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公开(公告)号：KR101161151B1
公开(公告)日：2012-07-02
申请号：KR1020090115872
申请日：2009-11-27
Applicant: 한국과학기술연구원
Abstract: 본 발명은 (a) 코팅 용액을 분사 노즐에 공급하는 공정, (b) 고전압을 인가하여 상기 코팅 용액을 하전시키는 공정, 및 (c) 하전된 코팅 용액을 분사 노즐을 이용하여 분사하여 스텐트 또는 생체 이식물의 표면을 코팅하는 공정을 포함하는, 스텐트 또는 생체 이식물의 표면 코팅 방법, 상기 방법에 이용되는 전기 분사 코팅 장치, 및 표면 코팅된 스텐트 또는 생체 이식물의 제조 방법에 관한 것이다. 본 발명에서는 코팅 두께를 나노미터부터 마이크로미터 수준까지 조절할 수 있고, 다층 구조의 코팅을 형성시킬 수 있으며, 약물 방출형 기능성 코팅을 할 수 있으므로, 다양한 물질의 표면을 코팅하여 부가 가치가 높은 스텐트 또는 생체 이식물을 제공할 수 있다.
스텐트, 생체 이식물, 전기 분사, 코팅, 고분자, 약물, 생리 활성 물질-
公开(公告)号：KR1020110051579A
公开(公告)日：2011-05-18
申请号：KR1020090108221
申请日：2009-11-10
Applicant: 한국과학기술연구원
CPC classification number: B05D7/14 , A61L27/00 , A61L27/28 , A61L27/34 , A61L31/10 , A61L2400/12 , A61L2400/18 , B05D1/18 , B05D3/142 , Y10T428/273 , Y10T428/31678 , C08L67/04
Abstract: PURPOSE: A method for manufacturing a surface-modified metal substrate is provided to simplify process and to reduce production cost. CONSTITUTION: A surface-modified metal substrate contains a metal substrate and polymer layer which is chemically conjugated to the surface through oxygen atoms. A method for manufacturing the surface-modified metal substrate comprises: a step of introducing a hydroxy group to the surface of the metal substrate; a step of polymerizing monomers on the surface to chemically bind polymers onto the surface through oxygen atoms. The metal is selected from stainless steel, covalt-chrome, titanium, nitinol, gold, silver, platinum, tantalum, magnesium, and metal alloy thereof.
Abstract translation: 目的：提供一种制造表面改性金属基材的方法，以简化工艺并降低生产成本。 构成：表面改性的金属基材含有金属基材和通过氧原子与表面化学偶合的聚合物层。 制造表面改性金属基材的方法包括：将羟基引入金属基材的表面的步骤; 在表面上聚合单体以通过氧原子将聚合物化学结合到表面上的步骤。 金属选自不锈钢，钴铬，钛，镍钛诺，金，银，铂，钽，镁及其金属合金。
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公开(公告)号：KR1020110023399A
公开(公告)日：2011-03-08
申请号：KR1020090081256
申请日：2009-08-31
Applicant: 한국과학기술연구원
CPC classification number: A61L24/106 , A61L24/0015 , A61L24/04 , A61L24/08 , A61L33/126
Abstract: PURPOSE: An intelligent fibrin bio-adhesive with superior hemostasis effect and mechanical properties is provided to obtain an anti-bacteria property by adding natural polymer and/or antibiotics. CONSTITUTION: Fibrin and natural polymer form crosslinkage, and interpenetrating network or semi-interpenetrating network is obtained. The natural polymer is one or more selected from a group including alginate, chitosan, chitin, cellulose, agarose, amylase, dextran, proteoglycan, glycosaminoglycan, collagen, gelatin, heparin, hyaluronic acid, pectin, carrageena, chondroitin sulfate, dextran sulfate, polylysine, pullulan, carboxylmethyl chitin, and the salt of the same. Antibiotics are additionally introduced into the interpenetrating network or the semi-interpenetrating network.
Abstract translation: 目的：提供具有优异止血效果和机械性能的智能纤维蛋白生物粘合剂，通过加入天然聚合物和/或抗生素获得抗细菌性能。 构成：纤维蛋白和天然聚合物形成交联，获得互穿网络或半互穿网络。 天然聚合物是选自藻酸盐，壳聚糖，壳多糖，纤维素，琼脂糖，淀粉酶，葡聚糖，蛋白聚糖，糖胺聚糖，胶原，明胶，肝素，透明质酸，果胶，角叉菜胶，硫酸软骨素，硫酸葡聚糖，聚赖氨酸 ，支链淀粉，羧甲基甲壳质及其盐。 抗生素还被引入到互穿网络或半互穿网络中。
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公开(公告)号：KR1020100077770A
公开(公告)日：2010-07-08
申请号：KR1020080135808
申请日：2008-12-29
Applicant: 한국과학기술연구원
CPC classification number: A61L31/16 , A61L31/10 , A61L31/14 , A61L31/148 , A61L2300/61 , A61L2400/12 , A61L2400/18 , A61F2/82 , A61L27/34 , A61L27/54 , C08L67/04
Abstract: PURPOSE: A method of manufacturing a medical stent for releasing medical drugs and a medical stent for releasing medical drugs using the same method are provided, which have the nano-structured pattern using the plasma-assisted chemical vapor deposition. CONSTITUTION: A method of manufacturing medical stent for releasing medical drug having the nano-structured pattern includes: a step of coating the surface of stent with the biodegradable polymer; a step of forming the nano-structured pattern on the surface of the stent coated with the biodegradable polymer through the ion beam or the plasma process using the method of plasma-assisted chemical vapor deposition; and a step of dipping the medical drugs within the biodegradable polymer in which the nano-structured pattern is formed. The biodegradable polymer is the biodegradable polymer in which the medical drugs are dipped.
Abstract translation: 目的：提供一种使用等离子体辅助化学气相沉积制造具有纳米结构图案的用于使用相同方法制造用于释放药物的医用支架和用于释放药物的药物支架的方法。 构成：制造具有纳米结构图案的医药用医用支架的方法，其特征在于，包括以下步骤：用生物降解性聚合物涂布支架表面; 使用等离子体辅助化学气相沉积的方法通过离子束或等离子体处理在涂覆有可生物降解的聚合物的支架的表面上形成纳米结构图案的步骤; 以及将药物浸渍在其中形成纳米结构图案的生物可降解聚合物中的步骤。 可生物降解的聚合物是医用药物浸渍的可生物降解的聚合物。
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公开(公告)号：KR100794174B1
公开(公告)日：2008-01-14
申请号：KR1020060113227
申请日：2006-11-16
Applicant: 한국과학기술연구원
Abstract: A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface is provided to produce the biodegradable porous polymer scaffolds having improved cell affinity and osteoconductivity in a simple and effective manner. A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface includes the steps of: (1) graft-polymerizing a functional group-containing hydrophilic monomer on the surface of a biodegradable porous polymer scaffold; and (2) immersing the obtained functional group-containing polymer scaffold in a simulated body fluid solution to form hydroxyapatite on the surface of the scaffold. The functional group-containing hydrophilic monomer is selected from the group consisting of organic acids having carboxylic acids at the terminals, monomers having phosphoric acids at the terminals, and mixtures thereof.
Abstract translation: 提供了一种在表面上制备具有羟基磷灰石的可生物降解的多孔聚合物支架的方法，以简单且有效的方式制备具有改善的细胞亲和力和骨传导性的可生物降解的多孔聚合物支架。 一种在表面上制备具有羟基磷灰石的可生物降解的多孔聚合物支架的方法包括以下步骤：（1）在可生物降解的多孔聚合物支架的表面上接枝聚合含官能团的亲水单体; 和（2）将获得的含官能团的聚合物支架浸入模拟的体液溶液中以在支架的表面上形成羟基磷灰石。 含官能团的亲水性单体选自末端具有羧酸的有机酸，末端具有磷酸的单体及其混合物。
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Patent Agency Ranking
公开(公告)号：KR100752100B1
公开(公告)日：2007-08-27
申请号：KR1020060104844
申请日：2006-10-27
Applicant: 한국과학기술연구원
Abstract: A cardiovascular system transplanting metallic material is provided to improve blood compatibility by modifying the surface of the metallic material with a sulfobetaine poly(ethylene glycol) derivative having anions. A metallic material has improved blood compatibility by modifying a surface of the metallic material with a sulfobetaine poly(ethylene glycol) derivative of the formula 1, X-R1-PEG-R1-Y, where R1 is one or more functional groups connected by urethane, urea, amide, ester, ether or anhydride comprising 0 to 20 alkyl groups or aryl groups; X is -NCO or -CHO; and Y is sulfobetaine(-N^+ -R2 -SO3^-) as a zwitterionic derivative, wherein R2 is an alkyl group or an aryl group. A manufacturing method of a metallic material of which surface is modified with a sulfobetaine poly(ethylene glycol) derivative comprises the steps of: oxidizing the surface of the metallic material to introduce a hydroxyl group(-OH) into the surface thereof; and chemically bonding the sulfobetaine poly(ethylene glycol) derivative to the hydroxyl group of the metallic material surface.
Abstract translation: 提供心血管系统移植金属材料以通过用具有阴离子的磺基甜菜碱聚（乙二醇）衍生物修饰金属材料的表面来改善血液相容性。 金属材料通过用式1的磺基甜菜碱聚（乙二醇）衍生物X-R1-PEG-R1-Y对金属材料的表面进行改性来改善血液相容性，其中R1是通过氨基甲酸酯连接的一个或多个官能团 ，包含0至20个烷基或芳基的脲，酰胺，酯，醚或酸酐; X是-NCO或-CHO; 并且Y是磺基甜菜碱（-N ^ + -R 2 -SO 3 - ） - 作为两性离子衍生物，其中R 2是烷基或芳基。 其表面用磺基甜菜碱聚（乙二醇）衍生物改性的金属材料的制造方法包括以下步骤：氧化金属材料的表面以将羟基（-OH）引入其表面; 并将磺基甜菜碱聚（乙二醇）衍生物化学结合到金属材料表面的羟基上。
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公开(公告)号：KR102264117B1
公开(公告)日：2021-06-14
申请号：KR1020200019168
申请日：2020-02-17
Applicant: 한국과학기술연구원
IPC: C12N5/0775 , A23L33/10 , A61K35/28 , A61K35/407 , A61P1/16
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公开(公告)号：KR1020170022173A
公开(公告)日：2017-03-02
申请号：KR1020150116841
申请日：2015-08-19
Applicant: 한국과학기술연구원
Abstract: 본발명은조직재생용지지체및 이의제조방법에관한것이다. 일양태에따른조직재생용지지체는생분해성고분자및 세포외기질을이용함으로써조직재생용지지체에요구되는적절한물리적강도및 세포부착및 분화를촉진시키는최적의세포친화적환경을제공할수 있다.
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公开(公告)号：KR1020170000189A
公开(公告)日：2017-01-02
申请号：KR1020150089090
申请日：2015-06-23
Applicant: 한국과학기술연구원
CPC classification number: C12N5/0662 , C12N2320/10 , C12N2506/13 , C12N2513/00 , G01N33/50 , G01N33/5008
Abstract: 간엽세포로부터분화된세포집합체를포함하고, 상기세포집합체는섬유증의병리학적특징을나타내는것인인 비트로섬유증모델, 그의제조방법및 용도를제공한다.
Abstract translation: 提供：体外纤维化模型，其包含从间充质细胞分化的细胞聚集体，所述细胞聚集体显示纤维化的病理特征; 其制备方法; 及其用途。
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