公开(公告)号：BR9813319A

公开(公告)日：2000-08-22

申请号：BR9813319

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： LY TAM PHAN ,  OR YAT SUN ,  CHU DANIEL T ,  PLATTNER JACOB J ,  CHEN YAN ,  CLARK RICHARD F

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：NO20002190L

公开(公告)日：2000-06-29

申请号：NO20002190

申请日：2000-04-27

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  OR YAT SUN ,  CHU DANIEL T ,  PLATTNER JACOB J ,  CHEN YAN ,  CLARK RICHARD F

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07H

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：NO20002190A

公开(公告)日：2000-06-29

申请号：NO20002190

申请日：2000-04-27

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  OR YAT SUN ,  CHU DANIEL T ,  PLATTNER JACOB J ,  CHEN YAN ,  CLARK RICHARD F

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07H

CPC classification number: C07H17/08 ,  Y02P20/55

公开(公告)号：AU1288199A

公开(公告)日：1999-05-17

申请号：AU1288199

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  OR YAT SUN ,  CHU DANIEL T ,  PLATTNER JACOB J ,  CHEN YAN ,  CLARK RICHARD F

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：CA2307788A1

公开(公告)日：1999-05-06

申请号：CA2307788

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： PLATTNER JACOB J ,  CHU DANIEL T ,  OR YAT SUN ,  CHEN YAN ,  CLARK RICHARD F ,  PHAN LY TAM

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：ZA989845B

公开(公告)日：1999-04-29

申请号：ZA989845

申请日：1998-10-28

Applicant: ABBOTT LAB

Inventor： PHAN LY T ,  OR YAT S ,  CHU DANIEL T ,  PLATTNER JACOB J ,  CHEN YAN ,  CLARK RICHARD F

IPC: A61K20060101 ,  A61K31/70 ,  C07D20060101 ,  C07H17/08 ,  C07D ,  A61K

公开(公告)号：UA102503C2

公开(公告)日：2013-07-25

申请号：UAA200903345

申请日：2007-09-07

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  DIXON RICHARD W ,  BELK JONATHAN P ,  YING HUA ,  ARGIRIADI MARIA A ,  CUFF CAROLYN A ,  HINTON PAUL R ,  KUMAR SHANKAR ,  MELIM TERRY L ,  CHEN YAN

IPC: C07K16/24 ,  A61K39/395 ,  A61P37/00 ,  C07K14/00 ,  C12N15/13 ,  C12P21/08

Abstract: Изобретениеотноситсяк белку (антителу), способномусвязыватьсяс IL-13, конъюгатуантитела, выделенноймолекуленуклеиновойкислоты, вектору, клетке-хозяина, способуполучениябелка. Изобретениетакжеотноситсяк фармацевтическойкомпозиции, способулеченияу индивидазаболеванияилинарушения, вкоторомактивность IL-13 отрицательновлияетназдоровье, способууменьшенияактивности IL-13 уиндивидаи т.п.

公开(公告)号：NO20091411A

公开(公告)日：2009-05-22

申请号：NO20091411

申请日：2009-04-07

Applicant: ABBOTT LAB

Inventor： HINTON PAUL R ,  BELK JONATHAN P ,  DIXON RICHARD W ,  KUMAR SHANKAR ,  WU CHENGBIN ,  YING HUA ,  ARGIRIADI MARIA A ,  CUFF CAROLYN A ,  MELIM TERRY L ,  CHEN YAN

IPC: C07K16/28 ,  A61K39/395 ,  A61P37/00 ,  C07K16/46 ,  C12N5/06 ,  C12N5/10 ,  C12N15/13 ,  C12P21/08

CPC classification number: A61K45/06 ,  A61K38/00 ,  A61K39/3955 ,  C07K14/47 ,  C07K16/244 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/463 ,  Y02A50/473 ,  Y02A50/478 ,  Y02A50/481

Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.

公开(公告)号：CR10656A

公开(公告)日：2009-05-22

申请号：CR10656

申请日：2009-03-06

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  DIXON RICHARD W ,  BELK JONATHAN P ,  YING HUA ,  ARGIRIADI MARIA A ,  CUFF CAROLYN A ,  HINTON PAUL ,  KUMAR SHANKAR ,  MELIM TERRY L ,  CHEN YAN

IPC: C07H21/00 ,  C07K14/00 ,  C07K16/00 ,  C12N1/15 ,  C12N1/16 ,  C12N1/21 ,  C12N5/00 ,  C12N5/04 ,  C12P21/00

Abstract: Proteinas de union a IL-13. Especificamente, la invencion se relaciona con anticuerpos que son quimericos, con injertos de CDR y anticuerpos humanizados. Los anticuerpos preferidos tienen gran afinidad por la hIL-13 y neutralizan la actividad de la hIIL-13 in vitro e in vivo. Un anticuerpo de la invencion puede ser un anticuerpo de longitud completa o una porcion de union al antigeno del mismo.

公开(公告)号：CA2307788C

公开(公告)日：2008-05-20

申请号：CA2307788

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  OR YAT SUN ,  CHU DANIEL T ,  CLARK RICHARD F ,  CHEN YAN ,  PLATTNER JACOB J

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention , and processes for their preparation.