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公开(公告)号：KR1020110118859A
公开(公告)日：2011-11-02
申请号：KR1020100038221
申请日：2010-04-26
Applicant: 한국과학기술연구원
CPC classification number: C12N5/0075 , A61K9/1647 , A61K9/5036 , C12N2533/40
Abstract: PURPOSE: A method for preparing a delivery system for supporting physiologically active growth factors which are necessary for cell differentiation and proliferation is provided to maximize stem cell differentiation ability in vitro. CONSTITUTION: A growth factor delivery system comprises a core and shell structure containing two kinds of ingredients which are necessary for cell differentiation or proliferation. The delivery system is in the form of a microsphere of 100-400 um in dianeter. The delivery system is treated with a crosslinking agent of ethyl dimethyl amino propyl carbodiimide, genipin, or glutaraldehyde in the shell. A method for preparing the delivery system comprises: a step of preparing a polymeric microsphere containing a first ingredient needed for cell differentiation or proliferation; and a step of introducing the polymeric microsphere into other polymers containing a second ingredient needed for cell differentiation or proliferation.
Abstract translation: 目的：提供一种用于制备支持细胞分化和增殖所必需的生理活性生长因子的递送系统的方法，以使体外干细胞分化能力最大化。 构成：生长因子递送系统包括含有细胞分化或增殖所必需的两种成分的核心和壳结构。 递送系统为dianeter中100-400微米的微球形式。 递送系统在壳中用乙基二甲基氨基丙基碳二亚胺，天鹅蛋白或戊二醛的交联剂处理。 制备递送系统的方法包括：制备含有细胞分化或增殖所需的第一成分的聚合物微球的步骤; 以及将聚合物微球引入含有细胞分化或增殖所需的第二成分的其它聚合物的步骤。
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32.发明授权생분해성 및 생체친화성이 우수한 조직재생용 주입형 온도감응성 플루로닉 유도체 하이드로겔 및 이의 제조방법 有权具有高生物降解性和组织再生的生物活性的可注射的热致生物衍生水合物及其制备方法
公开(公告)号：KR101001855B1
公开(公告)日：2010-12-17
申请号：KR1020080103809
申请日：2008-10-22
Applicant: 한국과학기술연구원
IPC: C08G65/332 , C08G65/26 , C08J3/075
Abstract: 본 발명은 생분해성 및 생체친화성이 우수한 조직재생용 주입형 온도감응성 생분해 플루로닉(pluronic) 유도체 하이드로겔 및 이의 제조방법에 관한 것으로, 구체적으로 플루로닉 고분자의 한쪽 또는 양쪽 말단에 생분해성 고분자가 도입되고, 상기 생분해성 고분자에 메타크릴옥시에틸 트라이멜리트산(methacryloxyethyl trimellitic acid) 무수물이 결합되고, 상기 메타크릴옥시에틸 트라이멜리트산 무수물의 카르복실기에 생리활성물질이 중합된 구조를 갖는, 조직재생용 주입형 온도감응성 생분해 플루로닉 유도체 하이드로겔 및 이의 제조방법에 관한 것이다. 본 발명에 따른 플루로닉 유도체 하이드로겔은 플루로닉 고분자의 온도감응성(thermosentitive)은 그대로 유지하면서 생분해성 고분자의 도입으로 인해 생체 내에서 일정 기간 후에 분해되어 배설될 수 있는 생분해성(biodegradability)이 탁월하고, 세포증식성 또는 세포분화성을 향상시킬 수 있는 생리활성물질이 결합되어 있어 생체친화성(biocompatibility)이 우수하기 때문에, 인공조직이나 장기를 조직공학적으로 재생하는데 유용하게 사용될 수 있다.
조직재생, 하이드로겔, 플루로닉 유도체, 생분해성, 생체친화성, 생리활성물질-
公开(公告)号：KR1020090131975A
公开(公告)日：2009-12-30
申请号：KR1020080058006
申请日：2008-06-19
Applicant: 한국과학기술연구원
CPC classification number: A61K9/1647 , A61K9/1694 , A61K38/00
Abstract: PURPOSE: A method for preparing biodegradable covered porous polymer microspheres is provided to control a pore size of microspheres, and to prepare porous polymer microspheres capable of ensuring sustained release control and persistence of a sealed drug. CONSTITUTION: A method for preparing biodegradable covered porous polymer microspheres comprises the steps of: dissolving or suspending a bio-active material in a polymer solution that a biodegradable polymer is dissolved in an organic solvent to prepare a polymer solution containing a bio-active material; adding a hydrogen peroxide-containing compound to the polymer solution and mixing the mixture to prepare water-in-oil type emulsion; emulsifying the water-in-oil type emulsion in a emulsion stabilizer solution to prepare oil-in-water type emulsion; and adding a hydrogen peroxide decomposition catalyst to the oil-in-water type emulsion to degrade hydrogen peroxide and evaporate organic solvent.
Abstract translation: 目的：提供一种制备可生物降解的覆盖多孔聚合物微球的方法，以控制微球的孔径，并制备能够确保密封药物的持续释放控制和持久性的多孔聚合物微球。 构成：制备可生物降解的覆盖多孔聚合物微球的方法包括以下步骤：将生物活性物质溶解或悬浮在可生物降解聚合物溶于有机溶剂中的聚合物溶液中以制备含有生物活性物质的聚合物溶液; 向聚合物溶液中加入含过氧化氢的化合物，混合该混合物以制备油包水型乳液; 将油包水型乳液乳化在乳化稳定剂溶液中以制备水包油型乳液; 并向水包油型乳液中加入过氧化氢分解催化剂以降解过氧化氢并蒸发有机溶剂。
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公开(公告)号：KR100786648B1
公开(公告)日：2007-12-21
申请号：KR1020060104859
申请日：2006-10-27
Applicant: 한국과학기술연구원
Abstract: A photopolymerizable composite material composition for dental service and orthopedics is provided to improve physical properties, mechanical properties and biocompatibility. A photopolymerizable composite material composition comprises 5-95 wt% of an organic matrix component; and 5-95 wt% of an inorganic filler. The organic matrix component comprises 15-80 wt% of a multifunctional methacrylate prepolymer selected from a bifunctional methacrylate prepolymer represented by the formula 2, a trifunctional methacrylate prepolymer represented by the formula 3, a tetrafunctional methacrylate prepolymer represented by the formula 4 and their mixture; 5-50 wt% of a diluent; 1-40 wt% of a polymerization monomer; 0.1-10 wt% of a photoinitiator; and 0.1-10 wt% of other additives, wherein n is a number of 0-2; and R is H, CH3, CH2CH3 or -C(CH3)3.
Abstract translation: 提供用于牙科服务和骨科的可光聚合复合材料组合物以改善物理性能，机械性能和生物相容性。 可光聚合复合材料组合物包含5-95重量％的有机基质组分; 和5-95重量％的无机填料。 有机基质组分包含15-80重量％的选自由式2表示的双官能甲基丙烯酸酯预聚物，由式3表示的三官能甲基丙烯酸酯预聚物，由式4表示的四官能甲基丙烯酸酯预聚物及其混合物的多官能甲基丙烯酸酯预聚物; 5-50重量％的稀释剂; 1-40重量％的聚合单体; 0.1-10重量％的光引发剂; 和0.1-10重量％的其它添加剂，其中n为0-2的数; 且R为H，CH 3，CH 2 CH 3或-C（CH 3）3。
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公开(公告)号：KR100760511B1
公开(公告)日：2007-10-04
申请号：KR1020060113167
申请日：2006-11-16
Applicant: 한국과학기술연구원
Abstract: A method for preparing a biodegradable porous polymer scaffold is provided to produce a biodegradable porous polymer scaffold for tissue engineering, which has no phenomena for pore clogging and harmful substances excretion and remain, and has an open structure with higher surface area and porosity. A method for preparing a biodegradable porous polymer scaffold for tissue engineering comprises the steps of: (a) adding a hydrogen peroxide-containing compound to a polymer solution which is obtained by dissolving a biodegradable polymer into a solvent, and mixing the resulting solution homogeneously; (b) allowing the solution obtained in the step (a) to stand at a temperature of -196 deg.C to a normal temperature so as to evaporate the solvent; and (c) introducing the polymer specimen obtained in the step (b) into an aqueous solution containing a catalyst for decomposition of hydrogen peroxide and foaming the resultant, followed by drying.
Abstract translation: 提供了一种制备可生物降解的多孔聚合物支架的方法，以生产组织工程的生物可降解多孔聚合物支架，其不存在孔堵塞和有害物质排泄现象，并具有较高表面积和孔隙率的开放结构。 制备用于组织工程的可生物降解的多孔聚合物支架的方法包括以下步骤：（a）向通过将可生物降解的聚合物溶解到溶剂中而获得的聚合物溶液中加入含过氧化氢的化合物，并均匀混合所得溶液; （b）使步骤（a）中得到的溶液在-196℃的温度下放置在常温下使溶剂蒸发; 和（c）将步骤（b）中获得的聚合物样品引入含有用于分解过氧化氢的催化剂的水溶液中并使所得物发泡，然后干燥。
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Patent Agency Ranking
公开(公告)号：KR100590132B1
公开(公告)日：2006-06-15
申请号：KR1020030013271
申请日：2003-03-04
IPC: A61K6/00
CPC classification number: A61K6/0023 , C08L33/00
Abstract: 본 발명은 치과용 접착제 조성물에 관한 것으로, 생체와 조성물의 내수성, 강도, 접착, 색조 및 저장 안정성에 영향을 미치는 일정 온도 범위 및 습윤 범위 내에서 경화성이 우수한 치과용 접착성 조성물에 관한 것이다. 구체적으로 복합레진과 치아와의 접착성을 향상시키는 기존의 제품인 2,2-비스(4-(2-히드록시-3-메타크릴로일옥시프로폭시)페닐)프로판(Bis-GMA)에, 이 Bis-GMA 분자 중의 히드록시기 (-OH)의 수소원자를 메타크릴레이트기로 치환한 멀티메타크릴레이트기 함유 다관능성 프리폴리머를 혼합한 프리폴리머 혼합물을 기재로 하고, 접착 단량체, 친수성 단량체, 광개시제 및 환원제, 희석용매를 함유하는 것을 특징으로 하며, 본 발명의 조성물은 Bis-GMA를 포함하는 종래의 것보다 법랑질 및 상아질에 접착효과가 좋을 뿐만 아니라 우수한 물리적 특성을 보이고 시술을 간편하게 하는 효과를 나타낸다.
치과용 접착제, 다관능성 프리폴리머 혼합물, 접착 단량체, 친수성 단량체, 광경화성, 법랑질 접착, 상아질 접착-
公开(公告)号：KR1020050116927A
公开(公告)日：2005-12-14
申请号：KR1020040042043
申请日：2004-06-09
CPC classification number: A61K6/0023 , Y10S522/908 , C08L33/00
Abstract: 본 발명은 1단계 시술을 위한 치과용 고기능성 접착제 조성물에 관한 것으로, 본 발명에 따른 조성물은 2,2-비스[4-(2-히드록시-3-메타크릴로일옥시프로폭시)페닐]프로판 (이하, "Bis-GMA"라 칭함)에, 이 Bis-GMA 분자 중의 히드록시기의 수소 원자를 메타크릴레이트기로 치환한 멀티메타크릴레이트기 함유 다관능성 프리폴리머를 혼합한 프리폴리머 혼합물을 기재로 하고, 산성 단량체, 접착 단량체, 친수성 단량체, 희석 용매, 물, 무기 충전재, 광개시제 시스템을 포함하는 1단계 광중합형 치과용 고기능성 접착제 조성물에 관한 것이다. 본 발명의 조성물은 산부식제 처리 없이도 접착효과가 좋을 뿐만 아니라 치아와의 접착성이 뛰어나고 지각과민 현상 억제와 항우식성 등의 뛰어난 물성을 나타내고 생체 친화성도 우수한 효과를 나타낸다.
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公开(公告)号：KR1020020004331A
公开(公告)日：2002-01-16
申请号：KR1020000038132
申请日：2000-07-05
IPC: A61K6/00
CPC classification number: C08F2/46 , A61K6/083 , C08F222/1006 , C08F2222/1046 , Y10S522/908 , C08F2222/1033 , C08F2222/1013 , C08L33/00
Abstract: PURPOSE: A photopolymerizable composite resin composition for dental restoration using a multifunctional prepolymer mixture as a base material is provided, which has increased biocompatibility as well as exhibiting better physical and mechanical properties as compared to conventional compositions based on only Bis-GMA itself. CONSTITUTION: This composite resin composition comprises 2 to 40% by weight of multifunctional prepolymer mixture of 2,2-bis-(4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl)propane ("Bis-GMA") of formula 1 and tri-GMA of formula 2 in a ratio of 95:5 to 5:95, 1 to 20% by weight of a diluent, 40 to 95% by weight of an inorganic filler, a photoinitiation system, and other additives. The composition has almost no cytotoxicity and high strength and hardness.
Abstract translation: 目的：提供一种使用多官能预聚物混合物作为基础材料的用于牙科修复的可光聚合复合树脂组合物，与仅基于Bis-GMA本身的常规组合物相比，其具有增加的生物相容性以及表现出更好的物理和机械性能。 构成：该复合树脂组合物包含2至40重量％的式1的2,2-双 - （4-（2-羟基-3-甲基丙烯酰氧基丙氧基）苯基）丙烷（“Bis-GMA”）的多官能预聚物混合物和 式2的三-GMA比例为95:5至5:95,1至20重量％的稀释剂，40至95重量％的无机填料，光引发体系和其它添加剂。 该组合物几乎没有细胞毒性和高强度和硬度。
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公开(公告)号：KR1020010038527A
公开(公告)日：2001-05-15
申请号：KR1019990046514
申请日：1999-10-26
Applicant: 한국과학기술연구원
IPC: C07D263/54
Abstract: PURPOSE: The pyridyl benzoxazole derivatives, their copolymers, and a fluorescence image making method are provided, thereby the pyridyl benzoxazole copolymers have good sensor properties in solution, film and particle status, so that they can be used as recording materials or sensor materials. CONSTITUTION: The pyridyl benzoxazole derivative is represented by formula (1), in which A and B are independently CH and N; R1 is alkyl or phenyl; R2 is O or NH, R3 is vinyl, acryl, allyl, alpha-methylvinyl or 4-vinylphenyl; m is an integer from 0 to 20. The pyridyl benzoxazole copolymer represented by formula (2) is produced by radical polymerization of comonomer selected from the group consisting of pyridyl benzoxazole derivatives, styrene, maleimide and methacrylate, in which A and B are independently CH and N; R1 is alkyl or phenyl; R2 is O or NH, m is an integer from 0 to 20; R4 is hydrogen or methyl; R5 is methyloxycarbonyl or phenyl; and x and y are integer from 10 to 5000. The fluorescence image making method comprises the steps of: dissolving pyridyl benzoxazole copolymer of formula (2) wherein A is CH and B is N, AIBN, organic acid or inorganic acid in an organic solvent; coating the solution on board and drying to form a thin layer; prebaking the thin layer; and exposing the thin layer to light using photomask and post-exposure baking it.
Abstract translation: 目的：提供吡啶基苯并恶唑衍生物，其共聚物和荧光图像制备方法，因此吡啶基苯并恶唑共聚物在溶液，膜和颗粒状态下具有良好的传感器性质，因此可用作记录材料或传感器材料。 构成：吡啶基苯并恶唑衍生物由式（1）表示，其中A和B独立地为CH和N; R1是烷基或苯基; R2是O或NH，R3是乙烯基，丙烯基，烯丙基，α-甲基乙烯基或4-乙烯基苯基; m是0至20的整数。由式（2）表示的吡啶基苯并恶唑共聚物是通过选自吡啶基苯并恶唑衍生物，苯乙烯，马来酰亚胺和甲基丙烯酸酯的共聚单体的自由基聚合制备的，其中A和B独立地为CH 和N; R1是烷基或苯基; R2是O或NH，m是0至20的整数; R4是氢或甲基; R5是甲氧基羰基或苯基; 荧光图像的制造方法包括以下步骤：将有机溶剂中A为CH且B为N的式（2）的吡啶基苯并恶唑共聚物，AIBN，有机酸或无机酸溶解 ; 将溶液涂布在板上并干燥以形成薄层; 预制薄层; 并使用光掩模将该薄层曝光并曝光后烘烤。
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公开(公告)号：KR1020010038524A
公开(公告)日：2001-05-15
申请号：KR1019990046511
申请日：1999-10-26
Applicant: 한국과학기술연구원
IPC: C07C50/16
CPC classification number: Y02P20/55
Abstract: PURPOSE: Provided are hydroxy protected 1,4-dihydroxyanthraquinone derivatives used as a precursor of material for forming fine fluorescent image, copolymers thereof applied to material for recording and a sensor, and a process for forming the fine fluorescent image by using the copolymers. CONSTITUTION: The hydroxy protected 1,4-dihydroxyanthraquinone derivatives are represented by the formula (1), and the copolymers thereof represented by the formula (2) are produced by radical polymerizing the hydroxy protected 1,4-dihydroxyanthraquinone derivatives and comonomers selected from the group consisting of styrene, maleimide, and methacrylate in the presence of a polymerization initiator. And the process for forming the fine fluorescent image comprises the steps of: dissolving the copolymers containing the hydroxy protected 1,4-dihydroxyanthraquinone and a photoacid generator in an organic solvent; spreading the solution on a substrate and drying to from a thin film; prebaking the thin film coated substrate; treating under the condition of chemical amplification to remove the hydroxy protecting group from the copolymers. In the formula, R1 is hydroxy protecting group, one of A and B is H, R2 is O or NH, R3 is vinyl, alpha-methyl vinyl, or 4-biphenyl, one of C and D is H and the other is represented by the formula (c) or (d), R4 is hydrogen or methyl, R5 is methyloxycarbonyl or phenyl, m is an integer of 0-20, x and y are independently an integer of 10-5000.
Abstract translation: 目的：提供用作形成细荧光图像的材料的前体的羟基保护的1,4-二羟基蒽醌衍生物，其用于记录材料的共聚物和传感器，以及通过使用该共聚物形成微细荧光图像的方法。 构成：羟基保护的1,4-二羟基蒽醌衍生物由式（1）表示，其由式（2）表示的共聚物通过自由基聚合羟基保护的1,4-二羟基蒽醌衍生物和选自以下的共聚单体制备： 在聚合引发剂存在下由苯乙烯，马来酰亚胺和甲基丙烯酸酯组成的组。 并且形成细荧光图像的方法包括以下步骤：将含有羟基保护的1,4-二羟基蒽醌和光致酸产生剂的共聚物溶解在有机溶剂中; 将溶液铺展在基材上并从薄膜干燥; 预烘烤薄膜涂布基材; 在化学扩增条件下处理以从共聚物中除去羟基保护基团。 在该式中，R 1是羟基保护基，A和B之一是H，R 2是O或NH，R 3是乙烯基，α-甲基乙烯基或4-联苯基，C和D之一是H，另一个被表示 通过式（c）或（d），R 4是氢或甲基，R 5是甲氧基羰基或苯基，m是0-20的整数，x和y独立地是10-5000的整数。
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