公开(公告)号：JPH08325269A

公开(公告)日：1996-12-10

申请号：JP12778395

申请日：1995-05-26

Applicant: AGENCY IND SCIENCE TECHN

Inventor： OISHI AKIHIRO ,  TAGUCHI YOICHI ,  SHIBUYA ISAO ,  TSUCHIYA TORU

IPC: B01J3/00 ,  C07D491/048 ,  C07D493/04

Abstract: PURPOSE: To simply and efficiently obtain a β-thioloctam derivative useful as a physiologically active substance such as a penicillin-like antibiotic and as its synthetic intermediate by reacting dihydrofuran with an isothiocyanic acid ester which are easily available materials. CONSTITUTION: (A) An isothiocyanic acid ester of the formula: R-NCS (R is an alkyl, an aryl) and (B) 2,3-dihydrofuran preferably in a large excessive amount are subjected to an addition-cyclization reaction preferably under >=2000 atmospheric pressure (especially 2000-10000 atmospheric pressure) at 0-200 deg.C (especially 20-150 deg.C) usually for 1-50hrs. The reaction solvent includes an aliphatic hydrocarbon solvent, an alicyclic hydrocarbon solvent and an aromatic hydrocarbon solvent.

公开(公告)号：JPH0827148A

公开(公告)日：1996-01-30

申请号：JP16757694

申请日：1994-07-20

Applicant: AGENCY IND SCIENCE TECHN

Inventor： SHIBUYA ISAO ,  TSUCHIYA TORU ,  TAGUCHI YOICHI ,  OISHI AKIHIRO

IPC: G03C1/10 ,  A01N43/824 ,  C07D285/00 ,  C07D285/01 ,  C07D417/04 ,  C07D417/14

Abstract: PURPOSE:To readily obtain a dithiazolium salt in good yield and one pot under relatively mild conditions by reacting an N,N-di-substituted thiourea with isothiocyanate in the presence of a strong base and then acidifying and oxidizing the reactional product. CONSTITUTION:(A) An N,N-di-substituted thiourea of formula I (R and R are each an organic group) is reacted with (B) an isothiocyanate of the formula R -N=C=S (R is an organic group) in the presence of a strongly basic alkali metal (compound) such as sodium hydroxide and then, the reactional product solution is acidified and oxidized using an oxidizing agent, e.g. m- chloroperbenzoic acid or hydrogen hydroxide to provide the objective 1,2,4- dithiazolium salt of formula II (X is an acid radical).

公开(公告)号：JPH06220028A

公开(公告)日：1994-08-09

申请号：JP3139893

申请日：1993-01-27

Applicant: AGENCY IND SCIENCE TECHN ,  KONISHIROKU PHOTO IND

Inventor： YASUMOTO MASAHIKO ,  TAGUCHI YOICHI ,  TSUCHIYA TORU ,  TANAKA MARI

IPC: C07D263/56 ,  C07D277/22 ,  C07D277/64 ,  C07D293/10 ,  C09B57/00 ,  G03C1/08

Abstract: PURPOSE:To obtain a chalcogenite compound quaternary salt in high purity in a good yield, while suppressing side reactions, by reacting a compound such as naphthoxazole, naphthothiazole or benzothiazole with a sultone compound under a high pressure. CONSTITUTION:A compound of formula I [R1 is alkyl; R2-R4 are H, substituent; R5 is substituent; X is O, S, Ce, CR6R7, NR8 (R6-R8 are alkyl)] is reacted with a sultone compound under a high pressure of >=500 atmospheric pressure, especially >=2000 atmospheric pressure, to produce a compound of formula II (J is alkylene). Examples of the compound of formula I include 2- methylnaphtho[1,2-d]oxazole of formula III, 2-methylnaphtho[1,2-d]thiazole of material IV, and 2,4-dimethylbenzothiazole of formula V. The sultone compound is preferably 1,4-butane sultone. Examples of the compound of formula II include compounds of formulas VI-VIII. The quaternary salt of formula II is important as an intermediate for synthesizing photosensitive materials for photography, photosensitive dyestuffs, etc.

公开(公告)号：JPH04364178A

公开(公告)日：1992-12-16

申请号：JP7234591

申请日：1991-03-12

Applicant: AGENCY IND SCIENCE TECHN

Inventor： SHIBUYA ISAO ,  YONEMOTO KATSUMI ,  TSUCHIYA TORU ,  TAGUCHI YOICHI ,  YASUMOTO MASAHIKO

IPC: B01J27/122 ,  B01J27/25 ,  C07B61/00 ,  C07D327/04

Abstract: PURPOSE:To obtain the subject compound which is synthetic intermediate of sulfur-containing organic compounds such as medicines, agricultural chemicals, etc., without using toxic carbonyl sulfide gas by treating a di-substituted dithiocarbamic acid phenacylethyl with a specific soft metal salt. CONSTITUTION:A compound expressed by formula I (R is di-substituted amino; Ar is phenyl which may have a substituent group) is reacted with a salt of soft metal such as silver, copper (I) or mercury (II) (preferably a silver salt), preferably in an organic solvent such as alcohols in the presence of a strong acid to provide the objective compound expressed by formula II (X is silver radical).

公开(公告)号：JPH01230574A

公开(公告)日：1989-09-14

申请号：JP5719788

申请日：1988-03-10

Applicant: AGENCY IND SCIENCE TECHN

Inventor： TAGUCHI YOICHI ,  SHIBUYA ISAO ,  SUHARA YASUO

IPC: C07D339/06

Abstract: PURPOSE:To obtain the subject compound useful as a raw material for a dye for the dyeing of paper or pulp, in one step and high yield without using deadly poisonous phosgene, etc., by using easily available epoxide and carbon disulfide as raw materials and reacting the components in the presence of a base under high pressure. CONSTITUTION:The objective compound of formula II can be produced by reacting an epoxide of formula I (R is alkyl or aryl; R is alkyl or H) with carbon disulfide in the presence of a base (e.g., triethylamine or pyridine) under high pressure. The reaction pressure is preferably as high as possible and is usually 500-9,000kg/cm . The reaction is carried out at room temperature -120 deg.C for usually 5-50hr. The reaction solvent is hexane, benzene, etc., and the compound of formula I is used in an amount nearly equimolar to the amount of the carbon disulfide.