-
公开(公告)号：KR1020100077770A
公开(公告)日：2010-07-08
申请号：KR1020080135808
申请日：2008-12-29
Applicant: 한국과학기술연구원
CPC classification number: A61L31/16 , A61L31/10 , A61L31/14 , A61L31/148 , A61L2300/61 , A61L2400/12 , A61L2400/18 , A61F2/82 , A61L27/34 , A61L27/54 , C08L67/04
Abstract: PURPOSE: A method of manufacturing a medical stent for releasing medical drugs and a medical stent for releasing medical drugs using the same method are provided, which have the nano-structured pattern using the plasma-assisted chemical vapor deposition. CONSTITUTION: A method of manufacturing medical stent for releasing medical drug having the nano-structured pattern includes: a step of coating the surface of stent with the biodegradable polymer; a step of forming the nano-structured pattern on the surface of the stent coated with the biodegradable polymer through the ion beam or the plasma process using the method of plasma-assisted chemical vapor deposition; and a step of dipping the medical drugs within the biodegradable polymer in which the nano-structured pattern is formed. The biodegradable polymer is the biodegradable polymer in which the medical drugs are dipped.
Abstract translation: 目的：提供一种使用等离子体辅助化学气相沉积制造具有纳米结构图案的用于使用相同方法制造用于释放药物的医用支架和用于释放药物的药物支架的方法。 构成：制造具有纳米结构图案的医药用医用支架的方法，其特征在于，包括以下步骤：用生物降解性聚合物涂布支架表面; 使用等离子体辅助化学气相沉积的方法通过离子束或等离子体处理在涂覆有可生物降解的聚合物的支架的表面上形成纳米结构图案的步骤; 以及将药物浸渍在其中形成纳米结构图案的生物可降解聚合物中的步骤。 可生物降解的聚合物是医用药物浸渍的可生物降解的聚合物。
-
公开(公告)号：KR100794174B1
公开(公告)日：2008-01-14
申请号：KR1020060113227
申请日：2006-11-16
Applicant: 한국과학기술연구원
Abstract: A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface is provided to produce the biodegradable porous polymer scaffolds having improved cell affinity and osteoconductivity in a simple and effective manner. A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface includes the steps of: (1) graft-polymerizing a functional group-containing hydrophilic monomer on the surface of a biodegradable porous polymer scaffold; and (2) immersing the obtained functional group-containing polymer scaffold in a simulated body fluid solution to form hydroxyapatite on the surface of the scaffold. The functional group-containing hydrophilic monomer is selected from the group consisting of organic acids having carboxylic acids at the terminals, monomers having phosphoric acids at the terminals, and mixtures thereof.
Abstract translation: 提供了一种在表面上制备具有羟基磷灰石的可生物降解的多孔聚合物支架的方法，以简单且有效的方式制备具有改善的细胞亲和力和骨传导性的可生物降解的多孔聚合物支架。 一种在表面上制备具有羟基磷灰石的可生物降解的多孔聚合物支架的方法包括以下步骤：（1）在可生物降解的多孔聚合物支架的表面上接枝聚合含官能团的亲水单体; 和（2）将获得的含官能团的聚合物支架浸入模拟的体液溶液中以在支架的表面上形成羟基磷灰石。 含官能团的亲水性单体选自末端具有羧酸的有机酸，末端具有磷酸的单体及其混合物。
-
公开(公告)号：KR100752100B1
公开(公告)日：2007-08-27
申请号：KR1020060104844
申请日：2006-10-27
Applicant: 한국과학기술연구원
Abstract: A cardiovascular system transplanting metallic material is provided to improve blood compatibility by modifying the surface of the metallic material with a sulfobetaine poly(ethylene glycol) derivative having anions. A metallic material has improved blood compatibility by modifying a surface of the metallic material with a sulfobetaine poly(ethylene glycol) derivative of the formula 1, X-R1-PEG-R1-Y, where R1 is one or more functional groups connected by urethane, urea, amide, ester, ether or anhydride comprising 0 to 20 alkyl groups or aryl groups; X is -NCO or -CHO; and Y is sulfobetaine(-N^+ -R2 -SO3^-) as a zwitterionic derivative, wherein R2 is an alkyl group or an aryl group. A manufacturing method of a metallic material of which surface is modified with a sulfobetaine poly(ethylene glycol) derivative comprises the steps of: oxidizing the surface of the metallic material to introduce a hydroxyl group(-OH) into the surface thereof; and chemically bonding the sulfobetaine poly(ethylene glycol) derivative to the hydroxyl group of the metallic material surface.
Abstract translation: 提供心血管系统移植金属材料以通过用具有阴离子的磺基甜菜碱聚（乙二醇）衍生物修饰金属材料的表面来改善血液相容性。 金属材料通过用式1的磺基甜菜碱聚（乙二醇）衍生物X-R1-PEG-R1-Y对金属材料的表面进行改性来改善血液相容性，其中R1是通过氨基甲酸酯连接的一个或多个官能团 ，包含0至20个烷基或芳基的脲，酰胺，酯，醚或酸酐; X是-NCO或-CHO; 并且Y是磺基甜菜碱（-N ^ + -R 2 -SO 3 - ） - 作为两性离子衍生物，其中R 2是烷基或芳基。 其表面用磺基甜菜碱聚（乙二醇）衍生物改性的金属材料的制造方法包括以下步骤：氧化金属材料的表面以将羟基（-OH）引入其表面; 并将磺基甜菜碱聚（乙二醇）衍生物化学结合到金属材料表面的羟基上。
-
公开(公告)号：KR102264117B1
公开(公告)日：2021-06-14
申请号：KR1020200019168
申请日：2020-02-17
Applicant: 한국과학기술연구원
IPC: C12N5/0775 , A23L33/10 , A61K35/28 , A61K35/407 , A61P1/16
-
-
Patent Agency Ranking
-
-
公开(公告)号：KR1020170022173A
公开(公告)日：2017-03-02
申请号：KR1020150116841
申请日：2015-08-19
Applicant: 한국과학기술연구원
Abstract: 본발명은조직재생용지지체및 이의제조방법에관한것이다. 일양태에따른조직재생용지지체는생분해성고분자및 세포외기질을이용함으로써조직재생용지지체에요구되는적절한물리적강도및 세포부착및 분화를촉진시키는최적의세포친화적환경을제공할수 있다.
-
公开(公告)号：KR1020170000189A
公开(公告)日：2017-01-02
申请号：KR1020150089090
申请日：2015-06-23
Applicant: 한국과학기술연구원
CPC classification number: C12N5/0662 , C12N2320/10 , C12N2506/13 , C12N2513/00 , G01N33/50 , G01N33/5008
Abstract: 간엽세포로부터분화된세포집합체를포함하고, 상기세포집합체는섬유증의병리학적특징을나타내는것인인 비트로섬유증모델, 그의제조방법및 용도를제공한다.
Abstract translation: 提供：体外纤维化模型，其包含从间充质细胞分化的细胞聚集体，所述细胞聚集体显示纤维化的病理特征; 其制备方法; 及其用途。
-
公开(公告)号：KR101270161B1
公开(公告)日：2013-05-31
申请号：KR1020100038221
申请日：2010-04-26
Applicant: 한국과학기술연구원
CPC classification number: C12N5/0075 , A61K9/1647 , A61K9/5036 , C12N2533/40
Abstract: 본발명은세포분화및 증식에필수적인생리활성성장인자를담지할수 있는전달체의제조방법에관한것으로, 성장인자를포함한 2종의성분을하나의캐리어에담지함으로서복수의성장인자들이개별적으로시차를두고방출(temporally controlled release)될수 있는구조로고안된것이특징이다. 구체적으로, (1) 제1 성분을담지한고분자미립구(microsphere)를제조하고나서, 상기고분자미립구를전기적하(electrodropping)방식으로제2 성분이포함된다른고분자층에도입(encapsulation)하여코어-쉘구조를가진마이크로캡슐형태의전달체를제조하는단계, 또는 (2) 제1 성분을담지한고분자용액을전기적하방식으로제2 성분이포함된다른고분자내에도입하여마이크로캡슐형태의전달체를제조하는단계를포함한다. 본발명은또한, 본발명에따른복수의성장인자를담지한마이크로캡슐형전달체를줄기세포와접촉시키는단계를포함하는줄기세포분화방법을제공한다.
-
-
-
-
-
-
-
-
-
Search Results
61
records
(took 0.04 seconds)
