公开(公告)号：HK1016585A1

公开(公告)日：1999-11-05

申请号：HK99101462

申请日：1999-04-09

Applicant: ABBOTT LAB

Inventor： SHAM HING LEUNG ,  NORBECK DANIEL W ,  CHEN XIAOQI ,  BETEBENNER DAVID A ,  KEMPF DALE J ,  HERRIN THOMAS R ,  KUMAR GONDI N ,  CONDON STEPHEN L ,  COOPER ARTHUR J ,  DICKMAN DANIEL A ,  HANNICK STEVEN M ,  KOLACZKOWSKI LAWRENCE ,  OLIVER PATRICIA A ,  PLATA DANIEL J ,  STENGEL PETER J ,  STONER ERIC J ,  TIEN JIEH-HEH J ,  LIU JIH-HUA ,  PATEL KETAN M

IPC: A61K31/00 ,  A61K31/40 ,  C07D253/00 ,  A61K31/4015 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/421 ,  A61K31/425 ,  A61K31/427 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/505 ,  A61K31/513 ,  A61K31/53 ,  A61K31/55 ,  A61K38/05 ,  A61K45/00 ,  A61P31/18 ,  A61P43/00 ,  C07C231/12 ,  C07C235/20 ,  C07C273/18 ,  C07C275/16 ,  C07D20060101 ,  C07D207/22 ,  C07D207/26 ,  C07D207/27 ,  C07D207/273 ,  C07D207/34 ,  C07D207/40 ,  C07D207/404 ,  C07D207/408 ,  C07D207/416 ,  C07D211/72 ,  C07D211/84 ,  C07D223/06 ,  C07D233/28 ,  C07D233/30 ,  C07D233/32 ,  C07D233/36 ,  C07D233/40 ,  C07D233/42 ,  C07D233/66 ,  C07D239/06 ,  C07D239/10 ,  C07D239/20 ,  C07D239/22 ,  C07D241/06 ,  C07D241/08 ,  C07D241/18 ,  C07D243/04 ,  C07D253/06 ,  C07D263/16 ,  C07D263/20 ,  C07D263/22 ,  C07D263/34 ,  C07D265/04 ,  C07D267/04 ,  C07D277/12 ,  C07D277/32 ,  C07D277/34 ,  C07D279/06 ,  C07D281/02 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D ,  A61K

Abstract: A compound comprising a substituent of the formula (II) is disclosed as an HIV protease inhibitor. Intermediates for making such compounds and processes for making such intermediates are also disclosed.

公开(公告)号：CA1224783A

公开(公告)日：1987-07-28

申请号：CA466225

申请日：1984-10-24

Applicant: ABBOTT LAB

Inventor： FLENTGE CHARLES A ,  HERRIN THOMAS R

IPC: C07F9/40 ,  C07F9/553 ,  C07F9/6512 ,  C07F9/65

Abstract: The present invention relates to novel conjugates of phenobarbital and carbamazepine which can be used as tracers for acetylcholinesterase in immunoassays for the determination of phenobarbital and carbamazepine in serum or plasma, said conjugates having the formula: wherein R2 is selected from the group consisting of: and and wherein Z is a biologically compatible counter ion, n and m are each independently an integer from 2 to 6, and R and R1 are each independently lower alkyl.

公开(公告)号：CA1085833A

公开(公告)日：1980-09-16

申请号：CA275054

申请日：1977-03-29

Applicant: ABBOTT LAB

Inventor： HERRIN THOMAS R ,  FAIRGRIEVE JOHN S

IPC: A61K31/66 ,  A61P31/12 ,  C07F9/38 ,  C07F9/40

Abstract: A method of treating herpes simplex infections in warm-blooded animals by administering to said animals a carboxylic ester of phosphonoacetic acid of the formula (I) wherein R is a C3-C8 alkyl, aralkyl, , adamantyl, or glyceryl esters of the formula where R' is an alkyl of 2-20 carbon atoms, or its inorganic salts.