公开(公告)号：KR1020080085358A

公开(公告)日：2008-09-24

申请号：KR1020070026744

申请日：2007-03-19

Applicant: 한국과학기술연구원

Inventor： 정상훈 ,  이은하 ,  이정민 ,  김철영 ,  판철호 ,  이동언 ,  엄병헌

IPC: A61K36/14 ,  A61P3/10

Abstract: A composition comprising the extract, a fraction or an isolated compound of Thuja orientalis is provided to inhibit sorbitol accumulation and non-enzymatic saccharification causing neurological disorder and neurological damage by inhibiting aldose reductase, so that the composition is useful for prevention or treatment of diabetic complications. A composition for prevention or treatment of diabetic complications comprises the extract, a fraction or an isolated compound of Thuja orientalis such as quercitrin which is isolated by (1) extracting Thuja orientalis with water, C1-C4 lower alcohol or a mixture thereof, (2) fractionating the extract of Thuja orientalis with ethyl acetate, and (3) adding CH2Cl2-MeOH or hexane-ethylacetate into the fraction of Thuja orientalis, and is a pharmaceutical or health food composition.

Abstract translation: 提供包含提取物，部分或分离的东方蓟马化合物的组合物以抑制山梨醇积累和非酶促糖化，通过抑制醛糖还原酶引起神经障碍和神经损伤，使得该组合物可用于预防或治疗糖尿病并发症 。 用于预防或治疗糖尿病并发症的组合物包括通过（1）用水，C1-C4低级醇或其混合物（2）提取东方蓟马分离的提取物，部分或分离的东方桦木的化合物，例如槲皮素 ）用乙酸乙酯对东方蓟马的提取物进行分馏，和（3）将甲基叔丁基甲醇或己烷 - 乙酸乙酯加入到东方蓟马馏分中，是一种药物或保健食品组合物。

公开(公告)号：KR101266998B1

公开(公告)日：2013-05-30

申请号：KR1020110102492

申请日：2011-10-07

Applicant: 한국과학기술연구원

Inventor： 노주원 ,  김철영 ,  판철호 ,  정상훈 ,  엄병헌 ,  강경수 ,  유지혜 ,  이희주

IPC: A61K36/28 ,  A61P3/04 ,  A61P3/00

Abstract: 본발명은이고들빼기() 추출물을유효성분으로함유하는체중감량및 비만의예방과치료용조성물에관한것으로, 본발명에따른이고들빼기추출물은고지방식이를섭취한마우스의체중증가저해효과와고지방식이에따른비알코올성지방간억제효과가있으므로, 본발명에따른조성물은체중감량및 비만의예방과치료를위한약제및 건강기능식품에유용하게사용될수 있다.

公开(公告)号：KR1020100089549A

公开(公告)日：2010-08-12

申请号：KR1020090008855

申请日：2009-02-04

Applicant: 한국과학기술연구원

Inventor： 노주원 ,  판철호 ,  정상훈 ,  김철영 ,  엄병헌 ,  이샛별 ,  강경수 ,  유지혜 ,  차광현 ,  구송이 ,  송대근 ,  이은하 ,  이희주 ,  윤지호 ,  김명수 ,  안수용 ,  김종환 ,  강석우

IPC: A23L1/30 ,  A61P35/00 ,  A61K36/282 ,  A23L2/38

CPC classification number: A61K36/28 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/308 ,  A23V2250/21 ,  A23V2300/14 ,  A23V2300/18

Abstract: PURPOSE: A composition containing extract and portions of southernwood wild plants as an active ingredient is provided to activate quinone reductase which is an indicator enzyme for preventing cancer and to activate an antioxidant response element by including extracts and portions of the southernwood wild plants including Adenocaulon himalaicum or Artemisia dubia. CONSTITUTION: A composition for preventing cancers contains extracts and portions of southernwood wild plants including Adenocaulon himalaicum and Artemisia dubia as an active ingredient. The extracts are obtained by extracting dried Adenocaulon himalaicum or Artemisia dubia using alcohol having a carbon number of 1-4 or a mixed solvent. The portions are n-hexane portions, ethylacetate portions, n-butanol portions, or water portions.

Abstract translation: 目的：提供一种含有提取物和南部野生植物部分作为活性成分的组合物，用于活化醌还原酶，该还原酶是预防癌症的指示酶，并通过包括南木野生植物的提取物和部分，包括喜马拉松（Adenocaulon himalaicum） 或艾蒿（Artemisia dubia）。 构成：用于预防癌症的组合物含有南木野生植物的提取物和部分，其中包括Adenocaulon himalaicum和Artemisia dubia作为活性成分。 通过使用碳数为1-4的醇或混合溶剂提取干燥的Adenocaulon himalaicum或艾蒿，得到提取物。 这些部分是正己烷部分，乙酸乙酯部分，正丁醇部分或水部分。

公开(公告)号：KR100946727B1

公开(公告)日：2010-03-12

申请号：KR1020080025000

申请日：2008-03-18

Applicant: 한국과학기술연구원

Inventor： 구송이 ,  이동언 ,  차광현 ,  김철영

IPC: A23B7/01 ,  A23B7/00

Abstract: 초고압 처리를 통해 브로콜리 내의 설포라판 함량을 증폭시키는 방법이 개시된다. 상기 초고압 처리를 이용한 증폭 방법은, 브로콜리로부터 설포라판의 효과적인 증폭이 가능하고 비열처리 방식을 통해 제품 생산 분야에서 에너지 절감이 가능하다.
브로콜리, 설포라판, 글루코시놀레이트, 미로시나제, 초고압, 추출, 증폭

公开(公告)号：KR1020100001627A

公开(公告)日：2010-01-06

申请号：KR1020080061614

申请日：2008-06-27

Applicant: 한국과학기술연구원

Inventor： 엄병헌 ,  판철호 ,  이샛별 ,  이재권 ,  김철영 ,  노주원 ,  송대근 ,  양현옥 ,  김명수

IPC: A61K36/03 ,  A61P29/00

Abstract: PURPOSE: An anti-inflammatory composition containing Desmarestia viridis extract is provided to suppress the expression of iNOS and interleukin-1B without cytotoxicity. CONSTITUTION: An anti-inflammatory pharmaceutical composition contains 0.001~99.9 weight% of Desmarestia viridis extract as an active ingredient. The Desmarestia viridis extract is isolated using water, low alcohol of C1-C4, or their mixture solvent. The low alcohol is methanol or ethanol. A health functional food composition for preventing or relieving inflammation contains the Desmarestia viridis extract as an active ingredient. The daily dose of the Desmarestia viridis extract is 0.1-500 mg/kg.

Abstract translation: 目的：提供含有脱敏乳杆菌提取物的抗炎组合物，以抑制iNOS和白细胞介素-1B的表达而无细胞毒性。 构成：抗炎药物组合物含有0.001〜99.9重量％的脱丝乳杆菌提取物作为活性成分。 使用水，C1-C4的低级醇或其混合溶剂分离脱水乳杆菌提取物。 低级醇是甲醇或乙醇。 用于预防或减轻炎症的健康功能性食品组合物含有作为活性成分的脱丝乳杆菌提取物。 脱甲藻提取物的日剂量为0.1-500mg / kg。

公开(公告)号：KR1020080107049A

公开(公告)日：2008-12-10

申请号：KR1020070054855

申请日：2007-06-05

Applicant: 한국과학기술연구원

Inventor： 정상훈 ,  이은하 ,  판철호 ,  김철영 ,  엄병헌 ,  이동언 ,  송대근 ,  이주영

IPC: A61K36/22 ,  A61P3/10

CPC classification number: A61K36/22 ,  A61K31/34

Abstract: An agent for preventing and treating diabetes complication, and a health food are provided to inhibit the activity of the final sugar product and the aldose reductase. An agent for preventing and treating diabetes complication contains an extract of a lacquer tree (Rhus verniciflua) obtained by using water, an alcohol or their mixture as a solvent. Preferably the agent contains further an organic solvent fraction extracted by using an organic solvent. Preferably the organic solvent is n-hexane, methylene chloride, ethyl acetate or n-butanol.

Abstract translation: 提供了用于预防和治疗糖尿病并发症的药剂和保健食品以抑制最终糖产品和醛糖还原酶的活性。 用于预防和治疗糖尿病并发症的药剂含有通过使用水，醇或其混合物作为溶剂获得的漆树（Rhus verniciflua）的提取物。 优选地，该试剂还含有通过使用有机溶剂提取的有机溶剂级分。 有机溶剂优选为正己烷，二氯甲烷，乙酸乙酯或正丁醇。

公开(公告)号：KR100856486B1

公开(公告)日：2008-09-04

申请号：KR1020070032294

申请日：2007-04-02

Applicant: 한국과학기술연구원

Inventor： 김철영 ,  이희주 ,  정상훈 ,  이동언 ,  엄병헌 ,  판철호 ,  함정엽 ,  차광현 ,  이은하

IPC: A61K36/88

Abstract: A method for extraction of tectoridin and tectorigenin from the rhizomes of Belamcanda chinensis is provided to reduce the extraction time, improve the extraction yield and enhance environment and human affinity by using only water and ethanol as solvent under high temperature and high pressure. The tectoridin and tectorigenin are extracted from the rhizomes of Belamcanda chinensis through SWE(subcritical water extraction) by heating the rhizomes of Belamcanda chinensis in a mixed solvent containing water and 30-100 vol.% of ethanol to high temperature such as 80 deg. C or more, preferably 80-200 deg. C under high pressure condition such as 1-15 MPa.

Abstract translation: 提供了一种从中华白兰地根茎提取t idin素和t ector素的方法，通过在高温高压下仅使用水和乙醇作为溶剂，减少提取时间，提高提取产率，增强环境和人亲和力。 通过SWE（亚临界水提取），通过在含有水和30-100体积％乙醇的混合溶剂中加热中华白兰地根茎至80度的高温，从枸杞子根茎中提取鸢尾苷和t ector素。 ℃以上，优选为80〜200度。 C在高压条件下，如1-15MPa。

公开(公告)号：KR100824365B1

公开(公告)日：2008-04-22

申请号：KR1020060119768

申请日：2006-11-30

Applicant: 한국과학기술연구원

Inventor： 엄병헌 ,  정상훈 ,  김철영 ,  이희주 ,  이은하 ,  이정민

IPC: A61K36/899 ,  A61P3/10

Abstract: A composition comprising an extract of Phyllostachys nigra MUNRO, a fraction thereof or a compound isolated from the fraction is provided to inhibit accumulation of sorbitol, a fundamental cause of nephropathy and neuropathy shown as diabetic complications, by inhibiting aldose reductase, thereby being used as a pharmaceutical composition or a health food for preventing diseases related to the diabetic complications. A method for isolating a compound from Phyllostachys nigra MUNRO comprises the steps of: (a) extracting the Phyllostachys nigra MUNRO with ethanol and filtering the extract; (b) concentrating and freeze-drying the filtrate to obtain an extract; (c) fractionating an ethylacetate layer from the extract using a separation funnel; and (d) subjecting the fraction to silica gel column chromatography using CH2Cl2-MeOH as a solvent to obtain orientin, luteolin 6-C-(6''-O-transcaffeoylglucoside), tricetin 3',4',5'-trimethyl ether 7-O-b-D-glucopyranoside, tricine, p-coumaric acid or cis-coumaric acid. A pharmaceutical composition for preventing or treating diabetic retinopathy, diabetic neuropathy or diabetic nephropathy comprises the obtained compound as an effective ingredient.

Abstract translation: 提供了包含黑曲霉MUNRO提取物，其级分或从该级分分离的化合物的组合物，通过抑制醛糖还原酶来抑制山梨糖醇的积累，其是糖尿病并发症所示的肾病和神经病变的根本原因，因此被用作 药物组合物或用于预防与糖尿病并发症相关的疾病的保健食品。 一种从黑胫虫MUNRO中分离化合物的方法，包括以下步骤：（a）用乙醇萃取黑曲霉MUNRO，过滤提取物; （b）浓缩和冷冻滤液以获得提取物; （c）使用分液漏斗从提取物中分出乙酸乙酯层; 和（d）使用CH 2 Cl 2 -MeOH作为溶剂使级分进行硅胶柱色谱法，得到orientin，木犀草素6-C（6“-O-过氧基葡萄糖苷），三黄素3'，4'，5'-三甲基醚 7-ObD-吡喃葡萄糖苷，tricine，对香豆酸或顺式香豆酸。 用于预防或治疗糖尿病性视网膜病变，糖尿病性神经病变或糖尿病性肾病的药物组合物包含获得的化合物作为有效成分。