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公开(公告)号：KR101492960B1
公开(公告)日：2015-02-16
申请号：KR1020130010016
申请日：2013-01-29
Applicant: 한국과학기술연구원
IPC: C07D407/04 , A61K31/343
Abstract: 본 발명은 아릴 나프탈렌 리그난 화합물의 신규한 제조방법에 관한 것이다.
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公开(公告)号：KR1020140036734A
公开(公告)日：2014-03-26
申请号：KR1020120103203
申请日：2012-09-18
Applicant: 한국과학기술연구원
Abstract: The present invention provides a method for analyzing acidic herbicides comprising: a step of quantifying analysis objects by using isotope materials in which the elements of the analysis objects are substituted with isotopes as internal standard materials; a step of performing halogen alkylation on the analysis objects and isotope materials; and a step of analyzing the halogen-alkylated analysis objects and isotope materials by injecting the halogen-alkylated analysis objects and isotope materials into a gas chromatography-tandem mass spectrograph. The present invention exhibits excellent precision and accuracy by quantification through an isotope dilution method, enables the analysis of the minimum quantity of acidic herbicides by increasing detection sensitivity through the halogen alkylation step and is able to be applied to various samples by performing quantitative analysis with a tandem mass spectrograph and reducing the disturbance of foundation samples due to medium effects.
Abstract translation: 本发明提供了一种分析酸性除草剂的方法，包括：通过使用同位素材料来定量分析对象的步骤，其中分析对象的元素被同位素替代为内标物质; 在分析对象和同位素材料上进行卤代烷基化的步骤; 以及通过将卤烷基化分析对象和同位素材料注入气相色谱 - 串联质谱仪中分析卤烷基化分析对象和同位素材料的步骤。 本发明通过同位素稀释法进行定量显示出优异的精度和精度，通过提高通过卤代烷基化步骤的检测灵敏度能够分析最小量的酸性除草剂，并能够通过进行定量分析而应用于各种样品 串联质谱仪，由于中等效应，减少了基础样品的干扰。
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公开(公告)号：KR101371361B1
公开(公告)日：2014-03-07
申请号：KR1020120137304
申请日：2012-11-29
Applicant: 한국과학기술연구원
Abstract: The present invention relates to a method for quantifying fatty oil using means IV, and more specifically, to a method for quantifying fatty oil in a living body using means IV. According to one embodiment of the present invention, liquid chromatography (Nanospace SI-2, Shiseido co. Ltd, Tokyo, Japan) with high performance using a sunfire C8 column is used to separate an analyte (triolein, diolein, and monoolein) from an extracted solution. [Reference numerals] (AA) Weight of oil(mg) converted to Sudan IV; (BB) Weight of oil(mg) analyzed to LC/MS; (CC) Sudan recovery rate/Oil recovery rate; (DD) Amount of injected oil(쨉L)
Abstract translation: 本发明涉及使用方法IV定量脂肪油的方法，更具体地，涉及使用方法IV定量生物体中的脂肪油的方法。 根据本发明的一个实施方案，使用具有高性能的Sunfire C8柱的液相色谱（Nanospace SI-2，Shiseido co。Ltd，Tokyo，Japan）将分析物（三油酸甘油酯，二油烯和单油酸酯）从 提取溶液。 （附图标记）（AA）转换为苏丹的油重量（mg）IV; （BB）油液重量（mg）分析至LC / MS; （CC）苏丹回收率/回收率; （DD）注油量（쨉L）
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34.发明公开
公开(公告)号：KR1020130135424A
公开(公告)日：2013-12-11
申请号：KR1020120058960
申请日：2012-06-01
Applicant: 한국과학기술연구원
IPC: C07F5/02 , C07D249/06 , B01J23/72
CPC classification number: B01J23/72 , B01J27/128 , C07D249/06 , C07F5/02
Abstract: The present invention relates to a novel potassium organo-1H-1,2,3-triazole-4-yltrifluoroborate derivative and a manufacturing method thereof. The novel potassium organo-1H-1,2,3- triazole-4-yltrifluoroborate derivative according to the present invention can be usefully used in the manufacture of various kinds of organo 1,2,3-triazole through a general carbon-carbon coupling reaction utilizing a metallic catalyst such as Suzuki-Miyaura coupling, and can be applied to an organic combination reaction, an optical organic material manufacture, medicine production, a medical diagnosis material, a biocompatible material and a bioactive natural material. The manufacturing method for the potassium organo-1H-1,2,3-triazole-4-yltrifluoroborate derivative according to the present invention can manufacture the stable potassium organo-1H-1,2,3-triazole-4-yltrifluoroborate derivative with a single reaction. Accordingly, a manufacturing process is fast, convenient, efficient and economic.
Abstract translation: 本发明涉及一种新型的有机 - 1H-1,2,3-三唑-4-基三氟硼酸钾衍生物及其制造方法。 根据本发明的新型有机基团1H-1,2,3-三唑-4-基三氟硼酸衍生物可用于通过一般碳 - 碳偶联剂制备各种有机-1,2,3-三唑 利用金属催化剂如Suzuki-Miyaura偶联的反应，可以应用于有机组合反应，光学有机材料制造，医药生产，医学诊断材料，生物相容性材料和生物活性天然材料。 本发明的有机-1H-1,2,3-三唑-4-基三氟硼酸钾衍生物的制造方法可以制造稳定的有机-1H-1,2,3-三唑-4-基三氟硼酸钾衍生物， 单反应。 因此，制造过程快速，方便，高效，经济。
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公开(公告)号：KR101028042B1
公开(公告)日：2011-04-08
申请号：KR1020090043849
申请日：2009-05-20
Applicant: 한국과학기술연구원
IPC: G01N33/493 , G01N30/12 , G01N30/72
Abstract: 생체 뇨 시료 내 휘발성 유기 화합물(VOC) 대사체 농도 분석 방법으로서, 생체 뇨 시료로부터 휘발성 유기 화합물 대사체들을 추출하기 위하여 생체 뇨 시료의 pH를 산성으로 조절하고, 산성으로 조절된 생체 뇨 시료로부터 음이온 교환 카트리지를 이용하여 휘발성 유기 화합물 대사체들을 고체상 추출하는 방법을 제공한다. 본 발명의 일실시예에 따른 분석 방법을 이용함으로써, 적은 양의 생체 뇨 시료를 이용해서, 뇨 시료에서의 주요 VOC 대사체들의 농도를 동시에 정확하게 분석할 수 있다. 분석된 VOC 대사체들의 농도를 이용하여, 인체 내 VOC 유입에 따른 영향을 판별하기 위한 지표로 활용할 수 있다.
뇨 시료, 휘발성 유기 화합물, 대사체, 고체상 추출-
Patent Agency Ranking
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公开(公告)号：KR101746495B1
公开(公告)日：2017-06-14
申请号：KR1020150118744
申请日：2015-08-24
Applicant: 한국과학기술연구원
IPC: G01N30/72 , G01N33/483
Abstract: 본발명은생체시료내 디-2-에틸헥실프탈레이트 (di-2-ethylhexyl phthalate) 대사체비를이용한비만진단용키트및 진단을위한기초정보제공방법에관한것이다.
Abstract translation: 本发明涉及在生物样品中使用邻苯二甲酸二-2-乙基己酯代谢物比率的肥胖诊断试剂盒和提供用于诊断的基本信息的方法。
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公开(公告)号：KR1020140027735A
公开(公告)日：2014-03-07
申请号：KR1020120093684
申请日：2012-08-27
Applicant: 한국과학기술연구원
IPC: G01N33/493 , G01N30/72 , C12Q1/34
Abstract: The present invention relates to a method for the simultaneous analysis of a phenol compound in a biological material, and more specifically, to a method for the simultaneous analysis of a phenol compound in a biological material, wherein the method includes a step of adjusting the pH of a living body sample and a step of extracting a phenolic compound from the living body sample in a liquid phase. According to one embodiment of the present invention, the pH of the living body sample is adjusted using potassium carbonate (K2CO3).
Abstract translation: 本发明涉及生物材料中酚类化合物的同时分析方法，更具体地说，涉及生物材料中酚化合物的同时分析方法，其中该方法包括调节pH 的活体样品和从活体样品中以液相萃取酚类化合物的步骤。 根据本发明的一个实施方案，使用碳酸钾（K 2 CO 3）来调节活体样品的pH。
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公开(公告)号：KR1020100124910A
公开(公告)日：2010-11-30
申请号：KR1020090043849
申请日：2009-05-20
Applicant: 한국과학기술연구원
IPC: G01N33/493 , G01N30/12 , G01N30/72
Abstract: PURPOSE: A method for analyzing volatile organic compound(VOC) metabolite concentrate in urine sample is provided to accurately analyze VOC metabolites. CONSTITUTION: A method for analyzing VOC metabolite in urine sample comprises: a extracting VOC metabolite from the urine sample; and a step of performing quantitation by gas chromatography-mass spectrometry(GC-MS) of VOC metabolite. The volume of the urine sample is 0.1-1 mL.
Abstract translation: 目的：提供尿样中挥发性有机化合物（VOC）代谢物浓缩物的分析方法，准确分析VOC代谢产物。 构成：用于分析尿样中VOC代谢物的方法包括：从尿样中提取VOC代谢物; 以及通过VOC代谢物的气相色谱 - 质谱（GC-MS）进行定量的步骤。 尿液体积为0.1-1 mL。
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