxylated sorbitan comprises of: a surfactant being solid under 45°C, selected from sorbitan fatty ester and oxyethylated sorbitan fatty ester; one or more oil having over 400 of molecular weight; more than one of ionic pro-bipolar lipid selected from a group comprising alkalic salt of dicetyl and dimyristyl phosphate, alkalic salt of cholesterol sulfate, alkalic salt of cholesterol phosphate, lipoamino acid, sodium salt of phsphatidic acid, cationic pro-bipolar lipid, and alkyl sulfon derivatives; and weight ratio of oil phase to the surfactant is 2-10, and average size of oil globule of the nanoemulsion is smaller than 100nm.

Abstract translation: 目的：提供基于氧乙基化或非氧化脱水山梨醇的脂肪酯的纳米乳液，其在保存中是稳定的; 保持良好的透明度; 具有良好的化妆品性能; 并含有大量的油。 还提供了在化妆品，皮肤病学和/或眼科学领域中使用纳米乳剂。 构成：基于氧乙基化或非氧化脱水山梨糖醇的脂肪酸酯的纳米乳液包括：在45℃下为固体的表面活性剂，选自脱水山梨醇脂肪酸酯和氧乙基化脱水山梨醇脂肪酸酯; 一种或多种具有超过400分子量的油; 选自包括二鲸蜡基和二肉豆蔻基磷酸的碱性盐，胆固醇硫酸的碱性盐，胆固醇磷酸的碱性盐，脂氨基酸，硫磺酸的钠盐，阳离子亲双酚脂质和 烷基磺酸衍生物; 油相与表面活性剂的重量比为2-10，纳米乳液的油球平均粒径小于100nm。

公开(公告)号：KR1020150023541A

公开(公告)日：2015-03-05

申请号：KR1020147036914

申请日：2012-06-04

Applicant: 로레알

Inventor： 조우시안지 ,  부이히시 ,  시모네쟝-띠에리 ,  리춘후아

IPC: A61K8/35 ,  A61K8/55 ,  A61K8/81 ,  A61Q3/02

CPC classification number: A61K8/8164 ,  A61K8/35 ,  A61K8/55 ,  A61K8/8152 ,  A61K2800/81 ,  A61K2800/95 ,  A61Q3/02

Abstract: 본원에서는 (a) 하나 이상의 에틸렌계 불포화 중합가능한 화합물 및 (b) 약 350 ㎚ 초과의 하나 이상의 흡수 파장을 갖는 1종 이상의 광개시제를 포함한 하나 이상의 광개시제 시스템을 포함하는 화장품 조성물을 개시한다. 또한 본원에서는 (1) 상기 화장품 조성물을 케라틴성 기재에 적용함으로써 케라틴성 기재에 하나 이상의 필름을 형성하고 (2) 필름을 UV-LED 방사선에 노출시키는 것을 포함하는 케라틴성 기재의 외관을 메이크 업 및/또는 개선하는 방법을 개시한다.

公开(公告)号：KR100865061B1

公开(公告)日：2008-10-23

申请号：KR1020060091627

申请日：2006-09-21

Applicant: 로레알

Inventor： 꼴랭-쟝곤크리스틴 ,  시모네쟝-띠에리

IPC: C12N15/113 ,  C12N15/63

CPC classification number: C12N15/1137 ,  A61K8/606 ,  A61K2800/782 ,  A61Q19/02 ,  C12N2310/14 ,  C12Y114/18001

Abstract: 본 발명은 티로시나제 발현을 감소시키는 신규한 이중 가닥 RNA 올리고뉴클레오티드, 미용 및/또는 약학적 목적을 위한 이의 용도 및 제타 전위가 10 내지 80 mV 이고 크기가 1 ㎛ 이하인 양이온성 입자와 이의 결합에 관한 것이다.
티로시나제, RNA 올리고뉴클레오티드, 제타 전위, 양이온성 입자

Abstract translation: 组合物包含至少一种与阳离子颗粒大小和10-80mVζ电位相关联的双链RNA寡核苷酸（I）。 组合物包含至少一种尺寸为1μm的阳离子颗粒相关的双链RNA寡核苷酸（I）（SEQ ID No.1-48，包括在说明书中给出的48个完全限定的19-25个氨基酸序列之一） 10-80mV的ζ电位。 包括用于美容工艺漂白，清除颜色和/或使包含局部施用（I）的褐色皮肤的颜色均匀的独立权利要求。 活动：皮肤病学。 机制：酪氨酸酶表达抑制剂。 （I）对酪氨酸酶信使RNA降解的能力进行了测试。 结果表明，包含本说明书中给出的完全限定的25个氨基酸序列的SEQ ID No.43的双链RNA寡核苷酸表现出99.1％的酪氨酸酶抑制。

公开(公告)号：KR100757724B1

公开(公告)日：2007-09-11

申请号：KR1020057006841

申请日：2003-10-16

Applicant: 로레알

Inventor： 시모네쟝-띠에리

IPC: A61K8/55 ,  B82Y5/00 ,  B82Y40/00

CPC classification number: A61K8/0291 ,  A61K8/06 ,  A61K8/35 ,  A61K8/368 ,  A61K8/4966 ,  A61K8/63 ,  A61K8/90 ,  A61Q1/00 ,  A61Q13/00 ,  A61Q17/04 ,  A61Q19/00 ,  B01F17/0028 ,  B01F17/005 ,  B01F17/0057 ,  B01F17/0064 ,  B01F17/0071

Abstract: 본 발명은 하나 이상의 수성 상에서, 하나 이상의 친유성 화합물을 용해시키는 방법에 관한 것으로서, 상기 친유성 화합물을, 하나 이상의 이온성 및/또는 하나 이상의 비이온성 친수성 중합체 블록, 및 하나 이상의 소수성 중합체 블록을 포함하는, 유효량의 하나 이상의 양쪽친화성 블록 공중합체와 결합하는 단계를 포함하는 것을 특징으로 한다.
친유성 화합물, 화장 조성물

公开(公告)号：KR100447672B1

公开(公告)日：2004-09-08

申请号：KR1020010042132

申请日：2001-07-12

Applicant: 로레알

Inventor： 라로레플로렁스 ,  오브룅-손느빌오딜 ,  시모네쟝-띠에리

IPC: A61K7/00

CPC classification number: A61Q19/007 ,  A61K8/062 ,  A61K9/1075 ,  A61K2800/21 ,  A61K2800/262 ,  B01F17/0028 ,  B01F17/0085 ,  B82Y5/00

Abstract: An oil-in-water nanoemulsion (A) with oil globule size below 100 nm comprising at least one amphiphilic non-ionic or anionic lipid and at least one non-ionic hydrosoluble polymer has a weight ratio of oily phase to amphiphilic lipid of 1.2-10. An oil-in-water nanoemulsion (A) with oil globule size below 100 nm comprising at least one amphiphilic non-ionic or anionic lipid and at least one nonionic hydrosoluble polymer (B) has a weight ratio of oily phase to amphiphilic lipid of 1.2-10. (B) is homo- and copolymers of ethylene oxide, of vinylalcohols, of vinylpyrrolidone, of vinylcaprolactam, or of vinylmethylether; homo- and copolymers of neutral acrylics; (1-2C)alkylcelluloses and their derivatives; or (hydroxy)(1-3C)alkylguar. Independent claims are also included for: (1) a cosmetic or dermatological composition comprising (A); (2) an ophthalmic support containing (A); (3) a pharmaceutical composition containing (A); and (4) a process of thickening a nanoemulsion with the hydrosoluble polymers above.

Abstract translation: 包含至少一种两亲性非离子型或阴离子型脂质和至少一种非离子型水溶性聚合物的油滴尺寸小于100nm的水包油纳米乳液（A）具有的油相与两亲脂质的重量比为1.2- 10。 包含至少一种两亲性非离子型或阴离子型脂质和至少一种非离子型水溶性聚合物（B）的油滴尺寸小于100nm的水包油纳米乳液（A）具有1.2的油相与两亲脂质的重量比 -10。 （B）是环氧乙烷，乙烯醇，乙烯基吡咯烷酮，乙烯基己内酰胺或乙烯基甲基醚的均聚物和共聚物; 中性丙烯酸均聚物和共聚物; （1-2C）烷基纤维素及其衍生物; 或（羟基）（1-3C）烷基瓜尔胶。 独立权利要求还包括：（1）化妆品或皮肤病学组合物，其包含（A）; （2）含有（A）的眼科支架; （3）含有（A）的药物组合物; 和（4）用上述水溶性聚合物增稠纳米乳液的方法。

公开(公告)号：KR100359145B1

公开(公告)日：2002-10-31

申请号：KR1019990057227

申请日：1999-12-13

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K8/49 ,  A61Q19/02 ,  A61K8/04 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61K8/062 ,  A61K8/90 ,  A61K9/0048 ,  A61K9/1075 ,  A61K31/77 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  B01F17/0028 ,  Y10S514/873 ,  Y10S514/937 ,  Y10S514/938

Abstract: 본발명은에틸렌옥시드및 프로필렌옥시드블록공중합체로부터선택된계면활성제, 및분자량이 400 초과인하나이상의오일을함유하며, 계면활성제의양에대한오일상의양의중량비가 2 내지 10인것을특징으로하는, 오일구(球)의수평균크기가 100 nm 미만인나노에멀젼에관한것이다. 사용된계면활성제는예를들어하기식 (I) 의블록공중합체이다: HO(CHO)(CHO)(CHO)H (I) (식중, x, y 및 z 는정수이고, x + z 는 2 내지 100 이고, y 는 14 내지 60 이다). 블록공중합체는바람직하게는 2 내지 16 의 HLB 가지며, 특히상품명 Pluronic L81, Pluronic L92 및 Pluronic L44 (ICI 사) 으로시판되는제품이다. 수득되는에멀젼은투명하며, 저장에대해안정하다. 이는우수한투명도를유지하고우수한화장특성을가지면서다량의오일을함유할수 있다. 이는국부용조성물, 제약학적조성물또는안과학적조성물의구성성분이된다. 본발명은또한, 본발명에따른나노에멀젼의, 화장품및 피부과학분야에서의용도, 특히피부및/또는점막의보습, 및모발의트리트먼트를위한용도, 및눈의트리트먼트를위한안약으로서안과학분야에서의용도에관한것이다.

公开(公告)号：KR100345098B1

公开(公告)日：2002-07-24

申请号：KR1019990059292

申请日：1999-12-20

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K8/20 ,  A61Q11/00

CPC classification number: A61Q19/00 ,  A61K8/06 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  B01F17/0064 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/846 ,  Y10S514/88 ,  Y10S514/912

Abstract: 본발명은인산지방에스테르및 그의옥시에틸렌화유도체에서선택된음이온성계면활성제, 및분자량이 400 이상인하나이상의오일을함유하며, 계면활성제의양에대한오일상의양의중량비율이 2 내지 10인것을특징으로하는, 오일구(球)의수평균크기가 100 nm 미만인나노에멀젼에관한것이다. 사용되는음이온성계면활성제는예를들면, C~C알킬포스페이트의칼륨염, 스테아릴/이소스테아릴알콜과인산의에스테르, 세틸알콜과인산의에스테르 ,트리데실알콜과인산의에스테르, 이들에스테르의옥시에틸렌화유도체, 그리고이들의혼합물로부터선택된다. 수득되는에멀젼은투명하며, 저장에대해안정하다. 이들은우수한투명도를유지하고우수한화장특성을가지면서다량의오일을함유할수 있다. 이들은국소용조성물, 약학용조성물또는안과용조성물을구성할수 있다. 본발명은또한, 본발명에따른나노에멀젼의, 화장및 피부분야에서의용도, 특히피부및/또는점막의보습, 및모발의트리트먼트를위한용도, 및눈의트리트먼트를위한아이로션으로서안 분야에서의용도에관한것이다.

公开(公告)号：KR1020020006606A

公开(公告)日：2002-01-23

申请号：KR1020010042132

申请日：2001-07-12

Applicant: 로레알

Inventor： 라로레플로렁스 ,  오브룅-손느빌오딜 ,  시모네쟝-띠에리

IPC: A61K7/00

CPC classification number: A61Q19/007 ,  A61K8/062 ,  A61K9/1075 ,  A61K2800/21 ,  A61K2800/262 ,  B01F17/0028 ,  B01F17/0085 ,  B82Y5/00

Abstract: PURPOSE: Provided is an oil-in-water nanoemulsion including an oily phase which is dispersed in an aqueous phase and includes oil globules having a number-average size of less than 100nm. Therefore, the nanoemulsion obtained is preferably transparent and stable on storage and may form a composition for topical, preferably cosmetic or dermatological compositions, pharmaceutical compositions and ophthalmological compositions. CONSTITUTION: This nanoemulsion comprises: (i) at least one amphiphilic lipid selected from the group including nonionic amphiphilic lipids and anionic amphiphilic lipids; and (ii) at least one water-soluble nonionic polymer selected from the group including homopolymers and copolymers of ethylene oxide; polyvinyl alcohols; homopolymers and copolymers of vinylpyrrolidone; homopolymers and copolymers of vinylcaprolactam; homopolymers and copolymers of polyvinyl methyl ether; neutral acrylic homopolymers and copolymers; C1-2 alkyl celluloses and their derivatives; C1-3 alkyl guar; C1-3 hydroxyalkyl guar, wherein the weight ratio of the oily phase to the amphiphilic lipid is 1.2 to 10.

Abstract translation: 目的：提供一种包含油相的水包油纳米乳液，其分散在水相中并且包括数均粒径小于100nm的油球。 因此，所获得的纳米乳液优选在储存时是透明的和稳定的，并且可以形成用于局部，优选化妆品或皮肤病学组合物，药物组合物和眼科学组合物的组合物。 构成：该纳米乳液包含：（i）至少一种选自包括非离子两亲性脂质和阴离子两亲性脂质的两亲性脂质; 和（ii）至少一种选自包括环氧乙烷的均聚物和共聚物的水溶性非离子聚合物; 聚乙烯醇; 乙烯基吡咯烷酮的均聚物和共聚物; 乙烯基己内酰胺的均聚物和共聚物; 聚乙烯基甲醚的均聚物和共聚物; 中性丙烯酸均聚物和共聚物; C1-2烷基纤维素及其衍生物; C1-3烷基瓜尔胶 C1-3羟烷基瓜尔胶，其中油相与两亲性脂质的重量比为1.2〜10。

公开(公告)号：KR1020000052462A

公开(公告)日：2000-08-25

申请号：KR1019990057227

申请日：1999-12-13

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K8/49 ,  A61Q19/02 ,  A61K8/04 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61K8/062 ,  A61K8/90 ,  A61K9/0048 ,  A61K9/1075 ,  A61K31/77 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  B01F17/0028 ,  Y10S514/873 ,  Y10S514/937 ,  Y10S514/938

Abstract: PURPOSE: Nanoemulsion based on block copolymers of ethylene oxide and propylene oxide is provided to give the stability of storage, the maintenance of good transparency and the incorporation of bulky oil. In addition to the nanoemulsion above, their use in cosmetics, skin science and/or ophthalmology are provided. CONSTITUTION: A nanoemulsion is comprised of oil phase dispersed in water phase, has less than 100 nm of a number average size of oil small sphere, contains surfactants selected from block copolymers of ethylene oxide and propylene oxide, has also at least one oil having more than 400 of molecular weight, and has 2 to 10 at their ratios of oil phase for amounts of the surfactant. The surfactant is also characterized by selecting from block copolymers represented by formulae HO(C2H4O)x(C3H6O)y(C2H4O)zH (1), wherein x, y and z are integers, x + y is 2 to 100, and y is 14 to 60, and their mixtures, with 2 to 16 of HLB.

Abstract translation: 目的：提供基于环氧乙烷和环氧丙烷的嵌段共聚物的纳米乳液，以提供储存的稳定性，维持良好的透明度和引入大体积的油。 除了上述纳米乳液之外，还提供了它们在化妆品，皮肤科学和/或眼科学中的用途。 构成：纳米乳液由分散在水相中的油相组成，具有小于100nm的数均粒径的油小球，含有选自环氧乙烷和环氧丙烷的嵌段共聚物的表面活性剂，还具有至少一种具有更多的油的油 分子量大于400，对于表面活性剂的用量，油相的比例为2〜10。 表面活性剂的特征还在于选自式HO（C2H4O）x（C3H6O）y（C2H4O）zH（1）表示的嵌段共聚物，其中x，y和z为整数，x + y为2至100，y为 14至60，以及它们的混合物，具有2至16个HLB。

公开(公告)号：KR1020000048451A

公开(公告)日：2000-07-25

申请号：KR1019990063481

申请日：1999-12-28

Applicant: 로레알

Inventor： 리샤르파스칼 ,  시모네쟝-띠에리

IPC: A61K9/51 ,  B82Y5/00

CPC classification number: A61K9/5146 ,  A61K8/11 ,  A61K9/5153 ,  A61K2800/413 ,  A61Q19/00 ,  B01J13/04

Abstract: PURPOSE: A nanocapsule comprising a water-dispersive anionic polymer which effectively protects an active ingredient and makes a manufacturing process of the nanocapsule easy, a method for preparing thereof and a cosmetics or a dermatological composition containing thereof are provided. CONSTITUTION: A nanocapsule comprises: (a) a lipidic core which forms or contains a lipophilic active component; and (b) a water-insoluble, continued polymer envelope, wherein the polymer envelope contains at least one synthetic water-dispersive anionic polymer which is selected from the group consisting of polyester containing a functional group of carboxylic acid and/or sulfonic acid, poly(ester amide), polyurethane and vinyl copolymer and/or a natural water-dispersive anionic polymer which is selected from the group consisting of shellac resin, sandarac gum and dammar resin. The cosmetics or dermatological composition include the nanocapsule in physiologically acceptable carrier. The nanocapsule is prepared by: (i) dissolving a lipidic phase which forms or contains the lipophilic active component and a selective coating agent in an adequate, non-toxic organic solvent having lower boiling point than water; (ii) preparing an aqueous dispersed solution of the water-dispersive anionic polymer; (iii) adding a hydrophilic surfactant to the aqueous dispersed solution of the anionic polymer; (iv) mixing the organic phase prepared from the step (i) with the aqueous phase prepared from the step (iii); and (v) preparing a condensed nanocapsule suspension by evaporating all organic phases and possible, a little aqueous phase.

Abstract translation: 目的：提供一种纳米胶囊，其包含有效保护活性成分并使纳米胶囊制造过程容易的水分散性阴离子聚合物，其制备方法和含有其的化妆品或皮肤病学组合物。 构成：纳米胶囊包含：（a）形成或含有亲脂性活性成分的脂核; 和（b）水不溶性连续的聚合物包封，其中所述聚合物外壳包含至少一种合成水分散阴离子聚合物，其选自含有羧酸和/或磺酸官能团的聚酯，和 （酯酰胺），聚氨酯和乙烯基共聚物和/或天然水分散阴离子聚合物，其选自虫胶树脂，檀香胶和聚乙烯树脂。 化妆品或皮肤病学组合物包括生理上可接受的载体中的纳米胶囊。 纳米胶囊通过以下制备：（i）将形成或含有亲脂性活性成分和选择性涂层剂的脂质相溶解在沸点低于水的适当的无毒有机溶剂中; （ii）制备水分散性阴离子聚合物的水分散溶液; （iii）向阴离子聚合物的分散水溶液中加入亲水性表面活性剂; （iv）将由步骤（i）制备的有机相与步骤（iii）制备的水相混合; 和（v）通过蒸发所有有机相和可能的少量水相来制备缩合的纳米胶囊悬浮液。