公开(公告)号：EP0973777A1

公开(公告)日：2000-01-26

申请号：EP98913418.4

申请日：1998-04-10

Applicant: Abbott Laboratories

Inventor： ELLIOTT, Richard, L. ,  RYTHER, Keith, B. ,  HOLLADAY, Mark, W. ,  WASCIAK, James, T. ,  DAANEN, Jerome, F. ,  LIN, Nan-Horng ,  DART, Michael, J. ,  HE, Yun ,  LI, Yihong

IPC: C07D491/048 ,  A61K31/435 ,  C07D495/04 ,  C07D519/00

CPC classification number: C07D491/04 ,  A61K31/4355

Abstract: Novel heterocyclic ether compounds having formula (I) wherein A, m, R, X, Y?1, Y2 and Y3¿ are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：EP1682555A1

公开(公告)日：2006-07-26

申请号：EP04800653.0

申请日：2004-11-03

Applicant: ABBOTT LABORATORIES

Inventor： TAO, Zhi-Fu ,  LIN, Nan-Horng ,  WANG, Le ,  SOWIN, Thomas, J. ,  SULLIVAN, Gerard, M. ,  TONG, Yunsong ,  PRZYTULINSKA, Magdalenna ,  LI, Gaoquan

IPC: C07D498/08 ,  C07D498/18 ,  A61K31/4995 ,  A61K31/395 ,  A61P35/00

CPC classification number: C07D498/08 ,  C07D498/18

Abstract: Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds

公开(公告)号：EP1339695B1

公开(公告)日：2006-04-19

申请号：EP01273519.7

申请日：2001-11-30

Applicant: ABBOTT LABORATORIES

Inventor： CLAIBORNE, Akiyo, K. ,  GWALTNEY, Stephen, L, II ,  HASVOLD, Lisa, A. ,  LI, Qun ,  LI, Tomgmei ,  LIN, Nan-Horng ,  MANTEI, Robert, A. ,  ROCKWAY, Todd, W. ,  SHAM, Hing, L. ,  SULLIVAN, Gerard, M. ,  TONG, Yunsong ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WANG, Weibo

IPC: C07D233/64 ,  A61K31/4164 ,  C07D401/12 ,  A61P35/00

CPC classification number: C07D233/64 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

Abstract translation: 具有式（I）的取代的咪唑和噻唑可用于抑制法尼基转移酶。 还公开了法尼基转移酶抑制组合物和抑制患者中法尼基转移酶的方法。

公开(公告)号：EP1606268A1

公开(公告)日：2005-12-21

申请号：EP04715097.4

申请日：2004-02-26

Applicant: ABBOTT LABORATORIES

Inventor： HASVOLD, Lisa, A. ,  HEXAMER, Laura ,  LI, Gaoquan ,  LIN, Nan-Horng ,  SHAM, Hing ,  SOWIN, Tom ,  SULLIVAN, Gerard, M. ,  WANG, Le ,  XIA, Ping Xia

IPC: C07D243/38 ,  A61K31/551 ,  A61P35/00

CPC classification number: C07D243/38 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D491/10

Abstract: Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：EP1603885A1

公开(公告)日：2005-12-14

申请号：EP04717503.9

申请日：2004-03-04

Applicant: ABBOTT LABORATORIES

Inventor： TONG, Yunsong ,  CLAIBORNE, Akiyo, K. ,  LI, Gaoquan ,  LIN, Nan-Horng ,  SHAM, Hing ,  TAO, Zhi-Fu ,  SOWIN, Tom

IPC: C07D231/54 ,  C07D401/06 ,  C07D401/04 ,  C07D403/10 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D405/12 ,  C07D417/12 ,  C07D403/04 ,  A61K31/416 ,  A61P35/00

CPC classification number: C07D249/08 ,  C07D231/12 ,  C07D231/54 ,  C07D233/56 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

Abstract: Compounds having the formula (I) (I), are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：EP0950057B1

公开(公告)日：2002-11-13

申请号：EP97952392.5

申请日：1997-12-10

Applicant: Abbott Laboratories

Inventor： HOLLADAY, Mark, W. ,  ARNERIC, Stephen, P. ,  BAI, Hao ,  DART, Michael, J. ,  LIN, Nan-Horng ,  LYNCH, John, K. ,  OR, Yat, Sun ,  RYTHER, Keith, B. ,  SULLIVAN, James, P. ,  WASICAK, James, T. ,  EHRLICH, Paul, P.

IPC: C07D401/12 ,  A61K31/44 ,  C07D205/04

CPC classification number: C07D401/12 ,  A61K31/4427 ,  A61K31/485 ,  C07D205/04 ,  Y02P20/55 ,  A61K2300/00

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：EP0970083A1

公开(公告)日：2000-01-12

申请号：EP98907359.8

申请日：1998-02-05

Applicant: Abbott Laboratories

Inventor： WASICAK, James, T. ,  GARVEY, David, S. ,  HOLLADAY, Mark, W. ,  LIN, Nan-Horng ,  RYTHER, Keith, B.

IPC: C07D487/04 ,  A61K31/44

CPC classification number: C07D487/04

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having formula (I), wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：EP0950057A1

公开(公告)日：1999-10-20

申请号：EP97952392.0

申请日：1997-12-10

Applicant: Abbott Laboratories

Inventor： HOLLADAY, Mark, W. ,  ARNERIC, Stephen, P. ,  BAI, Hao ,  DART, Michael, J. ,  LIN, Nan-Horng ,  LYNCH, John, K. ,  OR, Yat, Sun ,  RYTHER, Keith, B. ,  SULLIVAN, James, P. ,  WASICAK, James, T. ,  EHRLICH, Paul, P.

IPC: A61P25 ,  A61K31 ,  A61P29 ,  C07D205 ,  C07D401 ,  C07D405

CPC classification number: C07D401/12 ,  A61K31/4427 ,  A61K31/485 ,  C07D205/04 ,  Y02P20/55 ,  A61K2300/00

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：EP0717741A1

公开(公告)日：1996-06-26

申请号：EP94931741.0

申请日：1994-08-30

Applicant: ABBOTT LABORATORIES

Inventor： LIN, Nan-Horng ,  HE, Yun ,  ELLIOTT, Richard, L. ,  CHORGHADE, Mukund, S. ,  WITTENBERGER, Steven, J. ,  BUNNELLE, William, H. ,  NARAYANAN, Bikshandar, A. ,  SINGAM, Pulla R., Apartment 302 ,  ESCH, Thomas, K., J. ,  BEER, Dieter, O. ,  WITZIG, Christian, C. ,  HERZIG, Thomas, C. ,  RAO, Alla, V. Rama, Residence of Director

IPC: C07D413

CPC classification number: C07D413/04

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

公开(公告)号：EP0663912A1

公开(公告)日：1995-07-26

申请号：EP93923826.0

申请日：1993-10-08

Applicant: ABBOTT LABORATORIES

Inventor： ABREO, Melwyn A. ,  GUNN, David E. ,  LIN, Nan-Horng ,  ELLIOTT, Richard L. ,  GARVEY, David S. ,  LEBOLD, Suzanne A. ,  WASICAK, James T.

IPC: A61K31 ,  A61P25 ,  C07D401 ,  C07D403 ,  C07D411 ,  C07D417 ,  C07D471 ,  C07D487

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R2 are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.